Na-ion batteries(NIBs)have attracted considerable attention in recent years owing to the high abundance and low cost of Na.It is well known that S doping can improve the electrochemical performance of carbon materials...Na-ion batteries(NIBs)have attracted considerable attention in recent years owing to the high abundance and low cost of Na.It is well known that S doping can improve the electrochemical performance of carbon materials for NIBs.However,the current methods for S doping in carbons normally involve toxic precursors or rigorous conditions.In this work,we report a creative and facile strategy for preparing S-doped porous carbons(SCs)via the pyrolysis of conjugated microporous polymers(CMPs).Briefly,thiophene-based CMPs served as the precursors and doping sources simultaneously.Simple direct carbonization of CMPs produced S-doped carbon materials with highly porous structures.When used as an anode for NIBs,the SCs exhibited a high reversible capacity of 440 mAh g?1 at 50 mA g?1 after 100 cycles,superior rate capability,and excellent cycling stability(297 mAh g?1 after 1000 cycles at 500 mA g?1),outperforming most S-doped carbon materials reported thus far.The excellent performance of the SCs is attributed to the expanded lattice distance after S doping.Furthermore,we employed ex situ X-ray photoelectron spectroscopy to investigate the electrochemical reaction mechanism of the SCs during sodiation-desodiation,which can highlight the role of doped S for Na-ion storage.展开更多
Flexible aqueous Ni//Zn batteries have attracted much attention as promising candidates for energy storage in the field of flexible electronics.However,the Ni-based cathodes still face the challenges of poor conductiv...Flexible aqueous Ni//Zn batteries have attracted much attention as promising candidates for energy storage in the field of flexible electronics.However,the Ni-based cathodes still face the challenges of poor conductivity,confined charge/mass transfer,and non-flexibility.In this work,we designed a hollow tubular structure consisting of a conductive silver nanowire (Ag NW) wrapped by active Ni Co layered double hydroxide (LDH),for enhancing the electrical conductivity,improving the charge/mass transfer kinetics,and facilitating the ion penetration.By optimizing the contents of Ni,Co and Ag NW,the Ni_(4)Co LDH@Ag_(1.5)NW composite shows a maximum specific capacity of 115.83 m Ah g^(-1)at 0.1 A g^(-1)measured in a two-electrode system.Highlightingly,the flexible aqueous Ni//Zn battery assembled by Ni_(4)Co LDH@Ag_(1.5)NW interwoven with multi-walled carbon nanotube cathode and Zn foil anode realizes a high power density of 160μW cm^(-2)at the energy density of 23.14μWh cm^(-2),which is superior compared with those of oxide/hydroxide based devices and even higher than those of many carbon-based supercapacitors,showing its promising potentials for flexible energy storage applications.展开更多
Hereditary gingival fibromatosis(HGF)is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity.Five distinct loci related to non-syndromic HGF have bee...Hereditary gingival fibromatosis(HGF)is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity.Five distinct loci related to non-syndromic HGF have been identified;however,only two diseasecausing genes,SOS1 and REST,inducing HGF have been identified at two loci,GINGF1 and GINGF5,respectively.Here,based on a family pedigree with 26 members,including nine patients with HGF,we identified double heterozygous pathogenic mutations in the ZNF513(c.C748T,p.R250W)and KIF3C(c.G1229A,p.R410H)genes within the GINGF3 locus related to HGF.Functional studies demonstrated that the ZNF513 p.R250W and KIF3C p.R410H variants significantly increased the expression of ZNF513 and KIF3C in vitro and in vivo.ZNF513,a transcription factor,binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts.Furthermore,a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513(p.R250W)or Kif3c(p.R412H)alone do not led to clear phenotypes with gingival fibromatosis,whereas the double mutations led to gingival hyperplasia phenotypes.In addition,we found that ZNF513 binds to the SOS1 promoter and plays an important positive role in regulating the expression of SOS1.Moreover,the KIF3C p.R410H mutation could activate the PI3K and KCNQ1 potassium channels.ZNF513 combined with KIF3C regulates gingival fibroblast proliferation,migration,and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways.In summary,these results demonstrate ZNF513+KIF3C as an important genetic combination in HGF manifestation and suggest that ZNF513 mutation may be a major risk factor for HGF.展开更多
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular,and cellular interactions. Ameloblastin(AMBN, also named "amelin" or "sheathl...Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular,and cellular interactions. Ameloblastin(AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta(AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. The hereditary dentin disorders comprise a variety of autosomal-dominant genetic symptoms characterized by abnormal dentin structure affecting either the primary or both the primary and secondary teeth. The vital role of Ambn in amelogenesis has been confirmed experimentally using mouse models. Only two cases have been reported of mutations of AMBN associated with non-syndromic human AI. However, no AMBN missense mutations have been reported to be associated with both human AI and dentin disorders.We recruited one kindred with autosomal-dominant amelogenesis imperfecta(ADAI) and dentinogenesis imperfecta/dysplasia characterized by generalized severe enamel and dentin defects. Whole exome sequencing of the proband identified a novel heterozygous C-T point mutation at nucleotide position 1069 of the AMBN gene, causing a Pro to Ser mutation at the conserved amino acid position 357 of the protein. Exfoliated third molar teeth from the affected family members were found to have enamel and dentin of lower mineral density than control teeth, with thinner and easily fractured enamel, short and thick roots, and pulp obliteration. This study demonstrates, for the first time, that an AMBN missense mutation causes non-syndromic human AI and dentin disorders.展开更多
