Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is ...Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is refractory,recurrent and severe in winter and mild in summer,which has a great impact on patients'physical and mental health and quality of life.Traditional Chinese medicine has unique insights in the treatment of psoriasis,both curative effect and safety,have obvious advantages.Based on the concept of"winter disease and summer treatment",long-snake moxibustion gives full play to its functions of warming the kidney,invigorating the marrow,warming the meridians,activating blood circulation and removing blood stasis,so as to restore the deficiency of Yang in patients with psoriasis with external cold syndrome,enhance disease resistance,and prevent psoriasis recurrence or aggravation in winter.Therefore,based on the theory of"winter disease and summer treatment",this paper preliminarily discusses the mechanism of long-snake moxibustion in the prevention and treatment of psoriasis with external cold syndrome of Yang deficiency,and provides new ideas and directions for the prevention and treatment of psoriasis with traditional Chinese medicine.展开更多
Erythema tuberculum is a common disease in dermatology and difficult to treat.Chang an cheng's skin under the successive generations of the successor,unique,unique experience.Yan xiaoning summarized the etiology a...Erythema tuberculum is a common disease in dermatology and difficult to treat.Chang an cheng's skin under the successive generations of the successor,unique,unique experience.Yan xiaoning summarized the etiology and pathogenesis of nodular erythema as heat and humidity toxicity,and divided the syndrome differentiation into two syndromes:wind and heat toxicity containing moisture and heat.The prescription drug emphasizes in the overall concept of the foundation,both inside and outside treatment,treatment of the need to reconcile,both the spleen and stomach for the specimens.In this paper,Professor Yan Xiaoning's experience in the treatment of erythema nodule is summarized,and case 1 is attached as evidence.展开更多
The metabolic syndrome(MS)in adolescents and children can cause serious consequences that lead researchers to pay efforts to study in such area.Presently,MS definition is still not standardized.Different versions of M...The metabolic syndrome(MS)in adolescents and children can cause serious consequences that lead researchers to pay efforts to study in such area.Presently,MS definition is still not standardized.Different versions of MS definition have been used by numerous studies,which may be a problem to identify MS and then to predict and prevent clinical diseases.The pediatric literature shows that insulin resistance and obesity might be the key underlying pathophysiology of MS to cause many related diseases.High prevalence of MS is in overweight and obese children and adolescents.This article focuses on such above issues and also effects of MS on two main disease outcomes:cardiovascular disease and type 2 diabetes.展开更多
Objective:To determine medication regularity external therapies of Traditional Chinese medicine of eczema by data mining.Methods:Papers were retrieved from databases Pubmed,CNKI,WF,VIP,CBM,Web of Science and Embase.Fr...Objective:To determine medication regularity external therapies of Traditional Chinese medicine of eczema by data mining.Methods:Papers were retrieved from databases Pubmed,CNKI,WF,VIP,CBM,Web of Science and Embase.From the establishment of the database to April 2020 were searched.The main points of Medication Regularity were established with Excel 2016 software;the characteristics and laws in external therapies of Traditional Chinese medicine Treatment of eczema were analyzed with the relevance rule and cluster analysis Methods in data mining technology.Results:The property and flavor of the herbs mainly used were cold,bitter,while the channel which are mostly involved included liver meridian,lung meridian and Bladder Meridian,The analysis of association rules showed that kushen and difuzi had the highest correlation.The clustering analysis figured out 7groups of the herbs.Conclusion:The study presents the common pair herbs in the treatment of external therapies of Traditional Chinese medicine of eczema,which provides the approach to syndrome differentiation and medication in clinical treatment of eczema.展开更多
