1.Introduction 2020 is an unusual year in which the COVID-19 pandemic has raged through the globe,infecting tens of millions of people and killing hundreds of thousands.The pandemic has not only wreaked havoc on publi...1.Introduction 2020 is an unusual year in which the COVID-19 pandemic has raged through the globe,infecting tens of millions of people and killing hundreds of thousands.The pandemic has not only wreaked havoc on public health systems,economic activities,and people's lives,but also has greatly affected and will continue to reshape the world's political,economic,and trade patterns.展开更多
Presently,the full implementation of the negotiations and collaborations under the Paris Agreement faces new key problems and severe challenges.These problems and challenges include the following:how to honor the prin...Presently,the full implementation of the negotiations and collaborations under the Paris Agreement faces new key problems and severe challenges.These problems and challenges include the following:how to honor the principle of“common but differentiated responsibilities”to facilitate a comprehensive,balanced,and effective implementation of the key elements of the Paris Agreement,such as adaptation,mitigation,finance,technology,capacity building,and transparency;how to uphold and maintain the status of China and other emerging countries as developing countries in light of the requirements of the United Nations Framework Convention on Climate Change and the historical responsibilities of these countries;and how to assess the goal of limiting the global temperature increase to 1.5℃and what constitutes an equitable carbon mitigation pathway for different types of countries.Developed countries and developing countries have drastically diverging views on carbon border adjustment measures for trade with developing countries proposed by several developed countries such as the European Union.Developed countries have demonstrated obvious intentions and actions designed to weaken and neglect the principle of“common but differentiated responsibilities”,to impose mitigation pressure on developing countries,to shift the responsibilities for emissions onto others,and to pass on the costs of mitigation.The maneuvering among different types of countries and interest groups has become increasingly intense.In response,China must maintain its strategic focus,adhere to the goals and principles established by the Paris Agreement,stick to its strategic positioning as a developing country,solidify strategic support from the developing world,and safeguard the legitimate rights and interests of developing countries.China played a conducive role in facilitating the Paris Agreement and has become an active participant,contributor,and leader in global climate governance.China must continue to follow Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and its conception of ecological civilization and the concept of building a community of common destiny,to actively lead the cooperation process in the construction of a global climate governance system characterized by equity,justice,and win-win collaborations,and to promote compliance with the Paris Agreement.At the same time,China should accelerate the green,low-carbon,circular transformation of its economy;accelerate the coordinated governance of the economy,environment,and climate change;and formulate and implement a long-term low-carbon development strategy.By the middle of the 21st century,while achieving the goal of building a great modern socialist country,China can also achieve a deep decarbonization development path that is in line with the goal of limiting the global temperature increase to well below 2°C and pursuing efforts to limit the increase to 1.5℃.展开更多
Recombinant adenovirus serotype 5(Ad5)vector has been widely applied in vaccine development targeting infectious diseases,such as Ebola virus disease and coronavirus disease 2019(COVID-19).However,the high prevalence ...Recombinant adenovirus serotype 5(Ad5)vector has been widely applied in vaccine development targeting infectious diseases,such as Ebola virus disease and coronavirus disease 2019(COVID-19).However,the high prevalence of preexisting anti-vector immunity compromises the immunogenicity of Ad5-based vaccines.Thus,there is a substantial unmet need to minimize preexisting immunity while improving the insert-induced immunity of Ad5 vectors.Herein,we address this need by utilizing biocompatible nanoparticles to modulate Ad5–host interactions.We show that positively charged human serum albumin nanoparticles((+)HSAnp),which are capable of forming a complex with Ad5,significantly increase the transgene expression of Ad5 in both coxsackievirus–adenovirus receptor-positive and-negative cells.Furthermore,in charge-and dose-dependent manners,Ad5/(+)HSAnp complexes achieve robust(up to227-fold higher)and long-term(up to 60 days)transgene expression in the lungs of mice following intranasal instillation.Importantly,in the presence of preexisting anti-Ad5 immunity,complexed Ad5-based Ebola and COVID-19 vaccines significantly enhance antigen-specific humoral response and mucosal immunity.These findings suggest that viral aggregation and charge modification could be leveraged to engineer enhanced viral vectors for vaccines and gene therapies.展开更多