In a coordinated road network,the optimal common cycle time is determined by evaluating the performance of the network in the given range of cycles. Normally,this range is determined by users 'experience. And a la...In a coordinated road network,the optimal common cycle time is determined by evaluating the performance of the network in the given range of cycles. Normally,this range is determined by users 'experience. And a large range of common cycle time,e. g. [30,200] is chosen,which requires long computation time. This study considers that the optimal common cycle time ranges between the minimal and maximal value of intersections' individual optimal cycle time. It is proved mathematically from the convexity condition,that the delay of the network and each individual intersection are convex functions of the cycle time according to Webster delay model. Finally,2 000 random cases for the network composed of two intersections and of eight intersections are created to underline the proposed conclusions. The results of all cases confirm the validity,and show up to 90% improvement in computation time to compare with experience range. The signal optimization tool,Synchro,is also used to validate the conclusion by 50 random cases. The results confirm reliability further.展开更多
Golgi apparatus,together with endoplasmic reticula,vacuoles and plasma membrane,constitutes the endoplasmic system of plant cells.It plays an important role in the secretion pathway of eukaryotic cells and is responsi...Golgi apparatus,together with endoplasmic reticula,vacuoles and plasma membrane,constitutes the endoplasmic system of plant cells.It plays an important role in the secretion pathway of eukaryotic cells and is responsible for various intracellular events,such as protein classification,protein modification and glycosylation.At present,much less is known about plant Golgi proteins.The research on its function is still insufficient.In order to provide a comprehensive research background and research ideas for related researchers,this paper systematically and comprehensively evaluated the structure of plant endoplasmic system,the common endoplasmic reticulum-Golgi transport pathway in plant cells,various possible transport models between endoplasmic reticula and Golgi bodies,Golgi-associated specific proteins and functions,and Golgi biogenesis pathway.The latest research progress in this field was reviewed and analyzed in detail.This paper will provide an important reference for related researchers to carry out the research of plant Golgi.展开更多
Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and fatalities.Despite the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an u...Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and fatalities.Despite the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment modalities.Current strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell responses.Taking into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived exosomes.Specifically,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive microenvironment.After immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T cells.Simultaneously,they also play an immunoregulatory role by converting M2 macrophages into M1 macrophages.This two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB patients.When combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum adjuvant.This combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.展开更多
Green trade barriers are often seen as a catalyst that promotes exporting countries to develop green technologies.However,by distinguishing the green technology behavior of enterprises into green technology transforma...Green trade barriers are often seen as a catalyst that promotes exporting countries to develop green technologies.However,by distinguishing the green technology behavior of enterprises into green technology transformation and green technology innovation,this paper finds that although green trade barriers can encourage enterprises in exporting countries to increase investment in green technology transformation in order to obtain rapid market access,they crowd out the resources of green technology innovation of enterprises.In other words,green trade barriers will strengthen enterprises’dependence on the introduction of green technologies,weaken their innovation capabilities,and increase the risk of being locked in the middle of the global industrial chain,creating a trap effect.Using the data of enterprises in the heavily polluting industry of A-shares from 2009 to 2021,this paper confirms the existence of the trap effect.In addition,this paper finds that due to the infl uence of short-sightedness of managers,alleviating corporate financing constraints can enhance the promotion effect of green trade barriers on the green technological transformation of enterprises,but cannot reduce its inhibiting effect on green technology innovation.The study also finds that even if the time window is extended to the medium and long term,green trade barriers cannot have a significant positive impact on enterprises’green technology innovation.Therefore,the government should not overestimate the role of green trade barriers in encouraging green development and green technology innovation,nor should it rely too much on loose financing policies.In contrast,government should formulate targeted industrial policies to help enterprises overcome green trade barriers through technological innovation.展开更多
