Objective To investigate the role of peffusion-weighted magnetic resonance imaging （MRI） in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride （ 1 ml/kg） was selectively in...Objective To investigate the role of peffusion-weighted magnetic resonance imaging （MRI） in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride （ 1 ml/kg） was selectively injected into fight or left hepatic artery of 12 dogs fortnightly. The half fiver into which carbon tetrachloride was injected was called as study side （SS）, while the other half fiver without carbon tetrachloride injection was called as study control side （SCS）. Conventional and peffusion-weighted MRI were performed in every 4 weeks. Via a 4F catheter, 5ml gadolinium diethylentriamine pentaaceti acid （Gd-DTPA） dilution was injected into superior mesenteric artery at the 5th scan. The signal intensity-thne curves of SS, SCS, and portal vein were completed in MR workstation. The maximal relative signal increase （ MRSI）, peak time （ tp）, and slope of the curves were measured. Results On conventional MR images, no abnormalities of externality and signal intensity were observed in both SS and SCS of fiver at each stage. The mean tp, MP, SI, and slope of intensity-time curves in normal fiver were 10. 56 seconds, 1.01, and 10. 23 arbitrary unit （au）/s, respectively. Three parameters of curves didn＇t show obvious change in SCS of fiver at every stage. Abnormal perfusion curves occurred in SS of fiver at the 12th week after the 1st injection. The abnormality of perfusion curve in SS was more and more serious as the times of injection increased. The mean tp, IVlRSI, and slope intensity-time curves in SS of fiver were 19.45 seconds, 0. 43, and 3. 60 au/s respectively at the 24th week. Conclusion Perfusion-weighted imaging can potentially provide information about portal peffusion of hepatic parenchyma, and to some degree, reflect the severity of cirrhosis.展开更多
The MnFe_(2) O_(4)/g-C_(3) N_(4)/diatomite composites(Mn/G/D) were prepared via a facile precipitation-calcination method in this study.The Mn/G/D possessed higher specific surface area,lower electron-hole pairs' ...The MnFe_(2) O_(4)/g-C_(3) N_(4)/diatomite composites(Mn/G/D) were prepared via a facile precipitation-calcination method in this study.The Mn/G/D possessed higher specific surface area,lower electron-hole pairs' recombination rate,as well as wider and stronger visible light absorption capacity.Since the synergistic effect between g-C_(3 )N_(4) and MnFe_(2) O_(4),the photogene rated electron could transfer from g-C3 N4 to MnFe_(2) O_(4),which could promote the migration of electrons as well as enhance the photocatalytic activity and peroxymonosulfate(PMS) activation efficiency.Mn/G/D-5% composite displayed the excellent degradation performance of bisphenol A(BPA) with the removal efficiency of 99.9% under PMS/Vis system,which was approximately 2.47 and 63.8 times as high as that of the Mn/G/D-5%/PMS and Mn/G/D-5%/Vis system,respectively.Moreover,negative electricity derived from diatomite surface also promoted the photogenerated carriers' migration,and the degradation rate constant was around 2.4 times higher than that of MnFe_(2) O_(4)/g-C_(3) N_(4)(Mn/G).In addition,quenching experiments showed that both radical pathway(h^(+),·OH,·O_(2)^(-)and SO_(4)·^(-)) and non-radical pathway(^(1) O_(2)) were responsible for the degradation of BPA.展开更多
The development of service industry has shaken off the bondage of geographical locations in the information age.Tianjin FTZ features financial leasing industry,Guangdong FTZ involves high-end financial service,while F...The development of service industry has shaken off the bondage of geographical locations in the information age.Tianjin FTZ features financial leasing industry,Guangdong FTZ involves high-end financial service,while Fujian FTZ focuses on trade financing cooperation with Taiwan.The scenario will probably develop towards homogeneity of financial services and competitions will shift to talent attraction and policy optimization.展开更多
china’s traditional manufacturing industries are facing a desperate situation after the government slashed import taxes on some consumer goods,including skincare products and western suits,by more than 50percent on a...china’s traditional manufacturing industries are facing a desperate situation after the government slashed import taxes on some consumer goods,including skincare products and western suits,by more than 50percent on average from June1.Ye tan,a financial commentator,believes it’s bound todeal a heavy blow to domestic manufacturers reliant on low- price strategies. Excerpts of her arguments follow：展开更多