We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe(EP)and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength telescopes.The new transient was fi...We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe(EP)and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength telescopes.The new transient was first detected with Wide-field X-ray Telescope(WXT)on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for 12 s.The flare reached a peak flux of 3:9×10^(−9) erg cm^(−2) s^(−1) in 0.5-4 keV,∼300 times brighter than the underlying X-ray emission detected throughout the observation.Rapid and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new transient.Its X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying within 1.8-2.5.The X-ray light curve shows a plateau lasting for∼4 d,followed by a steep decay till becoming undetectable∼10 d after the initial detection.Based on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term transients.No counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these bands.We demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical transients.The nature of EP240408a thus remains an enigma.We suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of∼10 d.The detection and follow-ups of more of such objects are essential for revealing their origin.展开更多
Dear Editor,In the era of COVID-19,the prevalence of viruses from other families poses new threats to humans.Despite the eradication of smallpox in 1980,the global outbreak of monkeypox in 2022(Lum et al.,2022;Nuzzo e...Dear Editor,In the era of COVID-19,the prevalence of viruses from other families poses new threats to humans.Despite the eradication of smallpox in 1980,the global outbreak of monkeypox in 2022(Lum et al.,2022;Nuzzo et al.,2022)alerted that the re-emerging orthopoxvirus(OPXV)remained a persistent threat to global health.OPXV includes a number of viruses with a broad host range,including variola virus(VARV),monkeypox virus(MPXV),vaccinia virus(VACV).展开更多
As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray as...As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.展开更多
Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundament...Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundamental physics. On Aug. 17, 2017, Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope （HE） onboard Insight-HXMT （Hard X-ray Modulation Telescope） is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart （SSS17a/AT2017gfo） with very large collection area （M000 cm2） and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity （TOO） observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy （0.2-5 MeV） radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints （-10-7 to 104 erg/cm2/s） for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.展开更多
The Low Energy X-ray telescope(LE) is one of the three main instruments of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT). It is equipped with Swept Charge Device(SCD) sensor arrays with a total geometrical...The Low Energy X-ray telescope(LE) is one of the three main instruments of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT). It is equipped with Swept Charge Device(SCD) sensor arrays with a total geometrical area of 384 cm^2 and an energy band from 0.7 to 13 ke V. In order to evaluate the particle induced X-ray background and the cosmic X-ray background simultaneously, LE adopts collimators to define four types of Field Of Views(FOVs), i.e., 1.6°×6°, 4°×6°, 50°-60°×2°-6 oand the blocked ones which block the X-ray by an aluminum cover. LE is constituted of three detector boxes(LEDs) and an electric control box(LEB) and achieves a good energy resolution of 140 e V@5.9 ke V, an excellent time resolution of 0.98 ms, as well as an extremely low pileup(<1%@18000 cts/s). Detailed performance tests and calibration on the ground have been performed,including energy-channel relation, energy response, detection efficiency and time response.展开更多
As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fu...As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans.展开更多