Since the concept of artificial psychology and artificial emotion was first presented, it has become a topic of interest in academic circles and enterprises. In this article, we first briefly introduce the basic conce...Since the concept of artificial psychology and artificial emotion was first presented, it has become a topic of interest in academic circles and enterprises. In this article, we first briefly introduce the basic concepts and principles of artificial psychology and artificial emotion, analyzing the unified macro-model of the cross-disciplinary system architecture against the need-motivation-behavior framework. Second, we discuss the origin of artificial psychology and artificial emotion, its course of development, and its present situation in China. We also present a review of the published papers and research endeavors of Chinese universities and research institutions and the technical engineering applications of artificial psychology and artificial emotion. Finally, we summarize the challenges to the further development of artificial psychology and artificial emotion and our recommendations for improving the cognitive computing model of psychological states and developing reliable and accurate humanoid interaction and cooperation technology, robot platforms with emotions and humanoid interaction and cooperation capabilities, and humanoid robots for the elderly and the disabled in smart homes. We believe that, with intensive research, artificial psychology and artificial emotion may be developed further and may eventually reach maturity.展开更多
Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits.One important class of syntheti...Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits.One important class of synthetic circuits currently under active development concerns the programming of bacterial cellular communication and collective population-scale behaviors.Because of the ubiquity of cell-cell interactions within bacterial communities,having an ability of engineering these circuits is vital to programming robust cellular behaviors.Here,we highlight recent advances in communication-based synthetic gene circuits by first discussing natural communication systems and then surveying various functional engineered circuits,including those for population density control,temporal synchronization,spatial organization,and ecosystem formation.We conclude by summarizing recent advances,outlining existing challenges,and discussing potential applications and future opportunities.展开更多
The increasingly mature computer vision(CV)technology represented by convolutional neural networks(CNN)and available high-resolution remote sensing images(HR-RSIs)provide opportunities to accurately measure the evolut...The increasingly mature computer vision(CV)technology represented by convolutional neural networks(CNN)and available high-resolution remote sensing images(HR-RSIs)provide opportunities to accurately measure the evolution of natural and artificial environments on Earth at a large scale.Based on the advanced CNN method high-resolution net(HRNet)and multi-temporal HR-RSIs,a framework is proposed for monitoring a green evolution of courtyard buildings characterized by their courtyards being roofed(CBR).The proposed framework consists of an expert module focusing on scenes analysis,a CV module for automatic detection,an evaluation module containing thresholds,and an output module for data analysis.Based on this,the changes in the adoption of different CBR technologies(CBRTs),including light-translucent CBRTs(LT-CBRTs)and non-lighttranslucent CBRTs(NLT-CBRTs),in 24 villages in southern Hebei were identified from 2007 to 2021.The evolution of CBRTs was featured as an inverse S-curve,and differences were found in their evolution stage,adoption ratio,and development speed for different villages.LT-CBRTs are the dominant type but are being replaced and surpassed by NLT-CBRTs in some villages,characterizing different preferences for the technology type of villages.The proposed research framework provides a reference for the evolution monitoring of vernacular buildings,and the identified evolution laws enable to trace and predict the adoption of different CBRTs in a particular village.This work lays a foundation for future exploration of the occurrence and development mechanism of the CBR phenomenon and provides an important reference for the optimization and promotion of CBRTs.展开更多
The grain yield data collected by the intelligent yield measurement system of the combine harvester is generated into a field plot yield distribution map,which is of great significance for guiding agricultural product...The grain yield data collected by the intelligent yield measurement system of the combine harvester is generated into a field plot yield distribution map,which is of great significance for guiding agricultural production.However,in the process of drawing the yield map,the combine harvester is affected by vibration during operation and the generated error data in the process of collecting data which will cause the drawing results to be inaccurate.This study researched two factors that cause errors,then,the influence of vibration interference on the measurement signal was eliminated by filtering,vibration isolation,and designing a double-plates differential grain flow sensor.Three methods were taken to eliminate random errors,gross errors and systematic errors,including using the arithmetic average value to replace the true value,the 3σcriterion,and removing the filling time data and the delaying time data.Finally,the grain yield distribution map was obtained through Matlab and Excel.The results showed that the interference frequency above 50 Hz could be eliminated by filtering,but it was difficult to filter the low-frequency signal which was close to the grain impact frequency.The vibration amplitude was reduced to 14.29%by adding a vibration isolation plate,and the SNR was increased from−4.67 dB to 29.21 dB by combining low-pass filtering and damping vibration isolation.When the grain feeding rate was 2 kg/s,the natural vibration amplitude of the sensor after difference was about 0.02 V and evenly distributed around the zero voltage 0.2 V.The influence of positive and negative offset on the average value of grain impact signal could be ignored,and the signal-to-noise ratio was increased from 29.21 dB to 62.49 dB.The results of field experiments showed that the yield map drawn can clearly display the yield value of the harvest area,which is used to guide agricultural production.展开更多
