BACKGROUND The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.AIM To explore the intervention value of a drug-p...BACKGROUND The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.AIM To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.METHODS Overall,98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study(50 patients)and control groups(48 patients).For 3 months,the control group was treated with conventional drugs,and the research group with a comprehensive intervention model of drug-psychology-society-skills.Data were obtained for the mini mental assessment scale(MMSE),Montreal cognitive assessment scale(MoCA),positive and negative symptom scale,insight and treatment attitude scale,cognitive ability scale and social skills[personal and social function scale(PSP)].The adverse reactions were observed.RESULTS After the intervention,the MMSE and MoCA scores improved in both groups.MoCA scores in the study group(26.58±3.21)were significantly(P<0.05)higher than those in the control group(24.68±3.02),MMSE scores were not significantly higher.Post-intervention,positive and negative symptom scores improved in both groups,and the positive and negative symptom scores in the study group[(12.01±2.58)and(32.51±2.11)]were significantly(P<0.05)different than those in the control group[(14.54±2.33)and(33.74±2.55)].Post-intervention,insight and treatment attitudes questionnaire scores of both groups were improved and compared with the control group(7.97±3.02),the study group(13.56±6.35)had significantly(P<0.05)higher scores.Post-intervention,the MATRICS consensus cognitive battery score of both groups was improved and compared with the control group(38.44±6.23),the score of the study group was significantly(P<0.05)increased(43.51±6.01).Post-intervention,the PSP score of the study group(78.38±6.63)was significantly(P<0.05)higher than that of the control group(74.52±7.01).During the intervention period,the incidence of adverse reactions in the study group was 6.25%,not significantly different from that in the control group(8.33%).During the intervention,both groups experienced adverse reactions,with no significant difference between groups(P>0.05).CONCLUSION The comprehensive intervention model based on drug-psychology-society-skills has obvious intervention effects on patients with chronic schizophrenia,which improves their cognitive ability and reduces their positive and negative symptoms.Simultaneously,it improves the self-knowledge of patients,improves their attitude toward treatment,effectively promotes the recovery of patients'social functions,and is safe.Therefore,it is worthy of being vigorously promoted and widely used in clinics.展开更多
Benign prostatic hyperplasia （BPH） is one of the most common medical conditions in middle aged and older men. This study investigated the relationship between serum levels of sex hormones and measures of BPH in the ...Benign prostatic hyperplasia （BPH） is one of the most common medical conditions in middle aged and older men. This study investigated the relationship between serum levels of sex hormones and measures of BPH in the aging male population of China. Prostate symptoms were assessed as part of a free health screening program for men ~40 years of age. The examination included digital rectal examination, determination of serum prostate-specific antigen levels, International Prostate Symptom Score （IPSS） and transrectal ultrasonography. Serum levels of total testosterone （TT）, sex hormone binding globulin （SHBG）, free testosterone （FT）, luteinizing hormone （LH）, follicle-stimulating hormone （FSH）, prolactin （PRL） and estradiol （E2） were evaluated. The men also completed a health and demographics questionnaire and received a detailed physical examination. The final study population consisted of 949 men with a mean age of 58.9 years. Pearson correlation analysis indicated that there were significant correlations between age and levels of all sex hormones except TT, and between age and prostate volume （PV; r=0.243; P〈0.01） or IPSS （r=0.263; P〈0.01）. Additional significant correlations were found between IPSS and serum levels of LH （r=0. 112; P〈0.01） and FSH （r=0.074; P〈0.05）, but there were no significant correlations between sex hormone levels and PV. Multivariate linear regression analysis showed significant correlations between age and body mass index （BMI） with PV （P〈0.0001）. In addition, there was a significant correlation between age and PV with IPSS （P〈0.0001）. Serum sex hormone levels did not correlate with PV or IPSS. The effects of endocrine changes on measures of BPH in aging men require further investigation in longitudinal and multicenter studies that include oatients with all severities of BPH.展开更多
SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer （PCa） tissues and cells and to preliminarily investigate the ...SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer （PCa） tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis in vitro. Quantitative reverse transcription polymerase chain reaction （qRT-PCR） and immunohistochemistry （IHC） were used to detect the expression of SETDB1 in PCa tissues, adjacent normal tissues, benign prostatic hyperplasia （BPH） tissues, PCa cell lines and normal prostate epithelial cells. The results suggested that SETDB1 was upregulated in human PCa tissues compared with normal tissues at the mRNA and protein levels. The role of SETDB1 in proliferation was analyzed with cell counting kit-8, colony-forming efficiency and flow cytometry assays. The results indicated that downregulation of SETDB1 by siRNA inhibited PCa cell growth, and induced GO/G1 cell cycle arrest. The PCa cell migration and invasion decreased by silcencing SETDBt which were assessed by using in vitro scratch and transwell invasion assay respectively. Our data suggested that SETDB1 is overexpressed in human PCa. Silencing SETDB1 inhibited PCa cell proliferation, migration and invasion.展开更多
The method of describing deformation camouflage spots based on feature space has some shortcomings,such as inaccurate description and difficult reproduction.Depending on the strong fitting ability of the generative ad...The method of describing deformation camouflage spots based on feature space has some shortcomings,such as inaccurate description and difficult reproduction.Depending on the strong fitting ability of the generative adversarial network model,the distribution of deformation camouflage spot pattern can be directly fitted,thus simplifying the process of spot extraction and reproduction.The requirements of background spot extraction are analyzed theoretically.The calculation formula of limiting the range of image spot pixels is given and two kinds of spot data sets,forestland and snowfield,are established.Spot feature is decomposed into shape,size and color features,and a GAN(Generative Adversarial Network)framework is established.The effects of different loss functions on network training results are analyzed in the experiment.In the meantime,when the input dimension of generator network is 128,the balance between sample diversity and quality can be achieved.The effects of sample generation are investigated in two aspects.Subjectively,the probability of the generated spots being distinguished in the background is counted,and the results are all less than 20% and mostly close to zero.Objectively,the features of the spot shape are calculated and the independent sample T-test is applied to verify that the features are from the same distribution,and all the P-Values are much higher than 0.05.Both subjective and objective methods prove that the spots generated by this method are similar to the background spots.The proposed method can directly generate the desired camouflage pattern spots,which provides a new technical method for the deformation camouflage pattern design and camouflage effect evaluation.展开更多
The evaluation index of camouflage patterns is important in the field of military application.It is the goal that researchers have always pursued to make the computable evaluation indicators more in line with the huma...The evaluation index of camouflage patterns is important in the field of military application.It is the goal that researchers have always pursued to make the computable evaluation indicators more in line with the human visual mechanism.In order to make the evaluation method more computationally intelligent,a Multi-Feature Camouflage Fused Index(MF-CFI)is proposed based on the comparison of grayscale,color and texture features between the target and the background.In order to verify the effectiveness of the proposed index,eye movement experiments are conducted to compare the proposed index with existing indexes including Universal Image Quality Index(UIQI),Camouflage Similarity Index(CSI)and Structural Similarity(SSIM).Twenty-four different simulated targets are designed in a grassland background,28 observers participate in the experiment and record the eye movement data during the observation process.The results show that the highest Pearson correlation coefficient is observed between MF-CFI and the eye movement data,both in the designed digital camouflage patterns and largespot camouflage patterns.Since MF-CFI is more in line with the detection law of camouflage targets in human visual perception,the proposed index can be used for the comparison and parameter optimization of camouflage design algorithms.展开更多
