Objective： To summarize experience in the diagnosis and treatment of pancreatic cystic neoplasms.Methods： This is a retrospective study of 207 patients who were diagnosed with pancreatic cystic tumors at Peking Unio...Objective： To summarize experience in the diagnosis and treatment of pancreatic cystic neoplasms.Methods： This is a retrospective study of 207 patients who were diagnosed with pancreatic cystic tumors at Peking Union Medical College Hospital between Jan 2009 and Mar 2014. Clinical data, such as clinical manifestations, radiologieal and pathological images and surgical recordings, were collected. Results： Of the 207 included patients, females accounted for 76.81%, and the mean patient age was 52.04 years. Malignancy was more common in older patients who presented with marasmus and jaundice. Other risk factors included solid components in the tumor, a large tumor size, and elevated levels of tumor markers. Surgical treatment was required when a malignant tumor was suspected. The operation approach was selected based on the location, size and characteristics of the tumor. The position of the tumor relative to the pancreatic duct also played a significant role.展开更多
In order to discuss the role of MYB gene in capsaicine synthesis process, one CcMYB gene was cloned from Capsicum chinense Jacq. by RT-PCR. Its cDNA has a total length of 1 038 bp, and was speculated to code 345 amino...In order to discuss the role of MYB gene in capsaicine synthesis process, one CcMYB gene was cloned from Capsicum chinense Jacq. by RT-PCR. Its cDNA has a total length of 1 038 bp, and was speculated to code 345 amino acids, comprising an complete open reading frame. The isoelectric point is 8.57, and the molecular weight is 38.2 KD. The protein is a neutral hydrophobin without transmentbrane structure. There are two MYBDNA domains at the N terminal. The fluorescence quantitative PCR results showed that CcMYB gene was expressed in all the root, stem, leaf, flower, placenta and fruit tissue of pepper, and the expression level was the highest in fruit ; and CcMYB was expressed in fruit at the highest level at turning stage, and at the second highest level at expansion stage, which accords with the expression profile of punl gene in fruit development period. It is speculated that CcMYB gene plays an important role in the regulation of capsaicine synthesis in C. chinense fruit.展开更多
Long-term deposition of atmospheric pollutants emitted from coal combustion and their effects on the eco-environment have been extensively studied around coal-fired power plants.However,the effects of coal-fired power...Long-term deposition of atmospheric pollutants emitted from coal combustion and their effects on the eco-environment have been extensively studied around coal-fired power plants.However,the effects of coal-fired power plants on soil microbial communities have received little attention through atmospheric pollutant deposition and coal-stacking.Here,we collected the samples of power plant soils(PS),coal-stacking soils(CSS)and agricultural soils(AS)around three coal-fired power plants and background control soils(BG)in Huainan,a typical mineral resource-based city in East China,and investigated the microbial diversity and community structures through a high-throughput sequencing technique.Coal-stacking significantly increased(p<0.05)the contents of total carbon,total nitrogen,total sulfur and Mo in the soils,whereas the deposition of atmospheric pollutants enhanced the levels of V,Cu,Zn and Pb.Proteobacteria,Actinobacteria,Thaumarchaeota,Thermoplasmata,Ascomycota and Basidiomycota were the dominant taxa in all soils.The bacterial community showed significant differences(p<0.05)among PS,CSS,AS and BG,whereas archaeal and fungal communities showed significant differences(p<0.01)according to soil samples around three coal-fired power plants.The predominant environmental variables affecting soil bacterial,archaeal and fungal communities were Mo-TN-TS,Cu-V-Mo,and organic matter(OM)-Mo,respectively.Certain soil microbial genera were closely related to multiple key factors associated with stacking coal and heavy metal deposition from power plants.This study provided useful insight into better understanding of the relationships between soil microbial communities and long-term disturbances from coal-fired power plants.展开更多