Fatty acids (FAs) are building blocks required for the threedomains of life. The machinery of type II fatty acid synthesis is longrecognized as a druggable pathway against deadly infections withdrug-resistant bacteria...Fatty acids (FAs) are building blocks required for the threedomains of life. The machinery of type II fatty acid synthesis is longrecognized as a druggable pathway against deadly infections withdrug-resistant bacterial pathogens [1]. However, an everincreasing body of exogenous FAs (eFA) utilization routes posesthe possibility of replacing bacterial de novo FA synthesis, whichmight compromise the FAS II-directed antimicrobials, like cerulenin[2–4]. As for Gram-negative species, the paradigm executorof an eFA recycling denotes an acyl-ACP synthetase (AasS) of thezoonotic pathogen Vibrio harveyi [5]. In contrast, a unique twocomponent system of fatty acid kinase called FakA/B [6], is exclusively present in Staphylococcus and Enterococcus/Streptococcus,two important lineages of Gram-positive bacterium (Fig. S1a, bonline) [6,7].展开更多
Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to in...Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future.展开更多
Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil ...Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil and water,is recognized as an opportunistic pathogen causing recalcitrant infections.Carbapenem-resistant P.aeruginosa(CRPA)is listed by the World Health Organization(WHO)as an important member of top priority“ESKAPE”pathogens.This is largely supported by the fact that in 2020,CRPA had caused28,8000 nosocomial infections with about 2500 deaths.Apart from porin mutations,the acquisition of Klebsiella pneumoniae carbapenemase(termed as KPC-2)constitutes an alternative mechanism for carbapenem resistance in P.aeruginosa,which compromises the clinical efficacy of the carbapenem as a“last resort”option.Notably,the transferability of blaKPC-2 determinants facilitates global dissemination of CRPA in the context of“one health”consisting of humans,animals,plants/crops,and environmental settings.In addition to antimicrobial stewardship,coordinated global action is necessary to mitigate AMR progression.展开更多
具有电化学变色功能的柔性电池在智能电子领域显示出巨大的应用潜力.然而,具有可视化电量预警功能的镍锌电池目前尚未见报道.在此,我们设计了一种用于柔性镍锌电池的电致变色镍钴氢氧化物/镍/氧化铟锡(NiCo BH/Ni/ITO)柔性电极.通过优...具有电化学变色功能的柔性电池在智能电子领域显示出巨大的应用潜力.然而,具有可视化电量预警功能的镍锌电池目前尚未见报道.在此,我们设计了一种用于柔性镍锌电池的电致变色镍钴氢氧化物/镍/氧化铟锡(NiCo BH/Ni/ITO)柔性电极.通过优化Ni层厚度,电极在电流密度为0.1 mA cm^(-2)时,着色效率为59.89 cm^(2)C^(-1),容量为7.15μA h cm^(-2).相应组装的电致变色镍锌电池功率密度为160μW cm^(-2)时,能量密度为12.69μW h cm^(-2),优于部分文献报道的透明柔性超级电容器和电致变色电池.值得注意的是,组装的镍锌电池在充放电过程中显示出可逆的颜色变化,提供了一种可视化监测电池剩余电量的新功能.展开更多
This paper investigates how institutional holding and earnings quality influence the liquidity of assets. Contrary to findings in developed markets, we document several novel results in China＇s stock market： （1） i...This paper investigates how institutional holding and earnings quality influence the liquidity of assets. Contrary to findings in developed markets, we document several novel results in China＇s stock market： （1） institutional holding negatively affects assets＇ liquidity, （2） earnings quality is negatively related with liquidity. Since earnings quality captures asymmetric information, low earnings quality induces high divergence in investor opinions and thus boosts market trading, and （3） interestingly, the effect of earnings quality on liquidity is greater if institutional investors＇ holding is at a high level. Overall, our findings cast doubt on the conventional wisdom that institutional investors and earnings quality improve market liquidity. The results are robust to different measures and alternative model specifications.展开更多
Inflammatory fibroid polyp （IFP） is a group of rare benign mesenchymal tumors throughout the gastrointestinal tract.The most involved sites are stomach and large intestines,followed by small intestines,esophagus,and...Inflammatory fibroid polyp （IFP） is a group of rare benign mesenchymal tumors throughout the gastrointestinal tract.The most involved sites are stomach and large intestines,followed by small intestines,esophagus,and anal canal.However,even in the stomach,its incidence is only 0.1% of all gastric polyps.[1] We here reported an IFP located in the cecum.展开更多
Recently,Coordination Polymers(CPs)have been widely utilized as energy storage materials for reversible Lithium-Ion Batteries(LIBs)benefiting from their tunable building blocks and adjusted electrochemical properties....Recently,Coordination Polymers(CPs)have been widely utilized as energy storage materials for reversible Lithium-Ion Batteries(LIBs)benefiting from their tunable building blocks and adjusted electrochemical properties.However,the unsatisfied electrochemical behavior of CPs with poor conductivity and sluggish ion transport kinetics is still a bottle-neck for their large-scale energy storage applications in LIBs.Herein,we display the rational fabrication of a conductive Sn-based coordination polymer(Sn-DHTPA)via judiciously choosing suitable building units.The Sn-DHTPA is employed as anode for LIBs,exhibiting superior reversible storage capacity of 1142.6 m A h g^(-1) at 0.1 A g^(-1) after 100 cycles and impressive rate storage capability of 287.7 m A h g^(-1)at 20 A g^(-1).More importantly,a robust cycling performance of 205.5 m A h g^(-1) at an extra-high current density of 20 A g^(-1) are observed without remarkable capacity-fading up to1000 cycles.The behavior superiority of Sn-DHTPA is related to its advanced architecture with abundant lithium storage sites,high electrical conductivity and rapid lithium transport.A series of ex-situ characterizations reveal that the impressive lithium storage capacity is contributed by the redox active sites of both the aromatic linker and metal center related to in-situ generated metallic nanoparticles dispersed in the skeleton.展开更多
基金Financial support from National Natural Science Foundation of China(Nos.51702056 and 51772135)the Ministry of Education of China(6141A02022516)China Postdoctoral Science Foundation(2017M622902 and 2019T120790).
