The Yunkai Area is located at the southern South China Block and is part of the Qinzhou Bay-Hangzhou Bay Metallogenic Belt, which is a famous polymetallic mineralization belt. The Xinhua Pb–Zn–(Ag)deposit is located...The Yunkai Area is located at the southern South China Block and is part of the Qinzhou Bay-Hangzhou Bay Metallogenic Belt, which is a famous polymetallic mineralization belt. The Xinhua Pb–Zn–(Ag)deposit is located in the western part of Yunkai Area, with an abundance of Pubei batholiths. Zircon U–Pb geochronology of Pubei batholiths shows that crystallization age ranges from 251.9 ± 2.2 to 244.3 ± 1.8 Ma, thus belonging to Indosinian orogeny. Geochemistry and Sr isotopic compositions of the Pubei batholiths show that it is derived from the partial melting of large scale crustal melting during the stage of exhumation and uplifting of the lower-middle crust. In addition, strontium isotope of sphalerite from the Xinhua Pb–Zn–(Ag) deposit, has limited ranges in ^(87)Rb/^(86)Sr and ^(87)Sr/^(86)Sr, ranging from 0.4077 to 1.0449, and 0.718720 to 0.725245, respectively. The initial ^(87)Sr/^(86)Sr ratios of sphalerite ranges between 0.718720 and 0.725245, which is higher than that of upper continental crust and lower than that of the Pubei batholiths, illustrating the fluid might be derived from the mixing of Pubei pluton and upper continental crust.展开更多
The orthogonal supersegment of the ultraslow-spreading Southwest Indian Ridge at 16°–25°E is characterized by significant along-axis variations of mantle potential temperature.A detailed analysis of multibe...The orthogonal supersegment of the ultraslow-spreading Southwest Indian Ridge at 16°–25°E is characterized by significant along-axis variations of mantle potential temperature.A detailed analysis of multibeam bathymetry,gravity,and magnetic data were performed to investigate its variations in magma supply and crustal accretion process.The results revealed distinct across-axis variations of magma supply.Specifically,the regionally averaged crustal thickness reduced systematically from around 7 Ma to the present,indicating a regionally decreasing magma supply.The crustal structure is asymmetric in regional scale between the conjugate ridge flanks,with the faster-spreading southern flank showing thinner crust and greater degree of tectonic extension.Geodynamic models of mantle melting suggested that the observed variations in axial crustal thickness and major element geochemistry can be adequately explained by an eastward decrease in mantle potential temperature of about40℃ beneath the ridge axis.In this work,a synthesized model was proposed to explain the axial variations of magma supply and ridge segmentation stabilities.The existence of large ridge-axis offsets may play important roles in controlling melt supply.Several large ridge-axis offsets in the eastern section(21°–25°E)caused sustained along-axis focusing of magma supply at the centers of eastern ridge segments,enabling quasi-stable segmentation.In contrast,the western section(16°–21°E),which lacks large ridge-axis offsets,is associated with unstable segmentation patterns.展开更多
Lipid homeostasis is crucial for growth and development of organisms.Several cytochrome P450 monooxygenases(CYPs)are involved in lipid metabolism.The function of Cyp3llal in the anterior midgut as a regulator of phosp...Lipid homeostasis is crucial for growth and development of organisms.Several cytochrome P450 monooxygenases(CYPs)are involved in lipid metabolism.The function of Cyp3llal in the anterior midgut as a regulator of phosphatidylethanolamine(PE)metabolism in Drosophila melanogaster has been demonstrated,as depletion of Cyp31lal caused larval growth arrest that was partially rescued by supplying PE.In this study,we investigated the role of CYP311A1 in wing morphogenesis in Drosophila.Using the GAL4-UAS system,Cyp31lal was selectively knocked down in the wing disc.A deformed wing phenotype was observed in flies with reduced Cyp31lal transcripts.BODIPY and oil red O staining revealed a reduction of neutral lipids in the wing disc after the depletion of Cyp31lal.In addition,we observed an enhanced sensitivity to Eosin Y penetration in the wings of Cyp31lal knocked-down flies.Moreover,the reduction of CYP311A1 function in developing wings does not affect cell proliferation and apoptosis,but entails disordered Phalloidin or Cadherin distribution,suggesting an abnormal cell morphology and cell cortex structure in wing epithelial cells.Taken together,our results suggest that Cyp3llal is needed for wing morphogenesis by participating in lipid assembly and cell homeostasis.展开更多
基金supported by grants by the National Natural Science Foundation of China (No.41272097)the China Geological Survey Project (No.12120114016601)+1 种基金the Special Fund for Basic Scientific Research of Central Colleges, China University of Geosciences (Wuhan) (No.CUG120702)the Teaching Laboratory Foundation of China University of Geosciences (Wuhan) (No.SKJ2013085,SKJ2014010)
文摘The Yunkai Area is located at the southern South China Block and is part of the Qinzhou Bay-Hangzhou Bay Metallogenic Belt, which is a famous polymetallic mineralization belt. The Xinhua Pb–Zn–(Ag)deposit is located in the western part of Yunkai Area, with an abundance of Pubei batholiths. Zircon U–Pb geochronology of Pubei batholiths shows that crystallization age ranges from 251.9 ± 2.2 to 244.3 ± 1.8 Ma, thus belonging to Indosinian orogeny. Geochemistry and Sr isotopic compositions of the Pubei batholiths show that it is derived from the partial melting of large scale crustal melting during the stage of exhumation and uplifting of the lower-middle crust. In addition, strontium isotope of sphalerite from the Xinhua Pb–Zn–(Ag) deposit, has limited ranges in ^(87)Rb/^(86)Sr and ^(87)Sr/^(86)Sr, ranging from 0.4077 to 1.0449, and 0.718720 to 0.725245, respectively. The initial ^(87)Sr/^(86)Sr ratios of sphalerite ranges between 0.718720 and 0.725245, which is higher than that of upper continental crust and lower than that of the Pubei batholiths, illustrating the fluid might be derived from the mixing of Pubei pluton and upper continental crust.