A novel Ag/g-C_(3)N_(4)/kaolinite composite photocatalyst was fabricated for the first time through a two-step assembly strategy by employing in situ calcination and a photodeposition process.The synthesized Ag/g-C_(3...A novel Ag/g-C_(3)N_(4)/kaolinite composite photocatalyst was fabricated for the first time through a two-step assembly strategy by employing in situ calcination and a photodeposition process.The synthesized Ag/g-C_(3)N_(4)/kaolinite composite reached a higher degradation rate of ibuprofen(IBP)with a reaction rate constant of 0.0113 min^(-1) at an Ag content of 7% under visible-light irradiation,which was approximately 1.87 times that of the Ag/g-C_(3)N_(4) composite.Based on the physicochemical properties,the enhanced photocatalytic activity was attributed to the stronger adsorption property,wider photoresponse range and more efficient separation and transfer of electron-hole pairs.Furthermore,the incorporation of monodispersed Ag nanoparticles onto the g-C_(3)N_(4)/kaolinite sheets provided more reactive sites for the IBP degradation.In addition,according to the EPR study and trapping experiments,it was demonstrated that holes(h^(+))should be the key reactive species.A possible pathway of IBP degradation was also proposed based on the detected intermediates.Overall,the results of this work may facilitate the design of a novel visible-light-driven photocatalyst with a high efficiency that is derived from a natural mineral for environmental remediation.展开更多
Diatomite supported nano zero valent iron(n ZVI)catalyst(NDA)with complex network structure was prepared via a mild reduction precipitation method in this work.The pore structure and pore distribution of NDA can be re...Diatomite supported nano zero valent iron(n ZVI)catalyst(NDA)with complex network structure was prepared via a mild reduction precipitation method in this work.The pore structure and pore distribution of NDA can be regulated and controlled through adjusting the loading amount of n ZVI.In general,the nano three-dimensional network formed by n ZVI and diatomite channels greatly increase the specific surface area and pore volume of NDA,and further formed more active sites,which made NDA have better performance in activating PMS to degrade BPA than pure n ZVI.The pseudo-first-order reaction rate constant of 50-NDA(50%-n ZVI/diatomite)is almost 3 times higher than that of pure n ZVI.Besides,the electron paramagnetic resonance(EPR)and radical quenching experiments showed that the activation process was dominated by the sulfate radical(SO_(4)^(-))and hydroxyl radical(·OH)produced by Fe;oxidation.The generated electrons promote the self-decomposition of PMS to produce singlet oxygen(^(1)O_(2)),and then the valence state of iron changes to produce free radicals.In addition,the possible degradation pathway of BPA was inferred from the intermediate products identified by liquid chromatograph-mass spectrometer(LC-MS).This study provides a novel strategy for the design and preparation of three-dimensional composite catalysts derived from natural mineral.展开更多
Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumoursuppression, but whether its downregulation in cancers is associated with posttranslational regu...Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumoursuppression, but whether its downregulation in cancers is associated with posttranslational regulation remains unclear. Here, weobserved that HLTF was significantly downregulated in hepatocellular carcinoma (HCC) tissues and positively associated with thesurvival of HCC patients. Mechanistically, the decreased expression of HLTF in HCC was attributed to elevated β-TrCP-mediated ubiquitination and degradation. Knockdown of HLTF enhanced p62 transcriptional activity and mammalian target of rapamycin (mTOR)activation, leading to HCC tumourigenesis. Inhibition of mTOR effectively blocked β-TrCP overexpression- or HLTF knockdownmediated HCC tumourigenesis and metastasis. Furthermore, in clinical tissues, decreased HLTF expression was positively correlatedwith elevated expression of β-TrCP, p62, or p-mTOR in HCC patients. Overall, our data not only uncover new roles of HLTF in HCCcell proliferation and metastasis, but also reveal a novel posttranslational modification of HLTF by β-TrCP, indicating that theβ-TrCP/HLTF/p62/mTOR axis may be a new oncogenic driver involved in HCC development. This finding provides a potentialtherapeutic strategy for HCC patients by targeting the β-TrCP/HLTF/p62/mTOR axis.展开更多