文摘Na-ion batteries(NIBs)have attracted considerable attention in recent years owing to the high abundance and low cost of Na.It is well known that S doping can improve the electrochemical performance of carbon materials for NIBs.However,the current methods for S doping in carbons normally involve toxic precursors or rigorous conditions.In this work,we report a creative and facile strategy for preparing S-doped porous carbons(SCs)via the pyrolysis of conjugated microporous polymers(CMPs).Briefly,thiophene-based CMPs served as the precursors and doping sources simultaneously.Simple direct carbonization of CMPs produced S-doped carbon materials with highly porous structures.When used as an anode for NIBs,the SCs exhibited a high reversible capacity of 440 mAh g?1 at 50 mA g?1 after 100 cycles,superior rate capability,and excellent cycling stability(297 mAh g?1 after 1000 cycles at 500 mA g?1),outperforming most S-doped carbon materials reported thus far.The excellent performance of the SCs is attributed to the expanded lattice distance after S doping.Furthermore,we employed ex situ X-ray photoelectron spectroscopy to investigate the electrochemical reaction mechanism of the SCs during sodiation-desodiation,which can highlight the role of doped S for Na-ion storage.
基金sponsored by the National Natural Science Foundation of China(61804054)the Natural Science Foundation of Shanghai(18ZR1410400)+2 种基金the Shanghai Sailing Program(17YF1403300)the Shanghai Aerospace Science and Technology Innovation Fundation(SISP2018)the Shanghai Aerospace Science and Technology Innovation Fund(SAST2019-067)。
文摘Flexible aqueous Ni//Zn batteries have attracted much attention as promising candidates for energy storage in the field of flexible electronics.However,the Ni-based cathodes still face the challenges of poor conductivity,confined charge/mass transfer,and non-flexibility.In this work,we designed a hollow tubular structure consisting of a conductive silver nanowire (Ag NW) wrapped by active Ni Co layered double hydroxide (LDH),for enhancing the electrical conductivity,improving the charge/mass transfer kinetics,and facilitating the ion penetration.By optimizing the contents of Ni,Co and Ag NW,the Ni_(4)Co LDH@Ag_(1.5)NW composite shows a maximum specific capacity of 115.83 m Ah g^(-1)at 0.1 A g^(-1)measured in a two-electrode system.Highlightingly,the flexible aqueous Ni//Zn battery assembled by Ni_(4)Co LDH@Ag_(1.5)NW interwoven with multi-walled carbon nanotube cathode and Zn foil anode realizes a high power density of 160μW cm^(-2)at the energy density of 23.14μWh cm^(-2),which is superior compared with those of oxide/hydroxide based devices and even higher than those of many carbon-based supercapacitors,showing its promising potentials for flexible energy storage applications.
基金supported by National Natural Science Foundation of China(82302078,32170617,31970558,82170920)National Key R&D Program of China(2021YFC1005301,2022YFC2703303)+1 种基金Natural Science Foundation of Guangdong Province of China(2022A1515012621)Grant for joint research projects from Shenzhen Hospital,Southern Medical University(22H3AUN04).
文摘Hereditary gingival fibromatosis(HGF)is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity.Five distinct loci related to non-syndromic HGF have been identified;however,only two diseasecausing genes,SOS1 and REST,inducing HGF have been identified at two loci,GINGF1 and GINGF5,respectively.Here,based on a family pedigree with 26 members,including nine patients with HGF,we identified double heterozygous pathogenic mutations in the ZNF513(c.C748T,p.R250W)and KIF3C(c.G1229A,p.R410H)genes within the GINGF3 locus related to HGF.Functional studies demonstrated that the ZNF513 p.R250W and KIF3C p.R410H variants significantly increased the expression of ZNF513 and KIF3C in vitro and in vivo.ZNF513,a transcription factor,binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts.Furthermore,a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513(p.R250W)or Kif3c(p.R412H)alone do not led to clear phenotypes with gingival fibromatosis,whereas the double mutations led to gingival hyperplasia phenotypes.In addition,we found that ZNF513 binds to the SOS1 promoter and plays an important positive role in regulating the expression of SOS1.Moreover,the KIF3C p.R410H mutation could activate the PI3K and KCNQ1 potassium channels.ZNF513 combined with KIF3C regulates gingival fibroblast proliferation,migration,and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways.In summary,these results demonstrate ZNF513+KIF3C as an important genetic combination in HGF manifestation and suggest that ZNF513 mutation may be a major risk factor for HGF.
基金partially supported by a grant from the National Natural Science Foundation of China 31371279 (to Fu Xiong)the National Natural Science Foundation of China 81371137 (to Bu-Ling Wu)the Science and Technology Program of Guangzhou 201707010301 (to Fu Xiong)
文摘Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular,and cellular interactions. Ameloblastin(AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta(AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. The hereditary dentin disorders comprise a variety of autosomal-dominant genetic symptoms characterized by abnormal dentin structure affecting either the primary or both the primary and secondary teeth. The vital role of Ambn in amelogenesis has been confirmed experimentally using mouse models. Only two cases have been reported of mutations of AMBN associated with non-syndromic human AI. However, no AMBN missense mutations have been reported to be associated with both human AI and dentin disorders.We recruited one kindred with autosomal-dominant amelogenesis imperfecta(ADAI) and dentinogenesis imperfecta/dysplasia characterized by generalized severe enamel and dentin defects. Whole exome sequencing of the proband identified a novel heterozygous C-T point mutation at nucleotide position 1069 of the AMBN gene, causing a Pro to Ser mutation at the conserved amino acid position 357 of the protein. Exfoliated third molar teeth from the affected family members were found to have enamel and dentin of lower mineral density than control teeth, with thinner and easily fractured enamel, short and thick roots, and pulp obliteration. This study demonstrates, for the first time, that an AMBN missense mutation causes non-syndromic human AI and dentin disorders.
