The Missing Children Mobile GIS Mutual Assistance System of China (MCMAS) is a mobile service software based on mobile GIS platform software, and it is committed to providing the most convenient and efficient system o...The Missing Children Mobile GIS Mutual Assistance System of China (MCMAS) is a mobile service software based on mobile GIS platform software, and it is committed to providing the most convenient and efficient system of personally mutual tracing services for missing children family and society. Relying on collaborative utilization of location-based service technology, face image intelligent recognition technology, cloud computing technology, public big data sharing technology, and mobile GIS technology, the MCMAS has achieved prominent application effects since it was deployed. At present, the MCMAS is running soundly, and it has received and released the information about 1011 missing children from May 25, 2016 to May 25, 2017. In order to explore the geographical distribution features and the influencing factors of missing children, the data of missing children are used for spatial and visual analysis by the data mining and GIS technologies. At the same time, we have built the spatial thermodynamic diagram of the big data of China missing children. By comparing provinces and cities with a higher proportion of missing children, the results showed that: 1) The high proportion of missing children spatially concentrated in the eastern part of the China. 2) The number of missing children was significantly correlated with the population density and economic status of the city. Furthermore, the paper macro-levelly presents a basic basis for rescuing the missing children from two aspects: regionally spatial characteristics and influencing factors.展开更多
Due to the insufficient Cu^(+)accumulation,Cu^(+)efflux mechanism,and highly immunosuppressive tumor microenvironment(TME)in lung metastasis,the cuproptosis efficacy is limited.Herein,an inhalable nanodevice(CLDCu)is ...Due to the insufficient Cu^(+)accumulation,Cu^(+)efflux mechanism,and highly immunosuppressive tumor microenvironment(TME)in lung metastasis,the cuproptosis efficacy is limited.Herein,an inhalable nanodevice(CLDCu)is constructed to successfully overcome the drawbacks of cuproptosis.CLDCu consists of a Cu^(2+)-chitosan shell and low molecular weight heparin-tocopherol succinate(LMWH-TOS,LT)core with disulfiram(DSF)loading.The prepared CLDCu can be inhaled and accumulate in large amounts in lung lesions(63.6%)with 56.5 times higher than intravenous injection.Within tumor cells,the mild acidity triggers the co-release of DSF and Cu2+,thus generating bis(diethyldithiocarbamate)-copper(CuET)to block Cu^(+)efflux protein ATP7B and forming toxic Cu^(+),leading to enhanced cuproptosis.Meanwhile,the released chitosan cooperates with CLDCu-induced cuproptosis to activate stimulator of interferon genes(STING)pathway,which significantly potentiates dendritic cells(DCs)maturation,as wells as evokes innate and adaptive immunity.In lung metastatic mice model,CLDCu is found to induce cuproptosis and reverse the immunosuppressive TME by inhalation administration.Moreover,CLDCu combined with anti-programmed cell death protein ligand-1 antibody(aPD-L1)provokes stronger antitumor immunity.Therefore,nanomedicine that combines cuproptosis with STING activation is a novel strategy for tumor immunotherapy.展开更多
Addressing peripheral nerve defects remains a significant challenge in regenerative neurobiology.Autograftsemerged as the gold-standard management,however,are hindered by limited availability and potential neuromaform...Addressing peripheral nerve defects remains a significant challenge in regenerative neurobiology.Autograftsemerged as the gold-standard management,however,are hindered by limited availability and potential neuromaformation.Numerous recent studies report the potential of wireless electronic system for nerve defects repair.Unfortunately,few has met clinical needs for inadequate electrode precision,poor nerve entrapment andinsufficient bioactivity of the matrix material.Herein,we present an advanced wireless electrical nerve stimulator,based on water-responsive self-curling silk membrane with excellent bioabsorbable and biocompatibleproperties.We constructed a unique bilayer structure with an oriented pre-stretched inner layer and a generalsilk membrane as outer layer.After wetting,the simultaneous contraction of inner layer and expansion of outerlayer achieved controllable super-contraction from 2D flat surface to 3D structural reconfiguration.It enablesshape-adaptive wrapping to cover around nerves,overcomes the technical obstacle of preparing electrodes on theinner wall of the conduit,and prevents electrode breakage caused by material expansion in water.The use of forkcapacitor-like metal interface increases the contact points between the metal and the regenerating nerve,solvingthe challenge of inefficient and rough electrical stimulation methods in the past.Newly developed electronicstimulator is effective in restoring 10 mm rat sciatic nerve defects comparable to autologous grafts.The underlyingmechanism involves that electric stimulation enhances anterograde mitochondrial transport to matchenergy demands.This newly introduced device thereby demonstrated the potential as a viable and efficaciousalternative to autografts for enhancing peripheral nerve repair and functional recovery.展开更多