BACKGROUND Mortality rates after pancreaticoduodenectomy(PD)have significantly decreased in specialized centers.However,postoperative morbidity,particularly delayed gastric emptying(DGE),remains the most frequent comp...BACKGROUND Mortality rates after pancreaticoduodenectomy(PD)have significantly decreased in specialized centers.However,postoperative morbidity,particularly delayed gastric emptying(DGE),remains the most frequent complication following PD.AIM To identify risk factors associated with DGE after the PD procedure.METHODS In this retrospective,cross-sectional study,clinical data were collected from 114 patients who underwent PD between January 2015 and June 2018.Demographic factors,pre-and perioperative characteristics,and surgical complications were assessed.Univariate and multivariate analyses were performed to identify risk factors for post-PD DGE.RESULTS The study included 66 males(57.9%)and 48 females(42.1%),aged 33-83 years(mean:62.5),with a male-to-female ratio of approximately 1.4:1.There were 63 cases(55.3%)of PD and 51 cases(44.7%)of pylorus-preserving pancreatoduodenectomy.Among the 114 patients who underwent PD,33(28.9%)developed postoperative DGE.Univariate analysis revealed significant differences in four of the 14 clinical indexes observed:pylorus preservation,retrocolonic anastomosis,postoperative abdominal complications,and early postoperative albumin(ALB).Logistic regression analysis further identified postoperative abdominal complic-ations[odds ratio(OR)=4.768,P=0.002],preoperative systemic diseases(OR=2.516,P=0.049),and early postoperative ALB(OR=1.195,P=0.003)as significant risk factors.CONCLUSION Postoperative severe abdominal complications,preoperative systemic diseases,and early postoperative ALB are identified as risk factors for post-PD DGE.展开更多
In order to solve the problem of poor fusion between the spots of deformation camouflage and the background,a small-spot deformation camouflage design algorithm based on background texture matching is proposed in this...In order to solve the problem of poor fusion between the spots of deformation camouflage and the background,a small-spot deformation camouflage design algorithm based on background texture matching is proposed in this research.The combination of spots and textures improved the fusion of the spot pattern and the background.An adversarial autoencoder convolutional network was designed to extract background texture features.The image adversarial loss was added and the reconstruction loss was improved to improve the clarity of the generated texture pattern and the generalization ability of the model.The digital camouflage was formed by obtaining the mean value of the square area and replacing the main color.At the same time,the spots in the square area with a side length of 2 s were subjected to simple linear iterative clustering to form irregular small-spot camouflage.A dataset with a scale of 1050 was established in the experiment.The training results of three different loss functions were investigated.The results showed that the proposed loss function could enhance the generalization of the model and improve the quality of the generated texture image.A variety of digital camouflages with main colors and irregular small-spot camouflage were generated,and their efficiency was tested.On the one hand,intuitive evaluation was given by personnel observing the camouflage pattern embedded in the background and its contour map calculated by the canny operator.On the other hand,objective comparison result was formed by calculating the 4 evaluation indexes between the camouflage pattern and the background.Both results showed that the generated pattern had a high degree of fusion with the background.This model could balance the relationship between the spot size,the number of main colors and the actual effect according to actual needs.展开更多
The surgical spectrum for radical prostatectomy(RP)has evolved from open surgery to novel minimally invasive approaches during the past few decades,with roboticassisted radical prostatectomy(RARP)being collectively re...The surgical spectrum for radical prostatectomy(RP)has evolved from open surgery to novel minimally invasive approaches during the past few decades,with roboticassisted radical prostatectomy(RARP)being collectively reckoned as an increasingly popular option for prostate cancer(PCa).A previous study has demonstrated the safety and effectiveness of radical-assisted Laparoscopic radical Prostatectomy(RALP).[1]While the transperitoneal route is the most popular surgical access option,alternative propositions include extraperitoneal,perineal,or transvesical access.Since the advent of the next-generation da Vinci Xi and single-port(SP)platforms,robotic laparoendoscopic single-site surgery(R-LESS)has emerged as an intriguing concept in various general or gynecological procedures and in partial nephrectomy.The first single-port robotic-assisted radical prostatectomy(spRARP)was reported in 2008,[2]but has not seen much improvement in surgical techniques and popularity thereafter,with less than 60 total cases reported globally.[3]A previous report[4]demonstrated that the adoption of transumbilical incision in spRARP surgery may cause reduced flexibility,limited working space,and frequent instrument clashing,potentially leading to longer surgeries and increased difficulty.Extraperitoneal RARP has been widely reported in the literature with similar trifecta outcomes and shows more rapid recovery and reduced peri-operative complication rates.[5]The current study aims to investigate the feasibility of extraperitoneal single-port RARP(espRARP)with the use of the da Vinci Si HD model.展开更多