We fabricate a pair of fiber Bragg gratings(FBGs)by a visible femtosecond laser phase mask scanning technique on passive large-mode-area double-cladding fibers for multi-kilowatt fiber oscillators.The bandwidth of hig...We fabricate a pair of fiber Bragg gratings(FBGs)by a visible femtosecond laser phase mask scanning technique on passive large-mode-area double-cladding fibers for multi-kilowatt fiber oscillators.The bandwidth of high-reflection(HR)and lowreflection(LR)FBG is~1.6 nm and 0.3 nm,respectively.The reflection of the HR-FBG is higher than 99%,and that of the LR-FBG is about 10%.A bidirectional pumped all-fiber oscillator is constructed using this pair of FBGs,a record output power of 5027 W located in the signal core is achieved with a slope efficiency of~82.1%,and the beam quality factor M2is measured to be~1.6 at the maximum power.The FBGs are simply fixed on a water cooling plate without a special package,and the thermal efficiency of the HR-FBG and the LR-FBG is 2.76℃/kW and 1℃/kW,respectively.Our research provides an effective solution for robust high-power all-fiber laser oscillators.展开更多
Side pumping combiners are widely used in fiber laser schemes for their high coupling efficiency, low insertion loss, and multi-point pumping capability. However, side pumping combiners perform differently in coupling...Side pumping combiners are widely used in fiber laser schemes for their high coupling efficiency, low insertion loss, and multi-point pumping capability. However, side pumping combiners perform differently in coupling efficiency when pumping with a laser diode(LD) and a high-brightness 1018 nm Yb-doped fiber laser(YDFL). In this paper, for the first time, to the best of our knowledge, we investigated the different parameters to fabricate the(2 + 1) × 1 combiner with high coupling efficiency when pumping with an LD and a YDFL, respectively. After optimization, the maximum coupled pump power from one single-pump port of the combiner was 1200 W and 2730 W when pumping with a LD and a YDFL, respectively.展开更多
Purpose The low-energy X-ray telescope(LE)is a main instrument of the Insight-HXMT mission and consists of 96 swept charge devices covering the 1–10 keV energy band.The energy gain and resolution are continuously cal...Purpose The low-energy X-ray telescope(LE)is a main instrument of the Insight-HXMT mission and consists of 96 swept charge devices covering the 1–10 keV energy band.The energy gain and resolution are continuously calibrated by analyzing Cassiopeia A(Cas A)and blank sky data,while the effective areas are also calibrated with the observations of the Crab Nebula.In this paper,we present the evolution of the in-orbit performances of LE in the first 5 years since launch.Methods The Insight-HXMT data analysis software package(HXMTDAS)is utilized to extract the spectra of Cas A,blank sky,and Crab Nebula using different good time interval selections.We fit a model with a power-law continuum and several Gaussian lines to different ranges of Cas A and blank sky spectra to get peak energies of their lines through xspec.After updating the energy gain calibration in CALibration DataBase(CALDB),we rerun the Cas A data to obtain the energy resolution.An empirical function is used to modify the simulated effective areas so that the background-subtracted spectrum of the Crab Nebula can best match the standard model of the Crab Nebula.Results The energy gain,resolution,and effective areas are calibrated every month.The corresponding calibration results are duly updated in CALDB,which can be downloaded and used for the analysis of Insight-HXMT data.Simultaneous observations with NuSTAR and NICER can also be used to verify our derived results.Conclusion LE is a well-calibrated X-ray telescope working in 1–10 keV band.The uncertainty of LE gain is less than 20eV in 2–9 keV band,and the uncertainty of LE resolution is less than 15eV.The systematic errors of LE,compared to the model of the Crab Nebula,are lower than 1.5%in 1–10 keV.展开更多
We consider the problem of packing d-dimensional cubes into the minimum number of 2-space bounded unit cubes. Given a sequence of items, each of which is a d-dimensional （d ≥ 3） hypercube with side length not great...We consider the problem of packing d-dimensional cubes into the minimum number of 2-space bounded unit cubes. Given a sequence of items, each of which is a d-dimensional （d ≥ 3） hypercube with side length not greater than 1 and an infinite number of d-dimensional （d ≥ 3） hypercube bins with unit length on each side, we want to pack all of the items in the sequence into the minimum number of bins. The constraint is that only two bins are active at anytime during the packing process. Each item should be orthogonally packed without overlapping other items. Items are given in an online manner without the knowledge of or information about the subsequent items. We extend the technique of brick partitioning for square packing and obtain two results： a three-dimensional box and d-dimensional hyperbox partitioning schemes for cube and hypercube packing, respectively. We design 32 5.43-competitive and 32/21·2d-competitive algorithms for cube and hypercube packing, respectively. To the best of our knowledge these are the first known results on 2-space bounded cube and hypercube packing.展开更多
In this paper, the authors study the Cohen-Fischman-Westreich's double centralizer theorem for triangular Hopf algebras in the setting of almost-triangular Hopf algebras.
