目的探讨原发性涎腺黏液表皮样癌(mucoepidermoid carcinoma,MEC)中MAML2基因重排与临床病理特征的相关性。方法采用荧光原位杂交(fluorescence in situ hybridization,FISH)检测28例原发性涎腺MEC中MAML2基因重排;应用免疫组化EnVisio...目的探讨原发性涎腺黏液表皮样癌(mucoepidermoid carcinoma,MEC)中MAML2基因重排与临床病理特征的相关性。方法采用荧光原位杂交(fluorescence in situ hybridization,FISH)检测28例原发性涎腺MEC中MAML2基因重排;应用免疫组化EnVision两步法检测CK7、p63、CK5/6、S-100、CD117的表达,并进行诊断及鉴别诊断。结果28例MEC中有17例(14例低级别、3例中级别)MAML2基因重排,检出率为60.7%(17/28),其中包含Warthin瘤样变异型和透明细胞变异型。MAML2基因重排与肿瘤部位、病理分级密切相关,发生在腮腺、低级别的MEC中MAML2基因重排发生率显著增高(P<0.05),MAML2基因重排与患者年龄、性别、肿瘤最大径、淋巴结有无转移、临床分期无相关性(P>0.05)。结论MAML2基因重排与肿瘤发生部位、病理分级密切相关,MAML2基因重排阳性可以辅助诊断变异型MEC。展开更多
A crucial region for China's ‘Grain-forGreen Policy' is located within a traditional farmpastoral area, between 2000 to 3000 m above sea level, on the eastern Qinghai-Tibetan Plateau.However, the responses of...A crucial region for China's ‘Grain-forGreen Policy' is located within a traditional farmpastoral area, between 2000 to 3000 m above sea level, on the eastern Qinghai-Tibetan Plateau.However, the responses of soil organic carbon(SOC) to different land-use patterns in this region are unclear. Here, we determined the SOC(0–20 cm) content of grasslands and forests that are being converted from farmlands, as well as in abandoned arable land and arable land in this region. The factors influencing the reclaimed lands were analyzed along altitudes from 2030 to 3132 m. Our results showed that SOC content was higher for grassland and abandoned arable land than forest and arable land. The SOC content increased with the increase in altitude for total land-use patterns. Further, the grassland and abandoned arable land had higher SOC content than the forest with almost parallel trends along the increase in altitude. However, the proportion of regulated factors of altitude and species richness varied among forest, grassland, and abandoned arable land. Our results indicated that the land-use pattern of returning farmland to grassland and abandoned arable land was more effective in terms of the SOC storage in the superficial layer in this altitude range in the Qinghai-Tibetan Plateau, thereby being beneficial to optimizing land management in this region.展开更多
文摘目的探讨原发性涎腺黏液表皮样癌(mucoepidermoid carcinoma,MEC)中MAML2基因重排与临床病理特征的相关性。方法采用荧光原位杂交(fluorescence in situ hybridization,FISH)检测28例原发性涎腺MEC中MAML2基因重排;应用免疫组化EnVision两步法检测CK7、p63、CK5/6、S-100、CD117的表达,并进行诊断及鉴别诊断。结果28例MEC中有17例(14例低级别、3例中级别)MAML2基因重排,检出率为60.7%(17/28),其中包含Warthin瘤样变异型和透明细胞变异型。MAML2基因重排与肿瘤部位、病理分级密切相关,发生在腮腺、低级别的MEC中MAML2基因重排发生率显著增高(P<0.05),MAML2基因重排与患者年龄、性别、肿瘤最大径、淋巴结有无转移、临床分期无相关性(P>0.05)。结论MAML2基因重排与肿瘤发生部位、病理分级密切相关,MAML2基因重排阳性可以辅助诊断变异型MEC。
基金supported by the National Key Research and Development Project of China (Grant Nos. 2016YFC0501903, 2016YFC0501901)Province Natural Foundation of Qinghai (Grant Nos. 2016-ZJ-910, 2017-S-1-04)+2 种基金the Qinghai Provincial High-end and Innovative 1000 Talents PlanQinghai Innovation Platform Construction Project (Grant Nos. 2017-ZJ-Y20, 2017-ZJ-Y13)National Natural Foundation of China (Grant Nos. 31572354, 31472135)
文摘A crucial region for China's ‘Grain-forGreen Policy' is located within a traditional farmpastoral area, between 2000 to 3000 m above sea level, on the eastern Qinghai-Tibetan Plateau.However, the responses of soil organic carbon(SOC) to different land-use patterns in this region are unclear. Here, we determined the SOC(0–20 cm) content of grasslands and forests that are being converted from farmlands, as well as in abandoned arable land and arable land in this region. The factors influencing the reclaimed lands were analyzed along altitudes from 2030 to 3132 m. Our results showed that SOC content was higher for grassland and abandoned arable land than forest and arable land. The SOC content increased with the increase in altitude for total land-use patterns. Further, the grassland and abandoned arable land had higher SOC content than the forest with almost parallel trends along the increase in altitude. However, the proportion of regulated factors of altitude and species richness varied among forest, grassland, and abandoned arable land. Our results indicated that the land-use pattern of returning farmland to grassland and abandoned arable land was more effective in terms of the SOC storage in the superficial layer in this altitude range in the Qinghai-Tibetan Plateau, thereby being beneficial to optimizing land management in this region.
