Color tunable quantum dots（QDs） based on the Cu, Mn, Ag co-doped Zn In S core and Zn S outer-shell were synthesized by using an eco-friendly method. Core-shell doped QDs with the average size of 3.85 nm were obtaine...Color tunable quantum dots（QDs） based on the Cu, Mn, Ag co-doped Zn In S core and Zn S outer-shell were synthesized by using an eco-friendly method. Core-shell doped QDs with the average size of 3.85 nm were obtained by using a one-pot synthesis followed by a hot injection with n-dodecanethiol（DDT） and oleylamine（OLA） as stabilizers in oil phase. Cu, Mn and Ag ions were introduced as single-dopant or co-dopants during the synthesis, providing an effective means to control the emission color of the QDs. The as-synthesized QDs showed photoluminescence emission ranging from green（530 nm） to near-red（613 nm）, adjusted by doping components, dopant concentration, and Zn/In ratio. Importantly, quasi-white emission has been achieved by controlling the concentration of co-doped metal ions（Mn, Cu and Ag）. The primary results demonstrated the promising potential of co-doped QDs as alternative materials for future high quality white LED applications.展开更多
Introduction Psoriasis is a common chronic recurrent inflammatory skin disease with most common clinical form of chronic plaque type (90%).For moderate-to-severe psoriasis vulgaris patients,who were inadequately respo...Introduction Psoriasis is a common chronic recurrent inflammatory skin disease with most common clinical form of chronic plaque type (90%).For moderate-to-severe psoriasis vulgaris patients,who were inadequately responding to other synthetic therapies,targeting therapeutic drugs may have unexpected effects.And with the deepening understanding of pathogenesis,the targeted therapy for psoriasis is increasingly diverse and accurate.Biologic agents can block T cell activation,antagonise T cell secretion of tumor necrosis factor alpha (TNF-α),interleukin (IL)-17,IL-23,and other cytokines,and then effectively block the immune inflammatory response.展开更多
Introduction Pyoderma gangrenosum (PG) is a chronic skin disease characterized by progressive lesions that present as painful suppurative ulcers and tend to recur. The pathogenesis of the disease is incompletely under...Introduction Pyoderma gangrenosum (PG) is a chronic skin disease characterized by progressive lesions that present as painful suppurative ulcers and tend to recur. The pathogenesis of the disease is incompletely under-stood;however, 50%to 70%of affected persons have an associated concomitant systemic disease such as inflammatory bowel disease (IBD) (1)Any site of the body can be affected;however, involvement of the oropharynx is rare. Here, we present a patient with disseminated PG with oropharyngeal involvement.展开更多
Introduction Dowling-Degos disease (DDD) was first described as a benign form of acanthosis nigricans by Dowling and Freudenthal in 1938, then referred to as'dermatose reticulée des plis'by Degos and Ossi...Introduction Dowling-Degos disease (DDD) was first described as a benign form of acanthosis nigricans by Dowling and Freudenthal in 1938, then referred to as'dermatose reticulée des plis'by Degos and Ossipowski in 1954, and was first named DDD by Wilson-Jones and Grice in 1978(1)The disease has been reported worldwide and affects both genders equally. As an autosomal dominant pigment disorder, it usually occurs in post-pubertal individuals, and is seldom seen in children(2)However, a Chinese newborn with DDD was reported in 2008(3)In this review, we summarize features of DDD, emphasizing advances in genetics research and looking to the future for further understanding of its etiology and the development of therapeutic methods.展开更多
基金Projects(61675049,61377046,61144010,61177021) supported by the National Natural Science Foundation of China
文摘Color tunable quantum dots（QDs） based on the Cu, Mn, Ag co-doped Zn In S core and Zn S outer-shell were synthesized by using an eco-friendly method. Core-shell doped QDs with the average size of 3.85 nm were obtained by using a one-pot synthesis followed by a hot injection with n-dodecanethiol（DDT） and oleylamine（OLA） as stabilizers in oil phase. Cu, Mn and Ag ions were introduced as single-dopant or co-dopants during the synthesis, providing an effective means to control the emission color of the QDs. The as-synthesized QDs showed photoluminescence emission ranging from green（530 nm） to near-red（613 nm）, adjusted by doping components, dopant concentration, and Zn/In ratio. Importantly, quasi-white emission has been achieved by controlling the concentration of co-doped metal ions（Mn, Cu and Ag）. The primary results demonstrated the promising potential of co-doped QDs as alternative materials for future high quality white LED applications.
基金CAMS Innovation Fund for Medical Sciences(No.2016-I2M-1-002)the National Natural Science Foundation of China(No.81472872).
文摘Introduction Psoriasis is a common chronic recurrent inflammatory skin disease with most common clinical form of chronic plaque type (90%).For moderate-to-severe psoriasis vulgaris patients,who were inadequately responding to other synthetic therapies,targeting therapeutic drugs may have unexpected effects.And with the deepening understanding of pathogenesis,the targeted therapy for psoriasis is increasingly diverse and accurate.Biologic agents can block T cell activation,antagonise T cell secretion of tumor necrosis factor alpha (TNF-α),interleukin (IL)-17,IL-23,and other cytokines,and then effectively block the immune inflammatory response.
基金National Nature Science Foundation of China(81472872)CAMS Innovation Fund for Medical Sciences(CIFMS, 2016-I2M-1-002).
文摘Introduction Pyoderma gangrenosum (PG) is a chronic skin disease characterized by progressive lesions that present as painful suppurative ulcers and tend to recur. The pathogenesis of the disease is incompletely under-stood;however, 50%to 70%of affected persons have an associated concomitant systemic disease such as inflammatory bowel disease (IBD) (1)Any site of the body can be affected;however, involvement of the oropharynx is rare. Here, we present a patient with disseminated PG with oropharyngeal involvement.
基金the National Natural Science Foundation of China(81472872)the Project of Six Talent Peaks(WSN-126)the CAMS Innovation Fund for Medical Sciences(2016-I2M-1-002).
文摘Introduction Dowling-Degos disease (DDD) was first described as a benign form of acanthosis nigricans by Dowling and Freudenthal in 1938, then referred to as'dermatose reticulée des plis'by Degos and Ossipowski in 1954, and was first named DDD by Wilson-Jones and Grice in 1978(1)The disease has been reported worldwide and affects both genders equally. As an autosomal dominant pigment disorder, it usually occurs in post-pubertal individuals, and is seldom seen in children(2)However, a Chinese newborn with DDD was reported in 2008(3)In this review, we summarize features of DDD, emphasizing advances in genetics research and looking to the future for further understanding of its etiology and the development of therapeutic methods.