Aluminum(alum)adjuvant is the most extensively used protein subunit vaccine adjuvant,and its effectiveness and safety have been widely recognized.The surface charge of the antigen determines its electrostatic adsorpti...Aluminum(alum)adjuvant is the most extensively used protein subunit vaccine adjuvant,and its effectiveness and safety have been widely recognized.The surface charge of the antigen determines its electrostatic adsorption to alum adjuvant,which directly affects the immune efficacy of the protein vaccine.In our study,we precisely modified its surface charge by inserting charged amino acids into the flexible region of the SARS-CoV-2 receptorbinding domain(RBD),achieving electrostatic adsorption and a site-specific anchor between the immunogen and alum adjuvant.展开更多
基金Thanks for the support of the Special Fund for Global Green Development and Climate Change of Tsinghua University Education Foundation and the Energy Foundation.
文摘1.Introduction 2020 is an unusual year in which the COVID-19 pandemic has raged through the globe,infecting tens of millions of people and killing hundreds of thousands.The pandemic has not only wreaked havoc on public health systems,economic activities,and people's lives,but also has greatly affected and will continue to reshape the world's political,economic,and trade patterns.
基金This research was supported by the Ministry of Science and Technology of the People’s Republic of China[Grant number.2018YFC 1509001]the National Natural Science Foundation of China[Grant number.72174105]by Tsinghua University-INDITEX Sustainable Development Fund[Grant number.TISD201909].
文摘Presently,the full implementation of the negotiations and collaborations under the Paris Agreement faces new key problems and severe challenges.These problems and challenges include the following:how to honor the principle of“common but differentiated responsibilities”to facilitate a comprehensive,balanced,and effective implementation of the key elements of the Paris Agreement,such as adaptation,mitigation,finance,technology,capacity building,and transparency;how to uphold and maintain the status of China and other emerging countries as developing countries in light of the requirements of the United Nations Framework Convention on Climate Change and the historical responsibilities of these countries;and how to assess the goal of limiting the global temperature increase to 1.5℃and what constitutes an equitable carbon mitigation pathway for different types of countries.Developed countries and developing countries have drastically diverging views on carbon border adjustment measures for trade with developing countries proposed by several developed countries such as the European Union.Developed countries have demonstrated obvious intentions and actions designed to weaken and neglect the principle of“common but differentiated responsibilities”,to impose mitigation pressure on developing countries,to shift the responsibilities for emissions onto others,and to pass on the costs of mitigation.The maneuvering among different types of countries and interest groups has become increasingly intense.In response,China must maintain its strategic focus,adhere to the goals and principles established by the Paris Agreement,stick to its strategic positioning as a developing country,solidify strategic support from the developing world,and safeguard the legitimate rights and interests of developing countries.China played a conducive role in facilitating the Paris Agreement and has become an active participant,contributor,and leader in global climate governance.China must continue to follow Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and its conception of ecological civilization and the concept of building a community of common destiny,to actively lead the cooperation process in the construction of a global climate governance system characterized by equity,justice,and win-win collaborations,and to promote compliance with the Paris Agreement.At the same time,China should accelerate the green,low-carbon,circular transformation of its economy;accelerate the coordinated governance of the economy,environment,and climate change;and formulate and implement a long-term low-carbon development strategy.By the middle of the 21st century,while achieving the goal of building a great modern socialist country,China can also achieve a deep decarbonization development path that is in line with the goal of limiting the global temperature increase to well below 2°C and pursuing efforts to limit the increase to 1.5℃.
