Since the COVID-19 pandemic began,a plethora of modeling studies relatedto COVID-19 have been released.While some models stand out due to their innovative approaches,others are flawed in their methodology.To assist no...Since the COVID-19 pandemic began,a plethora of modeling studies relatedto COVID-19 have been released.While some models stand out due to their innovative approaches,others are flawed in their methodology.To assist novices,frontline healthcare workers,and public health policymakers in navigating the complex landscape of these models,we introduced a structured framework named MODELS.This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model,offering direction to researchers engaged in epidemic modeling endeavors.展开更多
Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly...Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired"stress-response"method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells.展开更多
Although studies have compared the relative severity of Omicron and Delta variants by assessing the relative risks,there are still gaps in the knowledge of the potential COVID-19 burden these variations may cause.And ...Although studies have compared the relative severity of Omicron and Delta variants by assessing the relative risks,there are still gaps in the knowledge of the potential COVID-19 burden these variations may cause.And the contact patterns in Fujian Province,China,have not been described.We identified 8969 transmission pairs in Fujian,China,by analyzing a contact-tracing database that recorded a SARS-CoV-2 outbreak in September 2021.We estimated the waning vaccine effectiveness against Delta variant infection,contact patterns,and epidemiology distributions,then simulated potential outbreaks of Delta and Omicron variants using a multi-group mathematical model.For instance,in the contact setting without stringent lockdowns,we estimated that in a potential Omicron wave,only 4.7%of infections would occur in Fujian Province among individuals aged>60 years.In comparison,58.75%of the death toll would occur in unvaccinated individuals aged>60 years.Compared with no strict lockdowns,combining school or factory closure alone reduced cumulative deaths of Delta and Omicron by 28.5%and 6.1%,respectively.In conclusion,this study validates the need for continuous mass immunization,especially among elderly aged over 60 years old.And it confirms that the effect of lockdowns alone in reducing infections or deaths is minimal.However,these measurements will still contribute to lowering peak daily incidence and delaying the epidemic,easing the healthcare system's burden.展开更多
The half-smooth tongue sole Cynoglossus semilaevis is an important cultured marine fish and a promising model fish for the study of sex determination. Sex-specific genetic linkage maps of half-smooth tongue sole were ...The half-smooth tongue sole Cynoglossus semilaevis is an important cultured marine fish and a promising model fish for the study of sex determination. Sex-specific genetic linkage maps of half-smooth tongue sole were developed with 567 mark- ers （565 microsatellite markers and two SCAR markers）. The parents and F1 progeny （92 individuals） were used as segregating populations. The female map was composed of 480 markers in 21 linkage groups, covering a total of 1388.1 cM, with an average interval 3.06 cM between markers. The male map consisted of 417 markers in 21 linkage groups, spanning 1480.9 cM, with an average interval of 3.75 cM. The female and male maps had 474 and 416 unique positions, respectively. The genome length of half-smooth tongue sole was estimated to be 1522.9 cM for females and 1649.1cM for males. Based on estimations of map length, the female and male maps covered 91.1% and 89.8% of the genome, respectively. Furthermore, two female-specific SCAR mark- ers, f-382 and f-783, were mapped on LG15f （linkage group 15 in female maps）. The present study presents a mid-density genetic linkage map for half-smooth tongue sole. These improved genetic linkage maps may facilitate systematic genome searches to identify quantitative trait loci （QTL）, such as disease resistance, growth and sex-related traits, and are very useful for marker-assisted selection breeding programs for economically important traits in half-smooth tongue sole [Current Zoology 59 （1）： 99-108, 2013].展开更多
Dear Editor,The emergence of COVID-19 since December 2019 has attracted great attention around the world and reminds the powerful pathogenic potential of viruses(Zhou et al.2020).The subfamily Orthocoronavirinae of th...Dear Editor,The emergence of COVID-19 since December 2019 has attracted great attention around the world and reminds the powerful pathogenic potential of viruses(Zhou et al.2020).The subfamily Orthocoronavirinae of the family Coronaviridae contains four genera Alphacoronavirus,Betacoronavirus,Gammacoronavirus,and Deltacoronavirus,which are the largest group of positive-sense,non-segmented,single-stranded,enveloped RNA viruses(Woo et al.2012;Shi et al.2016).The genus Gammacoronavirus currently has five species(https://talk.ictvonline.org/taxonomy/),which are primarily spread through birds(Woo et al.2012).展开更多
