BACKGROUND Hem-o-lock clip,a versatile and reliable non-absorbable tissue clip,has gained widespread acceptance in laparoscopic surgeries for vessel ligation and tissue approximation.Its efficacy and safety have been ...BACKGROUND Hem-o-lock clip,a versatile and reliable non-absorbable tissue clip,has gained widespread acceptance in laparoscopic surgeries for vessel ligation and tissue approximation.Its efficacy and safety have been well-documented.CASE SUMMARY This case report describes the occurrence of a bronchopleural fistula following the application of the Hem-o-lock clip for the treatment of a lobar bronchial stump after lobectomy.CONCLUSION This case underscores the importance of exercising caution when using the Hem-o-lock clip for the management of non-vascular tissues during thoracic surgery.展开更多
In the production of castings,intrusive gas pore represents a kind of common defects which can lead to leakage in high gas-tightness requirement castings,such as cylinder blocks and cylinder heads for engines.It occur...In the production of castings,intrusive gas pore represents a kind of common defects which can lead to leakage in high gas-tightness requirement castings,such as cylinder blocks and cylinder heads for engines.It occurs due to the intrusion of gases generated during the resin burning of the sand core into castings during the casting process.Therefore,a gas generation and flow constitution model was established,in which the gas generation rate is a function of temperature and time,and the flow of gas is controlled by the gas release,conservation,and Darcy's law.The heat transfer and gas flow during casting process was numerically simulated.The dangerous point of cores is firstly identified by a virtual heat transfer method based on the similarity between heat transfer and gas flow in the sand core.The gas pores in castings are predicted by the gas pressure,the viscosity and state of the melt for these dangerous points.Three distinct sand core structures were designed and used for the production of iron castings,and the simulated gas pore results were validated by the obtained castings.展开更多
The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used ...The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector geometry.This paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation framework.The geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV level.The overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.展开更多
In the present study,the effects of process parameters(output voltage x,nitrogen flux l and specific strengthening time s)on the microstructure and wear resistance properties of TiN coatings prepared by electrospark d...In the present study,the effects of process parameters(output voltage x,nitrogen flux l and specific strengthening time s)on the microstructure and wear resistance properties of TiN coatings prepared by electrospark deposition(ESD)were investigatedsystematically.The microstructure of the coatings was characterized for thickness(TOC),content of TiN(CON)and porosity(POC).A statistical model was developed to identify the significant factors affecting the microstructure and wear resistance of the coatings.The results show that the output voltage x and nitrogen flux l present significant effects on majority of the evaluation indexes such asTOC,friction coefficient(COF)and wear mass loss(Id),while the specific strengthening time s has a significant effect on POC and asmall effect on the other indexes.The optimal process parameters were obtained as follows:output voltage(x,60V),nitrogen flux(l,15L/min)and specific strengthening time(s,3min/cm2).The variation of wear mass loss(Id)by the variation of the outputvoltage(x)and nitrogen flux(l)is attributed to the change of wear mechanisms of TiN coatings.The main wear mechanism of TiNcoating prepared under optimal process parameters is micro-cutting wear accompanied by micro-fracture wear.展开更多
Gallium oxide(Ga_2O_3), a typical ultra wide bandgap semiconductor, with a bandgap of ~4.9 e V, critical breakdown field of 8 MV/cm, and Baliga's figure of merit of 3444, is promising to be used in high-power and ...Gallium oxide(Ga_2O_3), a typical ultra wide bandgap semiconductor, with a bandgap of ~4.9 e V, critical breakdown field of 8 MV/cm, and Baliga's figure of merit of 3444, is promising to be used in high-power and high-voltage devices.Recently, a keen interest in employing Ga_2O_3 in power devices has been aroused. Many researches have verified that Ga_2O_3 is an ideal candidate for fabricating power devices. In this review, we summarized the recent progress of field-effect transistors(FETs) and Schottky barrier diodes(SBDs) based on Ga_2O_3, which may provide a guideline for Ga_2O_3 to be preferably used in power devices fabrication.展开更多
Transferrin receptor 1(TfR1),encoded by the TFRC gene,is the gatekeeper of cellular iron uptake for cells.A variety of molecular mechanisms are at work to tightly regulate TfR1 expression,and abnormal TfR1 expression ...Transferrin receptor 1(TfR1),encoded by the TFRC gene,is the gatekeeper of cellular iron uptake for cells.A variety of molecular mechanisms are at work to tightly regulate TfR1 expression,and abnormal TfR1 expression has been associated with various diseases.In the current study,to determine the regulation pattern of TfR1,we cloned and overexpressed the human TFRC gene in HeLa cells.RNA-sequencing(RNA-seq)was used to analyze the global transcript levels in overexpressed(OE)and normal control(NC)samples.A total of 1669 differentially expressed genes(DEGs)were identified between OE and NC.Gene ontology(GO)analysis was carried out to explore the functions of the DEGs.It was found that multiple DEGs were associated with ion transport and immunity.Moreover,the regulatory network was constructed on basis of DEGs associated with ion transport and immunity,highlighting that TFRC was the node gene of the network.These results together suggested that precisely controlled TfR1 expression might be not only essential for iron homeostasis,but also globally important for cell physiology,including ion transport and immunity.展开更多
