BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early preventi...BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early prevention and management,especially in underrepresented areas like Guizhou Province,China,where geographic and ethnic diversity may influence the disease’s prevalence and risk profiles.AIM To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province,providing essential data for early prevention strategies.METHODS A multi-center retrospective study was conducted,dividing participants into GDM and non-GDM groups according to standardized diagnostic criteria.Data were collected from 103629 deliveries across 40 hospitals in Guizhou.Various demographic,clinical,and laboratory parameters were analyzed using logistic regression to identify risk and protective factors for GDM.RESULTS Among the 103629 deliveries,18957 cases of GDM were identified,with an incidence of approximately 18.3%.The risk of GDM was higher in the Han ethnic group compared to minority ethnic groups.The Dong ethnic group had the lowest incidence among the minorities.Key risk factors identified included older age(especially>35 years),higher pre-pregnancy body mass index(BMI),light physical activity,gravidity,family history of diabetes,hemoglobin,aspartate aminotransferase,alanine aminotransferase,and direct bilirubin.Protective factors included higher education level,total protein,and albumin.There were also differences based on blood type,with type A associated with higher risk.CONCLUSION The incidence rate in Guizhou is 18.3%.Older age(especially>35 years),Han ethnicity,lower education level,higher pre-pregnancy BMI,light physical activity,and higher gravidity are the main risk factors for GDM.Laboratory findings indicate that higher hemoglobin,higher liver function parameters(alanine aminotransferase,aspartate aminotransferase,and direct bilirubin),and lower total protein and albumin are associated with a higher risk of GDM.Blood type A has a higher risk of GDM compared to blood types AB and O.展开更多
In two-photon microscopy,low illumination powers on samples and a high signal-to-noise ratio(SNR)of the excitation laser are highly desired for alleviating the problems of photobleaching and phototoxicity,as well as p...In two-photon microscopy,low illumination powers on samples and a high signal-to-noise ratio(SNR)of the excitation laser are highly desired for alleviating the problems of photobleaching and phototoxicity,as well as providing clean backgrounds for images.However,the high-repetition-rate Ti:sapphire laser and the low-SNR Raman-shift lasers fall short of meeting these demands,especially when used for deep penetrations.Here,we demonstrate a 937-nm laser frequency-doubled from an all-fiber mode-locked laser at 1.8μm with a low repetition rate of∼9 MHz and a high SNR of 74 dB.We showcase two-photon excitations with low illumination powers on multiple types of biological tissues,including fluorescence imaging of mouse brain neurons labeled with green and yellow fluorescence proteins(GFP and YFP),DiI-stained and GFP-labeled blood vessels,Alexa Fluor 488/568-stained mouse kidney,and second-harmonic-generation imaging of the mouse skull,leg,and tail.We achieve a penetration depth in mouse brain tissues up to 620μm with an illumination power as low as∼10 mW,and,even for the DiI dye with an extremely low excitation efficiency of 3.3%,the penetration depth is still up to 530μm,indicating that the low-repetition-rate source works efficiently for a wide range of dyes with a fixed excitation wavelength.The low-repetition-rate and high-SNR excitation source holds great potential for biological investigations,such as in vivo deep-tissue imaging.展开更多
基金National Natural Science Foundation of China,No.81960284Science and Technology Support Program of Science and Technology Department of Guizhou Province,No.Qian Ke He Zhi Cheng[2022]Yi Ban 183.
文摘BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early prevention and management,especially in underrepresented areas like Guizhou Province,China,where geographic and ethnic diversity may influence the disease’s prevalence and risk profiles.AIM To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province,providing essential data for early prevention strategies.METHODS A multi-center retrospective study was conducted,dividing participants into GDM and non-GDM groups according to standardized diagnostic criteria.Data were collected from 103629 deliveries across 40 hospitals in Guizhou.Various demographic,clinical,and laboratory parameters were analyzed using logistic regression to identify risk and protective factors for GDM.RESULTS Among the 103629 deliveries,18957 cases of GDM were identified,with an incidence of approximately 18.3%.The risk of GDM was higher in the Han ethnic group compared to minority ethnic groups.The Dong ethnic group had the lowest incidence among the minorities.Key risk factors identified included older age(especially>35 years),higher pre-pregnancy body mass index(BMI),light physical activity,gravidity,family history of diabetes,hemoglobin,aspartate aminotransferase,alanine aminotransferase,and direct bilirubin.Protective factors included higher education level,total protein,and albumin.There were also differences based on blood type,with type A associated with higher risk.CONCLUSION The incidence rate in Guizhou is 18.3%.Older age(especially>35 years),Han ethnicity,lower education level,higher pre-pregnancy BMI,light physical activity,and higher gravidity are the main risk factors for GDM.Laboratory findings indicate that higher hemoglobin,higher liver function parameters(alanine aminotransferase,aspartate aminotransferase,and direct bilirubin),and lower total protein and albumin are associated with a higher risk of GDM.Blood type A has a higher risk of GDM compared to blood types AB and O.
基金Research Grants Council of the Hong Kong Special Administrative Region of China(HKU C7074-21GF,HKU 17205321,HKU 17200219,HKU 17209018,CityU T42-103/16-N)and Health@InnoHK program of the Innovation and Technology Commission of the Hong Kong SAR Government.
文摘In two-photon microscopy,low illumination powers on samples and a high signal-to-noise ratio(SNR)of the excitation laser are highly desired for alleviating the problems of photobleaching and phototoxicity,as well as providing clean backgrounds for images.However,the high-repetition-rate Ti:sapphire laser and the low-SNR Raman-shift lasers fall short of meeting these demands,especially when used for deep penetrations.Here,we demonstrate a 937-nm laser frequency-doubled from an all-fiber mode-locked laser at 1.8μm with a low repetition rate of∼9 MHz and a high SNR of 74 dB.We showcase two-photon excitations with low illumination powers on multiple types of biological tissues,including fluorescence imaging of mouse brain neurons labeled with green and yellow fluorescence proteins(GFP and YFP),DiI-stained and GFP-labeled blood vessels,Alexa Fluor 488/568-stained mouse kidney,and second-harmonic-generation imaging of the mouse skull,leg,and tail.We achieve a penetration depth in mouse brain tissues up to 620μm with an illumination power as low as∼10 mW,and,even for the DiI dye with an extremely low excitation efficiency of 3.3%,the penetration depth is still up to 530μm,indicating that the low-repetition-rate source works efficiently for a wide range of dyes with a fixed excitation wavelength.The low-repetition-rate and high-SNR excitation source holds great potential for biological investigations,such as in vivo deep-tissue imaging.