A SnSb nanocrystal/graphene hybrid nanocomposite was synthesized by a facile one-step solvothermal route using graphite oxide,SnCl_(2).2H_(2)O and SbCl_(3) as the starting materials,absolute ethanol as the solvent,and...A SnSb nanocrystal/graphene hybrid nanocomposite was synthesized by a facile one-step solvothermal route using graphite oxide,SnCl_(2).2H_(2)O and SbCl_(3) as the starting materials,absolute ethanol as the solvent,and NaBH4 as the reductant.The formation of SnSb alloy and the reduction of the graphene oxide occur simultaneously.SnSb nanoparticles with a size of 30–40 nm were uniformly anchored and confined by the graphene sheets,forming a unique SnSb/graphene hybrid nanostructure.The electrostatic attraction between the positively charged ions(Sn^(2+) and Sb^(3+))and the negatively charged graphene oxide plays an important role in the uniform distribution of the SnSb particles on the graphene sheets.The electrochemical Li-storage properties of the nanocomposite were investigated as a potential high-capacity anode material for Li-ion batteries.The results show that the nanocomposite exhibits an obvious enhanced Li-storage performance compared with bare SnSb.The improvement of the electrochemical performance could be attributed to the formation of two-dimensional conductive networks,homogeneous dispersion and confinement of SnSb nanoparticles and the enhanced wetting of active material with the electrolyte for increased specific surface area by the introduction of graphene into SnSb nanoparticles.Li-ion chemical diffusion coefficient and ac impedance were measured to understand the underlying mechanism for the improved electrochemical performance.展开更多
After the policy adjustment,China no longer carries out COVID-19 PCR testing for all people,and antigen testing has become the main way to detect and manage infectious sources.We developed a dynamic model to evaluate ...After the policy adjustment,China no longer carries out COVID-19 PCR testing for all people,and antigen testing has become the main way to detect and manage infectious sources.We developed a dynamic model to evaluate and compare the effects between PCR and antigen testing for controlling the pandemic.Due to the increase of contact degree,the peak reduction effect of PCR testing in population is lower than that of antigen testing.Even if it was only 20%of people isolated at home after antigen testing,the peak of the epidemic could be reduced by 9.46%.If the proportion of antigen testing is further increased to 80%,the peak of the pandemic can be reduced by 31.41%.Antigen testing performed better effects in school(reduction proportion 29.27%)and community(29.34%)than in workplace(27.75%).Therefore,we recommend that antigen testing in the popu-lation should be encouraged during the pandemic,and home isolation of infected persons should be advocated,especially in crowded places.To improve the availability of antigen,the testing proportion should be further enhanced.展开更多
Jiangxi Provincial Center for Disease Control and Prevention(Jiangxi CDC)received an alert at 23:45 on November 7,2019 from Nanchang Customs that yellow fever virus was detected in a foreign national.On November 8,cou...Jiangxi Provincial Center for Disease Control and Prevention(Jiangxi CDC)received an alert at 23:45 on November 7,2019 from Nanchang Customs that yellow fever virus was detected in a foreign national.On November 8,county,municipal,and provincial CDCs of Jiangxi Province carried out epidemiological investigations to show that the suspected case was found in a 35-year-old male patient from Addis Ababa,Ethiopia.On November 5,this patient began to have yellow-fever-like symptoms such as onset of fever,chills,and headache.展开更多
基金supported by the National Key R&D Program of China(2021YFC2301604)Fundamental Research Funds for the Central Universities(20720230001)the Self-supporting Program of Guangzhou Laboratory(SRPG22-007)
文摘Since the COVID-19 pandemic began,a plethora of modeling studies relatedto COVID-19 have been released.While some models stand out due to their innovative approaches,others are flawed in their methodology.To assist novices,frontline healthcare workers,and public health policymakers in navigating the complex landscape of these models,we introduced a structured framework named MODELS.This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model,offering direction to researchers engaged in epidemic modeling endeavors.