Objective:To systematically evaluate the clinical efficacy of acupuncture bloodletting therapy for herpes zoster.Methods:The computer searched the CNKI,WanFang,VIP,CBM,PubMed,and Cochrane Library databases.The time li...Objective:To systematically evaluate the clinical efficacy of acupuncture bloodletting therapy for herpes zoster.Methods:The computer searched the CNKI,WanFang,VIP,CBM,PubMed,and Cochrane Library databases.The time limit was from the establishment of the database to December 31,2019.Relevant literatures on randomized controlled trials of spinal bloodletting for shingles were retrieved.Data were extracted and quality evaluated based on the Cochrane bias risk assessment method.Meta analysis was performed using Rev Man5.3 and Stata15 statistical software.Results:(1)A total of 21 Chinese literatures were included,with a total of 1,533 patients;(2)Meta-analysis was performed using a fixed effect model,and the results showed that the total effective rate of the experimental group(OR=5.11,95%CI:(3.48,7.50),Z=8.33,P<0.00001)is better than the control group,the difference is statistically significant;(3)VAS score analysis using a random effects model(MD-2.23,95%CI(-2.46,-1.99),p<0.0001)(4)The incidence of sequela neuralgia was analyzed using a random effects model(OR=0.21,95%CI:(0.09,0.51),Z=3.48,P=0.0005).Conclusion:The effect of spinal bloodletting on the treatment of shingles and VAS scores,symptomatic relief,and the incidence of sequela neuralgia have advantages.展开更多
Objective:To evaluate the effect of Qingreliangxue method compared with Acitretin Capsules on clinical efficacy of psoriasis and serum inflammatory cytokines.Methods:The computer searches databases such as CNKI,Wanfan...Objective:To evaluate the effect of Qingreliangxue method compared with Acitretin Capsules on clinical efficacy of psoriasis and serum inflammatory cytokines.Methods:The computer searches databases such as CNKI,Wanfang,VIP,PubMed,Embase and Cochrane Library.The search time is from the time the library is built until December 2019.According to the criteria for screening and selection of studies,extract data,use risk assessment tools for quality evaluation,and use Revman 5.3 software to perform meta-analysis on the outcome indicators of the included studis.Results:Finally,20 studies were included,with a total of 1592 patients.The analysis results showed that the total effective rate(OR=3.70,95%CI[2.58,5.30],P<0.00001)and cure rate(OR=2.40,95%CI[1.86,3.10],P<0.00001),PASI score(OR=-2.65,95%CI[-3.60,-1.70],P<0.00001),serum inflammatory cytokines(OR=-8.84,95%CI[-10.52,-7.16],P<0.00001),adverse reactions(OR=0.25,95%CI[0.11,0.57],P=0.001)are superior to Acitretin Capsules.Statistics of the top 10 Chinese medicines in clinical used frequency are,in order,habitat,red peony root,paeonol,honeysuckle,comfrey,soil tuckahoe,salvia miltiorrhiza,buffalo horn,heliotrope,angelica.Conclusion:Based on the current evidence,the treatment of psoriasis with clearing heat and cooling blood as the mainstay of Chinese medicine alone or in combination with Acitretin Capsules can better improve the efficacy,and its mechanism may be related to reducing inflammation.Due to the limitation of the included literature,this conclusion needs to be further verified.展开更多
Objective:To evaluate the clinical efficacy of traditional Chinese medicine Jiedu therapy in treatment of psoriasis.Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literatur...Objective:To evaluate the clinical efficacy of traditional Chinese medicine Jiedu therapy in treatment of psoriasis.Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database ( CBM), PubMed, the Cochrane Library and EMbase database from the establishment of the database to March 2020 were searched for the randomized controlled trials (Rcts) on traditional Chinese medicine Jiedu therapy in treatment of psoriasis. Literature selection and information extraction was completed and screened by two independent reviewers, and then the Cochrane recommended bias risk assessment method was used to evaluate the bias risk, and Review Manager5.3 was used for the data analysis. Totally 17clinical Rcts were included in this study, involving 1376 patients.Results:Analysis results showed that traditional Chinese medicine Jiedu therapy had higher clinical effective rate, with statistically significant difference ( OR= 4.53, 95% CI[3.17,6.46], Z =8.32, P<0. 00001);the improvement of score was more evident, PASI score (WMD =-2.21, 95%CI[-2.77, -1.64], Z = 7.60, P<0. 00001);and trial-related adverse events were reported in 6RCTs. Conclusion: Studies have shown that traditional Chinese medicine Jiedu therapy had higher clinical efficacy.展开更多