We design an 850 nm tunable vertical-cavity surface-emitting laser(VCSEL)structure using an internal-cavity sub-wavelength grating.The use of such a tuning structure allows for wider wavelength tuning range and more s...We design an 850 nm tunable vertical-cavity surface-emitting laser(VCSEL)structure using an internal-cavity sub-wavelength grating.The use of such a tuning structure allows for wider wavelength tuning range and more stable single-polarization as compared to conventional tunable VCSELs.The features of the internal-cavity grating effect on the wavelength tuning and polarization characteristics of the tunable VCSEL are analyzed.The simulation results show that the largest wavelength tuning range achieves 44.2 nm,and the maximum orthogonal polarization suppression ratio(OPSR)is 33.4 dB(TE-type)and 38.7 dB(TM-type).展开更多
We present an analysis of 288 young stellar objects(YSOs)in the Perseus molecular cloud that have well defined g and r-band lightcurves from the Zwicky Transient Facility.Of the 288 YSOs,238 sources(83%of our working ...We present an analysis of 288 young stellar objects(YSOs)in the Perseus molecular cloud that have well defined g and r-band lightcurves from the Zwicky Transient Facility.Of the 288 YSOs,238 sources(83%of our working sample)are identified as variables based on the normalized peak-to-peak variability metric,with variability fraction of 92%for stars with disks and 77%for the diskless populations.These variables are classified into different categories using the quasiperiodicity(Q)and flux asymmetry(M)metrics.Fifty-three variables are classified as strictly periodic objects that are well phased and can be attributed to spot modulated stellar rotation.We also identify 22 bursters and 25 dippers,which can be attributed to accretion burst and variable extinction,respectively.YSOs with disks tend to have asymmetric and non-repeatable lightcurves,while the YSOs without disks tend to have(quasi)periodic lightcurves.The periodic variables have the steepest change in g versus g-r,while bursters have much flatter changes than dippers in g versus g-r.Periodic and quasiperiodic variables display the lowest variability amplitude.Simple models suggest that the variability amplitudes of periodic variables correspond to changes of the spot coverage of 30%-40%,burster variables are attributed to accretion luminosity changes in the range of L_(acc)/L_(*)=0.1-0.3,and dippers are due to variable extinction with A_(V)changes in the range of 0.5-1.3 mag.展开更多
We present large-scale(2°×2°)observations toward the molecular cloud M120.1+3.0,using ^(12)CO,^(13)CO and C^(18)O(J=1-0)data from the Purple Mountain Observatory 13.7 m millimeter telescope.The distance...We present large-scale(2°×2°)observations toward the molecular cloud M120.1+3.0,using ^(12)CO,^(13)CO and C^(18)O(J=1-0)data from the Purple Mountain Observatory 13.7 m millimeter telescope.The distance of the cloud is measured to be~1.1 kpc.Using the ^(13)CO data,we identify a main filament F1 and two sub-filaments F2 and F3 in the cloud,which together show a"hub-filament"structure.Filaments F1 and F2 are thermally supercritical.Furthermore,F1 displays clear localized systematic motions in the ^(13)CO position-velocity diagram,which could be explained by accretion along the filament.The mean estimated accretion rate is~132M_(⊙)Myr^(-1).Approximately 150 ^(13)CO clumps are identified in the cloud,of which 39 are gravitationally bound.Most of these virialized clumps are well distributed along the supercritical filaments F1 and F2.Based on the complementary infrared and optical data,we identify~186 young stellar objects in the observed area and extract five clusters within the dense ridge of F1.The calculated star formation rate(SFR)surface densities(∑_(SFR))in the clusters range from 1.4 to 2.5 M_(⊙)Myr^(-1)pc^(-2),with a mean value of~2.0M_(⊙)Myr^(-1)pc^(-2).We therefore regard them as mini-starburst cluster candidates.The comparison between ∑_(SFR) and column density N_(gas) along the skeleton of F1 suggests that star formation is closely related to the dense gas in the cloud.Along the main filament F1,five bipolar outflows are also found.All these results indicate intense star-forming activities in the M120.1+3.0 molecular cloud.展开更多
The genetic diversity of the exon2 of BoLA-DRB3 (BoLA-DRB3.2) in Chinese Holstein cattle of the south China was investigated by hemi-nested polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...The genetic diversity of the exon2 of BoLA-DRB3 (BoLA-DRB3.2) in Chinese Holstein cattle of the south China was investigated by hemi-nested polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Six, four and eleven RFLP patterns were found after digestion with the restriction enzymes Hae III, Bst YI and Rsa I, respectively. The DNA sequence showed and twenty- five DRB3.2 alleles. GLM model analysis indicated that lactation and calving season have positive correlation with SCC (Somatic Cell Count) (p<0.01), BoLA-DRB3.2*3, *8, *18 and *26 were associated with lower SCC (p<0.01). The present findings concluded that mastitis is a severe hinder of milk production and technology. Therefore, future re-searches should focus on associations of mastitis with BoLA haplotypes rather than single BoLA展开更多