Background:The Teaching Personal and Social Responsibility(TPSR)model in physical education(PE)has been shown to promote Social and emotional competence(SEC).However,the underlying mechanisms through which TPSR enhanc...Background:The Teaching Personal and Social Responsibility(TPSR)model in physical education(PE)has been shown to promote Social and emotional competence(SEC).However,the underlying mechanisms through which TPSR enhances SEC,particularly in university students within the Chinese context,remain unclear.This study aims to explore the effects of TPSR and the mediating roles of self-efficacy and grit in improving SEC.Methods:71 Chinese university students were in the TPSR group,and 39 in the Traditional Teaching Model(TTM)control group,assessed before and after a 14-week intervention.The Adapted Social and Emotional Competence Scale(ASECS),General Self-Efficacy Scale(GSES),and Short Grit Scale(SGS)were used for measurement.A mixed-design ANOVA assessed TPSR’s effects,with post-hoc t-tests for pre-post differences and mediation analysis for underlying mechanisms.Results:The mixed-design ANOVA revealed a significant interaction between time and intervention on SEC.The TPSR group showed significant improvement from pre-test to post-test(t(70)=−2.63,p=0.011,Cohen’s d=−0.31),whereas the TTM control group did not(t(38)=1.40,p=0.170,Cohen’s d=0.22).The TPSR group also showed a significant increase in self-efficacy(t(70)=−3.67,p<0.001,Cohen’s d=−0.44),while no change was observed in the TTM group(t(38)=0.62,p=0.540,Cohen’s d=0.10).No significant effects were found for grit(F=0.342,p=0.560).Mediation analysis confirmed that self-efficacy significantly mediated the effects of the TPSR intervention on SEC(95%CI:0.0277 to 0.2897).Conclusion:The TPSR intervention led to significant improvements in university students’SEC and self-efficacy,with no significant changes observed in grit.Self-efficacy served as a mediator in the relationship between the intervention and SEC.展开更多
Aging is characterized by systemic chronic inflammation,which is accompanied by cellular senescence,immunosenescence,organ dysfunction,and age-related diseases.Given the multidimensional complexity of aging,there is a...Aging is characterized by systemic chronic inflammation,which is accompanied by cellular senescence,immunosenescence,organ dysfunction,and age-related diseases.Given the multidimensional complexity of aging,there is an urgent need for a systematic organization of inflammaging through dimensionality reduction.展开更多
In this study, the distribution of five Alzheimer's disease(AD)-related single nucleotide polymorphisms(SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain p...In this study, the distribution of five Alzheimer's disease(AD)-related single nucleotide polymorphisms(SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs,clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College(CAMS/PUMC) Human Brain Bank.APOE ?4(OR = 4.482, P = 0.004), the RS2305421 GG genotype(adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype(adjusted OR = 2.375,P = 0.028) were associated with a higher score on the ABC(Ab plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD,the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research.展开更多
Optic-electric responsive materials have attracted much attention for their applications in temperaturesensing,actuators,and memory switches.However,it is a challenge to integrate various functions to form multifuncti...Optic-electric responsive materials have attracted much attention for their applications in temperaturesensing,actuators,and memory switches.However,it is a challenge to integrate various functions to form multifunctional responsive materials.As molecule-based hybrid materials usually consist of organic and inorganic components,the introduction of multiple functions can be achieved through structural construction.Thus far,even though fulltemperature