基金supported in part by the grant from National Natural Science Foundation of China(82171818,81703048,82041019,and 82101919)the grant from Defense Industrial Technology Development Program of China(JCKY2020802B001)Beijing Municipal Science and Technology Commission(Z201100005420024)。
文摘Recombinant adenovirus serotype 5(Ad5)vector has been widely applied in vaccine development targeting infectious diseases,such as Ebola virus disease and coronavirus disease 2019(COVID-19).However,the high prevalence of preexisting anti-vector immunity compromises the immunogenicity of Ad5-based vaccines.Thus,there is a substantial unmet need to minimize preexisting immunity while improving the insert-induced immunity of Ad5 vectors.Herein,we address this need by utilizing biocompatible nanoparticles to modulate Ad5–host interactions.We show that positively charged human serum albumin nanoparticles((+)HSAnp),which are capable of forming a complex with Ad5,significantly increase the transgene expression of Ad5 in both coxsackievirus–adenovirus receptor-positive and-negative cells.Furthermore,in charge-and dose-dependent manners,Ad5/(+)HSAnp complexes achieve robust(up to227-fold higher)and long-term(up to 60 days)transgene expression in the lungs of mice following intranasal instillation.Importantly,in the presence of preexisting anti-Ad5 immunity,complexed Ad5-based Ebola and COVID-19 vaccines significantly enhance antigen-specific humoral response and mucosal immunity.These findings suggest that viral aggregation and charge modification could be leveraged to engineer enhanced viral vectors for vaccines and gene therapies.
基金based on data obtained with Einstein Probe,a space mission supported by Strategic Priority Program on Space Science of Chinese Academy of Sciences,in collaboration with ESA,MPE and CNES(Grant No.XDA15310000)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0550200)+5 种基金the National Key R&D Program of China(Grant No.2022YFF0711500)the support by the National Natural Science Foundation of China(Grant Nos.12333004,12321003,12103065,12373040,12021003,12025303,12393814,and 12203071)the China Manned Space Project(Grant Nos.CMS-CSST-2021-A13,and CMS-CSST-2021-B11)the Youth Innovation Promotion Association of the Chinese Academy of Sciencessupported by a Ramón y Cajal fellowship(Grant No.RYC2021-030888-I)financial support from AGAUR,CSIC,MCIN and AEI 10.13039/501100011033(Grant Nos.PID2023-151307NB-I00,PIE 20215AT016,CEX2020-001058-M,and 2021-SGR-01270)。
文摘We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe(EP)and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength telescopes.The new transient was first detected with Wide-field X-ray Telescope(WXT)on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for 12 s.The flare reached a peak flux of 3:9×10^(−9) erg cm^(−2) s^(−1) in 0.5-4 keV,∼300 times brighter than the underlying X-ray emission detected throughout the observation.Rapid and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new transient.Its X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying within 1.8-2.5.The X-ray light curve shows a plateau lasting for∼4 d,followed by a steep decay till becoming undetectable∼10 d after the initial detection.Based on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term transients.No counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these bands.We demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical transients.The nature of EP240408a thus remains an enigma.We suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of∼10 d.The detection and follow-ups of more of such objects are essential for revealing their origin.
基金supported in part by Beijing Nova Program of Science and Technology(20220484127)National Natural Science Foundation of China(82171818)。
文摘Dear Editor,In the era of COVID-19,the prevalence of viruses from other families poses new threats to humans.Despite the eradication of smallpox in 1980,the global outbreak of monkeypox in 2022(Lum et al.,2022;Nuzzo et al.,2022)alerted that the re-emerging orthopoxvirus(OPXV)remained a persistent threat to global health.OPXV includes a number of viruses with a broad host range,including variola virus(VARV),monkeypox virus(MPXV),vaccinia virus(VACV).
