Objective:To assess the feasibility of single-port transperitoneal robotic-assisted laparoscopic radical prostatectomy(spRALP)and discuss its surgical technique.Methods:A 60-year-old male was admitted with an elevated...Objective:To assess the feasibility of single-port transperitoneal robotic-assisted laparoscopic radical prostatectomy(spRALP)and discuss its surgical technique.Methods:A 60-year-old male was admitted with an elevated prostate-specific antigen(PSA)level of 13.89 ng/mL and confirmed with prostate cancer on biopsy showing three of 22 positive cores with a Gleason score of 3þ4=7.Multiparametric magnetic resonance(MR)and bone scintigraphy showed organ-confined disease.spRALP was performed using da Vinci Si HD surgical system,with access of a quadri-channel laparoscopic port placed supraumbilically.Two drainage tubes were placed before wound closure.The surgical procedure was largely in consistence with a conventional robotic-assisted laparoscopic radical prostatectomy.Results:The surgery was successfully carried out with a duration of 152 min and an estimated blood loss of 100 mL.The patient was discharged on postoperative Day 4 after removal of both pelvic drainage tubes.Foley catheter was removed on postoperative Day 14.No major complications were encountered.Postoperative pathology showed a Gleason score of 3þ4=7 with no extraprostatic extension and negative surgical margins.Conclusion:Single-port robotic prostatectomy is feasible using the currently available robotic instruments in most Chinese robotic urological centers.Meticulous preoperative planning and careful patient selection are mandatory.Further studies concerning perioperative complications and pentafecta outcome compared with the conventional multi-port robotic prostatectomy is required.展开更多
The integrated energy system(IES)is an important energy supply method for mitigating the energy crisis.A station-and-network–coordinated planning method for the IES,which considers the integrated demand responses(IDR...The integrated energy system(IES)is an important energy supply method for mitigating the energy crisis.A station-and-network–coordinated planning method for the IES,which considers the integrated demand responses(IDRs)of flexible loads,electric vehicles,and energy storage is proposed in this work.First,based on load substitution at the user side,an energy-station model considering the IDR is established.Then,based on the characteristics of the energy network,a collaborative planning model is established for the energy station and energy network of the IES,considering the comprehensive system investment,operation and maintenance,and clean energy shortage penalty costs,to minimize the total cost.This can help optimize the locations of the power lines and natural gas pipelines and the capacities of the equipment in an energy station.Finally,simulations are performed to demonstrate that the proposed planning method can help delay or reduce the construction of new lines and energy-station equipment,thereby reducing the investment required and improving the planning economics of the IES.展开更多
The accumulation of pathological α-synuclein(α-syn)in the central nervous system and the progressive loss of dopaminergic neurons in the substantia nigra pars compacta are the neuropathological features of Parkinson...The accumulation of pathological α-synuclein(α-syn)in the central nervous system and the progressive loss of dopaminergic neurons in the substantia nigra pars compacta are the neuropathological features of Parkinson's disease(PD).Recently,the findings of prion-like transmission of α-syn pathology have expanded our understanding of the region-specific distribution ofα-syn in PD patients.Accumulating evidence suggests that α-syn aggregates are released from neurons and endocytosed by glial cells,which contributes to the clearance of α-syn.However,the activation of glial cells by α-syn species produces pro-inflammatory factors that decrease the uptake of α-syn aggregates by glial cells and promote the transmission of α-syn between neurons,which promotes the spread of α-syn pathology.In this article,we provide an overview of current knowledge on the role of glia and α-syn pathology in PD pathogenesis,highlighting the relationships between glial responses and the spread ofα-syn pathology.展开更多
This paper is concerned with the decay estimate of high-order energy for a class of special time-dependent structural damped systems represented by Fourier multipliers. This model is widely used in the fields of semic...This paper is concerned with the decay estimate of high-order energy for a class of special time-dependent structural damped systems represented by Fourier multipliers. This model is widely used in the fields of semiconductivity, superconductivity, electromagnetic waves, electrolyte and electrode materials, etc.展开更多
基金This study is supported by the Shanghai“Top Priority”Medical Center Project(No.2017ZZ01005)the National Natural Science Foundation of China(Youth Grant,No.81502198)the Shanghai Pujiang Talent Project(No.15PJD001).