cover is required for device applications,fulltemperature covered multi-switchable hybrid materials have rarely been successfully synthesized.Herein,the dynamic[(CH3)3NOH]+cation and luminous center Mn(II)were introduced to form a hybrid material[(CH3)3NOH][Mn Cl3],showing multiple temperature-responsive behaviors.Upon temperature change,it exhibits multi-state dielectric switching response and intensity or peak shift response of luminous in full-temperature range(low,room,and high temperatures).These responsive behaviors are triggered by the motion or reorientation of[(CH3)3NOH]+cations and inorganic framework.Overall,the switchable photoelectric material has potential applications in multiple encrypted storage and sensor devices.展开更多
Asthma is a chronic inflammatory disease,characterized by reversible airflow obstruction and airway hyperresponsiveness.There has been a sharp increase in the prevalence,morbidity,mortality and economic burden associa...Asthma is a chronic inflammatory disease,characterized by reversible airflow obstruction and airway hyperresponsiveness.There has been a sharp increase in the prevalence,morbidity,mortality and economic burden associated with this disorder over the last several decades,which triggers the development of various antiasthmatic agents[1].Maintenance of airway tone is the key in asthma therapy.展开更多
Stimulus re s ponsive materials can provide a variety of desirable properties in one equipment unit,such as optoelectronic devices,data communications,actuators,memories,sensors and capacitors.However,it remains a lar...Stimulus re s ponsive materials can provide a variety of desirable properties in one equipment unit,such as optoelectronic devices,data communications,actuators,memories,sensors and capacitors.However,it remains a large challenge to design such stimulus responsive materials,especially functional materials having both dielectric switch and second harmonic generation(SHG).Here,a new stimuli-responsive switchable material [(CH_(3))_(3)N(CH_(2))_(2)Cl]_(2)]Mn(SCN)_(4)(H_(2)O)_(2)] was discovered as a potential secondharmonic generation(SHG) dielectric switch.It is worth noting that it has SHG characteristics before and after undergoing reversible high-temperature phase transitions.In this work,we successfully refined the tetramethylammonium cation to obtain a quasi-spherical cation,which is tetramethylchloroethylamine(TMCEM) cation.By substituting H with a halogen,the increased steric hindrance of the molecular makes energy barrier increased,resulting in the reversible high-temperature phase transition.At the same time,the interactions of quasi-spherical cations and [Mn(SCN)_(4)(H_(2)O)_(2)]^(2-) anions affect a noncentrosymmetric structure to induce the SHG effect.These findings provide a new approach to design novel functional switch materials.展开更多
基金supported by grants from the Research Special Fund for the Public Welfare Industry of Health (201202007)the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (2014BAI09B11)+2 种基金the National Natural Science Foundation of China (81472327)the Fundamental Research Funds for the Central Universitiesthe PUMC Youth Fund (3332015004)
文摘Objective： To summarize experience in the diagnosis and treatment of pancreatic cystic neoplasms.Methods： This is a retrospective study of 207 patients who were diagnosed with pancreatic cystic tumors at Peking Union Medical College Hospital between Jan 2009 and Mar 2014. Clinical data, such as clinical manifestations, radiologieal and pathological images and surgical recordings, were collected. Results： Of the 207 included patients, females accounted for 76.81%, and the mean patient age was 52.04 years. Malignancy was more common in older patients who presented with marasmus and jaundice. Other risk factors included solid components in the tumor, a large tumor size, and elevated levels of tumor markers. Surgical treatment was required when a malignant tumor was suspected. The operation approach was selected based on the location, size and characteristics of the tumor. The position of the tumor relative to the pancreatic duct also played a significant role.
