The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomateria...The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs. In addition, hemostatic biomaterials with porous structures, biochemical substances, and strongly adhesive hydrogels can be used to achieve rapid and effective hemostasis via physical or biochemical mechanisms. This article reviews methods of preparing anticoagulant coatings on material surfaces and the current status of rapid hemostatic materials. It also summarizes fundamental concepts for the design and synthesis of anticoagulant and hemostatic materials by discussing thrombosis and hemostasis mechanisms in biomedical devices and normal organisms. Because there are relatively few reports reviewing the progress in surface-functionalized design for anticoagulation and hemostasis, it is anticipated that this review can provide a useful summary of the applications of both bio-adhesion and bio-lubrication techniques in the field of biomedical engineering.展开更多
The evolution of electronic systems towards small,flexible,portable and human-centered forms drives the demand for onbody power supplies with lightweight and high flexibility.Fiber solar cells that can be integrated i...The evolution of electronic systems towards small,flexible,portable and human-centered forms drives the demand for onbody power supplies with lightweight and high flexibility.Fiber solar cells that can be integrated into soft and lightweight textiles are considered as potential sustainable power sources for the next generation of wearable electronics.To this end,they have been extensively investigated in the past decade aiming to improve their photovoltaic performances,but there is still a big gap between the high-performance devices and real applications.Herein,the key advances of configurations,fabrications and performances of fiber solar cells are highlighted and analyzed.Based on the current progress,the latest ideas with regard to the remaining challenges and opportunities beyond the reach of the previous studies are presented.展开更多
基金This study was financially supported by National Natural Science Foundation of China(52022043)Precision Medicine Foundation,Tsinghua University,China(10001020120)+2 种基金Capital’s Funds for Health Improvement and Research(2020-2Z-40810)Natural Science Foundation of Hebei Province(H2021201005)Research Project of State Key Laboratory of Mechanical System and Vibration(MSV202209).
文摘The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs. In addition, hemostatic biomaterials with porous structures, biochemical substances, and strongly adhesive hydrogels can be used to achieve rapid and effective hemostasis via physical or biochemical mechanisms. This article reviews methods of preparing anticoagulant coatings on material surfaces and the current status of rapid hemostatic materials. It also summarizes fundamental concepts for the design and synthesis of anticoagulant and hemostatic materials by discussing thrombosis and hemostasis mechanisms in biomedical devices and normal organisms. Because there are relatively few reports reviewing the progress in surface-functionalized design for anticoagulation and hemostasis, it is anticipated that this review can provide a useful summary of the applications of both bio-adhesion and bio-lubrication techniques in the field of biomedical engineering.
基金This work was supported by STCSM(20JC1414902,21511104900),SHMEC(2017-01-07-00-07-E00062)the China Postdoctoral Science Foundation(KLH1717008).
文摘The evolution of electronic systems towards small,flexible,portable and human-centered forms drives the demand for onbody power supplies with lightweight and high flexibility.Fiber solar cells that can be integrated into soft and lightweight textiles are considered as potential sustainable power sources for the next generation of wearable electronics.To this end,they have been extensively investigated in the past decade aiming to improve their photovoltaic performances,but there is still a big gap between the high-performance devices and real applications.Herein,the key advances of configurations,fabrications and performances of fiber solar cells are highlighted and analyzed.Based on the current progress,the latest ideas with regard to the remaining challenges and opportunities beyond the reach of the previous studies are presented.