文摘BACKGROUND The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.AIM To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.METHODS Overall,98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study(50 patients)and control groups(48 patients).For 3 months,the control group was treated with conventional drugs,and the research group with a comprehensive intervention model of drug-psychology-society-skills.Data were obtained for the mini mental assessment scale(MMSE),Montreal cognitive assessment scale(MoCA),positive and negative symptom scale,insight and treatment attitude scale,cognitive ability scale and social skills[personal and social function scale(PSP)].The adverse reactions were observed.RESULTS After the intervention,the MMSE and MoCA scores improved in both groups.MoCA scores in the study group(26.58±3.21)were significantly(P<0.05)higher than those in the control group(24.68±3.02),MMSE scores were not significantly higher.Post-intervention,positive and negative symptom scores improved in both groups,and the positive and negative symptom scores in the study group[(12.01±2.58)and(32.51±2.11)]were significantly(P<0.05)different than those in the control group[(14.54±2.33)and(33.74±2.55)].Post-intervention,insight and treatment attitudes questionnaire scores of both groups were improved and compared with the control group(7.97±3.02),the study group(13.56±6.35)had significantly(P<0.05)higher scores.Post-intervention,the MATRICS consensus cognitive battery score of both groups was improved and compared with the control group(38.44±6.23),the score of the study group was significantly(P<0.05)increased(43.51±6.01).Post-intervention,the PSP score of the study group(78.38±6.63)was significantly(P<0.05)higher than that of the control group(74.52±7.01).During the intervention period,the incidence of adverse reactions in the study group was 6.25%,not significantly different from that in the control group(8.33%).During the intervention,both groups experienced adverse reactions,with no significant difference between groups(P>0.05).CONCLUSION The comprehensive intervention model based on drug-psychology-society-skills has obvious intervention effects on patients with chronic schizophrenia,which improves their cognitive ability and reduces their positive and negative symptoms.Simultaneously,it improves the self-knowledge of patients,improves their attitude toward treatment,effectively promotes the recovery of patients'social functions,and is safe.Therefore,it is worthy of being vigorously promoted and widely used in clinics.
文摘Benign prostatic hyperplasia （BPH） is one of the most common medical conditions in middle aged and older men. This study investigated the relationship between serum levels of sex hormones and measures of BPH in the aging male population of China. Prostate symptoms were assessed as part of a free health screening program for men ~40 years of age. The examination included digital rectal examination, determination of serum prostate-specific antigen levels, International Prostate Symptom Score （IPSS） and transrectal ultrasonography. Serum levels of total testosterone （TT）, sex hormone binding globulin （SHBG）, free testosterone （FT）, luteinizing hormone （LH）, follicle-stimulating hormone （FSH）, prolactin （PRL） and estradiol （E2） were evaluated. The men also completed a health and demographics questionnaire and received a detailed physical examination. The final study population consisted of 949 men with a mean age of 58.9 years. Pearson correlation analysis indicated that there were significant correlations between age and levels of all sex hormones except TT, and between age and prostate volume （PV; r=0.243; P〈0.01） or IPSS （r=0.263; P〈0.01）. Additional significant correlations were found between IPSS and serum levels of LH （r=0. 112; P〈0.01） and FSH （r=0.074; P〈0.05）, but there were no significant correlations between sex hormone levels and PV. Multivariate linear regression analysis showed significant correlations between age and body mass index （BMI） with PV （P〈0.0001）. In addition, there was a significant correlation between age and PV with IPSS （P〈0.0001）. Serum sex hormone levels did not correlate with PV or IPSS. The effects of endocrine changes on measures of BPH in aging men require further investigation in longitudinal and multicenter studies that include oatients with all severities of BPH.
基金This study was supported by the National Basic Research Program of China （No. 2012CB518306）, the National Natural Science Foundation of China （No. 81101946）, the Prostate Cancer Foundation Young Investigator Award and the Shanghai Pujiang Program （No. 12PID008）.