基金The Program of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)under contract No.GML2019ZD0205the National Natural Science Foundation of China under contract Nos 41890813,41976066,41976064,91858207,91958211 and 91628301+3 种基金the Program of Chinese Academy of Sciences under contract Nos Y4SL021001,QYZDY-SSW-DQC005 and133244KYSB20180029the National Key Research and Development Program of China under contract Nos 2018YFC0309800 and2018YFC0310105the Guangdong Basic and Applied Basic Research Foundation under contract No.2021A1515012227the Program of China Ocean Mineral Resources Research and Development Association under contract No.DY135-S2-1-04。
文摘The orthogonal supersegment of the ultraslow-spreading Southwest Indian Ridge at 16°–25°E is characterized by significant along-axis variations of mantle potential temperature.A detailed analysis of multibeam bathymetry,gravity,and magnetic data were performed to investigate its variations in magma supply and crustal accretion process.The results revealed distinct across-axis variations of magma supply.Specifically,the regionally averaged crustal thickness reduced systematically from around 7 Ma to the present,indicating a regionally decreasing magma supply.The crustal structure is asymmetric in regional scale between the conjugate ridge flanks,with the faster-spreading southern flank showing thinner crust and greater degree of tectonic extension.Geodynamic models of mantle melting suggested that the observed variations in axial crustal thickness and major element geochemistry can be adequately explained by an eastward decrease in mantle potential temperature of about40℃ beneath the ridge axis.In this work,a synthesized model was proposed to explain the axial variations of magma supply and ridge segmentation stabilities.The existence of large ridge-axis offsets may play important roles in controlling melt supply.Several large ridge-axis offsets in the eastern section(21°–25°E)caused sustained along-axis focusing of magma supply at the centers of eastern ridge segments,enabling quasi-stable segmentation.In contrast,the western section(16°–21°E),which lacks large ridge-axis offsets,is associated with unstable segmentation patterns.
基金supported by the National Natural Science Foundation of China(Grant No.3217050532170526)Natural Science Foundation of Shanxi Province(Grant No.20210302123473).
文摘Lipid homeostasis is crucial for growth and development of organisms.Several cytochrome P450 monooxygenases(CYPs)are involved in lipid metabolism.The function of Cyp3llal in the anterior midgut as a regulator of phosphatidylethanolamine(PE)metabolism in Drosophila melanogaster has been demonstrated,as depletion of Cyp31lal caused larval growth arrest that was partially rescued by supplying PE.In this study,we investigated the role of CYP311A1 in wing morphogenesis in Drosophila.Using the GAL4-UAS system,Cyp31lal was selectively knocked down in the wing disc.A deformed wing phenotype was observed in flies with reduced Cyp31lal transcripts.BODIPY and oil red O staining revealed a reduction of neutral lipids in the wing disc after the depletion of Cyp31lal.In addition,we observed an enhanced sensitivity to Eosin Y penetration in the wings of Cyp31lal knocked-down flies.Moreover,the reduction of CYP311A1 function in developing wings does not affect cell proliferation and apoptosis,but entails disordered Phalloidin or Cadherin distribution,suggesting an abnormal cell morphology and cell cortex structure in wing epithelial cells.Taken together,our results suggest that Cyp3llal is needed for wing morphogenesis by participating in lipid assembly and cell homeostasis.