China's traditional manufacturing industries have been cornered into a desperate situation-it's either change or die. The Ministry of Finance said in a statement on May 25 that China would slash import taxes ...China's traditional manufacturing industries have been cornered into a desperate situation-it's either change or die. The Ministry of Finance said in a statement on May 25 that China would slash import taxes on some consumer goods, including skincare products, Western-style suits, ankle-high boots and diapers, by more than 50 percent on average starting on June 1. The decision follows a statement by an executive meeting of the State Council on April 28 that it would look into reducing import tariffs on some consumer goods on a trial basis.展开更多
At the present time,China is in need of economic stimulus,a fact testified to by the struggling branches of some banks and the sluggish manufacturing industry.The country should no longer base its optimistic mood sole...At the present time,China is in need of economic stimulus,a fact testified to by the struggling branches of some banks and the sluggish manufacturing industry.The country should no longer base its optimistic mood solely on the explosive growth of the information technology（IT）and e-commerce industries.Without the upgrading of its manufacturing sector,展开更多
Due to China＇s latest moves to rein in property prices, the mainland stock exchange on March 4 saw plunges of stock prices in sectors like real estate, building materials, cement coal and steel. Without a doubt the r...Due to China＇s latest moves to rein in property prices, the mainland stock exchange on March 4 saw plunges of stock prices in sectors like real estate, building materials, cement coal and steel. Without a doubt the real estate sector still plays a predominant role in China＇s economy and investment market.展开更多
Some Chinese citizens are indisnant over the Volkswasen scandal, not because the company has published false emission data but because they and Volkswagen have the same imaginary enemy--the United States.
Sharp depreciation of the renminbi against the U.S. dollar will soon end. An official of the U,S. Department of the Treasury said the recent depreciation of the Chinese currency could raise ＂serious concerns＂ if it...Sharp depreciation of the renminbi against the U.S. dollar will soon end. An official of the U,S. Department of the Treasury said the recent depreciation of the Chinese currency could raise ＂serious concerns＂ if it signaled a policy shift away from allowing market-determined exchange rates.展开更多
文摘Objective To investigate the role of peffusion-weighted magnetic resonance imaging （MRI） in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride （ 1 ml/kg） was selectively injected into fight or left hepatic artery of 12 dogs fortnightly. The half fiver into which carbon tetrachloride was injected was called as study side （SS）, while the other half fiver without carbon tetrachloride injection was called as study control side （SCS）. Conventional and peffusion-weighted MRI were performed in every 4 weeks. Via a 4F catheter, 5ml gadolinium diethylentriamine pentaaceti acid （Gd-DTPA） dilution was injected into superior mesenteric artery at the 5th scan. The signal intensity-thne curves of SS, SCS, and portal vein were completed in MR workstation. The maximal relative signal increase （ MRSI）, peak time （ tp）, and slope of the curves were measured. Results On conventional MR images, no abnormalities of externality and signal intensity were observed in both SS and SCS of fiver at each stage. The mean tp, MP, SI, and slope of intensity-time curves in normal fiver were 10. 56 seconds, 1.01, and 10. 23 arbitrary unit （au）/s, respectively. Three parameters of curves didn＇t show obvious change in SCS of fiver at every stage. Abnormal perfusion curves occurred in SS of fiver at the 12th week after the 1st injection. The abnormality of perfusion curve in SS was more and more serious as the times of injection increased. The mean tp, IVlRSI, and slope intensity-time curves in SS of fiver were 19.45 seconds, 0. 43, and 3. 60 au/s respectively at the 24th week. Conclusion Perfusion-weighted imaging can potentially provide information about portal peffusion of hepatic parenchyma, and to some degree, reflect the severity of cirrhosis.
