Dear Editor,Polycomb group(Pc G)proteins represent important roles in repressing gene expression throughout development.The Polycomb repressive complexes(PRCs)have been subdivided into two central protein complexes,PR...Dear Editor,Polycomb group(Pc G)proteins represent important roles in repressing gene expression throughout development.The Polycomb repressive complexes(PRCs)have been subdivided into two central protein complexes,PRC1 and PRC2.PRC1 catalyzes H2AK119ub and PRC2catalyzes H3K27me1/2/3(Fursova et al.,2019).PRC1 is further categorized as CBX-containing canonical PRC1(c PRC1)and RYBP/YAF2-containing variant PRC1(v PRC1)(Blackledge and Klose,2021).展开更多
In neurons and myocytes,selective ion channels in the plasma membrane play a pivotal role in transducing chemical or sensory stimuli into electrical signals,underpinning neural and cardiac functionality.Recent advance...In neurons and myocytes,selective ion channels in the plasma membrane play a pivotal role in transducing chemical or sensory stimuli into electrical signals,underpinning neural and cardiac functionality.Recent advancements in biomedical research have increasingly spotlighted the interaction between ion channels and electromagnetic fields,especially terahertz(THz)radiation.This review synthesizes current findings on the impact of THz radiation,known for its deep penetration and non-ionizing properties,on ion channel kinetics and membrane fluid dynamics.It is organized into three parts:the biophysical effects of THz exposure on cells,the specific modulation of ion channels by THz radiation,and the potential pathophysiological consequences of THz exposure.Understanding the biophysical mechanisms underlying these effects could lead to new therapeutic strategies for diseases.展开更多
基金supported by the National Natural Science Foundation of China(31925009,U21A20195)the National Key Research and Development Program of China(2021YFA1100300)。
文摘Dear Editor,Polycomb group(Pc G)proteins represent important roles in repressing gene expression throughout development.The Polycomb repressive complexes(PRCs)have been subdivided into two central protein complexes,PRC1 and PRC2.PRC1 catalyzes H2AK119ub and PRC2catalyzes H3K27me1/2/3(Fursova et al.,2019).PRC1 is further categorized as CBX-containing canonical PRC1(c PRC1)and RYBP/YAF2-containing variant PRC1(v PRC1)(Blackledge and Klose,2021).
基金support from the Science and Technology Innovation 2030-Brain Science and Brain-Inspired Intelligence Project(2021ZD0201301 and 2021ZD0200204)and STI2030-Major Projects(2021ZD0202500)the National Natural Science Foundation of China(U20A20221,32130044,T2241002,32200807)+1 种基金the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01 and 2021SHZDZX0103)ZJLab,Shanghai Municipal Science and Technology Committee of Shanghai outstanding academic leaders plan(21XD1400400,21XD1400100).
文摘In neurons and myocytes,selective ion channels in the plasma membrane play a pivotal role in transducing chemical or sensory stimuli into electrical signals,underpinning neural and cardiac functionality.Recent advancements in biomedical research have increasingly spotlighted the interaction between ion channels and electromagnetic fields,especially terahertz(THz)radiation.This review synthesizes current findings on the impact of THz radiation,known for its deep penetration and non-ionizing properties,on ion channel kinetics and membrane fluid dynamics.It is organized into three parts:the biophysical effects of THz exposure on cells,the specific modulation of ion channels by THz radiation,and the potential pathophysiological consequences of THz exposure.Understanding the biophysical mechanisms underlying these effects could lead to new therapeutic strategies for diseases.
