The Fundamentals of Combustion course is an important compulsory course for Energy and Power Engineering Majors under the background of carbon peaking.According to the characteristics of teaching and scientific resear...The Fundamentals of Combustion course is an important compulsory course for Energy and Power Engineering Majors under the background of carbon peaking.According to the characteristics of teaching and scientific research at present,combined with the characteristics of complexity,interdisciplinary and rapid technology update of this course,this paper discusses the teaching content and teaching design of this course to meet the needs of talents of production,teaching and research under the background of new engineering course.It proposes more applicable teaching methods and practical means to broaden students horizons,stimulate students autonomous learning momentum,master the professional knowledge application ability,and cultivate innovative and competitive engineering professionals to adapt to the new energy strategy.展开更多
[Objectives]To observe the effects of Cigu Xiaozhi Formula on miR-378a-3p expression and Hh signaling pathway in TGF-β1 induced and activated LX2 cells.[Methods]Cells were divided into control group,induction group,d...[Objectives]To observe the effects of Cigu Xiaozhi Formula on miR-378a-3p expression and Hh signaling pathway in TGF-β1 induced and activated LX2 cells.[Methods]Cells were divided into control group,induction group,drug-containing serum group,miR-378a-3p inhibitor group,and miR inhibitor NC group.CCK-8 method was used to detect the cell viability of each group,and flow cytometry was used to detect the apoptosis rate of each group.RT-qPCR was used to detect the expression of miR-378a-3p in each group s cells,and RT-qPCR and Western blot were used to detect mRNA and protein expression of Shh,Gli1,Gli2,Col-I,andα-SMA in each group s cells.[Results]Compared with the control group,the cell viability and expression of Shh,Gli1,Gli2,Col-I,andα-SMA mRNA and protein in induction group increased(P<0.01),while the expression of miR-378a-3p decreased(P<0.01).Compared with the induction group,the cell viability and expression of Shh,Gli1,Gli2,Col-I,α-SMA mRNA andα-SMA and Gli2 protein decreased in drug-containing serum group(P<0.05),while cell apoptosis rate and miR-378a-3p expression increased(P<0.01).In miR-378a-3p inhibitor group,cell viability and the expression of Shh,Gli1,Gli2,Col-I,α-SMA mRNA and Gli1,Gli2,α-SMA protein increased(P<0.05,P<0.01),while the apoptosis rate and miR-378a-3p expression decreased(P<0.05,P<0.01).[Conclusions]Cigu Xiaozhi Formula containing serum can upregulate miR-378a-3p expression and downregulate the expression of Gli2 andα-SMA in TGF-β1 induced LX2 cells,thereby inhibiting the activation of LX2 cells and exerting the effects of anti liver fibrosis.展开更多
There are two types of gold ore in Shibaqinghao gold deposit, mylonite ore and quartz vein ore. Pyrite accompanying with native gold in mylonite ore has Fe from 43.66 to 45.32 wt 96 and S from 52.64 to 53.55 wt%. It i...There are two types of gold ore in Shibaqinghao gold deposit, mylonite ore and quartz vein ore. Pyrite accompanying with native gold in mylonite ore has Fe from 43.66 to 45.32 wt 96 and S from 52.64 to 53.55 wt%. It is clear that this kind of pyrite is poor in both sulphur and iron. That means that the mylonite oremay be related to metamorphic water. Pyrite in the quartz vein ore has Fe from 44.38 to 45.30 wt% and S from 53.08 to 54.00 wt%. It means that this kind of pyrite is poor in iron but rich in sulphur, while the quartz vein ore may be related to magma water.展开更多
Objective:To study the effects of Shang Ke Jie Gu tablet on fracture healing in rabbits.Methods:40 New Zealand rabbits,half male and half female,were randomly divided into two groups:normal saline group(N group)and Sh...Objective:To study the effects of Shang Ke Jie Gu tablet on fracture healing in rabbits.Methods:40 New Zealand rabbits,half male and half female,were randomly divided into two groups:normal saline group(N group)and Shang Ke Jie Gu tablet group(S group).Each group consisted of 20 rabbits.Left radial fracture models in upper and middle sections were made in rabbits and then intra-gastric administration was given.Five rabbits in each group were killed on the 10 th,20^(th),30^(th) and 40^(th) day after surgery,left radius was taken to get an X-ray.The degree of healing was assessed by the evaluation criteria of Shanghai Orthopaedics Institute.Results:The degree of fracture healing in S group was higher in the comparison with that in N group.Conclusions:Shang Ke Jie Gu tablet might affect endochondral ossification during fracture healing of rabbits,and promote porosis and fracture healing.展开更多