The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyp...The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that with the increase of hematocrit, the near-wall approaching of platelets is enhanced, with which platelets exhibit larger deformation and orientation angle of its near-wall tank-treading motion, and the lateral force pushing platelets to the wall is increased with larger fluctuation amplitude. Meanwhile the near-wall approaching is reduced by increasing the stiffness of erythrocytes.展开更多
We investigated the evolutionary stages and disk properties of 211 young stellar objects（YSOs） across the Perseus cloud by modeling their broadband optical to mid-infrared（IR） spectral energy distribution（SED）. ...We investigated the evolutionary stages and disk properties of 211 young stellar objects（YSOs） across the Perseus cloud by modeling their broadband optical to mid-infrared（IR） spectral energy distribution（SED）. Our optical gri photometry data were obtained from the recently finished Purple Mountain Observatory Xuyi Schmidt Telescope Photometric Survey of the Galactic Anti-center（XSTPS-GAC）.About 81% of our sample fall into the Stage II phase which is characterized by having optically thick disks, while 14% into the Stage I phase characterized by having significant infalling envelopes, and the remaining 5% into the Stage Ⅲ phase characterized by having optically thin disks. The median stellar age and mass of the Perseus YSOs are 3.1 Myr and 0.3 M⊙ respectively. By exploring the relationships among the turnoff wave bands λturnoff（longward of which significant IR excesses above the stellar photosphere are observed）, the excess spectral index αexcess as determined for λ 〉 λturnoff, and the disk inner radius Rin（determined from SED modeling） for YSOs at different evolutionary stages, we found that the median and standard deviation of αexcess for YSOs with optically thick disks tend to increase withλturnoff, especially at λturnoff ≥5.8 μm, whereas the median fractional dust luminosities Ldust/L★ tend to decrease with increasing λturnoff. This points to an inside-out process of disk clearing for small dust grains. Moreover, a positive correlation between αexcess and Rin was found at α〉excess ～ 0 and R〉in～ 10 × the dust sublimation radius Rsub, irrespective of λturnoff, Ldust/L★ and disk flaring. This suggests that the outer disk flaring either does not evolve synchronously with the inside-out disk clearing of small dust grains or has little appreciable influence on the spectral slopes at λ〈～ 24 μm. About 23% of our YSO disks are classified as transitional disks, which haveλturnoff ≥ 5.8 μm and Ldust/L★ 〉 10-3. The transitional disks and full disks occupy distinctly different regions on the Ldust/L★ vs. αexcess diagram. Taking Ldust/L★ as an approximate discriminator of disks with（〉0.1） and without（〈0.1） considerable accretion activity, we found that 65% and 35% of the transitional disks may be consistent with being dominantly cleared by photoevaporation and dynamical interaction with giant planets respectively. None of our transitional disks have αexcess（〈0.0） or Ldust/L★（〉0.1） values that would otherwise be suggestive of disk clearing dominanted by grain growth.展开更多
Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and devices.However,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely reported.Cy...Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and devices.However,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely reported.Cyanate ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal treatment.Combining CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both monomers.In this study,dielectric inks with acrylate and cyanate moieties were developed.The low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D printing.An internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.展开更多
Hot air sintering technology is used to improve the quality and production efficiency of sintered ore.However,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air si...Hot air sintering technology is used to improve the quality and production efficiency of sintered ore.However,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering layer.Therefore,it is considered to use oxygen enrichment sintering to improve the environment of hot air sintering.Traditional sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was clarified.Hot air reduced the vertical sintering velocity,while improved the yield and tumbler index.Oxygen-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production efficiency.Under the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was prolonged.After oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.展开更多