基金Supported by College Students'Innovation Fund of Jilin University(2017A82372)
文摘In order to discuss the role of MYB gene in capsaicine synthesis process, one CcMYB gene was cloned from Capsicum chinense Jacq. by RT-PCR. Its cDNA has a total length of 1 038 bp, and was speculated to code 345 amino acids, comprising an complete open reading frame. The isoelectric point is 8.57, and the molecular weight is 38.2 KD. The protein is a neutral hydrophobin without transmentbrane structure. There are two MYBDNA domains at the N terminal. The fluorescence quantitative PCR results showed that CcMYB gene was expressed in all the root, stem, leaf, flower, placenta and fruit tissue of pepper, and the expression level was the highest in fruit ; and CcMYB was expressed in fruit at the highest level at turning stage, and at the second highest level at expansion stage, which accords with the expression profile of punl gene in fruit development period. It is speculated that CcMYB gene plays an important role in the regulation of capsaicine synthesis in C. chinense fruit.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDB40010200)the National Natural Science Foundation of China (Nos.41976220 and 41776190)the National Key Research and Development Program of China (No.2020YFA0608501)。
文摘Long-term deposition of atmospheric pollutants emitted from coal combustion and their effects on the eco-environment have been extensively studied around coal-fired power plants.However,the effects of coal-fired power plants on soil microbial communities have received little attention through atmospheric pollutant deposition and coal-stacking.Here,we collected the samples of power plant soils(PS),coal-stacking soils(CSS)and agricultural soils(AS)around three coal-fired power plants and background control soils(BG)in Huainan,a typical mineral resource-based city in East China,and investigated the microbial diversity and community structures through a high-throughput sequencing technique.Coal-stacking significantly increased(p<0.05)the contents of total carbon,total nitrogen,total sulfur and Mo in the soils,whereas the deposition of atmospheric pollutants enhanced the levels of V,Cu,Zn and Pb.Proteobacteria,Actinobacteria,Thaumarchaeota,Thermoplasmata,Ascomycota and Basidiomycota were the dominant taxa in all soils.The bacterial community showed significant differences(p<0.05)among PS,CSS,AS and BG,whereas archaeal and fungal communities showed significant differences(p<0.01)according to soil samples around three coal-fired power plants.The predominant environmental variables affecting soil bacterial,archaeal and fungal communities were Mo-TN-TS,Cu-V-Mo,and organic matter(OM)-Mo,respectively.Certain soil microbial genera were closely related to multiple key factors associated with stacking coal and heavy metal deposition from power plants.This study provided useful insight into better understanding of the relationships between soil microbial communities and long-term disturbances from coal-fired power plants.
基金funded by the 2023 Scientific Research Platforms and Projects of Guangdong Provincial Education Department,Grant Number 2023WQNCX079.
文摘Background:The Teaching Personal and Social Responsibility(TPSR)model in physical education(PE)has been shown to promote Social and emotional competence(SEC).However,the underlying mechanisms through which TPSR enhances SEC,particularly in university students within the Chinese context,remain unclear.This study aims to explore the effects of TPSR and the mediating roles of self-efficacy and grit in improving SEC.Methods:71 Chinese university students were in the TPSR group,and 39 in the Traditional Teaching Model(TTM)control group,assessed before and after a 14-week intervention.The Adapted Social and Emotional Competence Scale(ASECS),General Self-Efficacy Scale(GSES),and Short Grit Scale(SGS)were used for measurement.A mixed-design ANOVA assessed TPSR’s effects,with post-hoc t-tests for pre-post differences and mediation analysis for underlying mechanisms.Results:The mixed-design ANOVA revealed a significant interaction between time and intervention on SEC.The TPSR group showed significant improvement from pre-test to post-test(t(70)=−2.63,p=0.011,Cohen’s d=−0.31),whereas the TTM control group did not(t(38)=1.40,p=0.170,Cohen’s d=0.22).The TPSR group also showed a significant increase in self-efficacy(t(70)=−3.67,p<0.001,Cohen’s d=−0.44),while no change was observed in the TTM group(t(38)=0.62,p=0.540,Cohen’s d=0.10).No significant effects were found for grit(F=0.342,p=0.560).Mediation analysis confirmed that self-efficacy significantly mediated the effects of the TPSR intervention on SEC(95%CI:0.0277 to 0.2897).Conclusion:The TPSR intervention led to significant improvements in university students’SEC and self-efficacy,with no significant changes observed in grit.Self-efficacy served as a mediator in the relationship between the intervention and SEC.
基金This work was supported by grants from the National Natural Science Foundation of China(81900176,82130003,82222003,92268117,82161138028)the National Key Research and Development Program of China(2022YFA1103500)+1 种基金Zhejiang Provincial Key Research and Development Program(2021C03010)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2020R01006).We thank Francis Kaming Chan,Yufei Li,Yufei Wang,and Yifei Shang for help with data collection and manuscript revision.Figures 2 and 3 were created with BioRender.com.