Bismuth-based electrocatalysts are promising candidates for electrochemical CO_(2)reduction to formate attributing to the accelerated formation of*OCHO intermediate,while the high-energy consumption remains a major ch...Bismuth-based electrocatalysts are promising candidates for electrochemical CO_(2)reduction to formate attributing to the accelerated formation of*OCHO intermediate,while the high-energy consumption remains a major challenge for practicability.Herein,we present the ultrathin Bi_(2)O_(2)CO_(3)nanosheets with abundant oxygen vacancy(Vo-BOC-NS)reconstructed from S,N-co-doped bismuth oxides that can act as durable electrocatalyst for CO_(2)-to-formate conversion with faradic efficiency(FEformate)of>95%,partial current density of 286 mA cm^(-2) with energy efficiency of 73.8%at-0.62 V(vs.RHE)and low overpotential of 200 mV in a flow electrolyzer.The theoretical calculations decipher that the oxygen vacancy can optimize*OCOH adsorption/desorption for the accelerated conversion kinetics.The pair-electrosynthesis tactic of formate co-production can enable a superior FE_(formate) of>90%at wide cell voltage of 2–3.3 V and total yield rate of 3742μmol cm^(-2)h^(-1)at 3.3 V,suggesting great potential for future industrialization.展开更多
A hybrid catalyst structure can provide abundant active sites and tailored electronic properties,but the major challenge lies in achieving delicate control over its composition and architecture to improve the catalyti...A hybrid catalyst structure can provide abundant active sites and tailored electronic properties,but the major challenge lies in achieving delicate control over its composition and architecture to improve the catalytic activity toward different electrochemical reactions simultaneously.Herein,we present the rational design of a magic hybrid structure with low Pt loading(5.90 wt%),composed of CoPt_(3)and CoPt nanoparticles supported on N-doped carbon(CoPt_(3)/CoPt⊂PLNC).Importantly,it shows superior multifunctional catalytic activity in alkaline conditions,requiring a low overpotential of 341 and 20 mV to achieve 10 mA cm^(−2)for the hydrazine oxidation reaction(HzOR)/hydrogen evolution reaction(HER),respectively,and it delivers a half-wave potential of 0.847 V for the oxygen reduction reaction(ORR).Theoretical calculations reveal that the metal-carbon hybrid modulates kinetic behavior and induces electron redistribution,achieving the energetic requirements for multiple electrocatalysis.We demonstrate sustainable H_(2)production utilizing solely the CoPt_(3)/CoPt⊂PLNC catalyst,without external electric power input,suggesting its inspiring practical utility.展开更多
文摘The Missing Children Mobile GIS Mutual Assistance System of China (MCMAS) is a mobile service software based on mobile GIS platform software, and it is committed to providing the most convenient and efficient system of personally mutual tracing services for missing children family and society. Relying on collaborative utilization of location-based service technology, face image intelligent recognition technology, cloud computing technology, public big data sharing technology, and mobile GIS technology, the MCMAS has achieved prominent application effects since it was deployed. At present, the MCMAS is running soundly, and it has received and released the information about 1011 missing children from May 25, 2016 to May 25, 2017. In order to explore the geographical distribution features and the influencing factors of missing children, the data of missing children are used for spatial and visual analysis by the data mining and GIS technologies. At the same time, we have built the spatial thermodynamic diagram of the big data of China missing children. By comparing provinces and cities with a higher proportion of missing children, the results showed that: 1) The high proportion of missing children spatially concentrated in the eastern part of the China. 2) The number of missing children was significantly correlated with the population density and economic status of the city. Furthermore, the paper macro-levelly presents a basic basis for rescuing the missing children from two aspects: regionally spatial characteristics and influencing factors.