Modern particle physics experiments usually rely on highly complex and large-scale spectrometer devices.In high energy physics experiments,visualization helps detector design,data quality monitoring,offline data proce...Modern particle physics experiments usually rely on highly complex and large-scale spectrometer devices.In high energy physics experiments,visualization helps detector design,data quality monitoring,offline data processing,and has great potential for improving physics analysis.In addi-tion to the traditional physics data analysis based on statistical methods,visualization provides unique intuitive advantages in searching for rare signal events and reducing background noises.By applying the event display tool to several physics analyses in the BESIII experiment,we demonstrate that visualization can benefit potential physics discovery and improve the signal significance.With the development of modern visual-ization techniques,it is expected to play a more important role in future data processing and physics analysis of particle physics experiments.展开更多
BACKGROUND Atrial fibrillation(AF)is a common cardiac arrhythmia in the elderly.This study aimed to evaluate urban-rural disparities in its prevalence and management in elderly Chinese.METHODS Consecutive participants...BACKGROUND Atrial fibrillation(AF)is a common cardiac arrhythmia in the elderly.This study aimed to evaluate urban-rural disparities in its prevalence and management in elderly Chinese.METHODS Consecutive participants aged≥65 years attending outpatient clinics were enrolled for AF screening using handheld single-lead electrocardiogram(ECG)from April 2017 to December 2022.Each ECG rhythm strip was reviewed from the research team.AF or uninterpretable single-lead ECGs were referred for 12-lead ECG.Primary study outcome comparison was between rural and urban areas for the prevalence of AF.The Student’s t-test was used to compare mean values of clinical characteristics between rural and urban participants,while the Pearson’s chi-square test was used to compare between-group proportions.Multivariate stepwise logistic regression analysis was performed to estimate the association between AF and various patient characteristics.RESULTS The 29,166 study participants included 13,253 men(45.4%)and had a mean age of 72.2 years.The 7073 rural participants differed significantly(P≤0.02)from the 22,093 urban participants in several major characteristics,such as older age,greater body mass index,and so on.The overall prevalence of AF was 4.6%(n=1347).AF was more prevalent in 7073 rural participants than 22,093 urban participants(5.6%vs.4.3%,P<0.01),before and after adjustment for age,body mass index,blood pressure,pulse rate,cigarette smoking,alcohol consumption and prior medical history.Multivariate logistic regression analysis identified overweight/obesity(OR=1.35,95%CI:1.17–1.54)in urban areas and cigarette smoking(OR=1.62,95%CI:1.20–2.17)and alcohol consumption(OR=1.42,95%CI:1.04–1.93)in rural areas as specific risk factors for prevalent AF.In patients with known AF in urban areas(n=781)and rural areas(n=338),60.6%and 45.9%,respectively,received AF treatment(P<0.01),and only 22.4%and 17.2%,respectively,received anticoagulation therapy(P=0.05).CONCLUSIONS In China,there are urban-rural disparities in AF in the elderly,with a higher prevalence and worse management in rural areas than urban areas.Our study findings provide insight for health policymakers to consider urban-rural disparity in the prevention and treatment of AF.展开更多
To improve the wear resistance of aluminum alloy frictional parts, Ti B2particles reinforced Ni-base alloy composite coatings were prepared on aluminum alloy 7005 by laser cladding. The microstructure and tribological...To improve the wear resistance of aluminum alloy frictional parts, Ti B2particles reinforced Ni-base alloy composite coatings were prepared on aluminum alloy 7005 by laser cladding. The microstructure and tribological properties of the composite coatings were investigated. The results show that the composite coating contains the phases of Ni Al, Ni3Al, Al3Ni2, TiB2, TiB, TiC, CrB, and Cr23C6.Its microhardness is HV0.5855.8, which is 15.4 % higher than that of the Ni-base alloy coating and is 6.7 times as high as that of the aluminum alloy. The friction coefficients of the composite coatings are reduced by 6.8 %–21.6 % and 13.2 %–32.4 % compared with those of the Ni-base alloy coatings and the aluminum alloys, while the wear losses are 27.4 %–43.2 % less than those of the Ni-base alloy coatings and are only 16.5 %–32.7 % of those of the aluminum alloys at different loads. At the light loads ranging from 3 to 6 N, the calculated maximum contact stress is smaller than the elastic limit contact stress. The wear mechanism of the composite coatings is micro-cutting wear, but changes into multi-plastic deformation wear at 9 N due to the higher calculated maximum contact stress than the elastic limit contact stress. As the loads increase to 12 N, the calculated flash temperature rises to 332.1 °C.The composite coating experiences multi-plastic deformation wear, micro-brittle fracture wear, and oxidative wear.展开更多
文摘BACKGROUND Hem-o-lock clip,a versatile and reliable non-absorbable tissue clip,has gained widespread acceptance in laparoscopic surgeries for vessel ligation and tissue approximation.Its efficacy and safety have been well-documented.CASE SUMMARY This case report describes the occurrence of a bronchopleural fistula following the application of the Hem-o-lock clip for the treatment of a lobar bronchial stump after lobectomy.CONCLUSION This case underscores the importance of exercising caution when using the Hem-o-lock clip for the management of non-vascular tissues during thoracic surgery.
