脑卒中是全球范围内致残致死的重要因素,偏瘫是其主要临床症状,下肢运动功能障碍是最常见的并发症之一,严重影响患者的步行能力及日常生活活动能力,给社会经济和个人健康带来了巨大负担。如何有效促进脑卒中后患者的下肢功能康复,是临...脑卒中是全球范围内致残致死的重要因素,偏瘫是其主要临床症状,下肢运动功能障碍是最常见的并发症之一,严重影响患者的步行能力及日常生活活动能力,给社会经济和个人健康带来了巨大负担。如何有效促进脑卒中后患者的下肢功能康复,是临床康复需解决的难题。重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)作为一种无创、无痛的神经调控技术,近年来成为改善脑卒中患者肢体功能障碍新的补充手段,广泛应用于脑卒中后运动功能障碍的恢复并取得了较好成效。本综述主要总结了TMS、rTMS及其不同刺激模式、双侧脑部rTMS及个体化靶向TMS在脑卒中患者下肢康复中的应用,以期为相关研究和临床应用提供参考。展开更多
A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibit...A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.展开更多
文摘脑卒中是全球范围内致残致死的重要因素,偏瘫是其主要临床症状,下肢运动功能障碍是最常见的并发症之一,严重影响患者的步行能力及日常生活活动能力,给社会经济和个人健康带来了巨大负担。如何有效促进脑卒中后患者的下肢功能康复,是临床康复需解决的难题。重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)作为一种无创、无痛的神经调控技术,近年来成为改善脑卒中患者肢体功能障碍新的补充手段,广泛应用于脑卒中后运动功能障碍的恢复并取得了较好成效。本综述主要总结了TMS、rTMS及其不同刺激模式、双侧脑部rTMS及个体化靶向TMS在脑卒中患者下肢康复中的应用,以期为相关研究和临床应用提供参考。
文摘A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.
