We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.Th...We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.The NMR spectra at low fields are consistent with a zigzag magnetic order,indicating a large easy-axis anisotropy.With the field applied along the c*axis,the NMR spectra confirm the existence of a 1/3-magnetization plateau phase between 5.1 T and 7.1 T.The transition from the zigzag order to the 1/3-magnetization plateau phase is also found to be a first-order type.A monotonic decrease of the spin gap is revealed in the 1/3-magnetization plateau phase,which reaches zero at a quantum critical field H_(C)≈8.35 T before entering the fully polarized phase.These data suggest the existence of exchange frustration in the system along with strong ferromagnetic interactions,hosting the possibility for Kitaev physics.Besides,well below the ordered phase,the 1/T_(1) at high fields shows either a level off or an enhancement upon cooling below 3 K,which suggests the existence of low-energy fluctuations.展开更多
Because of their large volume variation and inferior electrical conductivity,Mn_(3)O_(4)-based oxide anode materials have short cyclic lives and poor rate capability,which obstructs their development.In this study,we ...Because of their large volume variation and inferior electrical conductivity,Mn_(3)O_(4)-based oxide anode materials have short cyclic lives and poor rate capability,which obstructs their development.In this study,we successfully prepared a Mn_(3)O_(4)/N-doped honeycomb carbon composite using a smart and facile synthetic method.The Mn_(3)O_(4)nanopolyhedra are grown on N-doped honeycomb carbon,which evidently mitigates the volume change in the charging and discharging processes but also improves the electrochemical reaction kinetics.More importantly,the Mn-O-C bond in the Mn_(3)O_(4)/N-doped honeycomb carbon composite benefits electrochemical reversibility.These features of the Mn_(3)O_(4)/N-doped honeycomb carbon(NHC)composite are responsible for its superior electrochemical performance.When used for Li-ion batteries,the Mn_(3)O_(4)/N-doped honeycomb carbon anode exhibits a high reversible capacity of 598 mAh·g^(−1)after 350 cycles at 1 A·g^(−1).Even at 2 A·g^(−1),the Mn_(3)O_(4)/NHC anode still delivers a high capacity of 472 mAh·g^(−1).This work provides a new prospect for synthesizing and developing manganese-based oxide materials for energy storage.展开更多
This paper presents a dual-platform scanner for dental reconstruction based on a three-dimensional(3D)laser-scanning method.The scanner combines translation and rotation platforms to perform a holistic scanning.A hybr...This paper presents a dual-platform scanner for dental reconstruction based on a three-dimensional(3D)laser-scanning method.The scanner combines translation and rotation platforms to perform a holistic scanning.A hybrid calibration method for laser scanning is proposed to improve convenience and precision.This method includes an integrative method for data collection and a hybrid algorithm for data processing.The integrative method conveniently collects a substantial number of calibrating points with a stepped gauge and a pattern for both the translation and rotation scans.The hybrid algorithm,which consists of a basic model and a compensation network,achieves strong stability with a small degree of errors.The experiments verified the hybrid calibration method and the scanner application for the measurement of dental pieces.Two typical dental pieces were measured,and the experimental results demonstrated the validity of the measurement that was performed using the dual-platform scanner.This method is effective for the 3D reconstruction of dental pieces,as well as that of objects with irregular shapes in engineering fields.展开更多