基金funded by the Beijing Nature Sciences Fund Haidian Originality Cooperation Project (Grant No. L212002)。
文摘In the production of castings,intrusive gas pore represents a kind of common defects which can lead to leakage in high gas-tightness requirement castings,such as cylinder blocks and cylinder heads for engines.It occurs due to the intrusion of gases generated during the resin burning of the sand core into castings during the casting process.Therefore,a gas generation and flow constitution model was established,in which the gas generation rate is a function of temperature and time,and the flow of gas is controlled by the gas release,conservation,and Darcy's law.The heat transfer and gas flow during casting process was numerically simulated.The dangerous point of cores is firstly identified by a virtual heat transfer method based on the similarity between heat transfer and gas flow in the sand core.The gas pores in castings are predicted by the gas pressure,the viscosity and state of the melt for these dangerous points.Three distinct sand core structures were designed and used for the production of iron castings,and the simulated gas pore results were validated by the obtained castings.
基金supported by National Key R&D Program of China(Nos.2023YFA1606904 and 2023YFA1606900)National Natural Science Foundation of China(No.12150006)Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(No.21TQ1400209).
文摘The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector geometry.This paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation framework.The geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV level.The overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.
文摘In the present study,the effects of process parameters(output voltage x,nitrogen flux l and specific strengthening time s)on the microstructure and wear resistance properties of TiN coatings prepared by electrospark deposition(ESD)were investigatedsystematically.The microstructure of the coatings was characterized for thickness(TOC),content of TiN(CON)and porosity(POC).A statistical model was developed to identify the significant factors affecting the microstructure and wear resistance of the coatings.The results show that the output voltage x and nitrogen flux l present significant effects on majority of the evaluation indexes such asTOC,friction coefficient(COF)and wear mass loss(Id),while the specific strengthening time s has a significant effect on POC and asmall effect on the other indexes.The optimal process parameters were obtained as follows:output voltage(x,60V),nitrogen flux(l,15L/min)and specific strengthening time(s,3min/cm2).The variation of wear mass loss(Id)by the variation of the outputvoltage(x)and nitrogen flux(l)is attributed to the change of wear mechanisms of TiN coatings.The main wear mechanism of TiNcoating prepared under optimal process parameters is micro-cutting wear accompanied by micro-fracture wear.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61774019,51572033,and 51572241)the Beijing Municipal Commission of Science and Technology,China(Grant No.SX2018-04)
文摘Gallium oxide(Ga_2O_3), a typical ultra wide bandgap semiconductor, with a bandgap of ~4.9 e V, critical breakdown field of 8 MV/cm, and Baliga's figure of merit of 3444, is promising to be used in high-power and high-voltage devices.Recently, a keen interest in employing Ga_2O_3 in power devices has been aroused. Many researches have verified that Ga_2O_3 is an ideal candidate for fabricating power devices. In this review, we summarized the recent progress of field-effect transistors(FETs) and Schottky barrier diodes(SBDs) based on Ga_2O_3, which may provide a guideline for Ga_2O_3 to be preferably used in power devices fabrication.
基金The work was supported by the General Fund of Health Commission of Hubei Province(No.WJ2019M147).
文摘Transferrin receptor 1(TfR1),encoded by the TFRC gene,is the gatekeeper of cellular iron uptake for cells.A variety of molecular mechanisms are at work to tightly regulate TfR1 expression,and abnormal TfR1 expression has been associated with various diseases.In the current study,to determine the regulation pattern of TfR1,we cloned and overexpressed the human TFRC gene in HeLa cells.RNA-sequencing(RNA-seq)was used to analyze the global transcript levels in overexpressed(OE)and normal control(NC)samples.A total of 1669 differentially expressed genes(DEGs)were identified between OE and NC.Gene ontology(GO)analysis was carried out to explore the functions of the DEGs.It was found that multiple DEGs were associated with ion transport and immunity.Moreover,the regulatory network was constructed on basis of DEGs associated with ion transport and immunity,highlighting that TFRC was the node gene of the network.These results together suggested that precisely controlled TfR1 expression might be not only essential for iron homeostasis,but also globally important for cell physiology,including ion transport and immunity.
基金the Jilin Science and Technology Development Plan,China(Grant Nos.20180519018JH and 20190302052GX)Jilin Education Department“135”Science and Technology,China(Grant No.JJKH20190543KJ)+1 种基金the National Natural Science Foundation of China(Grant No.11474038)the Key Project of Equipment Pre-Research Fund of China(Grant No.61404140103)。
文摘We design an 850 nm tunable vertical-cavity surface-emitting laser(VCSEL)structure using an internal-cavity sub-wavelength grating.The use of such a tuning structure allows for wider wavelength tuning range and more stable single-polarization as compared to conventional tunable VCSELs.The features of the internal-cavity grating effect on the wavelength tuning and polarization characteristics of the tunable VCSEL are analyzed.The simulation results show that the largest wavelength tuning range achieves 44.2 nm,and the maximum orthogonal polarization suppression ratio(OPSR)is 33.4 dB(TE-type)and 38.7 dB(TM-type).