基金funded by the Key R&D Programs of Shandong Province,China(Grant Nos.2018CXGC1411 and 2021CXGC010514).
文摘Due to the insufficient Cu^(+)accumulation,Cu^(+)efflux mechanism,and highly immunosuppressive tumor microenvironment(TME)in lung metastasis,the cuproptosis efficacy is limited.Herein,an inhalable nanodevice(CLDCu)is constructed to successfully overcome the drawbacks of cuproptosis.CLDCu consists of a Cu^(2+)-chitosan shell and low molecular weight heparin-tocopherol succinate(LMWH-TOS,LT)core with disulfiram(DSF)loading.The prepared CLDCu can be inhaled and accumulate in large amounts in lung lesions(63.6%)with 56.5 times higher than intravenous injection.Within tumor cells,the mild acidity triggers the co-release of DSF and Cu2+,thus generating bis(diethyldithiocarbamate)-copper(CuET)to block Cu^(+)efflux protein ATP7B and forming toxic Cu^(+),leading to enhanced cuproptosis.Meanwhile,the released chitosan cooperates with CLDCu-induced cuproptosis to activate stimulator of interferon genes(STING)pathway,which significantly potentiates dendritic cells(DCs)maturation,as wells as evokes innate and adaptive immunity.In lung metastatic mice model,CLDCu is found to induce cuproptosis and reverse the immunosuppressive TME by inhalation administration.Moreover,CLDCu combined with anti-programmed cell death protein ligand-1 antibody(aPD-L1)provokes stronger antitumor immunity.Therefore,nanomedicine that combines cuproptosis with STING activation is a novel strategy for tumor immunotherapy.
基金This work was partially funded by the Key R&D Programs of Shandong Province,China(Grant Nos.2018CXGC1411 and 2021CXGC010514).
文摘Cuproptosis shows enormous application prospects in lung metastasis treatment.However,the glycolysis,Cu^(+)efflux mechanisms,and insufficient lung drug accumulation severely restrict cuproptosis efficacy.Herein,an inhalable poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate)(OPDEA)-coated copper-based metal–organic framework encapsulating pyruvate dehydrogenase kinase 1 siRNA(siPDK)is constructed for mediating cuproptosis and subsequently promoting lung metastasis immunotherapy,namely OMP.After inhalation,OMP shows highly efficient lung accumulation and long-term retention,ascribing to the OPDEA-mediated pulmonary mucosa penetration.Within tumor cells,OMP is degraded to release Cu2+under acidic condition,which will be reduced to toxic Cu^(+)to induce cuproptosis under glutathione(GSH)regulation.Meanwhile,siPDK released from OMP inhibits intracellular glycolysis and adenosine-5ʹ-triphosphate(ATP)production,then blocking the Cu^(+)efflux protein ATP7B,thereby rendering tumor cells more sensitive to OMP-mediated cuproptosis.Moreover,OMP-mediated cuproptosis triggers immunogenic cell death(ICD)to promote dendritic cells(DCs)maturation and CD8^(+)T cells infiltration.Notably,OMP-induced cuproptosis up-regulates membrane-associated programmed cell death-ligand 1(PD-L1)expression and induces soluble PD-L1 secretion,and thus synergizes with anti-PD-L1 antibodies(aPD-L1)to reprogram immunosuppressive tumor microenvironment,finally yielding improved immunotherapy efficacy.Overall,OMP may serve as an efficient inhalable nanoplatform and afford preferable efficacy against lung metastasis through inducing cuproptosis and combining with aPD-L1.
基金supported by the National Natural Science Foundation of China(82172476,82172393).