The excessive deformation of deep-sea sediments caused by the vibration of the mining machine will adversely affect the efficiency and safety of mining.Combined with the deep-sea environment,the coupled thermo-hydro-m...The excessive deformation of deep-sea sediments caused by the vibration of the mining machine will adversely affect the efficiency and safety of mining.Combined with the deep-sea environment,the coupled thermo-hydro-mechanical problem for saturated porous deep-sea sediments subject to the vibration of the mining vehicle is investigated.Based on the Green-Lindsay(G-L)generalized thermoelastic theory and Darcy’s law,the model of thermo-hydro-mechanical dynamic responses for saturated porous deep-sea sediments under the vibration of the mining vehicle is established.We obtain the analytical solutions of non-dimensional vertical displacement,excess pore water pressure,vertical stress,temperature,and change in the volume fraction field with the normal mode analysis method,and depict them graphically.The normal mode analysis method uses the canonical coordinate transformation to solve the equation,which can quickly decouple the equation by ignoring the modal coupling effect on the basis of the canonical mode.The results indicate that the vibration frequency has obvious influence on the vertical displacement,excess pore water pressure,vertical stress,and change in volume fraction field.The loading amplitude has a great effect on the physical quantities in the foundation,and the changes of the physical quantities increase with the increase in loading amplitude.展开更多
The three-dimensional physical model of the randomly packed powder material irradiated by the laser beam was established,taking into account the transformation of the material phase,the melt spreading and the interact...The three-dimensional physical model of the randomly packed powder material irradiated by the laser beam was established,taking into account the transformation of the material phase,the melt spreading and the interaction of the free surface of the molten pool and the recoiling pressure caused by the material evaporation during the selective laser melting.Influence of the processing parameters on the thermal behavior,the material evaporation,the surface morphology and the densification behavior in the connection region of the molten pool and the substrate was studied.It was shown that the powder material underwent the transformation from the partial melting state to the complete melting state and finally to the overheating state with the applied laser energy density increasing from 167 J/mm^(3) to 417 J/mm^(3).Therefore,the solidified track ranged from the discontinuous tracks with the rough surface to the continuous tracks with residual porosities,then to the continuous and dense tracks and terminally to the fluctuated tracks with the increase in the laser energy density.Meanwhile,the laser energy effect depth was maintained the positive relationship with the laser energy density.The vortex velocity obtained in the free surface of the molten pool towards to the rear region in the opposite laser scan direction promoted the melt convection to the edge region of the molten pool as the laser energy density was higher than 277 J/mm^(3),demonstrating the efficient energy dissipation from the center of the irradiation region to the whole part of the molten pool and the attendant production of the sufficient melt volume.Therefore,the efficient spreading of the molten pool and the metallurgical bonding ability of the melt with the substrate was obtained at the optimized laser energy density of 277 J/mm^(3).However,the severe material evaporation would take place as the melt was overheated,resulting in the formation of the residual pores and poor surface quality.展开更多
Complicated tribological behavior occurs when human fingers touch and perceive the surfaces of objects.In this process,people use their exploration style with different conditions,such as contact load,sliding speed,sl...Complicated tribological behavior occurs when human fingers touch and perceive the surfaces of objects.In this process,people use their exploration style with different conditions,such as contact load,sliding speed,sliding direction,and angle of orientation between fingers and object surface consciously or unconsciously.This work addressed interlaboratory experimental devices for finger active and passive tactile friction analysis,showing two types of finger movement.In active sliding experiment,the participant slid their finger freely against the object surface,requiring the subject to control the motion conditions themselves.For passive sliding experiments,these motion conditions were adjusted by the device.Several analysis parameters,such as contact force,vibration acceleration signals,vibration magnitude,and fingerprint deformation were recorded simultaneously.Noticeable friction differences were observed when comparing active sliding and passive sliding.For passive sliding,stick-slip behavior occurred when sliding in the distal direction,evidenced by observing the friction force and the related deformation of the fingerprint ridges.The employed devices showed good repeatability and high reliability,which enriched the design of the experimental platform and provided guidance to the standardization research in the field of tactile friction.展开更多
