目的探讨载药微球加载贝伐珠单抗经导管动脉化疗栓塞(TACE)治疗兔VX2肝癌模型的抗血管生成效果。方法构建30只新西兰大白兔VX2肝癌模型,随机分为HepaSphere载药微球加载贝伐珠单抗组(A组,n=10)、Embosphere微球联合贝伐珠单抗组(B组,n=...目的探讨载药微球加载贝伐珠单抗经导管动脉化疗栓塞(TACE)治疗兔VX2肝癌模型的抗血管生成效果。方法构建30只新西兰大白兔VX2肝癌模型,随机分为HepaSphere载药微球加载贝伐珠单抗组(A组,n=10)、Embosphere微球联合贝伐珠单抗组(B组,n=10)、单纯HepaSphere载药微球组(C组,n=10)。酶联免疫吸附试验(ELISA)法定量检测TACE术前1 d,术后1、7、14 d各组血清血管内皮细胞生长因子(VEGF)水平,术前1 d、术后14 d腹部MRI检测各组肿瘤直径,计算瘤体体积和肿瘤增长率。结果术后7 d A组、B组血清VEGF水平与C组相比均较低(P<0.05),且A组低于B组;术后14 d 3组血清VEGF水平两两比较差异均有统计学意义(P<0.05),A组最低,C组最高。术后14 d 3组肿瘤增长率两两比较差异均有统计学意义(P<0.05),A组最低。结论载药微球加载贝伐珠单抗TACE治疗可明显降低兔VX2肝癌模型术后血清VEGF水平和肿瘤增长率,疗效优于单纯载药微球或栓塞微球联合贝伐珠单抗治疗。展开更多
Based on new multibeam bathymetric data and about 300 km long single seismic profiles, three topographic units were identified： the canyons, fractural valley and submarine terrace on the north of Chiwei Island where ...Based on new multibeam bathymetric data and about 300 km long single seismic profiles, three topographic units were identified： the canyons, fractural valley and submarine terrace on the north of Chiwei Island where is a structural transition zone between the southern trough and the middle trough. The Chiwei Canyon and the North Chiwei Canyon are two of the largest canyons in the East China Sea （ECS） slope. Topographic features and architectures of them are described. The study shows that both of them are originated along faults. The evolution and spatial distribution of topographic units in the study area are controlled mainly by three groups of faults which were formed and reactive in the recent extensional phase of Okinawa Trough. The Chiwei Canyon was initia- ted during the middle Pleistocene and guided by F4 that is a N--S trending fault on the slope and F1, a large NW--SE trending fault on the trough. The pathway migration from the remnant channel to the present one of Chiwei Canyon is the result of uplift of tilted fault block that is coupled to the recent extension movements of the southern trough. The submarine terrace is detached from the ECS slope by the NEE -trending fault. The North Chiwei Canyon, developing during the late Pleistocene, is guided by FS, a N-S trending fault, diverted and blocked by the submarine terrace.展开更多
文摘目的探讨载药微球加载贝伐珠单抗经导管动脉化疗栓塞(TACE)治疗兔VX2肝癌模型的抗血管生成效果。方法构建30只新西兰大白兔VX2肝癌模型,随机分为HepaSphere载药微球加载贝伐珠单抗组(A组,n=10)、Embosphere微球联合贝伐珠单抗组(B组,n=10)、单纯HepaSphere载药微球组(C组,n=10)。酶联免疫吸附试验(ELISA)法定量检测TACE术前1 d,术后1、7、14 d各组血清血管内皮细胞生长因子(VEGF)水平,术前1 d、术后14 d腹部MRI检测各组肿瘤直径,计算瘤体体积和肿瘤增长率。结果术后7 d A组、B组血清VEGF水平与C组相比均较低(P<0.05),且A组低于B组;术后14 d 3组血清VEGF水平两两比较差异均有统计学意义(P<0.05),A组最低,C组最高。术后14 d 3组肿瘤增长率两两比较差异均有统计学意义(P<0.05),A组最低。结论载药微球加载贝伐珠单抗TACE治疗可明显降低兔VX2肝癌模型术后血清VEGF水平和肿瘤增长率,疗效优于单纯载药微球或栓塞微球联合贝伐珠单抗治疗。
基金The National Natural Science Foundation of China under contract Nos 40576033 and 40406013
文摘Based on new multibeam bathymetric data and about 300 km long single seismic profiles, three topographic units were identified： the canyons, fractural valley and submarine terrace on the north of Chiwei Island where is a structural transition zone between the southern trough and the middle trough. The Chiwei Canyon and the North Chiwei Canyon are two of the largest canyons in the East China Sea （ECS） slope. Topographic features and architectures of them are described. The study shows that both of them are originated along faults. The evolution and spatial distribution of topographic units in the study area are controlled mainly by three groups of faults which were formed and reactive in the recent extensional phase of Okinawa Trough. The Chiwei Canyon was initia- ted during the middle Pleistocene and guided by F4 that is a N--S trending fault on the slope and F1, a large NW--SE trending fault on the trough. The pathway migration from the remnant channel to the present one of Chiwei Canyon is the result of uplift of tilted fault block that is coupled to the recent extension movements of the southern trough. The submarine terrace is detached from the ECS slope by the NEE -trending fault. The North Chiwei Canyon, developing during the late Pleistocene, is guided by FS, a N-S trending fault, diverted and blocked by the submarine terrace.
