溶剂分子的存在会严重降低能量金属-有机框架(EMOFs)材料的爆热和稳定性,开发无溶剂的EMOFs已成为制备高能量密度材料的有效策略。本文将高能的2,3-二(5-1H-四唑基)吡嗪(H2DTPZ)配体与银离子作用在水热条件下制备了一例无溶剂的EMOF [Ag...溶剂分子的存在会严重降低能量金属-有机框架(EMOFs)材料的爆热和稳定性,开发无溶剂的EMOFs已成为制备高能量密度材料的有效策略。本文将高能的2,3-二(5-1H-四唑基)吡嗪(H2DTPZ)配体与银离子作用在水热条件下制备了一例无溶剂的EMOF [Ag2(DTPZ)]n(1)(含氮量:32.58%),并借助元素分析、红外光谱、X射线衍射以及热分析等技术对其组成和结构进行了表征。化合物1中,DTPZ2-配体构型高度扭转并以八齿配位模式桥联Ag+离子形成三维框架结构(ρ=2.812 g·cm-3),配体大的位阻效应和强的配位能力有效阻止了溶剂分子与金属配位或占据框架空腔;同时,不同配体四唑环间强的π–π堆积作用(质心-质心距离为0.34461(1) nm),使得化合物1呈现高的热稳定性(Te=619.1 K, Tp=658.7K)。热分析研究表明化合物1分解主要发生一步快速失重并伴有剧烈的放热,呈现出潜在的含能特质。通过差示扫描量热(DSC)技术对化合物1的热分解过程进行了非等温热动力学分析(基于Kissinger和Ozawa-Doyle方法)并获得了相应热动力学参数(活化能Ea=272.1 k J·mol^-1,Eo=268.9 k J·mol^-1;lgA=19.67 s^-1)。进一步基于升温速率趋于0时的分解峰温和外延起始温度,计算得到了相关热力学参数(活化焓?H≠=266.9 k J·mol^-1,活化熵?S≠=125.4 J·mol^-1·K-1,活化自由能?G≠=188.3 k J·mol^-1)以及热爆炸临界温度(Tb=607.1 K)和自加速分解温度(TSADT=595.8 K),结果表明该化合物具有良好的热安全性,其分解属非自发的熵驱动过程。借助精密转动弹热量计测定了化合物1的恒容燃烧能(Qv)并计算得其标准摩尔生成焓为(2165.99±0.81) k J·mol^-1。爆轰和安全性能测试表明,化合物1对撞击和摩擦均不敏感,爆热值达10.15 k J·g^-1,远高于常见硝铵类炸药奥克托金(HMX)、黑索金(RDX)和2,4,6-三硝基甲苯(TNT),是一例有前景的高能钝感含能材料。展开更多
Introduction Solitary fibrous tumor （SFT） of the kidney is a rare spindle cell neoplasm and all reported SFTs of the kidney were diagnosed through pathological examination and immunohistochemical study after open ne...Introduction Solitary fibrous tumor （SFT） of the kidney is a rare spindle cell neoplasm and all reported SFTs of the kidney were diagnosed through pathological examination and immunohistochemical study after open nephrectomy or open radical nephrectomy. We present a case of SFT of the kidney diagnosed through fine needle core biopsy preoperatively in a 50-year-old female and managed with laparoscopic partial nephrectomy. Due to the difficulty in discriminating between malignant and benign growth pattern of this tumor entity, a regular follow-up after conservative treatment is mandatory.展开更多
Focal adhesion kinase(FAK)plays a vital role in mediating the adaptability of tumor cells under mechanical stimuli.Previous studies revealed that FAK can locate to different cell compartments,and its regulation is hig...Focal adhesion kinase(FAK)plays a vital role in mediating the adaptability of tumor cells under mechanical stimuli.Previous studies revealed that FAK can locate to different cell compartments,and its regulation is highly dependent on its subcellular localization.However,the local FAK activities and its regulation mechanism in different cell compartments of tumor cells in response to fluid shear stress are still unclear.In this study,5 dyn/cm^(2) and 20 dyn/cm^(2) of shear stress was applied to HeLa cells for 30 min.The activities of FAK targeting different subcellular compartments(lipids rafts,non-rafts,focal adhesions and cytoplasm)were investigated with fluorescence resonance energy transfer(FRET)technology.Results showed that the activity of FAK in response to high shear stress at focal adhesion sites was lower than that of other three areas,while no difference among four areas was observed in response to low shear stress.Furthermore,high shear stress-induced distinct FAK activation at different compartments was inhibited by decreasing membrane fluidity,but Src inhibition prevented high shear stress-induced FAK activation only in the cytoplasm.This study revealed the spatiotemporal characteristics of FAK under the different magnitude of shear stress,which provides a deeper understanding of mechanotransduction in tumor cells.展开更多