基金Sponsored by German Aerospace Center(Grant I.MoVe AP3200 Nicht-kooperative Verkehrssteuerung)
文摘In a coordinated road network,the optimal common cycle time is determined by evaluating the performance of the network in the given range of cycles. Normally,this range is determined by users 'experience. And a large range of common cycle time,e. g. [30,200] is chosen,which requires long computation time. This study considers that the optimal common cycle time ranges between the minimal and maximal value of intersections' individual optimal cycle time. It is proved mathematically from the convexity condition,that the delay of the network and each individual intersection are convex functions of the cycle time according to Webster delay model. Finally,2 000 random cases for the network composed of two intersections and of eight intersections are created to underline the proposed conclusions. The results of all cases confirm the validity,and show up to 90% improvement in computation time to compare with experience range. The signal optimization tool,Synchro,is also used to validate the conclusion by 50 random cases. The results confirm reliability further.
基金Special Fund for the Research Team of Ecological Restoration and Governance Innovation of the Jinsha River Dry and Hot Valley(035200179)2020 Doctoral Research Startup Fund of Panzhihua University(035200254)。
文摘Golgi apparatus,together with endoplasmic reticula,vacuoles and plasma membrane,constitutes the endoplasmic system of plant cells.It plays an important role in the secretion pathway of eukaryotic cells and is responsible for various intracellular events,such as protein classification,protein modification and glycosylation.At present,much less is known about plant Golgi proteins.The research on its function is still insufficient.In order to provide a comprehensive research background and research ideas for related researchers,this paper systematically and comprehensively evaluated the structure of plant endoplasmic system,the common endoplasmic reticulum-Golgi transport pathway in plant cells,various possible transport models between endoplasmic reticula and Golgi bodies,Golgi-associated specific proteins and functions,and Golgi biogenesis pathway.The latest research progress in this field was reviewed and analyzed in detail.This paper will provide an important reference for related researchers to carry out the research of plant Golgi.
基金supported by National Key Research and Development Program of China(Nos.2023YFC2307704,and 2021YFC2302603)National Natural Science Foundation of China(Nos.82341405,and 32030062)+1 种基金CAS Project for Young Scientists in Basic Research(No.YSBR-083)IPE Project for Frontier Basic Research(No.QYJC-2022-012).
文摘Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and fatalities.Despite the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment modalities.Current strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell responses.Taking into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived exosomes.Specifically,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive microenvironment.After immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T cells.Simultaneously,they also play an immunoregulatory role by converting M2 macrophages into M1 macrophages.This two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB patients.When combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum adjuvant.This combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.
基金Key Research Base of Humanities and Social Sciences,Ministry of Education,“Research on the Impact of Global Industrial Chain Reconstruction on Global Economic Governance System and China’s Response”(22JJD790009)“Research on the Impact of Global Industrial Chain Restructuring and China’s Response”(22VRC086).
文摘Green trade barriers are often seen as a catalyst that promotes exporting countries to develop green technologies.However,by distinguishing the green technology behavior of enterprises into green technology transformation and green technology innovation,this paper finds that although green trade barriers can encourage enterprises in exporting countries to increase investment in green technology transformation in order to obtain rapid market access,they crowd out the resources of green technology innovation of enterprises.In other words,green trade barriers will strengthen enterprises’dependence on the introduction of green technologies,weaken their innovation capabilities,and increase the risk of being locked in the middle of the global industrial chain,creating a trap effect.Using the data of enterprises in the heavily polluting industry of A-shares from 2009 to 2021,this paper confirms the existence of the trap effect.In addition,this paper finds that due to the infl uence of short-sightedness of managers,alleviating corporate financing constraints can enhance the promotion effect of green trade barriers on the green technological transformation of enterprises,but cannot reduce its inhibiting effect on green technology innovation.The study also finds that even if the time window is extended to the medium and long term,green trade barriers cannot have a significant positive impact on enterprises’green technology innovation.Therefore,the government should not overestimate the role of green trade barriers in encouraging green development and green technology innovation,nor should it rely too much on loose financing policies.In contrast,government should formulate targeted industrial policies to help enterprises overcome green trade barriers through technological innovation.
文摘Since the concept of artificial psychology and artificial emotion was first presented, it has become a topic of interest in academic circles and enterprises. In this article, we first briefly introduce the basic concepts and principles of artificial psychology and artificial emotion, analyzing the unified macro-model of the cross-disciplinary system architecture against the need-motivation-behavior framework. Second, we discuss the origin of artificial psychology and artificial emotion, its course of development, and its present situation in China. We also present a review of the published papers and research endeavors of Chinese universities and research institutions and the technical engineering applications of artificial psychology and artificial emotion. Finally, we summarize the challenges to the further development of artificial psychology and artificial emotion and our recommendations for improving the cognitive computing model of psychological states and developing reliable and accurate humanoid interaction and cooperation technology, robot platforms with emotions and humanoid interaction and cooperation capabilities, and humanoid robots for the elderly and the disabled in smart homes. We believe that, with intensive research, artificial psychology and artificial emotion may be developed further and may eventually reach maturity.