基金the support of the CAS International Cooperation Program(Grant No.114332KYSB20190009)the National Natural Science Foundation of China(NSFC)Grant No.12033004+2 种基金supported by grant 12173003 from the NSFCFunding for the project has been provided by the National Development and Reform Commissionsupported by the National Science Foundation under grant Nos.AST1440341 and AST-2034437。
文摘We present an analysis of 288 young stellar objects(YSOs)in the Perseus molecular cloud that have well defined g and r-band lightcurves from the Zwicky Transient Facility.Of the 288 YSOs,238 sources(83%of our working sample)are identified as variables based on the normalized peak-to-peak variability metric,with variability fraction of 92%for stars with disks and 77%for the diskless populations.These variables are classified into different categories using the quasiperiodicity(Q)and flux asymmetry(M)metrics.Fifty-three variables are classified as strictly periodic objects that are well phased and can be attributed to spot modulated stellar rotation.We also identify 22 bursters and 25 dippers,which can be attributed to accretion burst and variable extinction,respectively.YSOs with disks tend to have asymmetric and non-repeatable lightcurves,while the YSOs without disks tend to have(quasi)periodic lightcurves.The periodic variables have the steepest change in g versus g-r,while bursters have much flatter changes than dippers in g versus g-r.Periodic and quasiperiodic variables display the lowest variability amplitude.Simple models suggest that the variability amplitudes of periodic variables correspond to changes of the spot coverage of 30%-40%,burster variables are attributed to accretion luminosity changes in the range of L_(acc)/L_(*)=0.1-0.3,and dippers are due to variable extinction with A_(V)changes in the range of 0.5-1.3 mag.
基金supported by the National Key R&D Program of China(grant No.2017YFA0402702)the National Natural Science Foundation of China(NSFC,Grant Nos.12041305,12173090 and 12073079)+2 种基金the CAS International Cooperation Program(grant No.114332KYSB20190009)sponsored by the National Key R&D Program of China with grant 2017YFA0402701the CAS Key Research Program of Frontier Sciences with grant QYZDJ-SSW-SLH047。
文摘We present large-scale(2°×2°)observations toward the molecular cloud M120.1+3.0,using ^(12)CO,^(13)CO and C^(18)O(J=1-0)data from the Purple Mountain Observatory 13.7 m millimeter telescope.The distance of the cloud is measured to be~1.1 kpc.Using the ^(13)CO data,we identify a main filament F1 and two sub-filaments F2 and F3 in the cloud,which together show a"hub-filament"structure.Filaments F1 and F2 are thermally supercritical.Furthermore,F1 displays clear localized systematic motions in the ^(13)CO position-velocity diagram,which could be explained by accretion along the filament.The mean estimated accretion rate is~132M_(⊙)Myr^(-1).Approximately 150 ^(13)CO clumps are identified in the cloud,of which 39 are gravitationally bound.Most of these virialized clumps are well distributed along the supercritical filaments F1 and F2.Based on the complementary infrared and optical data,we identify~186 young stellar objects in the observed area and extract five clusters within the dense ridge of F1.The calculated star formation rate(SFR)surface densities(∑_(SFR))in the clusters range from 1.4 to 2.5 M_(⊙)Myr^(-1)pc^(-2),with a mean value of~2.0M_(⊙)Myr^(-1)pc^(-2).We therefore regard them as mini-starburst cluster candidates.The comparison between ∑_(SFR) and column density N_(gas) along the skeleton of F1 suggests that star formation is closely related to the dense gas in the cloud.Along the main filament F1,five bipolar outflows are also found.All these results indicate intense star-forming activities in the M120.1+3.0 molecular cloud.
文摘The genetic diversity of the exon2 of BoLA-DRB3 (BoLA-DRB3.2) in Chinese Holstein cattle of the south China was investigated by hemi-nested polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Six, four and eleven RFLP patterns were found after digestion with the restriction enzymes Hae III, Bst YI and Rsa I, respectively. The DNA sequence showed and twenty- five DRB3.2 alleles. GLM model analysis indicated that lactation and calving season have positive correlation with SCC (Somatic Cell Count) (p<0.01), BoLA-DRB3.2*3, *8, *18 and *26 were associated with lower SCC (p<0.01). The present findings concluded that mastitis is a severe hinder of milk production and technology. Therefore, future re-searches should focus on associations of mastitis with BoLA haplotypes rather than single BoLA
基金supported by the National Natural Science Foundation of China(11072155 and 11232010)Doctoral Fund of Ministry of Education of China(20100073120009)
文摘The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that with the increase of hematocrit, the near-wall approaching of platelets is enhanced, with which platelets exhibit larger deformation and orientation angle of its near-wall tank-treading motion, and the lateral force pushing platelets to the wall is increased with larger fluctuation amplitude. Meanwhile the near-wall approaching is reduced by increasing the stiffness of erythrocytes.