基金This work was supported primarily by the National Key Research and Development Program of China(No.2018YFE0208500)the Major Research Plan of the National Natural Science Foundation of China(No.91963206)+3 种基金the National Natural Science Foundation of China(Nos.U1508202 and 51627810)the Natural Science Foundation of Jiangsu Province(No.SBK2018022120),the open fund of Wuhan National Laboratory for Optoelectronics(No.2018WNLOKF020)the open fund of Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies(No.EEST2018-1)the civil aerospace technology preliminary research project of the State Administration of Science,Technology and Industry for National Defense.
文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired"stress-response"method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells.
基金supported by the Bill&Melinda Gates Foundation(INV-005834),Natural Science Foundation of Fujian Province(NO.2021J01353,NO.2020J01094)National Science and Technology Major Project of the Ministry of Science and Technology of China(NO.2018ZX10734402-007)+1 种基金Research on accurate prediction and timely response system for out-breaks of new infectious diseases(SRPG2200702)Fundamental Research Funds for the Central Universities(No.20720230001).
文摘Although studies have compared the relative severity of Omicron and Delta variants by assessing the relative risks,there are still gaps in the knowledge of the potential COVID-19 burden these variations may cause.And the contact patterns in Fujian Province,China,have not been described.We identified 8969 transmission pairs in Fujian,China,by analyzing a contact-tracing database that recorded a SARS-CoV-2 outbreak in September 2021.We estimated the waning vaccine effectiveness against Delta variant infection,contact patterns,and epidemiology distributions,then simulated potential outbreaks of Delta and Omicron variants using a multi-group mathematical model.For instance,in the contact setting without stringent lockdowns,we estimated that in a potential Omicron wave,only 4.7%of infections would occur in Fujian Province among individuals aged>60 years.In comparison,58.75%of the death toll would occur in unvaccinated individuals aged>60 years.Compared with no strict lockdowns,combining school or factory closure alone reduced cumulative deaths of Delta and Omicron by 28.5%and 6.1%,respectively.In conclusion,this study validates the need for continuous mass immunization,especially among elderly aged over 60 years old.And it confirms that the effect of lockdowns alone in reducing infections or deaths is minimal.However,these measurements will still contribute to lowering peak daily incidence and delaying the epidemic,easing the healthcare system's burden.
文摘The half-smooth tongue sole Cynoglossus semilaevis is an important cultured marine fish and a promising model fish for the study of sex determination. Sex-specific genetic linkage maps of half-smooth tongue sole were developed with 567 mark- ers （565 microsatellite markers and two SCAR markers）. The parents and F1 progeny （92 individuals） were used as segregating populations. The female map was composed of 480 markers in 21 linkage groups, covering a total of 1388.1 cM, with an average interval 3.06 cM between markers. The male map consisted of 417 markers in 21 linkage groups, spanning 1480.9 cM, with an average interval of 3.75 cM. The female and male maps had 474 and 416 unique positions, respectively. The genome length of half-smooth tongue sole was estimated to be 1522.9 cM for females and 1649.1cM for males. Based on estimations of map length, the female and male maps covered 91.1% and 89.8% of the genome, respectively. Furthermore, two female-specific SCAR mark- ers, f-382 and f-783, were mapped on LG15f （linkage group 15 in female maps）. The present study presents a mid-density genetic linkage map for half-smooth tongue sole. These improved genetic linkage maps may facilitate systematic genome searches to identify quantitative trait loci （QTL）, such as disease resistance, growth and sex-related traits, and are very useful for marker-assisted selection breeding programs for economically important traits in half-smooth tongue sole [Current Zoology 59 （1）： 99-108, 2013].