文摘Objective:To assess the feasibility of single-port transperitoneal robotic-assisted laparoscopic radical prostatectomy(spRALP)and discuss its surgical technique.Methods:A 60-year-old male was admitted with an elevated prostate-specific antigen(PSA)level of 13.89 ng/mL and confirmed with prostate cancer on biopsy showing three of 22 positive cores with a Gleason score of 3þ4=7.Multiparametric magnetic resonance(MR)and bone scintigraphy showed organ-confined disease.spRALP was performed using da Vinci Si HD surgical system,with access of a quadri-channel laparoscopic port placed supraumbilically.Two drainage tubes were placed before wound closure.The surgical procedure was largely in consistence with a conventional robotic-assisted laparoscopic radical prostatectomy.Results:The surgery was successfully carried out with a duration of 152 min and an estimated blood loss of 100 mL.The patient was discharged on postoperative Day 4 after removal of both pelvic drainage tubes.Foley catheter was removed on postoperative Day 14.No major complications were encountered.Postoperative pathology showed a Gleason score of 3þ4=7 with no extraprostatic extension and negative surgical margins.Conclusion:Single-port robotic prostatectomy is feasible using the currently available robotic instruments in most Chinese robotic urological centers.Meticulous preoperative planning and careful patient selection are mandatory.Further studies concerning perioperative complications and pentafecta outcome compared with the conventional multi-port robotic prostatectomy is required.
基金supported in part by the National Key R&D Program of China(2018YFB0905000)the Science and Technology Project of the State Grid Corporation of China(SGTJDK00DWJS1800232)
文摘The integrated energy system(IES)is an important energy supply method for mitigating the energy crisis.A station-and-network–coordinated planning method for the IES,which considers the integrated demand responses(IDRs)of flexible loads,electric vehicles,and energy storage is proposed in this work.First,based on load substitution at the user side,an energy-station model considering the IDR is established.Then,based on the characteristics of the energy network,a collaborative planning model is established for the energy station and energy network of the IES,considering the comprehensive system investment,operation and maintenance,and clean energy shortage penalty costs,to minimize the total cost.This can help optimize the locations of the power lines and natural gas pipelines and the capacities of the equipment in an energy station.Finally,simulations are performed to demonstrate that the proposed planning method can help delay or reduce the construction of new lines and energy-station equipment,thereby reducing the investment required and improving the planning economics of the IES.
基金supported by the National Natural Science Foundation of China(32271039,32070970 and 31871023)the Joint Program RFBR-BRICS(17-54-80006)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘The accumulation of pathological α-synuclein(α-syn)in the central nervous system and the progressive loss of dopaminergic neurons in the substantia nigra pars compacta are the neuropathological features of Parkinson's disease(PD).Recently,the findings of prion-like transmission of α-syn pathology have expanded our understanding of the region-specific distribution ofα-syn in PD patients.Accumulating evidence suggests that α-syn aggregates are released from neurons and endocytosed by glial cells,which contributes to the clearance of α-syn.However,the activation of glial cells by α-syn species produces pro-inflammatory factors that decrease the uptake of α-syn aggregates by glial cells and promote the transmission of α-syn between neurons,which promotes the spread of α-syn pathology.In this article,we provide an overview of current knowledge on the role of glia and α-syn pathology in PD pathogenesis,highlighting the relationships between glial responses and the spread ofα-syn pathology.
基金supported by the National Natural Science Foundation of China (No.10871175)
文摘This paper is concerned with the decay estimate of high-order energy for a class of special time-dependent structural damped systems represented by Fourier multipliers. This model is widely used in the fields of semiconductivity, superconductivity, electromagnetic waves, electrolyte and electrode materials, etc.