基金support of the National Natural Science Foundation of China (NSFC, Grant No. 11390373)HXZ acknowledges support from the China Postdoctoral Science Foundation (Grant No. 2013M530008)+1 种基金the CAS-CONICYT Postdoctoral Fellowship, administered by the Chinese Academy of Sciences South America Center for Astronomy (CASSACA)MF acknowledges the NSFC (Grant No. 11203081)
文摘We investigated the evolutionary stages and disk properties of 211 young stellar objects（YSOs） across the Perseus cloud by modeling their broadband optical to mid-infrared（IR） spectral energy distribution（SED）. Our optical gri photometry data were obtained from the recently finished Purple Mountain Observatory Xuyi Schmidt Telescope Photometric Survey of the Galactic Anti-center（XSTPS-GAC）.About 81% of our sample fall into the Stage II phase which is characterized by having optically thick disks, while 14% into the Stage I phase characterized by having significant infalling envelopes, and the remaining 5% into the Stage Ⅲ phase characterized by having optically thin disks. The median stellar age and mass of the Perseus YSOs are 3.1 Myr and 0.3 M⊙ respectively. By exploring the relationships among the turnoff wave bands λturnoff（longward of which significant IR excesses above the stellar photosphere are observed）, the excess spectral index αexcess as determined for λ 〉 λturnoff, and the disk inner radius Rin（determined from SED modeling） for YSOs at different evolutionary stages, we found that the median and standard deviation of αexcess for YSOs with optically thick disks tend to increase withλturnoff, especially at λturnoff ≥5.8 μm, whereas the median fractional dust luminosities Ldust/L★ tend to decrease with increasing λturnoff. This points to an inside-out process of disk clearing for small dust grains. Moreover, a positive correlation between αexcess and Rin was found at α〉excess ～ 0 and R〉in～ 10 × the dust sublimation radius Rsub, irrespective of λturnoff, Ldust/L★ and disk flaring. This suggests that the outer disk flaring either does not evolve synchronously with the inside-out disk clearing of small dust grains or has little appreciable influence on the spectral slopes at λ〈～ 24 μm. About 23% of our YSO disks are classified as transitional disks, which haveλturnoff ≥ 5.8 μm and Ldust/L★ 〉 10-3. The transitional disks and full disks occupy distinctly different regions on the Ldust/L★ vs. αexcess diagram. Taking Ldust/L★ as an approximate discriminator of disks with（〉0.1） and without（〈0.1） considerable accretion activity, we found that 65% and 35% of the transitional disks may be consistent with being dominantly cleared by photoevaporation and dynamical interaction with giant planets respectively. None of our transitional disks have αexcess（〈0.0） or Ldust/L★（〉0.1） values that would otherwise be suggestive of disk clearing dominanted by grain growth.
基金supported by the National Key Researchand Development Programof China(No.2022YFB4600101)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB 0470303)+2 种基金the National Natural Science Foundation of China(No.21974057)the Western Light Project of Chinese Academy of Sciences(No.xbzg-zdsy-202007)the Oasis Scholar of Shihezi University and the Central Government to Guide Local Technological Development(No.23ZYQA315).
文摘Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and devices.However,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely reported.Cyanate ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal treatment.Combining CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both monomers.In this study,dielectric inks with acrylate and cyanate moieties were developed.The low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D printing.An internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.
基金supported by the National Natural Science Foundation of China(Nos.51974371 and 52274344)the Science and Technology Innovation Program of Hunan Province(No.2023RC3042)+1 种基金Provincial Natural Science Foundation of Hunan(Nos.2023JJ20068 and 2022JJ30723)China Baowu Low Carbon Metallurgy Innovation Foundation(BWLCF202118).
文摘Hot air sintering technology is used to improve the quality and production efficiency of sintered ore.However,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering layer.Therefore,it is considered to use oxygen enrichment sintering to improve the environment of hot air sintering.Traditional sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was clarified.Hot air reduced the vertical sintering velocity,while improved the yield and tumbler index.Oxygen-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production efficiency.Under the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was prolonged.After oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.