基金the financial support provided by the Beijing Natural Science Foundation (2202044)the Fok Ying Tung Education Foundation, China (171042)+1 种基金the National Postdoctoral Program for Innovative Talents (BX20190370)the Fundamental Research Funds for the Central Universities (2021JCCXHH04)。
文摘The MnFe_(2) O_(4)/g-C_(3) N_(4)/diatomite composites(Mn/G/D) were prepared via a facile precipitation-calcination method in this study.The Mn/G/D possessed higher specific surface area,lower electron-hole pairs' recombination rate,as well as wider and stronger visible light absorption capacity.Since the synergistic effect between g-C_(3 )N_(4) and MnFe_(2) O_(4),the photogene rated electron could transfer from g-C3 N4 to MnFe_(2) O_(4),which could promote the migration of electrons as well as enhance the photocatalytic activity and peroxymonosulfate(PMS) activation efficiency.Mn/G/D-5% composite displayed the excellent degradation performance of bisphenol A(BPA) with the removal efficiency of 99.9% under PMS/Vis system,which was approximately 2.47 and 63.8 times as high as that of the Mn/G/D-5%/PMS and Mn/G/D-5%/Vis system,respectively.Moreover,negative electricity derived from diatomite surface also promoted the photogenerated carriers' migration,and the degradation rate constant was around 2.4 times higher than that of MnFe_(2) O_(4)/g-C_(3) N_(4)(Mn/G).In addition,quenching experiments showed that both radical pathway(h^(+),·OH,·O_(2)^(-)and SO_(4)·^(-)) and non-radical pathway(^(1) O_(2)) were responsible for the degradation of BPA.
文摘The development of service industry has shaken off the bondage of geographical locations in the information age.Tianjin FTZ features financial leasing industry,Guangdong FTZ involves high-end financial service,while Fujian FTZ focuses on trade financing cooperation with Taiwan.The scenario will probably develop towards homogeneity of financial services and competitions will shift to talent attraction and policy optimization.
文摘china’s traditional manufacturing industries are facing a desperate situation after the government slashed import taxes on some consumer goods,including skincare products and western suits,by more than 50percent on average from June1.Ye tan,a financial commentator,believes it’s bound todeal a heavy blow to domestic manufacturers reliant on low- price strategies. Excerpts of her arguments follow：
基金the financial support provided by the Beijing Natural Science Foundation(2202044)the National Postdoctoral Program for Innovative Talents(BX20190370).
文摘A novel Ag/g-C_(3)N_(4)/kaolinite composite photocatalyst was fabricated for the first time through a two-step assembly strategy by employing in situ calcination and a photodeposition process.The synthesized Ag/g-C_(3)N_(4)/kaolinite composite reached a higher degradation rate of ibuprofen(IBP)with a reaction rate constant of 0.0113 min^(-1) at an Ag content of 7% under visible-light irradiation,which was approximately 1.87 times that of the Ag/g-C_(3)N_(4) composite.Based on the physicochemical properties,the enhanced photocatalytic activity was attributed to the stronger adsorption property,wider photoresponse range and more efficient separation and transfer of electron-hole pairs.Furthermore,the incorporation of monodispersed Ag nanoparticles onto the g-C_(3)N_(4)/kaolinite sheets provided more reactive sites for the IBP degradation.In addition,according to the EPR study and trapping experiments,it was demonstrated that holes(h^(+))should be the key reactive species.A possible pathway of IBP degradation was also proposed based on the detected intermediates.Overall,the results of this work may facilitate the design of a novel visible-light-driven photocatalyst with a high efficiency that is derived from a natural mineral for environmental remediation.