文摘Addressing peripheral nerve defects remains a significant challenge in regenerative neurobiology.Autograftsemerged as the gold-standard management,however,are hindered by limited availability and potential neuromaformation.Numerous recent studies report the potential of wireless electronic system for nerve defects repair.Unfortunately,few has met clinical needs for inadequate electrode precision,poor nerve entrapment andinsufficient bioactivity of the matrix material.Herein,we present an advanced wireless electrical nerve stimulator,based on water-responsive self-curling silk membrane with excellent bioabsorbable and biocompatibleproperties.We constructed a unique bilayer structure with an oriented pre-stretched inner layer and a generalsilk membrane as outer layer.After wetting,the simultaneous contraction of inner layer and expansion of outerlayer achieved controllable super-contraction from 2D flat surface to 3D structural reconfiguration.It enablesshape-adaptive wrapping to cover around nerves,overcomes the technical obstacle of preparing electrodes on theinner wall of the conduit,and prevents electrode breakage caused by material expansion in water.The use of forkcapacitor-like metal interface increases the contact points between the metal and the regenerating nerve,solvingthe challenge of inefficient and rough electrical stimulation methods in the past.Newly developed electronicstimulator is effective in restoring 10 mm rat sciatic nerve defects comparable to autologous grafts.The underlyingmechanism involves that electric stimulation enhances anterograde mitochondrial transport to matchenergy demands.This newly introduced device thereby demonstrated the potential as a viable and efficaciousalternative to autografts for enhancing peripheral nerve repair and functional recovery.
基金Genqiang Zhang acknowledges the financial support from the National Natural Science Foundation of China(Grant No.52072359)the Recruitment Program of Global Experts and the Fundamental Research Funds for the Central Universities(WK2060000016).
文摘Bismuth-based electrocatalysts are promising candidates for electrochemical CO_(2)reduction to formate attributing to the accelerated formation of*OCHO intermediate,while the high-energy consumption remains a major challenge for practicability.Herein,we present the ultrathin Bi_(2)O_(2)CO_(3)nanosheets with abundant oxygen vacancy(Vo-BOC-NS)reconstructed from S,N-co-doped bismuth oxides that can act as durable electrocatalyst for CO_(2)-to-formate conversion with faradic efficiency(FEformate)of>95%,partial current density of 286 mA cm^(-2) with energy efficiency of 73.8%at-0.62 V(vs.RHE)and low overpotential of 200 mV in a flow electrolyzer.The theoretical calculations decipher that the oxygen vacancy can optimize*OCOH adsorption/desorption for the accelerated conversion kinetics.The pair-electrosynthesis tactic of formate co-production can enable a superior FE_(formate) of>90%at wide cell voltage of 2–3.3 V and total yield rate of 3742μmol cm^(-2)h^(-1)at 3.3 V,suggesting great potential for future industrialization.
基金G.Q.Zhang acknowledges the financial support from the National Natural Science Foundation of China(Grant No.52072359)the Recruitment Program of Global Experts and the Fundamental Research Funds for the Central Universities(WK2060000016)The numerical calculations in this paper have been done in the Supercomputing Center of University of Science and Technology of China and TianHe-2 at LvLiang Cloud Computing Center of China.W.T.W.acknowledges the Natural Science Foundation from science and technology department of Guizhou Province(Nos.QHPT[2017]5790-02).
文摘A hybrid catalyst structure can provide abundant active sites and tailored electronic properties,but the major challenge lies in achieving delicate control over its composition and architecture to improve the catalytic activity toward different electrochemical reactions simultaneously.Herein,we present the rational design of a magic hybrid structure with low Pt loading(5.90 wt%),composed of CoPt_(3)and CoPt nanoparticles supported on N-doped carbon(CoPt_(3)/CoPt⊂PLNC).Importantly,it shows superior multifunctional catalytic activity in alkaline conditions,requiring a low overpotential of 341 and 20 mV to achieve 10 mA cm^(−2)for the hydrazine oxidation reaction(HzOR)/hydrogen evolution reaction(HER),respectively,and it delivers a half-wave potential of 0.847 V for the oxygen reduction reaction(ORR).Theoretical calculations reveal that the metal-carbon hybrid modulates kinetic behavior and induces electron redistribution,achieving the energetic requirements for multiple electrocatalysis.We demonstrate sustainable H_(2)production utilizing solely the CoPt_(3)/CoPt⊂PLNC catalyst,without external electric power input,suggesting its inspiring practical utility.