Objective:This study aimed to design an evaluation scale of traditional Chinese medicine(TCM)confidence and then evaluate its validity and reliability.Methods:Three parallel samples with TCM learning experience were i...Objective:This study aimed to design an evaluation scale of traditional Chinese medicine(TCM)confidence and then evaluate its validity and reliability.Methods:Three parallel samples with TCM learning experience were included in this current study.Randomly selected 500 nursing students were included factor analysis and reliability and validity analyses.After 4 weeks,200 nursing students were recruited to retest the reliability.The evaluation tool of TCM confidence included 6 dimensions and 25 entries.Results:Cronbach's a coefficient of the evaluation scale was 0.95 and that of the 6 observed aspects were higher than 0.90,and splithalf reliability was 0.81.For the retest reliability,Cronbach's a coefficient of the evaluation scale was 0.93 and that of the 6 examined aspects was all over 0.80.The index of content validity Scale Content Validity Index(S-CVI)was 0.92 and Item Content Validity Index(I-CVI)was 0.83–1.00.Conclusions:Observed results may indicate that the designed tool can be used to assess the TCM confidence level of students with TCM studied experience and also can evaluate results of TCM education during studying TCM lectures.展开更多
Background:To systematically evaluate the clinical efficacy of fire acupuncture(or needle)in the treatment of psoriasis vulgaris.Methods:The following electronic databases were retrieved by calculator:PubMed,Embase,Co...Background:To systematically evaluate the clinical efficacy of fire acupuncture(or needle)in the treatment of psoriasis vulgaris.Methods:The following electronic databases were retrieved by calculator:PubMed,Embase,Cochrane Library,CNKI,Wanfang Academic Journal Database,VIP Chinese Journal Database,etc.All the randomized controlled trials using fire needles in the treatment of psoriasis vulgaris from the self-established database to August 2021 were included,and the qualified literatures were included.Review manager 5.3 software was used for the combined analysis of the included literatures,TSA v0.9 Beta for sequential analysis,and GRADE pro V3.6 for evidence quality evaluation.Results:A total of 14 studies with 1,440 patients were included in this study.Meta analysis results showed:effective rate[RR=1.15,95%CI(1.10,1.19),P<0.00001,very low quality evidence];Psoriasis Area and Severity Index[PASI score,WMD=-2.15,95%CI(-2.40,-1.90),P<0.00001,evidence of low quality],Dermatology Life Quality Index scale[DLQI score,WMD=-3.56,95%CI(-4.86,-2.26),P<0.00001,very low quality evidence],the experimental group was better than the control group(P<0.05).Sequential analysis further showed that the use of fire needle as the primary treatment could significantly reduce PASI score.The adverse reactions rate of the experimental group was 6%,and that of the control group was 11%,P<0.05.Conclusion:Fire acupuncture as the main treatment can reduce PASI and QLDI scores of patients with psoriasis vulgaris,improve the treatment efficiency,and fewer adverse reactions.展开更多
Objective:To predict the mechanism of action of San Huang lotion for topical treatment of eczema at the level of network pharmacology and molecular docking technology.Methods:The active ingredients and corresponding t...Objective:To predict the mechanism of action of San Huang lotion for topical treatment of eczema at the level of network pharmacology and molecular docking technology.Methods:The active ingredients and corresponding targets of San Huang lotion were collected using the TCMSP data platform and UniProt;the relevant gene targets of San Huang lotion were collected using the GeneCards database,OMIM database,TTD database,and DrugBank database;the intersection targets of San Huang lotion and eczema were obtained by creating avenn diagram;the key active ingredients and targets were screened by constructing a disease-active ingredient-target map,and the key active ingredients and core targets were screened out by constructing disease-active ingredient-target diagrams and PPInetwork diagrams;GOand KEGGenrichment analyses were conducted using the metascapewebsite and the higher significant entries were selected to produce bar charts and bubble plots.Finally,molecular docking of key active ingredients and core targets was performed.Results:A total of 134 active ingredients and 3,320 eczema-related target genes were screened for San Huang lotion,and 126 intersecting targets were obtained for San Huang lotion and eczema.The five key active ingredients of San Huang lotion for topical treatment of eczema and six core targets ofAKT1,TNF,IL6,IL1B,TP53andVEGFA were obtained by drug-active ingredient-target map and PPInetwork map.The GOand KEGGenrichment analysis showed that the topical treatment of eczema withSanHuanglotion might be mediated throughIL-17signaling pathway,TNFsignaling pathway and Th17cell differentiation pathway.The molecular docking results showed that the docking binding energy of key active ingredients and core targets was mostly less than-5 kcal/mol,and the docking was good.Conclusion:The quercetin,luteolin,wogonin,formononetin,beta-sitosterol and other active ingredients in San Huang lotion may act on eczema through AKT1,TNF,IL6,IL1B,TP53,VEGFA and other targets,and through IL-17signaling pathway,TNFsignaling pathway,Th17cell differentiation and other pathways.展开更多