基金supported by the National Natural Science Foundation of China(Grant Nos.12175321,12150005,11975021,11675275,and U1932101)the National Key Research and Development Program of China(Nos.2023YFA1606000,2020YFA0406300,and 2020YFA0406400)+2 种基金the State Key Laboratory of Nuclear Physics and Technology,PekingUniversity(Nos.NPT2020KFY04 and NPT2020KFY05)Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility ProgramNational College Students Innovation and Entrepreneurship Training Program,Sun Yatsen University。
文摘Modern particle physics experiments usually rely on highly complex and large-scale spectrometer devices.In high energy physics experiments,visualization helps detector design,data quality monitoring,offline data processing,and has great potential for improving physics analysis.In addi-tion to the traditional physics data analysis based on statistical methods,visualization provides unique intuitive advantages in searching for rare signal events and reducing background noises.By applying the event display tool to several physics analyses in the BESIII experiment,we demonstrate that visualization can benefit potential physics discovery and improve the signal significance.With the development of modern visual-ization techniques,it is expected to play a more important role in future data processing and physics analysis of particle physics experiments.
基金supported by the National Natural Science Foundation of China(No.82070432&No.82070435&No.82270469&No.82370426)the Ministry of Science and Technology,Beijing,China(2018YFC1704902&2022YFC3601302)+2 种基金the Shanghai Commissions of Science and Technology and Health(a special grant for“leading academics”)(No.19DZ2340200)the Three-year Action Program of Shanghai Municipality for Strengthening the Construction of Public Health System Big Data and Artificial Intelligence Application,Shanghai,China(GWV-10.1-XK05)the Clinical Research Program,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine(2018CR010),Shanghai,China.
文摘BACKGROUND Atrial fibrillation(AF)is a common cardiac arrhythmia in the elderly.This study aimed to evaluate urban-rural disparities in its prevalence and management in elderly Chinese.METHODS Consecutive participants aged≥65 years attending outpatient clinics were enrolled for AF screening using handheld single-lead electrocardiogram(ECG)from April 2017 to December 2022.Each ECG rhythm strip was reviewed from the research team.AF or uninterpretable single-lead ECGs were referred for 12-lead ECG.Primary study outcome comparison was between rural and urban areas for the prevalence of AF.The Student’s t-test was used to compare mean values of clinical characteristics between rural and urban participants,while the Pearson’s chi-square test was used to compare between-group proportions.Multivariate stepwise logistic regression analysis was performed to estimate the association between AF and various patient characteristics.RESULTS The 29,166 study participants included 13,253 men(45.4%)and had a mean age of 72.2 years.The 7073 rural participants differed significantly(P≤0.02)from the 22,093 urban participants in several major characteristics,such as older age,greater body mass index,and so on.The overall prevalence of AF was 4.6%(n=1347).AF was more prevalent in 7073 rural participants than 22,093 urban participants(5.6%vs.4.3%,P<0.01),before and after adjustment for age,body mass index,blood pressure,pulse rate,cigarette smoking,alcohol consumption and prior medical history.Multivariate logistic regression analysis identified overweight/obesity(OR=1.35,95%CI:1.17–1.54)in urban areas and cigarette smoking(OR=1.62,95%CI:1.20–2.17)and alcohol consumption(OR=1.42,95%CI:1.04–1.93)in rural areas as specific risk factors for prevalent AF.In patients with known AF in urban areas(n=781)and rural areas(n=338),60.6%and 45.9%,respectively,received AF treatment(P<0.01),and only 22.4%and 17.2%,respectively,received anticoagulation therapy(P=0.05).CONCLUSIONS In China,there are urban-rural disparities in AF in the elderly,with a higher prevalence and worse management in rural areas than urban areas.Our study findings provide insight for health policymakers to consider urban-rural disparity in the prevention and treatment of AF.
基金financially supported by the Research Program of General Armament Department of China (No. 2012500)
文摘To improve the wear resistance of aluminum alloy frictional parts, Ti B2particles reinforced Ni-base alloy composite coatings were prepared on aluminum alloy 7005 by laser cladding. The microstructure and tribological properties of the composite coatings were investigated. The results show that the composite coating contains the phases of Ni Al, Ni3Al, Al3Ni2, TiB2, TiB, TiC, CrB, and Cr23C6.Its microhardness is HV0.5855.8, which is 15.4 % higher than that of the Ni-base alloy coating and is 6.7 times as high as that of the aluminum alloy. The friction coefficients of the composite coatings are reduced by 6.8 %–21.6 % and 13.2 %–32.4 % compared with those of the Ni-base alloy coatings and the aluminum alloys, while the wear losses are 27.4 %–43.2 % less than those of the Ni-base alloy coatings and are only 16.5 %–32.7 % of those of the aluminum alloys at different loads. At the light loads ranging from 3 to 6 N, the calculated maximum contact stress is smaller than the elastic limit contact stress. The wear mechanism of the composite coatings is micro-cutting wear, but changes into multi-plastic deformation wear at 9 N due to the higher calculated maximum contact stress than the elastic limit contact stress. As the loads increase to 12 N, the calculated flash temperature rises to 332.1 °C.The composite coating experiences multi-plastic deformation wear, micro-brittle fracture wear, and oxidative wear.