In this paper, we consider the large time behavior of the strong solutions to the three dimensional compressible viscoelastic flows with damping. Based on the energy method and spectral analysis, we analyze the influe...In this paper, we consider the large time behavior of the strong solutions to the three dimensional compressible viscoelastic flows with damping. Based on the energy method and spectral analysis, we analyze the influences of the damping on the global existence and decay rates of compressible viscoelastic flows under some small assumptions in H3-framework. Compared with the time decay rates of solutions to the compressible viscoelastic flows in?[1], our results imply that the friction of the damping is stronger than the dissipation effect of the viscosities.展开更多
Mesenchymal stem cells (MSCs) have been recognized as the best candidate for tissue engineering, while the mechanism of biomaterial-induced MSCs differentiation is not well understood. Most of research has been focuse...Mesenchymal stem cells (MSCs) have been recognized as the best candidate for tissue engineering, while the mechanism of biomaterial-induced MSCs differentiation is not well understood. Most of research has been focused on chemical signaling of biomaterial in the past, but a variety of non-chemical signals were also proved to play essential roles in cellular behaviors. In this paper, we reviewed the current reports about the effects of different kinds of biomaterial signals on MSCs differentiation.展开更多
Artemisia argyi is a traditional Chinese food and medicine which can improve multiple diseases such as asthma and gastrointestinal disorders.However,whether the beneficial bioactivities are associated with microbial f...Artemisia argyi is a traditional Chinese food and medicine which can improve multiple diseases such as asthma and gastrointestinal disorders.However,whether the beneficial bioactivities are associated with microbial fermentation remain unknown.The objective of this study was to investigate the effects of fermentation on bioactive compounds,antioxidant activity,and flavor characteristics of Artemisia argyi fermentation liquid(AAFL-LP)by an autochthonous strain,Lactiplantibacillus plantarum WLPL01.L.plantarum WLPL01 was found to utilize sugars and flavonoids to produce abundant organic acids,such as lactic acid and malic acid,improve antioxidant activity of Artemisia argyi including total superoxide dismutase content,1,1-diphenyl-2-picrylhydrazyl(DPPH)radical-scavenging capacity,and Fe-reducing antioxidant power,decrease largely bitter taste notes such as leucine,isoleucine,and phenylalanine,and enhance fruity,sweet,and flora notes such as terpenes and esters of AAFL-LP.Collectively,L.plantarum WLPL01 could improve the functionality of A.argyi and the flavor of the product,suggesting it a promising candidate in developing functional A.argyi food.展开更多