文摘Aging is characterized by systemic chronic inflammation,which is accompanied by cellular senescence,immunosenescence,organ dysfunction,and age-related diseases.Given the multidimensional complexity of aging,there is an urgent need for a systematic organization of inflammaging through dimensionality reduction.
基金supported by grants from the National Natural Science Foundation of China(81271239,81771205,and 91632113)the Institute of Basic Medical Sciences/Chinese Academy of Medical Sciences(CAMS)Dean’s Fund(2011RC01)+1 种基金the CAMS Innovation Fund for Medical Sciences(2016-I2M-1004)the Natural Science Foundation and Major Basic Research Program of Shanghai Municipality,China(16JC1420500 and 16JC1420502)
文摘In this study, the distribution of five Alzheimer's disease(AD)-related single nucleotide polymorphisms(SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs,clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College(CAMS/PUMC) Human Brain Bank.APOE ?4(OR = 4.482, P = 0.004), the RS2305421 GG genotype(adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype(adjusted OR = 2.375,P = 0.028) were associated with a higher score on the ABC(Ab plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD,the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research.
基金financially supported by the National Natural Science Foundation of China(21991141)the Natural Science Foundation of Zhejiang Province(LZ20B010001)Zhejiang Normal University。
文摘Optic-electric responsive materials have attracted much attention for their applications in temperaturesensing,actuators,and memory switches.However,it is a challenge to integrate various functions to form multifunctional responsive materials.As molecule-based hybrid materials usually consist of organic and inorganic components,the introduction of multiple functions can be achieved through structural construction.Thus far,even though fulltemperature cover is required for device applications,fulltemperature covered multi-switchable hybrid materials have rarely been successfully synthesized.Herein,the dynamic[(CH3)3NOH]+cation and luminous center Mn(II)were introduced to form a hybrid material[(CH3)3NOH][Mn Cl3],showing multiple temperature-responsive behaviors.Upon temperature change,it exhibits multi-state dielectric switching response and intensity or peak shift response of luminous in full-temperature range(low,room,and high temperatures).These responsive behaviors are triggered by the motion or reorientation of[(CH3)3NOH]+cations and inorganic framework.Overall,the switchable photoelectric material has potential applications in multiple encrypted storage and sensor devices.
基金supported by the Innovative Experimental Program for College Students in China (20120023060)the National Natural Science Foundation of China (81670313) to J.C
文摘Asthma is a chronic inflammatory disease,characterized by reversible airflow obstruction and airway hyperresponsiveness.There has been a sharp increase in the prevalence,morbidity,mortality and economic burden associated with this disorder over the last several decades,which triggers the development of various antiasthmatic agents[1].Maintenance of airway tone is the key in asthma therapy.
基金supported by the National Natural Science Foundation of China(Nos.21673038,21771037,21805033)Natural Science Foundation of Jiangsu Province(JSNSF,No.BK20170659)。
文摘Stimulus re s ponsive materials can provide a variety of desirable properties in one equipment unit,such as optoelectronic devices,data communications,actuators,memories,sensors and capacitors.However,it remains a large challenge to design such stimulus responsive materials,especially functional materials having both dielectric switch and second harmonic generation(SHG).Here,a new stimuli-responsive switchable material [(CH_(3))_(3)N(CH_(2))_(2)Cl]_(2)]Mn(SCN)_(4)(H_(2)O)_(2)] was discovered as a potential secondharmonic generation(SHG) dielectric switch.It is worth noting that it has SHG characteristics before and after undergoing reversible high-temperature phase transitions.In this work,we successfully refined the tetramethylammonium cation to obtain a quasi-spherical cation,which is tetramethylchloroethylamine(TMCEM) cation.By substituting H with a halogen,the increased steric hindrance of the molecular makes energy barrier increased,resulting in the reversible high-temperature phase transition.At the same time,the interactions of quasi-spherical cations and [Mn(SCN)_(4)(H_(2)O)_(2)]^(2-) anions affect a noncentrosymmetric structure to induce the SHG effect.These findings provide a new approach to design novel functional switch materials.