Seed treatment with endophytic fungi has been regarded as an effective method for plant parasitic nematode control.Endophytic fungi from cucumber seedlings were isolated and screened for their potential to be used as ...Seed treatment with endophytic fungi has been regarded as an effective method for plant parasitic nematode control.Endophytic fungi from cucumber seedlings were isolated and screened for their potential to be used as seed treatment agents against Meloidogyne incognita.Among the 294 isolates screened,23 significantly reduced galls formed by M.incognita in greenhouse test.The 10 most effective isolates were Fusarium(5),Trichoderma(1),Chaetomium(1),Acremonium(1),Paecilomyces(1),and Phyllosticta(1) .Their control efficacies were repeatedly tested and their colonizations as well as in vitro activity against M.incognita were studied.They reduced the number of galls by 24.0%-58.4%in the first screening and 15.6%-44.3%in the repeated test,respectively.Phyllosticta Ph511 and Chaetomium Ch1001 had high colonizations on both the roots and the aboveground parts of cucumber seedlings.Fusarium isolates had colonization preference on the roots,their root colonizations ranging from 20.1%to 47.3%of the total root area.Trichoderma Tr882,Paecilomyces Pa972,and Acremonium Ac985 had low colonizations on both the roots and the aboveground parts.Acremonium Ac985,Chaetomium Ch1001,Paecilomyces Pa972,and Phyllosticta Ph511 produced compounds affecting motility of the second stage juveniles of M.incognita.Based on these results,Chae-tomium Ch1001 was considered to have the highest potential as a seed treatment agent for M.incognita biocontrol.展开更多
基金National Key Research and Development Program:A Multicenter Randomized Controlled Study on the Treatment of Blood Stasis Syndrome in Psoriasis with the Method of Promoting Blood Circulation and Dispersing Blood Stasis(No.2018YFC1705303)Clinical Study of Long Snake Moxibustion in the Prevention and Treatment of Psoriasis of Yang Deficiency Syndrome Based on the Theory of"Treatment of Winter Disease in Summer"(No.2019SF-312)。
文摘Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is refractory,recurrent and severe in winter and mild in summer,which has a great impact on patients'physical and mental health and quality of life.Traditional Chinese medicine has unique insights in the treatment of psoriasis,both curative effect and safety,have obvious advantages.Based on the concept of"winter disease and summer treatment",long-snake moxibustion gives full play to its functions of warming the kidney,invigorating the marrow,warming the meridians,activating blood circulation and removing blood stasis,so as to restore the deficiency of Yang in patients with psoriasis with external cold syndrome,enhance disease resistance,and prevent psoriasis recurrence or aggravation in winter.Therefore,based on the theory of"winter disease and summer treatment",this paper preliminarily discusses the mechanism of long-snake moxibustion in the prevention and treatment of psoriasis with external cold syndrome of Yang deficiency,and provides new ideas and directions for the prevention and treatment of psoriasis with traditional Chinese medicine.
基金National key Research and development program“Key projects in the modernization of Traditional Chinese medicine”(No.2018YFC1705303)
文摘Erythema tuberculum is a common disease in dermatology and difficult to treat.Chang an cheng's skin under the successive generations of the successor,unique,unique experience.Yan xiaoning summarized the etiology and pathogenesis of nodular erythema as heat and humidity toxicity,and divided the syndrome differentiation into two syndromes:wind and heat toxicity containing moisture and heat.The prescription drug emphasizes in the overall concept of the foundation,both inside and outside treatment,treatment of the need to reconcile,both the spleen and stomach for the specimens.In this paper,Professor Yan Xiaoning's experience in the treatment of erythema nodule is summarized,and case 1 is attached as evidence.