Due to the influence of deep-sea environment,deep-sea sediments are usually heterogeneous,and their moduli of elasticity and density change as depth changes.Combined with the characteristics of deep-sea sediments,the ...Due to the influence of deep-sea environment,deep-sea sediments are usually heterogeneous,and their moduli of elasticity and density change as depth changes.Combined with the characteristics of deep-sea sediments,the thermo-hydro-mechanical coupling dynamic response model of heterogeneous saturated porous sediments can be established to study the influence of elastic modulus,density,frequency,and load amplitude changes on the model.Based on the Green-Lindsay generalized thermoelasticity theory and Darcy’s law,the thermo-hydro-mechanical coupled dynamic response model and governing equations of heterogeneous deep-sea sediments with nonlinear elastic modulus and density are established.The analytical solutions of dimensionless vertical displacement,vertical stress,excess pore water pressure,and temperature are obtained by means of normal modal analysis,which are depicted graphically.The results show that the changes of elastic modulus and density have few effects on vertical displacement,vertical stress,and temperature,but have great effects on excess pore water pressure.When the mining machine vibrates,the heterogeneity of deep-sea sediments has great influence on vertical displacement,vertical stress,and excess pore water pressure,but has few effects on temperature.In addition,the vertical displacement,vertical stress,and excess pore water pressure of heterogeneous deep-sea sediments change more gently.The variation trends of physical quantities for heterogeneous and homogeneous deep-sea sediments with frequency and load amplitude are basically the same.The results can provide theoretical guidance for deep-sea mining engineering construction.展开更多
The importance of geometrical control of three dimensional(3D)printable concrete without the support of formwork is widely acknowledged.In this study,a numerical model based on computational fluid dynamics was develop...The importance of geometrical control of three dimensional(3D)printable concrete without the support of formwork is widely acknowledged.In this study,a numerical model based on computational fluid dynamics was developed to evaluate the geometrical quality of a 3D printed layer.The numerical results were compared,using image analysis,with physical cross-sectional sawn samples.The influence of printing parameters(printing speed,nozzle height,and nozzle diameter)and the rheological behavior of printed materials(yield stress),on the geometrical quality of one printed layer was investigated.In addition,the yield zone of the printed layer was analyzed,giving insights on the critical factors for geometrical control in 3D concrete printing.Results indicated that the developed model can precisely describe the extrusion process,as well as the cross-sectional quality.展开更多
Non-alcoholic fatty liver disease(NAFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with NAFLD have the potential to progress to a more severe form of the condition k...Non-alcoholic fatty liver disease(NAFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with NAFLD have the potential to progress to a more severe form of the condition known as nonalcoholic steatohepatitis(NASH),accompanied by bridging fibrosis.This advancement is more likely if the patient has metabolic risk factors such as obesity or type 2 diabetes that deteriorate over time.Additionally,even slight inflammation or fibrosis in NAFLD can significantly increase the likelihood of progression compared to steatosis alone.This underscores the importance of revising the present methods of monitoring NAFLD patients to ensure early detection and effective management of the disease.展开更多