文摘SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer （PCa） tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis in vitro. Quantitative reverse transcription polymerase chain reaction （qRT-PCR） and immunohistochemistry （IHC） were used to detect the expression of SETDB1 in PCa tissues, adjacent normal tissues, benign prostatic hyperplasia （BPH） tissues, PCa cell lines and normal prostate epithelial cells. The results suggested that SETDB1 was upregulated in human PCa tissues compared with normal tissues at the mRNA and protein levels. The role of SETDB1 in proliferation was analyzed with cell counting kit-8, colony-forming efficiency and flow cytometry assays. The results indicated that downregulation of SETDB1 by siRNA inhibited PCa cell growth, and induced GO/G1 cell cycle arrest. The PCa cell migration and invasion decreased by silcencing SETDBt which were assessed by using in vitro scratch and transwell invasion assay respectively. Our data suggested that SETDB1 is overexpressed in human PCa. Silencing SETDB1 inhibited PCa cell proliferation, migration and invasion.
基金This research was funded by Natural Science Foundation of Jiangsu Province,grant number BK20180579.
文摘The method of describing deformation camouflage spots based on feature space has some shortcomings,such as inaccurate description and difficult reproduction.Depending on the strong fitting ability of the generative adversarial network model,the distribution of deformation camouflage spot pattern can be directly fitted,thus simplifying the process of spot extraction and reproduction.The requirements of background spot extraction are analyzed theoretically.The calculation formula of limiting the range of image spot pixels is given and two kinds of spot data sets,forestland and snowfield,are established.Spot feature is decomposed into shape,size and color features,and a GAN(Generative Adversarial Network)framework is established.The effects of different loss functions on network training results are analyzed in the experiment.In the meantime,when the input dimension of generator network is 128,the balance between sample diversity and quality can be achieved.The effects of sample generation are investigated in two aspects.Subjectively,the probability of the generated spots being distinguished in the background is counted,and the results are all less than 20% and mostly close to zero.Objectively,the features of the spot shape are calculated and the independent sample T-test is applied to verify that the features are from the same distribution,and all the P-Values are much higher than 0.05.Both subjective and objective methods prove that the spots generated by this method are similar to the background spots.The proposed method can directly generate the desired camouflage pattern spots,which provides a new technical method for the deformation camouflage pattern design and camouflage effect evaluation.
基金Natural Science Foundation of Jiangsu Province&Key Laboratory Foundation,grant number is BK20180579&6142206180204 respectively.
文摘The evaluation index of camouflage patterns is important in the field of military application.It is the goal that researchers have always pursued to make the computable evaluation indicators more in line with the human visual mechanism.In order to make the evaluation method more computationally intelligent,a Multi-Feature Camouflage Fused Index(MF-CFI)is proposed based on the comparison of grayscale,color and texture features between the target and the background.In order to verify the effectiveness of the proposed index,eye movement experiments are conducted to compare the proposed index with existing indexes including Universal Image Quality Index(UIQI),Camouflage Similarity Index(CSI)and Structural Similarity(SSIM).Twenty-four different simulated targets are designed in a grassland background,28 observers participate in the experiment and record the eye movement data during the observation process.The results show that the highest Pearson correlation coefficient is observed between MF-CFI and the eye movement data,both in the designed digital camouflage patterns and largespot camouflage patterns.Since MF-CFI is more in line with the detection law of camouflage targets in human visual perception,the proposed index can be used for the comparison and parameter optimization of camouflage design algorithms.