Debates persist regarding the efficacy and safety of azvudine,particularly its real-world outcomes.This study involved patients aged 60 years who were admitted to 25 hospitals in China's Mainland with confirmed SA...Debates persist regarding the efficacy and safety of azvudine,particularly its real-world outcomes.This study involved patients aged 60 years who were admitted to 25 hospitals in China's Mainland with confirmed SARS-CoV-2 infection between December 1,2022,and February 28,2023.Efficacy outcomes were all-cause mortality during hospitalization,the proportion of patients discharged with recovery,time to nucleic acid-negative conversion(TNANC),time to symptom improvement(TSI),and time of hospital stay(THS).Safety was also assessed.Among the 5884 participants identified,1999 received azvudine,and 1999 matched controls were included after exclusion and propensity score matching.Azvudine recipients exhibited lower all-cause mortality compared with controls in the overall population(13.3%vs.17.1%,RR,0.78;95%CI,0.67e0.90;P Z 0.001)and in the severe subgroup(25.7%vs.33.7%;RR,0.76;95%CI,0.66e0.88;P<0.001).A higher proportion of patients discharged with recovery,and a shorter TNANC were associated with azvudine recipients,especially in the severe subgroup.The incidence of adverse events in azvudine recipients was comparable to that in the control group(2.3%vs.1.7%,P Z 0.170).In conclusion,azvudine showed efficacy and safety in older patients hospitalized with COVID-19 during the SARS-CoV-2 omicron wave in China.展开更多
基金supported by the National Natural Science Foundation of China(21727805,21673180,21703135,21803042)Natural Science Basic Research Program of Shaanxi(2017JZ002,2018JM5180,2019JQ-249,2019JQ-067)+1 种基金the Project of Shaanxi Key Laboratory of Chemical Reaction Engineering(14JS112)the 64th China Postdoctoral Science Foundation Funded Project(2018M643706)。
文摘溶剂分子的存在会严重降低能量金属-有机框架(EMOFs)材料的爆热和稳定性,开发无溶剂的EMOFs已成为制备高能量密度材料的有效策略。本文将高能的2,3-二(5-1H-四唑基)吡嗪(H2DTPZ)配体与银离子作用在水热条件下制备了一例无溶剂的EMOF [Ag2(DTPZ)]n(1)(含氮量:32.58%),并借助元素分析、红外光谱、X射线衍射以及热分析等技术对其组成和结构进行了表征。化合物1中,DTPZ2-配体构型高度扭转并以八齿配位模式桥联Ag+离子形成三维框架结构(ρ=2.812 g·cm-3),配体大的位阻效应和强的配位能力有效阻止了溶剂分子与金属配位或占据框架空腔;同时,不同配体四唑环间强的π–π堆积作用(质心-质心距离为0.34461(1) nm),使得化合物1呈现高的热稳定性(Te=619.1 K, Tp=658.7K)。热分析研究表明化合物1分解主要发生一步快速失重并伴有剧烈的放热,呈现出潜在的含能特质。通过差示扫描量热(DSC)技术对化合物1的热分解过程进行了非等温热动力学分析(基于Kissinger和Ozawa-Doyle方法)并获得了相应热动力学参数(活化能Ea=272.1 k J·mol^-1,Eo=268.9 k J·mol^-1;lgA=19.67 s^-1)。进一步基于升温速率趋于0时的分解峰温和外延起始温度,计算得到了相关热力学参数(活化焓?H≠=266.9 k J·mol^-1,活化熵?S≠=125.4 J·mol^-1·K-1,活化自由能?G≠=188.3 k J·mol^-1)以及热爆炸临界温度(Tb=607.1 K)和自加速分解温度(TSADT=595.8 K),结果表明该化合物具有良好的热安全性,其分解属非自发的熵驱动过程。借助精密转动弹热量计测定了化合物1的恒容燃烧能(Qv)并计算得其标准摩尔生成焓为(2165.99±0.81) k J·mol^-1。爆轰和安全性能测试表明,化合物1对撞击和摩擦均不敏感,爆热值达10.15 k J·g^-1,远高于常见硝铵类炸药奥克托金(HMX)、黑索金(RDX)和2,4,6-三硝基甲苯(TNT),是一例有前景的高能钝感含能材料。
文摘Introduction Solitary fibrous tumor （SFT） of the kidney is a rare spindle cell neoplasm and all reported SFTs of the kidney were diagnosed through pathological examination and immunohistochemical study after open nephrectomy or open radical nephrectomy. We present a case of SFT of the kidney diagnosed through fine needle core biopsy preoperatively in a 50-year-old female and managed with laparoscopic partial nephrectomy. Due to the difficulty in discriminating between malignant and benign growth pattern of this tumor entity, a regular follow-up after conservative treatment is mandatory.
基金supported by National Natural Science Foundation of China(11532004,31670867,31670961)Natural Science Foundation Project of CQ(CSTCJCYJBX0003,CSTCJCYJAX0286)+1 种基金The Program for Innovation Teams in University of Chongqing(CXTDX201601032)and program of Chongqing University of Science&Technology(CK2017ZKYB017,YKJCX1720201)Cooperative Project of Academician Workstation of Chongqing University of Science&Technology.