To the editor:Hearing loss is the most common sensory disorder.TSPEAR gene encodes thrombospondin-type laminin G domain and epilepsy-associated repeats containing protein.1 While,patients with variants in the TSPEAR g...To the editor:Hearing loss is the most common sensory disorder.TSPEAR gene encodes thrombospondin-type laminin G domain and epilepsy-associated repeats containing protein.1 While,patients with variants in the TSPEAR gene may present with different clinical phenotypes,including autosomal recessive nonsyndromic deafness(DFNB98,MIM614861);ectodermal dysplasia 14 of the hair/tooth type with or without hypohidrosis(ECTD14,MIM618180);or selective tooth agenesis-10(STHAG10,MIM 620173).2–5 Here,we report a patient diagnosed with congenital sensorineural hearing loss,and a total of three unreported variants were detected.展开更多
As the COVID-19 pandemic evolves and new variants emerge,the development of more efficient identification approaches of variants is urgent to prevent continuous outbreaks of SARS-CoV-2.Field-effect transistors(FETs)wi...As the COVID-19 pandemic evolves and new variants emerge,the development of more efficient identification approaches of variants is urgent to prevent continuous outbreaks of SARS-CoV-2.Field-effect transistors(FETs)with two-dimensional(2D)materials are viable platforms for the detection of virus nucleic acids(NAs)but cannot yet provide accurate information on NA variations.Herein,2D Indium selenide(InSe)FETs were used to identify SARSCoV-2 variants.The device's mobility and stability were ensured by atomic layer deposition(ALD)of Al_(2)O_(3).The resulting FETs exhibited sub-fM detection limits ranging from 10^(–14)M to 10^(–8)M.The recognition of single-nucleotide variations was achieved within 15 min to enable the fast and direct identification of two core mutations(L452R,R203M)in Delta genomes(p<0.01).Such capability originated from the trap states in oxidized InSe(InSe_(1-x)O_(x))after ALD,resulting in traps-involved carrier transport responsive to the negative charges of NAs.In sum,the proposed approach might highly provide epidemiological information for timely surveillance of the COVID pandemic.展开更多
基金Project supported by the National Key R&D Program of China (Grant Nos. 2023YFA1406500, 2022YFA1402700, and 2021YFA1400400)the National Natural Science Foundation of China (Grant Nos. 12134020, 12374156, 12104503,12061131004, 12225407, and 12074174)。
文摘We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.The NMR spectra at low fields are consistent with a zigzag magnetic order,indicating a large easy-axis anisotropy.With the field applied along the c*axis,the NMR spectra confirm the existence of a 1/3-magnetization plateau phase between 5.1 T and 7.1 T.The transition from the zigzag order to the 1/3-magnetization plateau phase is also found to be a first-order type.A monotonic decrease of the spin gap is revealed in the 1/3-magnetization plateau phase,which reaches zero at a quantum critical field H_(C)≈8.35 T before entering the fully polarized phase.These data suggest the existence of exchange frustration in the system along with strong ferromagnetic interactions,hosting the possibility for Kitaev physics.Besides,well below the ordered phase,the 1/T_(1) at high fields shows either a level off or an enhancement upon cooling below 3 K,which suggests the existence of low-energy fluctuations.
基金financially supported by the Natural Science Foundation of Henan Province of China(No.222300420252)Nanyang Normal University(Nos.2020ZX013 and 2020ZX014).
文摘Because of their large volume variation and inferior electrical conductivity,Mn_(3)O_(4)-based oxide anode materials have short cyclic lives and poor rate capability,which obstructs their development.In this study,we successfully prepared a Mn_(3)O_(4)/N-doped honeycomb carbon composite using a smart and facile synthetic method.The Mn_(3)O_(4)nanopolyhedra are grown on N-doped honeycomb carbon,which evidently mitigates the volume change in the charging and discharging processes but also improves the electrochemical reaction kinetics.More importantly,the Mn-O-C bond in the Mn_(3)O_(4)/N-doped honeycomb carbon composite benefits electrochemical reversibility.These features of the Mn_(3)O_(4)/N-doped honeycomb carbon(NHC)composite are responsible for its superior electrochemical performance.When used for Li-ion batteries,the Mn_(3)O_(4)/N-doped honeycomb carbon anode exhibits a high reversible capacity of 598 mAh·g^(−1)after 350 cycles at 1 A·g^(−1).Even at 2 A·g^(−1),the Mn_(3)O_(4)/NHC anode still delivers a high capacity of 472 mAh·g^(−1).This work provides a new prospect for synthesizing and developing manganese-based oxide materials for energy storage.
