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SUZ12通过调控肝癌细胞及人脐静脉内皮细胞的血管生成发挥抑癌作用
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作者 何淦清 舒鑫妮 +6 位作者 胡晖 侯明君 曾观海 魏达强 王坤元 杨辉 聂玉强 《广州医药》 2025年第1期71-76,88,共7页
目的 探讨多梳蛋白SUZ12对肝细胞肝癌(HCC)细胞增殖、血管生成拟态形成和人脐静脉内皮细胞(HUVECs)血管生成的影响。方法 分别利用MTT比色法及体外血管生成实验检测SUZ12表达水平改变对HCC细胞SMMC-7721、Hep3B增殖、血管生成拟态形成和... 目的 探讨多梳蛋白SUZ12对肝细胞肝癌(HCC)细胞增殖、血管生成拟态形成和人脐静脉内皮细胞(HUVECs)血管生成的影响。方法 分别利用MTT比色法及体外血管生成实验检测SUZ12表达水平改变对HCC细胞SMMC-7721、Hep3B增殖、血管生成拟态形成和HUVECs血管生成的影响。结果 MTT结果显示,在HCC细胞中分别敲低或过表达SUZ12均对HCC细胞的增殖能力无明显影响。将SUZ12低表达HCC细胞与HUVECs共培养后,HCC细胞的血管生成拟态管样结构形成增多。此外,将SUZ12敲低组HCC细胞的培养上清用于培养HUVECs后,HUVECs的血管生成拟态管样结构形成也明显增多。结论 SUZ12对HCC细胞的增殖无影响,其在HCC中可抑制HCC细胞和HUVECs的血管生成拟态管样结构形成。上述结果提示SUZ12可能通过调控HCC细胞及HUVECs的血管生成发挥抑癌作用。 展开更多
关键词 多梳蛋白SUZ12 肝细胞肝癌 人脐静脉内皮细胞 血管生成
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Distribution law and susceptibility of geohazards across a gradient belt of the Western Sichuan Plateau
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作者 LI Tianbin WANG Jianfeng +4 位作者 HE Chaoyang MENG Lubo LI Chaofei MA Junjie wei daqiang 《Journal of Mountain Science》 SCIE CSCD 2024年第6期1849-1867,共19页
Across a gradient belt of the Western Sichuan Plateau,geohazards have seriously limited economic and social development.According to incomplete statistics,15,673 geohazards have been recorded in the study area.In orde... Across a gradient belt of the Western Sichuan Plateau,geohazards have seriously limited economic and social development.According to incomplete statistics,15,673 geohazards have been recorded in the study area.In order to mitigate the threat of geohazards to human engineering activities in the region,an overall understanding of the distribution pattern of geohazards and susceptibility assessment are necessary.In this paper,a gradient belt of the Western Sichuan Plateau and its zoning criteria were defined.Subsequently,on the basis of relief amplitude,distance to faults,rainfall,and human activities,three indicators of endogenic process were introduced:Bouguer gravity anomaly gradient,vertical deformation gradient,and horizontal deformation gradient.Thereafter,the distribution patterns of geohazards were investigated through mathematical statistics and ArcGIS software.By randomly selecting 10,449 hazards,a geohazard susceptibility map was generated using the Information Value(IV)model.Finally,the IV model was validated against 5224 hazards using the Area Under Curve(AUC)method.The results show that 47.6%of the geohazards were distributed in the zone of steep slope.Geohazards showed strong responses to distance to faults,human activities,and annual rainfall.The distribution of geohazards in the gradient belt of the Western Sichuan Plateau is more sensitive to vertical internal dynamics factors(such as vertical deformation gradient and Bouguer gravity anomaly gradient)without any apparent sensitivity to horizontal internal dynamics factors.The areas of high and very-high risk account for up to 32.22%,mainly distributed in the Longmenshan and Anning River faults.According to the AUC plot,the success rate of the IV model for generating the susceptibility map is 76%.This susceptibility map and geohazard distribution pattern can provide a reference for geological disaster monitoring,preparation of post-disaster emergency measures,and town planning. 展开更多
关键词 Gradient belt GEOHAZARDS Distribution law Bouguer Gravity anomaly gradient Vertical deformation gradient SUSCEPTIBILITY
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LNG罐箱内河运输风险辨识
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作者 张鹏 魏大强 +1 位作者 臧子璇 熊廉森 《科技资讯》 2022年第19期117-120,共4页
目前国内企业所做的LNG罐箱水上运输已有多项成功实例,但LNG罐箱内河运输安全问题依旧有待分析。为了对LNG罐箱内河运输进行风险辨识,该文先对内河运输的沿线环境和LNG罐箱在内河的运输过程进行风险分析,得出其中的风险因素,然后采用事... 目前国内企业所做的LNG罐箱水上运输已有多项成功实例,但LNG罐箱内河运输安全问题依旧有待分析。为了对LNG罐箱内河运输进行风险辨识,该文先对内河运输的沿线环境和LNG罐箱在内河的运输过程进行风险分析,得出其中的风险因素,然后采用事故树和事件树分析法,对内河环境进行风险识别和后果演绎,得到事故树的51个基本事件和事件树的17项后果事件,并计算了每个后果事件的概率。 展开更多
关键词 内河运输 事件树 事故树 风险辨识 概率计算
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