文摘Focal adhesion kinase(FAK)plays a vital role in mediating the adaptability of tumor cells under mechanical stimuli.Previous studies revealed that FAK can locate to different cell compartments,and its regulation is highly dependent on its subcellular localization.However,the local FAK activities and its regulation mechanism in different cell compartments of tumor cells in response to fluid shear stress are still unclear.In this study,5 dyn/cm^(2) and 20 dyn/cm^(2) of shear stress was applied to HeLa cells for 30 min.The activities of FAK targeting different subcellular compartments(lipids rafts,non-rafts,focal adhesions and cytoplasm)were investigated with fluorescence resonance energy transfer(FRET)technology.Results showed that the activity of FAK in response to high shear stress at focal adhesion sites was lower than that of other three areas,while no difference among four areas was observed in response to low shear stress.Furthermore,high shear stress-induced distinct FAK activation at different compartments was inhibited by decreasing membrane fluidity,but Src inhibition prevented high shear stress-induced FAK activation only in the cytoplasm.This study revealed the spatiotemporal characteristics of FAK under the different magnitude of shear stress,which provides a deeper understanding of mechanotransduction in tumor cells.
文摘In this paper, we consider the large time behavior of the strong solutions to the three dimensional compressible viscoelastic flows with damping. Based on the energy method and spectral analysis, we analyze the influences of the damping on the global existence and decay rates of compressible viscoelastic flows under some small assumptions in H3-framework. Compared with the time decay rates of solutions to the compressible viscoelastic flows in?[1], our results imply that the friction of the damping is stronger than the dissipation effect of the viscosities.
文摘Mesenchymal stem cells (MSCs) have been recognized as the best candidate for tissue engineering, while the mechanism of biomaterial-induced MSCs differentiation is not well understood. Most of research has been focused on chemical signaling of biomaterial in the past, but a variety of non-chemical signals were also proved to play essential roles in cellular behaviors. In this paper, we reviewed the current reports about the effects of different kinds of biomaterial signals on MSCs differentiation.
基金supported by National Natural Science Foundation of China(grant no.NSF 32060030,Beijing,China).
文摘Artemisia argyi is a traditional Chinese food and medicine which can improve multiple diseases such as asthma and gastrointestinal disorders.However,whether the beneficial bioactivities are associated with microbial fermentation remain unknown.The objective of this study was to investigate the effects of fermentation on bioactive compounds,antioxidant activity,and flavor characteristics of Artemisia argyi fermentation liquid(AAFL-LP)by an autochthonous strain,Lactiplantibacillus plantarum WLPL01.L.plantarum WLPL01 was found to utilize sugars and flavonoids to produce abundant organic acids,such as lactic acid and malic acid,improve antioxidant activity of Artemisia argyi including total superoxide dismutase content,1,1-diphenyl-2-picrylhydrazyl(DPPH)radical-scavenging capacity,and Fe-reducing antioxidant power,decrease largely bitter taste notes such as leucine,isoleucine,and phenylalanine,and enhance fruity,sweet,and flora notes such as terpenes and esters of AAFL-LP.Collectively,L.plantarum WLPL01 could improve the functionality of A.argyi and the flavor of the product,suggesting it a promising candidate in developing functional A.argyi food.
基金funded by National High Level Hospital Clinical Research Funding(BJ-2022-173,China)National Health Commission Clinical Research Projects for Innovative Drugs(WKZX2023CX210007,China).
文摘Debates persist regarding the efficacy and safety of azvudine,particularly its real-world outcomes.This study involved patients aged 60 years who were admitted to 25 hospitals in China's Mainland with confirmed SARS-CoV-2 infection between December 1,2022,and February 28,2023.Efficacy outcomes were all-cause mortality during hospitalization,the proportion of patients discharged with recovery,time to nucleic acid-negative conversion(TNANC),time to symptom improvement(TSI),and time of hospital stay(THS).Safety was also assessed.Among the 5884 participants identified,1999 received azvudine,and 1999 matched controls were included after exclusion and propensity score matching.Azvudine recipients exhibited lower all-cause mortality compared with controls in the overall population(13.3%vs.17.1%,RR,0.78;95%CI,0.67e0.90;P Z 0.001)and in the severe subgroup(25.7%vs.33.7%;RR,0.76;95%CI,0.66e0.88;P<0.001).A higher proportion of patients discharged with recovery,and a shorter TNANC were associated with azvudine recipients,especially in the severe subgroup.The incidence of adverse events in azvudine recipients was comparable to that in the control group(2.3%vs.1.7%,P Z 0.170).In conclusion,azvudine showed efficacy and safety in older patients hospitalized with COVID-19 during the SARS-CoV-2 omicron wave in China.