基金This work was supported by grants from National Science and Technology Major Project of China(2018ZX10712001-018)National Key R&D Program of China(2019YFC1200500 and 2019YFC1200505)+1 种基金National Natural Science Foundation of China(81802017)Research Units of Discovery of Unknown Bacteria and Function(2018RU010)。
文摘Dear Editor,The emergence of COVID-19 since December 2019 has attracted great attention around the world and reminds the powerful pathogenic potential of viruses(Zhou et al.2020).The subfamily Orthocoronavirinae of the family Coronaviridae contains four genera Alphacoronavirus,Betacoronavirus,Gammacoronavirus,and Deltacoronavirus,which are the largest group of positive-sense,non-segmented,single-stranded,enveloped RNA viruses(Woo et al.2012;Shi et al.2016).The genus Gammacoronavirus currently has five species(https://talk.ictvonline.org/taxonomy/),which are primarily spread through birds(Woo et al.2012).
基金supported by the Zijin Program of Zhejiang University,China,the Fundamental Research Funds for the Central Universities(No.2010QNA4003)the Ph.D.Programs Foundation of Ministry of Education of China(No.20100101120024)+2 种基金the Foundation of Education Office of Zhejiang Province(No.Y201016484)the Qianjiang Talents Project of Science Technology Department of Zhejiang Province(2011R10021)the National Natural Science Foundation of China(No.51101139).
文摘A SnSb nanocrystal/graphene hybrid nanocomposite was synthesized by a facile one-step solvothermal route using graphite oxide,SnCl_(2).2H_(2)O and SbCl_(3) as the starting materials,absolute ethanol as the solvent,and NaBH4 as the reductant.The formation of SnSb alloy and the reduction of the graphene oxide occur simultaneously.SnSb nanoparticles with a size of 30–40 nm were uniformly anchored and confined by the graphene sheets,forming a unique SnSb/graphene hybrid nanostructure.The electrostatic attraction between the positively charged ions(Sn^(2+) and Sb^(3+))and the negatively charged graphene oxide plays an important role in the uniform distribution of the SnSb particles on the graphene sheets.The electrochemical Li-storage properties of the nanocomposite were investigated as a potential high-capacity anode material for Li-ion batteries.The results show that the nanocomposite exhibits an obvious enhanced Li-storage performance compared with bare SnSb.The improvement of the electrochemical performance could be attributed to the formation of two-dimensional conductive networks,homogeneous dispersion and confinement of SnSb nanoparticles and the enhanced wetting of active material with the electrolyte for increased specific surface area by the introduction of graphene into SnSb nanoparticles.Li-ion chemical diffusion coefficient and ac impedance were measured to understand the underlying mechanism for the improved electrochemical performance.
基金supported by the National Key Research and Development Program of China (2021YFC2301604)Guiding projects of Science and Technology Program in Fujian Province (2019D014).
文摘After the policy adjustment,China no longer carries out COVID-19 PCR testing for all people,and antigen testing has become the main way to detect and manage infectious sources.We developed a dynamic model to evaluate and compare the effects between PCR and antigen testing for controlling the pandemic.Due to the increase of contact degree,the peak reduction effect of PCR testing in population is lower than that of antigen testing.Even if it was only 20%of people isolated at home after antigen testing,the peak of the epidemic could be reduced by 9.46%.If the proportion of antigen testing is further increased to 80%,the peak of the pandemic can be reduced by 31.41%.Antigen testing performed better effects in school(reduction proportion 29.27%)and community(29.34%)than in workplace(27.75%).Therefore,we recommend that antigen testing in the popu-lation should be encouraged during the pandemic,and home isolation of infected persons should be advocated,especially in crowded places.To improve the availability of antigen,the testing proportion should be further enhanced.
文摘Jiangxi Provincial Center for Disease Control and Prevention(Jiangxi CDC)received an alert at 23:45 on November 7,2019 from Nanchang Customs that yellow fever virus was detected in a foreign national.On November 8,county,municipal,and provincial CDCs of Jiangxi Province carried out epidemiological investigations to show that the suspected case was found in a 35-year-old male patient from Addis Ababa,Ethiopia.On November 5,this patient began to have yellow-fever-like symptoms such as onset of fever,chills,and headache.