文摘BACKGROUND Mortality rates after pancreaticoduodenectomy(PD)have significantly decreased in specialized centers.However,postoperative morbidity,particularly delayed gastric emptying(DGE),remains the most frequent complication following PD.AIM To identify risk factors associated with DGE after the PD procedure.METHODS In this retrospective,cross-sectional study,clinical data were collected from 114 patients who underwent PD between January 2015 and June 2018.Demographic factors,pre-and perioperative characteristics,and surgical complications were assessed.Univariate and multivariate analyses were performed to identify risk factors for post-PD DGE.RESULTS The study included 66 males(57.9%)and 48 females(42.1%),aged 33-83 years(mean:62.5),with a male-to-female ratio of approximately 1.4:1.There were 63 cases(55.3%)of PD and 51 cases(44.7%)of pylorus-preserving pancreatoduodenectomy.Among the 114 patients who underwent PD,33(28.9%)developed postoperative DGE.Univariate analysis revealed significant differences in four of the 14 clinical indexes observed:pylorus preservation,retrocolonic anastomosis,postoperative abdominal complications,and early postoperative albumin(ALB).Logistic regression analysis further identified postoperative abdominal complic-ations[odds ratio(OR)=4.768,P=0.002],preoperative systemic diseases(OR=2.516,P=0.049),and early postoperative ALB(OR=1.195,P=0.003)as significant risk factors.CONCLUSION Postoperative severe abdominal complications,preoperative systemic diseases,and early postoperative ALB are identified as risk factors for post-PD DGE.
基金funded by Natural Science Foundation of Jiangsu Province,China,grant number is BK20180579。
文摘In order to solve the problem of poor fusion between the spots of deformation camouflage and the background,a small-spot deformation camouflage design algorithm based on background texture matching is proposed in this research.The combination of spots and textures improved the fusion of the spot pattern and the background.An adversarial autoencoder convolutional network was designed to extract background texture features.The image adversarial loss was added and the reconstruction loss was improved to improve the clarity of the generated texture pattern and the generalization ability of the model.The digital camouflage was formed by obtaining the mean value of the square area and replacing the main color.At the same time,the spots in the square area with a side length of 2 s were subjected to simple linear iterative clustering to form irregular small-spot camouflage.A dataset with a scale of 1050 was established in the experiment.The training results of three different loss functions were investigated.The results showed that the proposed loss function could enhance the generalization of the model and improve the quality of the generated texture image.A variety of digital camouflages with main colors and irregular small-spot camouflage were generated,and their efficiency was tested.On the one hand,intuitive evaluation was given by personnel observing the camouflage pattern embedded in the background and its contour map calculated by the canny operator.On the other hand,objective comparison result was formed by calculating the 4 evaluation indexes between the camouflage pattern and the background.Both results showed that the generated pattern had a high degree of fusion with the background.This model could balance the relationship between the spot size,the number of main colors and the actual effect according to actual needs.
基金partially funded by the National Natural Science Foundation of China(No.81872105)the National Major R&D Program of China(No.2017YFC0908002)Shanghai Changhai Hospital(No.2019YXK058)。
文摘The surgical spectrum for radical prostatectomy(RP)has evolved from open surgery to novel minimally invasive approaches during the past few decades,with roboticassisted radical prostatectomy(RARP)being collectively reckoned as an increasingly popular option for prostate cancer(PCa).A previous study has demonstrated the safety and effectiveness of radical-assisted Laparoscopic radical Prostatectomy(RALP).[1]While the transperitoneal route is the most popular surgical access option,alternative propositions include extraperitoneal,perineal,or transvesical access.Since the advent of the next-generation da Vinci Xi and single-port(SP)platforms,robotic laparoendoscopic single-site surgery(R-LESS)has emerged as an intriguing concept in various general or gynecological procedures and in partial nephrectomy.The first single-port robotic-assisted radical prostatectomy(spRARP)was reported in 2008,[2]but has not seen much improvement in surgical techniques and popularity thereafter,with less than 60 total cases reported globally.[3]A previous report[4]demonstrated that the adoption of transumbilical incision in spRARP surgery may cause reduced flexibility,limited working space,and frequent instrument clashing,potentially leading to longer surgeries and increased difficulty.Extraperitoneal RARP has been widely reported in the literature with similar trifecta outcomes and shows more rapid recovery and reduced peri-operative complication rates.[5]The current study aims to investigate the feasibility of extraperitoneal single-port RARP(espRARP)with the use of the da Vinci Si HD model.