基金the National Science Fund for Excellent Young Scholars(51722509)the National Natural Science Foundation of China(51575440)+1 种基金the National Key R&D Program of China(2017YFB1104700)the Shaanxi Science and Technology Project(2016GY-011)。
文摘This paper presents a dual-platform scanner for dental reconstruction based on a three-dimensional(3D)laser-scanning method.The scanner combines translation and rotation platforms to perform a holistic scanning.A hybrid calibration method for laser scanning is proposed to improve convenience and precision.This method includes an integrative method for data collection and a hybrid algorithm for data processing.The integrative method conveniently collects a substantial number of calibrating points with a stepped gauge and a pattern for both the translation and rotation scans.The hybrid algorithm,which consists of a basic model and a compensation network,achieves strong stability with a small degree of errors.The experiments verified the hybrid calibration method and the scanner application for the measurement of dental pieces.Two typical dental pieces were measured,and the experimental results demonstrated the validity of the measurement that was performed using the dual-platform scanner.This method is effective for the 3D reconstruction of dental pieces,as well as that of objects with irregular shapes in engineering fields.
基金the National Natural Science Foundation of China(No.12072309)the Youth Fund Foundation of Education Bureau of Hunan Province of China(No.19B546)the High-Level Talent Gathering Project in Hunan Province of China(No.2019RS1059)。
文摘The excessive deformation of deep-sea sediments caused by the vibration of the mining machine will adversely affect the efficiency and safety of mining.Combined with the deep-sea environment,the coupled thermo-hydro-mechanical problem for saturated porous deep-sea sediments subject to the vibration of the mining vehicle is investigated.Based on the Green-Lindsay(G-L)generalized thermoelastic theory and Darcy’s law,the model of thermo-hydro-mechanical dynamic responses for saturated porous deep-sea sediments under the vibration of the mining vehicle is established.We obtain the analytical solutions of non-dimensional vertical displacement,excess pore water pressure,vertical stress,temperature,and change in the volume fraction field with the normal mode analysis method,and depict them graphically.The normal mode analysis method uses the canonical coordinate transformation to solve the equation,which can quickly decouple the equation by ignoring the modal coupling effect on the basis of the canonical mode.The results indicate that the vibration frequency has obvious influence on the vertical displacement,excess pore water pressure,vertical stress,and change in volume fraction field.The loading amplitude has a great effect on the physical quantities in the foundation,and the changes of the physical quantities increase with the increase in loading amplitude.
基金We are grateful for the financial support from the National Key Research and Development Program“Additive Manufacturing and Laser Manufacturing”(Nos.2016YFB1100101,2018YFB1106302)the National Natural Science Foundation of China(Nos.51790175,51735005)+3 种基金the Fundamental Research Funds for the Central Universities(No.NC2020004),the financial support from the Innovation Fund of National Engineering and Research Center for Commercial Aircraft Manufacturing(No.COMAC-SFGS-2016-33238)National Natural Science Foundation of China for Creative Research Groups(Grant No.51921003)The 15th Batch of“Six Talents Peaks”Innovative Talents Team Program“Laser Precise Additive Manufacturing of Structure-Performance Integrated Lightweight Alloy Components”(No.TD-GDZB-001)(Jiangsu Provincial Department of Human Resources and Social Security of China)2017 Excellent Scientific and Technological Innovation Teams of Universities in Jiangsu“Laser Additive Manufacturing Technologies for Metallic Components”(Jiangsu Provincial Department of Education of China).
文摘The three-dimensional physical model of the randomly packed powder material irradiated by the laser beam was established,taking into account the transformation of the material phase,the melt spreading and the interaction of the free surface of the molten pool and the recoiling pressure caused by the material evaporation during the selective laser melting.Influence of the processing parameters on the thermal behavior,the material evaporation,the surface morphology and the densification behavior in the connection region of the molten pool and the substrate was studied.It was shown that the powder material underwent the transformation from the partial melting state to the complete melting state and finally to the overheating state with the applied laser energy density increasing from 167 J/mm^(3) to 417 J/mm^(3).Therefore,the solidified track ranged from the discontinuous tracks with the rough surface to the continuous tracks with residual porosities,then to the continuous and dense tracks and terminally to the fluctuated tracks with the increase in the laser energy density.Meanwhile,the laser energy effect depth was maintained the positive relationship with the laser energy density.The vortex velocity obtained in the free surface of the molten pool towards to the rear region in the opposite laser scan direction promoted the melt convection to the edge region of the molten pool as the laser energy density was higher than 277 J/mm^(3),demonstrating the efficient energy dissipation from the center of the irradiation region to the whole part of the molten pool and the attendant production of the sufficient melt volume.Therefore,the efficient spreading of the molten pool and the metallurgical bonding ability of the melt with the substrate was obtained at the optimized laser energy density of 277 J/mm^(3).However,the severe material evaporation would take place as the melt was overheated,resulting in the formation of the residual pores and poor surface quality.
