According to Descartes,minds and bodies are distinct kinds of “substance”,and they cannot have causal interactions.However,in neuroscience,the two-way interaction between the brain and peripheral organs is an emergi...According to Descartes,minds and bodies are distinct kinds of “substance”,and they cannot have causal interactions.However,in neuroscience,the two-way interaction between the brain and peripheral organs is an emerging field of research.Several lines of evidence highlight the importance of such interactions.For example,the peripheral metabolic systems are overwhelmingly regulated by the mind(brain),and anxiety and depression greatly affect the functioning of these systems.Also,psychological stress can cause a variety of physical symptoms,such as bone loss.Moreover,the gut microbiota appears to play a key role in neuropsychiatric and neurodegenerative diseases.Mechanistically,as the command center of the body,the brain can regulate our internal organs and glands through the autonomic nervous system and neuroendocrine system,although it is generally considered to be outside the realm of voluntary control.The autonomic nervous system itself can be further subdivided into the sympathetic and parasympathetic systems.The sympathetic division functions a bit like the accelerator pedal on a car,and the parasympathetic division functions as the brake.The high center of the autonomic nervous system and the neuroendocrine system is the hypothalamus,which contains several subnuclei that control several basic physiological functions,such as the digestion of food and regulation of body temperature.Also,numerous peripheral signals contribute to the regulation of brain functions.Gastrointestinal(GI) hormones,insulin,and leptin are transported into the brain,where they regulate innate behaviors such as feeding,and they are also involved in emotional and cognitive functions.The brain can recognize peripheral inflammatory cytokines and induce a transient syndrome called sick behavior(SB),characterized by fatigue,reduced physical and social activity,and cognitive impairment.In summary,knowledge of the biological basis of the interactions between the central nervous system and peripheral organs will promote the full understanding of how our body works and the rational treatment of disorders.Thus,we summarize current development in our understanding of five types of central-peripheral interactions,including neural control of adipose tissues,energy expenditure,bone metabolism,feeding involving the brain-gut axis and gut microbiota.These interactions are essential for maintaining vital bodily functions,which result in homeostasis,i.e.,a natural balance in the body’s systems.展开更多
Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that m...Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network.展开更多
Predatory hunting is an important type of innate behavior evolutionarily conserved across the animal king-dom.It is typically composed of a set of sequential actions,including prey search,pursuit,attack,and consumptio...Predatory hunting is an important type of innate behavior evolutionarily conserved across the animal king-dom.It is typically composed of a set of sequential actions,including prey search,pursuit,attack,and consumption.This behavior is subject to control by the nervous system.Early studies used toads as a model to probe the neuroethology of hunting,which led to the proposal of a sensory-triggered release mechanism for hunting actions.More recent stud-ies have used genetically-trackable zebrafish and rodents and have made breakthrough discoveries in the neuroethol-ogy and neurocircuits underlying this behavior.Here,we review the sophisticated neurocircuitry involved in hunting and summarize the detailed mechanism for the circuitry to encode various aspects of hunting neuroethology,including sensory processing,sensorimotor transformation,motivation,and sequential encoding of hunting actions.We also discuss the overlapping brain circuits for hunting and feeding and point out the limitations of current studies.We propose that hunting is an ideal behavioral paradigm in which to study the neuroethology of motivated behaviors,which may shed new light on epidemic disorders,including bingeeating,obesity,and obsessive-compulsive disorders.展开更多
基金supported by the National Natural Science Foundation of China (31822026,31822018,31770936,82072489,32122039)the National Key R&D Program of China (2017YFA0205903,2017YFA0505800,2021ZD020390)+2 种基金the Key Research Program of Frontier Sciences of Chinese Academy of Sciences (QYZDB-SSW-SMC056)Beijing Natural Science Foundation (5222010)the Tsinghua University(School of Medicine)-Xiamen Changgeng Hospital Co.Ltd.Joint Research Center for Anaphylactic Disease。
文摘According to Descartes,minds and bodies are distinct kinds of “substance”,and they cannot have causal interactions.However,in neuroscience,the two-way interaction between the brain and peripheral organs is an emerging field of research.Several lines of evidence highlight the importance of such interactions.For example,the peripheral metabolic systems are overwhelmingly regulated by the mind(brain),and anxiety and depression greatly affect the functioning of these systems.Also,psychological stress can cause a variety of physical symptoms,such as bone loss.Moreover,the gut microbiota appears to play a key role in neuropsychiatric and neurodegenerative diseases.Mechanistically,as the command center of the body,the brain can regulate our internal organs and glands through the autonomic nervous system and neuroendocrine system,although it is generally considered to be outside the realm of voluntary control.The autonomic nervous system itself can be further subdivided into the sympathetic and parasympathetic systems.The sympathetic division functions a bit like the accelerator pedal on a car,and the parasympathetic division functions as the brake.The high center of the autonomic nervous system and the neuroendocrine system is the hypothalamus,which contains several subnuclei that control several basic physiological functions,such as the digestion of food and regulation of body temperature.Also,numerous peripheral signals contribute to the regulation of brain functions.Gastrointestinal(GI) hormones,insulin,and leptin are transported into the brain,where they regulate innate behaviors such as feeding,and they are also involved in emotional and cognitive functions.The brain can recognize peripheral inflammatory cytokines and induce a transient syndrome called sick behavior(SB),characterized by fatigue,reduced physical and social activity,and cognitive impairment.In summary,knowledge of the biological basis of the interactions between the central nervous system and peripheral organs will promote the full understanding of how our body works and the rational treatment of disorders.Thus,we summarize current development in our understanding of five types of central-peripheral interactions,including neural control of adipose tissues,energy expenditure,bone metabolism,feeding involving the brain-gut axis and gut microbiota.These interactions are essential for maintaining vital bodily functions,which result in homeostasis,i.e.,a natural balance in the body’s systems.
基金funded by the Pudong New Area Science and Technology Development Fund,China (J. Yang,#PKJ2014-Y08)Shanghai University of Medicine & Health Sciences Seed Foundation Project,China (J. Yang,#SPF-18-20-14-006)+2 种基金ational Natural Science Foundation of China (W. Shen,#31771169 and #91857104)Thousand Young Talents Program of China (W. Shen)ShanghaiTech University start-up fund (W. Shen)
文摘Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network.
文摘Predatory hunting is an important type of innate behavior evolutionarily conserved across the animal king-dom.It is typically composed of a set of sequential actions,including prey search,pursuit,attack,and consumption.This behavior is subject to control by the nervous system.Early studies used toads as a model to probe the neuroethology of hunting,which led to the proposal of a sensory-triggered release mechanism for hunting actions.More recent stud-ies have used genetically-trackable zebrafish and rodents and have made breakthrough discoveries in the neuroethol-ogy and neurocircuits underlying this behavior.Here,we review the sophisticated neurocircuitry involved in hunting and summarize the detailed mechanism for the circuitry to encode various aspects of hunting neuroethology,including sensory processing,sensorimotor transformation,motivation,and sequential encoding of hunting actions.We also discuss the overlapping brain circuits for hunting and feeding and point out the limitations of current studies.We propose that hunting is an ideal behavioral paradigm in which to study the neuroethology of motivated behaviors,which may shed new light on epidemic disorders,including bingeeating,obesity,and obsessive-compulsive disorders.