The combination of flexible sensors and deep learning has attracted much attention as an efficient method for the recognition of human postures.In this paper,an in situ polymerized MXene/polypyrrole(PPy)composite is d...The combination of flexible sensors and deep learning has attracted much attention as an efficient method for the recognition of human postures.In this paper,an in situ polymerized MXene/polypyrrole(PPy)composite is dip-coated on a polydimethylsiloxane(PDMS)sponge to fabricate an MXene/PPy@PDMS(MPP)piezoresistive sensor.The sponge sensor achieves ultrahigh sensitivity(6.8925 kPa^(−1))at 0-15 kPa,a short response/recovery time(100/110 ms),excellent stability(5000 cycles)and wash resistance.The synergistic effect of PPy and MXene improves the performance of the composite materials and facilitates the transfer of electrons,making the MPP sponge at least five times more sensitive than sponges based on each of the individual single materials.The large-area conductive network allows the MPP sensor to maintain excellent electrical performance over a large-scale pressure range.The MPP sensor can detect a variety of human body activity signals,such as radial artery pulse and different joint movements.The detection and analysis of human motion data,which is assisted by convolutional neural network(CNN)deep learning algorithms,enable the recognition and judgment of 16 types of human postures.The MXene/PPy flexible pressure sensor based on a PDMS sponge has broad application prospects in human motion detection,intelligent sensing and wearable devices.展开更多
An accurate and reliable turbofan engine model which can describe its dynamic behavior within the full flight envelop and lifecycle plays a critical role in performance optimization, controller design and fault diagno...An accurate and reliable turbofan engine model which can describe its dynamic behavior within the full flight envelop and lifecycle plays a critical role in performance optimization, controller design and fault diagnosis. However, due to the performance differences caused by the tolerance of engine manufacturing and assembly, and performance degradation during continuously stringent environmental regulations, the model accuracy is severely reduced. In this paper, an adaptive modification method of turbofan engine nonlinear Component-Llevel Model(CLM) based on Long Short-Term Memory(LSTM) Neural Network(NN) and hybrid optimization algorithm is pro-posed. First, a dynamic compensator with a combined LSTM NN architecture is constructed to compensate for the initial error between the experimental data and CLM of a turbofan engine under health condition. Then, a sensitivity analysis approach based on the entropy coefficient and technique for order preference by similarity to an ideal solution integrated evaluation is developed to choose the unmeasurable health parameters to be adjusted. Finally, a parallel hybrid optimization algorithm is developed to complete the adaptive model modification when the performance degrades. The proposed method is verified on a military low-bypass twin-spool turbofan engine, and the experimental results show the effectiveness of the proposed method.展开更多
Dear Editor,Akabane disease is an arthropod-borne viral disease caused by the Akabane virus(AKAV)that can affect cattle,sheep,and goats.Inapparent infections in adults can lead months later to abortions,stillbirths,co...Dear Editor,Akabane disease is an arthropod-borne viral disease caused by the Akabane virus(AKAV)that can affect cattle,sheep,and goats.Inapparent infections in adults can lead months later to abortions,stillbirths,congenital defects,and death in newborns(Kurogi et al.,1976).Wild ruminants can also be affected,but abnormalities of the offspring in these species have not been reported.One report suggests that this virus can also cause clinical signs in pigs(Yanase et al.,2018).展开更多
Actuator faults can be critical in turbofan engines as they can lead to stall,surge,loss of thrust and failure of speed control.Thus,fault diagnosis of gas turbine actuators has attracted considerable attention,from b...Actuator faults can be critical in turbofan engines as they can lead to stall,surge,loss of thrust and failure of speed control.Thus,fault diagnosis of gas turbine actuators has attracted considerable attention,from both academia and industry.However,the extensive literature that exists on this topic does not address identifying the severity of actuator faults and focuses mainly on actuator fault detection and isolation.In addition,previous studies of actuator fault identification have not dealt with multiple concurrent faults in real time,especially when these are accompanied by sudden failures under dynamic conditions.This study develops component-level models for fault identification in four typical actuators used in high-bypass ratio turbofan engines under both dynamic and steady-state conditions and these are then integrated with the engine performance model developed by the authors.The research results reported here present a novel method of quantifying actuator faults using dynamic effect compensation.The maximum error for each actuator is less than0.06%and 0.07%,with average computational time of less than 0.0058 s and 0.0086 s for steady-state and transient cases,respectively.These results confirm that the proposed method can accurately and efficiently identify concurrent actuator fault for an engine operating under either transient or steady-state conditions,even in the case of a sudden malfunction.The research results emonstrate the potential benefit to emergency response capabilities by introducing this method of monitoring the health of aero engines.展开更多
基金Supported by Ideological and Political Teaching Reform Project of Yunnan Agricultural University in 2022(YAUKCSZJG0050)Ideological and Political Teaching Reform Project of Yunnan Agricultural University in 2023(YNAUKCSZJG2023045)First-class Course Construction Project of Yunnan Agricultural University in 2023(2023YLKC019).