基金financially supported by the Beijing Natural Science Foundation(No.2202044)the National Postdoctoral Program for Innovative Talents(No.BX20190370)+1 种基金the China Postdoctoral Science Foundation(No.2020M680757)the Fundamental Research Funds for the Central Universities(No.2020YJSHH03)。
文摘Diatomite supported nano zero valent iron(n ZVI)catalyst(NDA)with complex network structure was prepared via a mild reduction precipitation method in this work.The pore structure and pore distribution of NDA can be regulated and controlled through adjusting the loading amount of n ZVI.In general,the nano three-dimensional network formed by n ZVI and diatomite channels greatly increase the specific surface area and pore volume of NDA,and further formed more active sites,which made NDA have better performance in activating PMS to degrade BPA than pure n ZVI.The pseudo-first-order reaction rate constant of 50-NDA(50%-n ZVI/diatomite)is almost 3 times higher than that of pure n ZVI.Besides,the electron paramagnetic resonance(EPR)and radical quenching experiments showed that the activation process was dominated by the sulfate radical(SO_(4)^(-))and hydroxyl radical(·OH)produced by Fe;oxidation.The generated electrons promote the self-decomposition of PMS to produce singlet oxygen(^(1)O_(2)),and then the valence state of iron changes to produce free radicals.In addition,the possible degradation pathway of BPA was inferred from the intermediate products identified by liquid chromatograph-mass spectrometer(LC-MS).This study provides a novel strategy for the design and preparation of three-dimensional composite catalysts derived from natural mineral.
基金supported by the Introduction of Special Funds for Talents from the Third Military Medical University(Army Medical University,4174C6)to C.-M.X.
文摘Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumoursuppression, but whether its downregulation in cancers is associated with posttranslational regulation remains unclear. Here, weobserved that HLTF was significantly downregulated in hepatocellular carcinoma (HCC) tissues and positively associated with thesurvival of HCC patients. Mechanistically, the decreased expression of HLTF in HCC was attributed to elevated β-TrCP-mediated ubiquitination and degradation. Knockdown of HLTF enhanced p62 transcriptional activity and mammalian target of rapamycin (mTOR)activation, leading to HCC tumourigenesis. Inhibition of mTOR effectively blocked β-TrCP overexpression- or HLTF knockdownmediated HCC tumourigenesis and metastasis. Furthermore, in clinical tissues, decreased HLTF expression was positively correlatedwith elevated expression of β-TrCP, p62, or p-mTOR in HCC patients. Overall, our data not only uncover new roles of HLTF in HCCcell proliferation and metastasis, but also reveal a novel posttranslational modification of HLTF by β-TrCP, indicating that theβ-TrCP/HLTF/p62/mTOR axis may be a new oncogenic driver involved in HCC development. This finding provides a potentialtherapeutic strategy for HCC patients by targeting the β-TrCP/HLTF/p62/mTOR axis.
文摘China's traditional manufacturing industries have been cornered into a desperate situation-it's either change or die. The Ministry of Finance said in a statement on May 25 that China would slash import taxes on some consumer goods, including skincare products, Western-style suits, ankle-high boots and diapers, by more than 50 percent on average starting on June 1. The decision follows a statement by an executive meeting of the State Council on April 28 that it would look into reducing import tariffs on some consumer goods on a trial basis.
文摘At the present time,China is in need of economic stimulus,a fact testified to by the struggling branches of some banks and the sluggish manufacturing industry.The country should no longer base its optimistic mood solely on the explosive growth of the information technology（IT）and e-commerce industries.Without the upgrading of its manufacturing sector,
文摘Due to China＇s latest moves to rein in property prices, the mainland stock exchange on March 4 saw plunges of stock prices in sectors like real estate, building materials, cement coal and steel. Without a doubt the real estate sector still plays a predominant role in China＇s economy and investment market.
文摘Some Chinese citizens are indisnant over the Volkswasen scandal, not because the company has published false emission data but because they and Volkswagen have the same imaginary enemy--the United States.
文摘Sharp depreciation of the renminbi against the U.S. dollar will soon end. An official of the U,S. Department of the Treasury said the recent depreciation of the Chinese currency could raise ＂serious concerns＂ if it signaled a policy shift away from allowing market-determined exchange rates.