基金supported by the American Heart Association(Grant No.12SDG12090025)the Network for Computational Nanotechnology at UIUC sponsored by National Science Foundation(Grant No.1227034),and the UIUC Research Board.
文摘Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits.One important class of synthetic circuits currently under active development concerns the programming of bacterial cellular communication and collective population-scale behaviors.Because of the ubiquity of cell-cell interactions within bacterial communities,having an ability of engineering these circuits is vital to programming robust cellular behaviors.Here,we highlight recent advances in communication-based synthetic gene circuits by first discussing natural communication systems and then surveying various functional engineered circuits,including those for population density control,temporal synchronization,spatial organization,and ecosystem formation.We conclude by summarizing recent advances,outlining existing challenges,and discussing potential applications and future opportunities.
基金supported by National Natural Science Foundation of China (No.52108010).
文摘The increasingly mature computer vision(CV)technology represented by convolutional neural networks(CNN)and available high-resolution remote sensing images(HR-RSIs)provide opportunities to accurately measure the evolution of natural and artificial environments on Earth at a large scale.Based on the advanced CNN method high-resolution net(HRNet)and multi-temporal HR-RSIs,a framework is proposed for monitoring a green evolution of courtyard buildings characterized by their courtyards being roofed(CBR).The proposed framework consists of an expert module focusing on scenes analysis,a CV module for automatic detection,an evaluation module containing thresholds,and an output module for data analysis.Based on this,the changes in the adoption of different CBR technologies(CBRTs),including light-translucent CBRTs(LT-CBRTs)and non-lighttranslucent CBRTs(NLT-CBRTs),in 24 villages in southern Hebei were identified from 2007 to 2021.The evolution of CBRTs was featured as an inverse S-curve,and differences were found in their evolution stage,adoption ratio,and development speed for different villages.LT-CBRTs are the dominant type but are being replaced and surpassed by NLT-CBRTs in some villages,characterizing different preferences for the technology type of villages.The proposed research framework provides a reference for the evolution monitoring of vernacular buildings,and the identified evolution laws enable to trace and predict the adoption of different CBRTs in a particular village.This work lays a foundation for future exploration of the occurrence and development mechanism of the CBR phenomenon and provides an important reference for the optimization and promotion of CBRTs.
基金supported by the Open Project of the Key Laboratory of Modern Agricultural Equipment and TechnologyMinistry of Education of the PRC(Grant No.JNZ201911)the Youth Talent Development and Program of Jiangsu University,and the Key Laboratory of Agricultural Equipment and Intelligent High Technology Research of Jiangsu Province.
文摘The grain yield data collected by the intelligent yield measurement system of the combine harvester is generated into a field plot yield distribution map,which is of great significance for guiding agricultural production.However,in the process of drawing the yield map,the combine harvester is affected by vibration during operation and the generated error data in the process of collecting data which will cause the drawing results to be inaccurate.This study researched two factors that cause errors,then,the influence of vibration interference on the measurement signal was eliminated by filtering,vibration isolation,and designing a double-plates differential grain flow sensor.Three methods were taken to eliminate random errors,gross errors and systematic errors,including using the arithmetic average value to replace the true value,the 3σcriterion,and removing the filling time data and the delaying time data.Finally,the grain yield distribution map was obtained through Matlab and Excel.The results showed that the interference frequency above 50 Hz could be eliminated by filtering,but it was difficult to filter the low-frequency signal which was close to the grain impact frequency.The vibration amplitude was reduced to 14.29%by adding a vibration isolation plate,and the SNR was increased from−4.67 dB to 29.21 dB by combining low-pass filtering and damping vibration isolation.When the grain feeding rate was 2 kg/s,the natural vibration amplitude of the sensor after difference was about 0.02 V and evenly distributed around the zero voltage 0.2 V.The influence of positive and negative offset on the average value of grain impact signal could be ignored,and the signal-to-noise ratio was increased from 29.21 dB to 62.49 dB.The results of field experiments showed that the yield map drawn can clearly display the yield value of the harvest area,which is used to guide agricultural production.
基金supported by the National Key Research&Development Program of China(2022YFC2303900 and 2022YFC3704700)the National Natural Science Foundation of China(32141001 and 31830001)+1 种基金the National Science Fund for Distinguished Young Scholar(32125003)China Postdoctoral Science Foundation(2022M712797).
文摘Fatty acids (FAs) are building blocks required for the threedomains of life. The machinery of type II fatty acid synthesis is longrecognized as a druggable pathway against deadly infections withdrug-resistant bacterial pathogens [1]. However, an everincreasing body of exogenous FAs (eFA) utilization routes posesthe possibility of replacing bacterial de novo FA synthesis, whichmight compromise the FAS II-directed antimicrobials, like cerulenin[2–4]. As for Gram-negative species, the paradigm executorof an eFA recycling denotes an acyl-ACP synthetase (AasS) of thezoonotic pathogen Vibrio harveyi [5]. In contrast, a unique twocomponent system of fatty acid kinase called FakA/B [6], is exclusively present in Staphylococcus and Enterococcus/Streptococcus,two important lineages of Gram-positive bacterium (Fig. S1a, bonline) [6,7].