文摘The Fundamentals of Combustion course is an important compulsory course for Energy and Power Engineering Majors under the background of carbon peaking.According to the characteristics of teaching and scientific research at present,combined with the characteristics of complexity,interdisciplinary and rapid technology update of this course,this paper discusses the teaching content and teaching design of this course to meet the needs of talents of production,teaching and research under the background of new engineering course.It proposes more applicable teaching methods and practical means to broaden students horizons,stimulate students autonomous learning momentum,master the professional knowledge application ability,and cultivate innovative and competitive engineering professionals to adapt to the new energy strategy.
基金Supported by Regional Fund Project of National Natural Science Foundation of China(81860821)Gansu Province Higher Education Innovation Ability Enhancement Project in 2019(2019B-104)Innovation and Entrepreneurship Fund for Graduate Students of Gansu University of Chinese Medicine(2022CX64).
文摘[Objectives]To observe the effects of Cigu Xiaozhi Formula on miR-378a-3p expression and Hh signaling pathway in TGF-β1 induced and activated LX2 cells.[Methods]Cells were divided into control group,induction group,drug-containing serum group,miR-378a-3p inhibitor group,and miR inhibitor NC group.CCK-8 method was used to detect the cell viability of each group,and flow cytometry was used to detect the apoptosis rate of each group.RT-qPCR was used to detect the expression of miR-378a-3p in each group s cells,and RT-qPCR and Western blot were used to detect mRNA and protein expression of Shh,Gli1,Gli2,Col-I,andα-SMA in each group s cells.[Results]Compared with the control group,the cell viability and expression of Shh,Gli1,Gli2,Col-I,andα-SMA mRNA and protein in induction group increased(P<0.01),while the expression of miR-378a-3p decreased(P<0.01).Compared with the induction group,the cell viability and expression of Shh,Gli1,Gli2,Col-I,α-SMA mRNA andα-SMA and Gli2 protein decreased in drug-containing serum group(P<0.05),while cell apoptosis rate and miR-378a-3p expression increased(P<0.01).In miR-378a-3p inhibitor group,cell viability and the expression of Shh,Gli1,Gli2,Col-I,α-SMA mRNA and Gli1,Gli2,α-SMA protein increased(P<0.05,P<0.01),while the apoptosis rate and miR-378a-3p expression decreased(P<0.05,P<0.01).[Conclusions]Cigu Xiaozhi Formula containing serum can upregulate miR-378a-3p expression and downregulate the expression of Gli2 andα-SMA in TGF-β1 induced LX2 cells,thereby inhibiting the activation of LX2 cells and exerting the effects of anti liver fibrosis.
文摘There are two types of gold ore in Shibaqinghao gold deposit, mylonite ore and quartz vein ore. Pyrite accompanying with native gold in mylonite ore has Fe from 43.66 to 45.32 wt 96 and S from 52.64 to 53.55 wt%. It is clear that this kind of pyrite is poor in both sulphur and iron. That means that the mylonite oremay be related to metamorphic water. Pyrite in the quartz vein ore has Fe from 44.38 to 45.30 wt% and S from 53.08 to 54.00 wt%. It means that this kind of pyrite is poor in iron but rich in sulphur, while the quartz vein ore may be related to magma water.
文摘Objective:To study the effects of Shang Ke Jie Gu tablet on fracture healing in rabbits.Methods:40 New Zealand rabbits,half male and half female,were randomly divided into two groups:normal saline group(N group)and Shang Ke Jie Gu tablet group(S group).Each group consisted of 20 rabbits.Left radial fracture models in upper and middle sections were made in rabbits and then intra-gastric administration was given.Five rabbits in each group were killed on the 10 th,20^(th),30^(th) and 40^(th) day after surgery,left radius was taken to get an X-ray.The degree of healing was assessed by the evaluation criteria of Shanghai Orthopaedics Institute.Results:The degree of fracture healing in S group was higher in the comparison with that in N group.Conclusions:Shang Ke Jie Gu tablet might affect endochondral ossification during fracture healing of rabbits,and promote porosis and fracture healing.