文摘The metabolic syndrome(MS)in adolescents and children can cause serious consequences that lead researchers to pay efforts to study in such area.Presently,MS definition is still not standardized.Different versions of MS definition have been used by numerous studies,which may be a problem to identify MS and then to predict and prevent clinical diseases.The pediatric literature shows that insulin resistance and obesity might be the key underlying pathophysiology of MS to cause many related diseases.High prevalence of MS is in overweight and obese children and adolescents.This article focuses on such above issues and also effects of MS on two main disease outcomes:cardiovascular disease and type 2 diabetes.
基金National key research plan(No.2018YFC1705303)Key research and development plan of Shanxi province(No.2019SF-312).
文摘Objective:To determine medication regularity external therapies of Traditional Chinese medicine of eczema by data mining.Methods:Papers were retrieved from databases Pubmed,CNKI,WF,VIP,CBM,Web of Science and Embase.From the establishment of the database to April 2020 were searched.The main points of Medication Regularity were established with Excel 2016 software;the characteristics and laws in external therapies of Traditional Chinese medicine Treatment of eczema were analyzed with the relevance rule and cluster analysis Methods in data mining technology.Results:The property and flavor of the herbs mainly used were cold,bitter,while the channel which are mostly involved included liver meridian,lung meridian and Bladder Meridian,The analysis of association rules showed that kushen and difuzi had the highest correlation.The clustering analysis figured out 7groups of the herbs.Conclusion:The study presents the common pair herbs in the treatment of external therapies of Traditional Chinese medicine of eczema,which provides the approach to syndrome differentiation and medication in clinical treatment of eczema.
基金National Key Research and Development Plan"Key Project of TCM Modernization Research"(No.2018YFC1705303)Science Foundation for Youth of National Natural Foundation of China(No.81704087)+1 种基金Innovation Talent Promotion Plan-Key Science and technology Innovation Team Plan(No.2017KCT-27)Key R&D project of Shaanxi Province(No.2018ZDXM-SF-010)
文摘Objective:To systematically evaluate the clinical efficacy of acupuncture bloodletting therapy for herpes zoster.Methods:The computer searched the CNKI,WanFang,VIP,CBM,PubMed,and Cochrane Library databases.The time limit was from the establishment of the database to December 31,2019.Relevant literatures on randomized controlled trials of spinal bloodletting for shingles were retrieved.Data were extracted and quality evaluated based on the Cochrane bias risk assessment method.Meta analysis was performed using Rev Man5.3 and Stata15 statistical software.Results:(1)A total of 21 Chinese literatures were included,with a total of 1,533 patients;(2)Meta-analysis was performed using a fixed effect model,and the results showed that the total effective rate of the experimental group(OR=5.11,95%CI:(3.48,7.50),Z=8.33,P<0.00001)is better than the control group,the difference is statistically significant;(3)VAS score analysis using a random effects model(MD-2.23,95%CI(-2.46,-1.99),p<0.0001)(4)The incidence of sequela neuralgia was analyzed using a random effects model(OR=0.21,95%CI:(0.09,0.51),Z=3.48,P=0.0005).Conclusion:The effect of spinal bloodletting on the treatment of shingles and VAS scores,symptomatic relief,and the incidence of sequela neuralgia have advantages.
基金National Key R&D Program"Key Special Project of Modernization of Traditional Chinese Medicine"(No.2018YFC1705303)
文摘Objective:To evaluate the effect of Qingreliangxue method compared with Acitretin Capsules on clinical efficacy of psoriasis and serum inflammatory cytokines.Methods:The computer searches databases such as CNKI,Wanfang,VIP,PubMed,Embase and Cochrane Library.The search time is from the time the library is built until December 2019.According to the criteria for screening and selection of studies,extract data,use risk assessment tools for quality evaluation,and use Revman 5.3 software to perform meta-analysis on the outcome indicators of the included studis.Results:Finally,20 studies were included,with a total of 1592 patients.The analysis results showed that the total effective rate(OR=3.70,95%CI[2.58,5.30],P<0.00001)and cure rate(OR=2.40,95%CI[1.86,3.10],P<0.00001),PASI score(OR=-2.65,95%CI[-3.60,-1.70],P<0.00001),serum inflammatory cytokines(OR=-8.84,95%CI[-10.52,-7.16],P<0.00001),adverse reactions(OR=0.25,95%CI[0.11,0.57],P=0.001)are superior to Acitretin Capsules.Statistics of the top 10 Chinese medicines in clinical used frequency are,in order,habitat,red peony root,paeonol,honeysuckle,comfrey,soil tuckahoe,salvia miltiorrhiza,buffalo horn,heliotrope,angelica.Conclusion:Based on the current evidence,the treatment of psoriasis with clearing heat and cooling blood as the mainstay of Chinese medicine alone or in combination with Acitretin Capsules can better improve the efficacy,and its mechanism may be related to reducing inflammation.Due to the limitation of the included literature,this conclusion needs to be further verified.