基金project funded by China National Space Administration(CNSA)and the Chinese Academy of Sciences(CAS)support from the National Key Research and Development Program of China(Grant No.2016YFA0400800)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA04010202,XDA04010300,and XDB23040400)the National Natural Science Foundation of China(Grant Nos.U1838201,and U1838102).
文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.
基金supported by the National Program on Key Research and Development Project(Grant No.2016YFA0400800)from the Ministry of Science and Technology of China(MOST)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB23040400)the Hundred Talent Program of Chinese Academy of Sciences,the National Natural Science Foundation of China(Grant Nos.11233001,11503027,11403026,11473027,and11733009)
文摘Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundamental physics. On Aug. 17, 2017, Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope （HE） onboard Insight-HXMT （Hard X-ray Modulation Telescope） is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart （SSS17a/AT2017gfo） with very large collection area （M000 cm2） and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity （TOO） observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy （0.2-5 MeV） radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints （-10-7 to 104 erg/cm2/s） for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.
基金the Strategic Priority Research Program on Space Science,the Chinese Academy of Sciences(Grant No.XDA040102).
文摘The Low Energy X-ray telescope(LE) is one of the three main instruments of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT). It is equipped with Swept Charge Device(SCD) sensor arrays with a total geometrical area of 384 cm^2 and an energy band from 0.7 to 13 ke V. In order to evaluate the particle induced X-ray background and the cosmic X-ray background simultaneously, LE adopts collimators to define four types of Field Of Views(FOVs), i.e., 1.6°×6°, 4°×6°, 50°-60°×2°-6 oand the blocked ones which block the X-ray by an aluminum cover. LE is constituted of three detector boxes(LEDs) and an electric control box(LEB) and achieves a good energy resolution of 140 e V@5.9 ke V, an excellent time resolution of 0.98 ms, as well as an extremely low pileup(<1%@18000 cts/s). Detailed performance tests and calibration on the ground have been performed,including energy-channel relation, energy response, detection efficiency and time response.
文摘As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans.
基金supported by the National Natural Science Foundation of China(NSFC)(Nos.11974427 and 12004431)State Key Laboratory of Pulsed Power Laser(Nos.SKL-2020ZR05 and SKL2021ZR01)Postgraduate Scientific Research Innovation Project of Hunan Province(No.CX20200046)。
文摘We fabricate a pair of fiber Bragg gratings(FBGs)by a visible femtosecond laser phase mask scanning technique on passive large-mode-area double-cladding fibers for multi-kilowatt fiber oscillators.The bandwidth of high-reflection(HR)and lowreflection(LR)FBG is~1.6 nm and 0.3 nm,respectively.The reflection of the HR-FBG is higher than 99%,and that of the LR-FBG is about 10%.A bidirectional pumped all-fiber oscillator is constructed using this pair of FBGs,a record output power of 5027 W located in the signal core is achieved with a slope efficiency of~82.1%,and the beam quality factor M2is measured to be~1.6 at the maximum power.The FBGs are simply fixed on a water cooling plate without a special package,and the thermal efficiency of the HR-FBG and the LR-FBG is 2.76℃/kW and 1℃/kW,respectively.Our research provides an effective solution for robust high-power all-fiber laser oscillators.
文摘Side pumping combiners are widely used in fiber laser schemes for their high coupling efficiency, low insertion loss, and multi-point pumping capability. However, side pumping combiners perform differently in coupling efficiency when pumping with a laser diode(LD) and a high-brightness 1018 nm Yb-doped fiber laser(YDFL). In this paper, for the first time, to the best of our knowledge, we investigated the different parameters to fabricate the(2 + 1) × 1 combiner with high coupling efficiency when pumping with an LD and a YDFL, respectively. After optimization, the maximum coupled pump power from one single-pump port of the combiner was 1200 W and 2730 W when pumping with a LD and a YDFL, respectively.