基金supported by the National Key R&D Program of China(2022YFB3205504)the National Natural Science Foundation of China(51777215)+2 种基金the Special Foundation of the Taishan Scholar Project(tsqn202211077)the Shandong Provincial Natural Science Foundation(ZR2023ME118)the Natural Science Foundation of Qingdao City(23-2-1-219-zyyd-jch).
文摘The combination of flexible sensors and deep learning has attracted much attention as an efficient method for the recognition of human postures.In this paper,an in situ polymerized MXene/polypyrrole(PPy)composite is dip-coated on a polydimethylsiloxane(PDMS)sponge to fabricate an MXene/PPy@PDMS(MPP)piezoresistive sensor.The sponge sensor achieves ultrahigh sensitivity(6.8925 kPa^(−1))at 0-15 kPa,a short response/recovery time(100/110 ms),excellent stability(5000 cycles)and wash resistance.The synergistic effect of PPy and MXene improves the performance of the composite materials and facilitates the transfer of electrons,making the MPP sponge at least five times more sensitive than sponges based on each of the individual single materials.The large-area conductive network allows the MPP sensor to maintain excellent electrical performance over a large-scale pressure range.The MPP sensor can detect a variety of human body activity signals,such as radial artery pulse and different joint movements.The detection and analysis of human motion data,which is assisted by convolutional neural network(CNN)deep learning algorithms,enable the recognition and judgment of 16 types of human postures.The MXene/PPy flexible pressure sensor based on a PDMS sponge has broad application prospects in human motion detection,intelligent sensing and wearable devices.
基金co-supported by the National Natural Science Foundation of China(Nos.61903061,61903059 and 61890925)Natural Science Foundation of Liaoning Province,China(No.2020-MS-098)+1 种基金Aeronautical Science Foundation of China(No.20200013063001)the Fundamental Research Funds for the Central Universities,China(No.DUT20JC22)。
文摘An accurate and reliable turbofan engine model which can describe its dynamic behavior within the full flight envelop and lifecycle plays a critical role in performance optimization, controller design and fault diagnosis. However, due to the performance differences caused by the tolerance of engine manufacturing and assembly, and performance degradation during continuously stringent environmental regulations, the model accuracy is severely reduced. In this paper, an adaptive modification method of turbofan engine nonlinear Component-Llevel Model(CLM) based on Long Short-Term Memory(LSTM) Neural Network(NN) and hybrid optimization algorithm is pro-posed. First, a dynamic compensator with a combined LSTM NN architecture is constructed to compensate for the initial error between the experimental data and CLM of a turbofan engine under health condition. Then, a sensitivity analysis approach based on the entropy coefficient and technique for order preference by similarity to an ideal solution integrated evaluation is developed to choose the unmeasurable health parameters to be adjusted. Finally, a parallel hybrid optimization algorithm is developed to complete the adaptive model modification when the performance degrades. The proposed method is verified on a military low-bypass twin-spool turbofan engine, and the experimental results show the effectiveness of the proposed method.
文摘Dear Editor,Akabane disease is an arthropod-borne viral disease caused by the Akabane virus(AKAV)that can affect cattle,sheep,and goats.Inapparent infections in adults can lead months later to abortions,stillbirths,congenital defects,and death in newborns(Kurogi et al.,1976).Wild ruminants can also be affected,but abnormalities of the offspring in these species have not been reported.One report suggests that this virus can also cause clinical signs in pigs(Yanase et al.,2018).
基金support by the National Natural Science Foundation of China(Grant No.52402520)。
文摘Actuator faults can be critical in turbofan engines as they can lead to stall,surge,loss of thrust and failure of speed control.Thus,fault diagnosis of gas turbine actuators has attracted considerable attention,from both academia and industry.However,the extensive literature that exists on this topic does not address identifying the severity of actuator faults and focuses mainly on actuator fault detection and isolation.In addition,previous studies of actuator fault identification have not dealt with multiple concurrent faults in real time,especially when these are accompanied by sudden failures under dynamic conditions.This study develops component-level models for fault identification in four typical actuators used in high-bypass ratio turbofan engines under both dynamic and steady-state conditions and these are then integrated with the engine performance model developed by the authors.The research results reported here present a novel method of quantifying actuator faults using dynamic effect compensation.The maximum error for each actuator is less than0.06%and 0.07%,with average computational time of less than 0.0058 s and 0.0086 s for steady-state and transient cases,respectively.These results confirm that the proposed method can accurately and efficiently identify concurrent actuator fault for an engine operating under either transient or steady-state conditions,even in the case of a sudden malfunction.The research results emonstrate the potential benefit to emergency response capabilities by introducing this method of monitoring the health of aero engines.