基金National key Research and development program(2018YFC1705303)Key research and development plan of Shaanxi Province(2019SF-312)
文摘Objective:To evaluate the clinical efficacy of traditional Chinese medicine Jiedu therapy in treatment of psoriasis.Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database ( CBM), PubMed, the Cochrane Library and EMbase database from the establishment of the database to March 2020 were searched for the randomized controlled trials (Rcts) on traditional Chinese medicine Jiedu therapy in treatment of psoriasis. Literature selection and information extraction was completed and screened by two independent reviewers, and then the Cochrane recommended bias risk assessment method was used to evaluate the bias risk, and Review Manager5.3 was used for the data analysis. Totally 17clinical Rcts were included in this study, involving 1376 patients.Results:Analysis results showed that traditional Chinese medicine Jiedu therapy had higher clinical effective rate, with statistically significant difference ( OR= 4.53, 95% CI[3.17,6.46], Z =8.32, P<0. 00001);the improvement of score was more evident, PASI score (WMD =-2.21, 95%CI[-2.77, -1.64], Z = 7.60, P<0. 00001);and trial-related adverse events were reported in 6RCTs. Conclusion: Studies have shown that traditional Chinese medicine Jiedu therapy had higher clinical efficacy.
文摘Objective:This study aimed to design an evaluation scale of traditional Chinese medicine(TCM)confidence and then evaluate its validity and reliability.Methods:Three parallel samples with TCM learning experience were included in this current study.Randomly selected 500 nursing students were included factor analysis and reliability and validity analyses.After 4 weeks,200 nursing students were recruited to retest the reliability.The evaluation tool of TCM confidence included 6 dimensions and 25 entries.Results:Cronbach's a coefficient of the evaluation scale was 0.95 and that of the 6 observed aspects were higher than 0.90,and splithalf reliability was 0.81.For the retest reliability,Cronbach's a coefficient of the evaluation scale was 0.93 and that of the 6 examined aspects was all over 0.80.The index of content validity Scale Content Validity Index(S-CVI)was 0.92 and Item Content Validity Index(I-CVI)was 0.83–1.00.Conclusions:Observed results may indicate that the designed tool can be used to assess the TCM confidence level of students with TCM studied experience and also can evaluate results of TCM education during studying TCM lectures.
基金supported by grants from the National Key Research and Development Program of"Traditional Chinese Medicine Modernization Research Key Special Project"(No.2018YFC1705303)the Key Industry Innovation Chain of Shaanxi Province(No.2019ZDLSF04-08)the Key Research and Development Program of Shaanxi Province(No.2021SF-409).
文摘Background:To systematically evaluate the clinical efficacy of fire acupuncture(or needle)in the treatment of psoriasis vulgaris.Methods:The following electronic databases were retrieved by calculator:PubMed,Embase,Cochrane Library,CNKI,Wanfang Academic Journal Database,VIP Chinese Journal Database,etc.All the randomized controlled trials using fire needles in the treatment of psoriasis vulgaris from the self-established database to August 2021 were included,and the qualified literatures were included.Review manager 5.3 software was used for the combined analysis of the included literatures,TSA v0.9 Beta for sequential analysis,and GRADE pro V3.6 for evidence quality evaluation.Results:A total of 14 studies with 1,440 patients were included in this study.Meta analysis results showed:effective rate[RR=1.15,95%CI(1.10,1.19),P<0.00001,very low quality evidence];Psoriasis Area and Severity Index[PASI score,WMD=-2.15,95%CI(-2.40,-1.90),P<0.00001,evidence of low quality],Dermatology Life Quality Index scale[DLQI score,WMD=-3.56,95%CI(-4.86,-2.26),P<0.00001,very low quality evidence],the experimental group was better than the control group(P<0.05).Sequential analysis further showed that the use of fire needle as the primary treatment could significantly reduce PASI score.The adverse reactions rate of the experimental group was 6%,and that of the control group was 11%,P<0.05.Conclusion:Fire acupuncture as the main treatment can reduce PASI and QLDI scores of patients with psoriasis vulgaris,improve the treatment efficiency,and fewer adverse reactions.