基金Supported by the China Scholarship Council (Grant No.201907000020)the 111 Project (Grant No.B20008)。
文摘Complicated tribological behavior occurs when human fingers touch and perceive the surfaces of objects.In this process,people use their exploration style with different conditions,such as contact load,sliding speed,sliding direction,and angle of orientation between fingers and object surface consciously or unconsciously.This work addressed interlaboratory experimental devices for finger active and passive tactile friction analysis,showing two types of finger movement.In active sliding experiment,the participant slid their finger freely against the object surface,requiring the subject to control the motion conditions themselves.For passive sliding experiments,these motion conditions were adjusted by the device.Several analysis parameters,such as contact force,vibration acceleration signals,vibration magnitude,and fingerprint deformation were recorded simultaneously.Noticeable friction differences were observed when comparing active sliding and passive sliding.For passive sliding,stick-slip behavior occurred when sliding in the distal direction,evidenced by observing the friction force and the related deformation of the fingerprint ridges.The employed devices showed good repeatability and high reliability,which enriched the design of the experimental platform and provided guidance to the standardization research in the field of tactile friction.
基金Project supported by the National Natural Science Foundation of China(Nos.12072309,61603322)。
文摘Due to the influence of deep-sea environment,deep-sea sediments are usually heterogeneous,and their moduli of elasticity and density change as depth changes.Combined with the characteristics of deep-sea sediments,the thermo-hydro-mechanical coupling dynamic response model of heterogeneous saturated porous sediments can be established to study the influence of elastic modulus,density,frequency,and load amplitude changes on the model.Based on the Green-Lindsay generalized thermoelasticity theory and Darcy’s law,the thermo-hydro-mechanical coupled dynamic response model and governing equations of heterogeneous deep-sea sediments with nonlinear elastic modulus and density are established.The analytical solutions of dimensionless vertical displacement,vertical stress,excess pore water pressure,and temperature are obtained by means of normal modal analysis,which are depicted graphically.The results show that the changes of elastic modulus and density have few effects on vertical displacement,vertical stress,and temperature,but have great effects on excess pore water pressure.When the mining machine vibrates,the heterogeneity of deep-sea sediments has great influence on vertical displacement,vertical stress,and excess pore water pressure,but has few effects on temperature.In addition,the vertical displacement,vertical stress,and excess pore water pressure of heterogeneous deep-sea sediments change more gently.The variation trends of physical quantities for heterogeneous and homogeneous deep-sea sediments with frequency and load amplitude are basically the same.The results can provide theoretical guidance for deep-sea mining engineering construction.
基金the National Natural Science Foundation of China(Grant No.52008224)the Open Fund of innovation institute for Sustainable Maritime Architecture Research and Technology(iSMART),Qingdao University of Technology(No.2020-031)+1 种基金the Key Technology Research and Development Program of Shandong(No.2019GSF110004)the financial support received from the Industrial Research Fund(IOF.PRO.2022.0010.01)from Ghent University.