文摘Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future.
基金This work was supported by the National Natural Science Foundation of China(32141001 and 31830001 to Y.F.)the National Science Fund for Distinguished Young Scholar(32125003 to Y.F.)the National Key Basic Research Program of China(2023YFC2307100 and 2023YFC2300021 to Y.F.).
文摘Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil and water,is recognized as an opportunistic pathogen causing recalcitrant infections.Carbapenem-resistant P.aeruginosa(CRPA)is listed by the World Health Organization(WHO)as an important member of top priority“ESKAPE”pathogens.This is largely supported by the fact that in 2020,CRPA had caused28,8000 nosocomial infections with about 2500 deaths.Apart from porin mutations,the acquisition of Klebsiella pneumoniae carbapenemase(termed as KPC-2)constitutes an alternative mechanism for carbapenem resistance in P.aeruginosa,which compromises the clinical efficacy of the carbapenem as a“last resort”option.Notably,the transferability of blaKPC-2 determinants facilitates global dissemination of CRPA in the context of“one health”consisting of humans,animals,plants/crops,and environmental settings.In addition to antimicrobial stewardship,coordinated global action is necessary to mitigate AMR progression.
基金supported by the National Natural Science Foundation of China(61804054)the Key Research Plan of the National Natural Science Foundation of China(12034007)+2 种基金the Natural Science Foundation of Shanghai(18ZR1410400)Shanghai Aerospace Science and Technology Innovation Foundation(SISP2018)Shanghai Aerospace Science and Technology Innovation Fund(SAST2019-067)。
文摘具有电化学变色功能的柔性电池在智能电子领域显示出巨大的应用潜力.然而,具有可视化电量预警功能的镍锌电池目前尚未见报道.在此,我们设计了一种用于柔性镍锌电池的电致变色镍钴氢氧化物/镍/氧化铟锡(NiCo BH/Ni/ITO)柔性电极.通过优化Ni层厚度,电极在电流密度为0.1 mA cm^(-2)时,着色效率为59.89 cm^(2)C^(-1),容量为7.15μA h cm^(-2).相应组装的电致变色镍锌电池功率密度为160μW cm^(-2)时,能量密度为12.69μW h cm^(-2),优于部分文献报道的透明柔性超级电容器和电致变色电池.值得注意的是,组装的镍锌电池在充放电过程中显示出可逆的颜色变化,提供了一种可视化监测电池剩余电量的新功能.
基金Acknowledgements We gratefully acknowledge the financial support from the National Natural Science Foundation of China （No. 71173078, 70803013）.
文摘This paper investigates how institutional holding and earnings quality influence the liquidity of assets. Contrary to findings in developed markets, we document several novel results in China＇s stock market： （1） institutional holding negatively affects assets＇ liquidity, （2） earnings quality is negatively related with liquidity. Since earnings quality captures asymmetric information, low earnings quality induces high divergence in investor opinions and thus boosts market trading, and （3） interestingly, the effect of earnings quality on liquidity is greater if institutional investors＇ holding is at a high level. Overall, our findings cast doubt on the conventional wisdom that institutional investors and earnings quality improve market liquidity. The results are robust to different measures and alternative model specifications.
文摘Inflammatory fibroid polyp （IFP） is a group of rare benign mesenchymal tumors throughout the gastrointestinal tract.The most involved sites are stomach and large intestines,followed by small intestines,esophagus,and anal canal.However,even in the stomach,its incidence is only 0.1% of all gastric polyps.[1] We here reported an IFP located in the cecum.
基金financially supported by National Natural Science Foundation of China(51702056)Fundamental Research Funds for the Central Universities(2162140621617330)+2 种基金Science and Technology Program of Guangzhou(202102020737,201605030008)Provincial Natural Science Foundation of Anhui(1908085ME120)Primary Research and Development Program of Anhui Province(201904a05020087)。
文摘Recently,Coordination Polymers(CPs)have been widely utilized as energy storage materials for reversible Lithium-Ion Batteries(LIBs)benefiting from their tunable building blocks and adjusted electrochemical properties.However,the unsatisfied electrochemical behavior of CPs with poor conductivity and sluggish ion transport kinetics is still a bottle-neck for their large-scale energy storage applications in LIBs.Herein,we display the rational fabrication of a conductive Sn-based coordination polymer(Sn-DHTPA)via judiciously choosing suitable building units.The Sn-DHTPA is employed as anode for LIBs,exhibiting superior reversible storage capacity of 1142.6 m A h g^(-1) at 0.1 A g^(-1) after 100 cycles and impressive rate storage capability of 287.7 m A h g^(-1)at 20 A g^(-1).More importantly,a robust cycling performance of 205.5 m A h g^(-1) at an extra-high current density of 20 A g^(-1) are observed without remarkable capacity-fading up to1000 cycles.The behavior superiority of Sn-DHTPA is related to its advanced architecture with abundant lithium storage sites,high electrical conductivity and rapid lithium transport.A series of ex-situ characterizations reveal that the impressive lithium storage capacity is contributed by the redox active sites of both the aromatic linker and metal center related to in-situ generated metallic nanoparticles dispersed in the skeleton.