基金supported by Innovative Talent Promotion Plan-Key Technology Innovation Team Plan(2017KCT-27).
文摘Objective:To predict the mechanism of action of San Huang lotion for topical treatment of eczema at the level of network pharmacology and molecular docking technology.Methods:The active ingredients and corresponding targets of San Huang lotion were collected using the TCMSP data platform and UniProt;the relevant gene targets of San Huang lotion were collected using the GeneCards database,OMIM database,TTD database,and DrugBank database;the intersection targets of San Huang lotion and eczema were obtained by creating avenn diagram;the key active ingredients and targets were screened by constructing a disease-active ingredient-target map,and the key active ingredients and core targets were screened out by constructing disease-active ingredient-target diagrams and PPInetwork diagrams;GOand KEGGenrichment analyses were conducted using the metascapewebsite and the higher significant entries were selected to produce bar charts and bubble plots.Finally,molecular docking of key active ingredients and core targets was performed.Results:A total of 134 active ingredients and 3,320 eczema-related target genes were screened for San Huang lotion,and 126 intersecting targets were obtained for San Huang lotion and eczema.The five key active ingredients of San Huang lotion for topical treatment of eczema and six core targets ofAKT1,TNF,IL6,IL1B,TP53andVEGFA were obtained by drug-active ingredient-target map and PPInetwork map.The GOand KEGGenrichment analysis showed that the topical treatment of eczema withSanHuanglotion might be mediated throughIL-17signaling pathway,TNFsignaling pathway and Th17cell differentiation pathway.The molecular docking results showed that the docking binding energy of key active ingredients and core targets was mostly less than-5 kcal/mol,and the docking was good.Conclusion:The quercetin,luteolin,wogonin,formononetin,beta-sitosterol and other active ingredients in San Huang lotion may act on eczema through AKT1,TNF,IL6,IL1B,TP53,VEGFA and other targets,and through IL-17signaling pathway,TNFsignaling pathway,Th17cell differentiation and other pathways.
基金Project supported by the German Academic Exchange Agency (DAAD),the China Scholarship Council(CSC),the Special Fund for Agro-scientific Research in the Public Interest(No.nyhezx07-050-6)the Science and Technology Department of Zhejiang Province of China(No.2008C22062)the Zhejiang Provincial Natural Science Foundation of China(No.R307396)
文摘Seed treatment with endophytic fungi has been regarded as an effective method for plant parasitic nematode control.Endophytic fungi from cucumber seedlings were isolated and screened for their potential to be used as seed treatment agents against Meloidogyne incognita.Among the 294 isolates screened,23 significantly reduced galls formed by M.incognita in greenhouse test.The 10 most effective isolates were Fusarium(5),Trichoderma(1),Chaetomium(1),Acremonium(1),Paecilomyces(1),and Phyllosticta(1) .Their control efficacies were repeatedly tested and their colonizations as well as in vitro activity against M.incognita were studied.They reduced the number of galls by 24.0%-58.4%in the first screening and 15.6%-44.3%in the repeated test,respectively.Phyllosticta Ph511 and Chaetomium Ch1001 had high colonizations on both the roots and the aboveground parts of cucumber seedlings.Fusarium isolates had colonization preference on the roots,their root colonizations ranging from 20.1%to 47.3%of the total root area.Trichoderma Tr882,Paecilomyces Pa972,and Acremonium Ac985 had low colonizations on both the roots and the aboveground parts.Acremonium Ac985,Chaetomium Ch1001,Paecilomyces Pa972,and Phyllosticta Ph511 produced compounds affecting motility of the second stage juveniles of M.incognita.Based on these results,Chae-tomium Ch1001 was considered to have the highest potential as a seed treatment agent for M.incognita biocontrol.