文摘The importance of geometrical control of three dimensional(3D)printable concrete without the support of formwork is widely acknowledged.In this study,a numerical model based on computational fluid dynamics was developed to evaluate the geometrical quality of a 3D printed layer.The numerical results were compared,using image analysis,with physical cross-sectional sawn samples.The influence of printing parameters(printing speed,nozzle height,and nozzle diameter)and the rheological behavior of printed materials(yield stress),on the geometrical quality of one printed layer was investigated.In addition,the yield zone of the printed layer was analyzed,giving insights on the critical factors for geometrical control in 3D concrete printing.Results indicated that the developed model can precisely describe the extrusion process,as well as the cross-sectional quality.
基金supported by a Three-year action plan for Shanghai(ZY(2021-2023)-0211)National Natural Science Foundation of China(No.81973730)+4 种基金Local Colleges Faculty Constitution of Shanghai MSTC 2022(No.22010504300)Shanghai Collaborative Innovation Center for Chronic Disease Prevention and Health Services(2021 Science and Technology 02-37)China Postdoctoral Science Foundation,No.72 General Fund,2022(No.2022M722164)Shanghai 2023"Science and Technology Innovation Action Plan"Qi Ming Xing Cultivation(Yang Fan Project,No.23YF1447700)Shanghai Health Commission for Traditional Chinese Medicine Research(No.2022QN014).
文摘Non-alcoholic fatty liver disease(NAFLD)is a liver condition that is widely prevalent across the world.A considerable number of people with NAFLD have the potential to progress to a more severe form of the condition known as nonalcoholic steatohepatitis(NASH),accompanied by bridging fibrosis.This advancement is more likely if the patient has metabolic risk factors such as obesity or type 2 diabetes that deteriorate over time.Additionally,even slight inflammation or fibrosis in NAFLD can significantly increase the likelihood of progression compared to steatosis alone.This underscores the importance of revising the present methods of monitoring NAFLD patients to ensure early detection and effective management of the disease.
基金funded by the Innovative Research Groups of Hubei Province(No.2023AFA038)the National Key Research and Development Program of China(No.2021YFF0702303,2023YFE0203200)the National Natural Science Foundation of China(No.82071058)
文摘To the editor:Hearing loss is the most common sensory disorder.TSPEAR gene encodes thrombospondin-type laminin G domain and epilepsy-associated repeats containing protein.1 While,patients with variants in the TSPEAR gene may present with different clinical phenotypes,including autosomal recessive nonsyndromic deafness(DFNB98,MIM614861);ectodermal dysplasia 14 of the hair/tooth type with or without hypohidrosis(ECTD14,MIM618180);or selective tooth agenesis-10(STHAG10,MIM 620173).2–5 Here,we report a patient diagnosed with congenital sensorineural hearing loss,and a total of three unreported variants were detected.
基金This work was financially supported by the National Natural Science Foundation of China(92064007,62001224,52131304)the Natural Science Foundation of Jiangsu Province(BK20190476,BK20190457,BZ2020063)the 69th batch of China Postdoctoral Science Foundation(2021M691600).
文摘As the COVID-19 pandemic evolves and new variants emerge,the development of more efficient identification approaches of variants is urgent to prevent continuous outbreaks of SARS-CoV-2.Field-effect transistors(FETs)with two-dimensional(2D)materials are viable platforms for the detection of virus nucleic acids(NAs)but cannot yet provide accurate information on NA variations.Herein,2D Indium selenide(InSe)FETs were used to identify SARSCoV-2 variants.The device's mobility and stability were ensured by atomic layer deposition(ALD)of Al_(2)O_(3).The resulting FETs exhibited sub-fM detection limits ranging from 10^(–14)M to 10^(–8)M.The recognition of single-nucleotide variations was achieved within 15 min to enable the fast and direct identification of two core mutations(L452R,R203M)in Delta genomes(p<0.01).Such capability originated from the trap states in oxidized InSe(InSe_(1-x)O_(x))after ALD,resulting in traps-involved carrier transport responsive to the negative charges of NAs.In sum,the proposed approach might highly provide epidemiological information for timely surveillance of the COVID pandemic.