基金support from the National Program on Key Research and Development Project(Grant No.2021YFA0718500)from the Minister of Science and Technology of China(MOST)The authors thank supports from the National Natural Science Foundation of China under Grants 12273043,U1838201,U1838202,U1938102,and U1938108This work was partially supported by the International Partnership Program of Chinese Academy of Sciences(Grant No.113111KYSB20190020).
文摘Purpose The low-energy X-ray telescope(LE)is a main instrument of the Insight-HXMT mission and consists of 96 swept charge devices covering the 1–10 keV energy band.The energy gain and resolution are continuously calibrated by analyzing Cassiopeia A(Cas A)and blank sky data,while the effective areas are also calibrated with the observations of the Crab Nebula.In this paper,we present the evolution of the in-orbit performances of LE in the first 5 years since launch.Methods The Insight-HXMT data analysis software package(HXMTDAS)is utilized to extract the spectra of Cas A,blank sky,and Crab Nebula using different good time interval selections.We fit a model with a power-law continuum and several Gaussian lines to different ranges of Cas A and blank sky spectra to get peak energies of their lines through xspec.After updating the energy gain calibration in CALibration DataBase(CALDB),we rerun the Cas A data to obtain the energy resolution.An empirical function is used to modify the simulated effective areas so that the background-subtracted spectrum of the Crab Nebula can best match the standard model of the Crab Nebula.Results The energy gain,resolution,and effective areas are calibrated every month.The corresponding calibration results are duly updated in CALDB,which can be downloaded and used for the analysis of Insight-HXMT data.Simultaneous observations with NuSTAR and NICER can also be used to verify our derived results.Conclusion LE is a well-calibrated X-ray telescope working in 1–10 keV band.The uncertainty of LE gain is less than 20eV in 2–9 keV band,and the uncertainty of LE resolution is less than 15eV.The systematic errors of LE,compared to the model of the Crab Nebula,are lower than 1.5%in 1–10 keV.
基金supported by the National Natural Science Foundation of China (No. 61170232)the 985 Project funding of Sun Yat-sen UniversityState Key Laboratory of Rail Traffic Control and Safety independent research (No. RS2012K011)
文摘We consider the problem of packing d-dimensional cubes into the minimum number of 2-space bounded unit cubes. Given a sequence of items, each of which is a d-dimensional （d ≥ 3） hypercube with side length not greater than 1 and an infinite number of d-dimensional （d ≥ 3） hypercube bins with unit length on each side, we want to pack all of the items in the sequence into the minimum number of bins. The constraint is that only two bins are active at anytime during the packing process. Each item should be orthogonally packed without overlapping other items. Items are given in an online manner without the knowledge of or information about the subsequent items. We extend the technique of brick partitioning for square packing and obtain two results： a three-dimensional box and d-dimensional hyperbox partitioning schemes for cube and hypercube packing, respectively. We design 32 5.43-competitive and 32/21·2d-competitive algorithms for cube and hypercube packing, respectively. To the best of our knowledge these are the first known results on 2-space bounded cube and hypercube packing.
基金supported by the National Natural Science Foundation of China(No.11371088)the Natural Science Foundation of Jiangsu Province(No.BK2012736)
文摘In this paper, the authors study the Cohen-Fischman-Westreich's double centralizer theorem for triangular Hopf algebras in the setting of almost-triangular Hopf algebras.
基金partially funded by the Defense Industrial Technology Development Program JCKY2020802B001 and the National Natural Science Foundation of China 82041019.
文摘Aluminum(alum)adjuvant is the most extensively used protein subunit vaccine adjuvant,and its effectiveness and safety have been widely recognized.The surface charge of the antigen determines its electrostatic adsorption to alum adjuvant,which directly affects the immune efficacy of the protein vaccine.In our study,we precisely modified its surface charge by inserting charged amino acids into the flexible region of the SARS-CoV-2 receptorbinding domain(RBD),achieving electrostatic adsorption and a site-specific anchor between the immunogen and alum adjuvant.
