目的构建经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤的预防性护理策略。方法于中国知网、维普、万方、Google学术、Cochrane Library、Up To Date等期刊数据库检索其2018至2022年收录关于经外周静脉置入中心静脉导管患者医...目的构建经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤的预防性护理策略。方法于中国知网、维普、万方、Google学术、Cochrane Library、Up To Date等期刊数据库检索其2018至2022年收录关于经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤的主题文献及质量评价,组成院内决策小组评价文献质量并制定2次专家函询问卷,比较调查结果并汇总统计后确定静脉导管置入部位及预防护理策略,将81例患者分为对照组(n=41例)和实验组(n=40例)实施护理干预,比较2组医用粘胶相关性皮肤损伤发生率。结果2轮函询结束后构建31条预防经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤的护理策略,全部条目重要性评分CV为0.01~0.11、可操作性评分CV为0.09~0.38(W=0.56、0.59,2=304.51、318.86,均P<0.001),全部条目可操作性及重要性评分均存在一致性;实施干预后,试验组观察组仅有1例发生医用粘胶相关性皮肤损伤,发生率2.50%(1/40),低于对照组14.63%(6/41)(χ^(2)=2.613,P=0.045)。结论经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤预防性护理策略的构建可行性较高,降低其发生率并满足临床要求,促进护理操作标准化、规范化发展。展开更多
Mole fractions of atmospheric CO2(XCO2)have been continuously measured from October 2014 to March 2016 at the Guangzhou Panyu Atmospheric Composition Site(23.00°N,113.21°E;140 m MSL)in the Pearl River Delta(...Mole fractions of atmospheric CO2(XCO2)have been continuously measured from October 2014 to March 2016 at the Guangzhou Panyu Atmospheric Composition Site(23.00°N,113.21°E;140 m MSL)in the Pearl River Delta(PRD)region using a cavity ring-down spectrometer.Approximately 66.63%,19.28%,and 14.09%of the observed values were filtered as background,pollutant source,and sink due to biospheric uptake,respectively,by applying a robust local regression procedure.Their corresponding mean values were 424.12±10.12 ppm(×10-6 mol mol-1),447.83±13.63 ppm,and 408.83±7.75 ppm.The background XCO2 levels were highest in spring and winter,moderate in autumn,and lowest in summer.The diurnal XCO2 was at a minimum from 1400-1600 LST(Local Standard Time)and a maximum at 0500 LST the next day.The increase of XCO2 in spring and summer was mainly associated with polluted air masses from south coastal Vietnam,the South China Sea,and the southeast Pearl River Estuary.With the exception of summer,airflow primarily from marine regions southeast of Taiwan that passed over the Pearl River Estuary had a greater impact on XCO2,suggesting an important potential source region.展开更多
Obtaining the wind load distribution on the telescope aperture is very important to estimate its influence and reduce the wind disturbance on the telescope system.The aperture of the radio telescope structure can be a...Obtaining the wind load distribution on the telescope aperture is very important to estimate its influence and reduce the wind disturbance on the telescope system.The aperture of the radio telescope structure can be as large as 100 m and therefore,the uniform wind load on the aperture assumption is not suitable for the radio telescope with large aperture.In this paper,a gradient segments superposition method for calculating the wind load has been proposed.The proposed method has been constructed by combining two regional divisions.First,reflecting surface has been evenly divided in the altitudinal direction.Second,the reflecting surface has been divided into several uniform rings assuming that the wind load coefficient on different rings are different.For the 110 m aperture radio telescope,the wind load estimation results differ by 28%.After that,a structural dynamics model of telescope has been established and a fuzzy PID controller has been designed to reduce wind disturbance.The Root Mean Square Error of telescope pointing under wind disturbance has been reduced by 67.8%.It is suggested that the proposed wind load estimation method has lay a solid foundation for the design of the large telescope system under wind disturbance.展开更多
A large,fully steerable radio telescope is susceptible to the wind load,leading to structure deformation andpointing deviation of the telescope.To effectively suppress the influence of dynamic wind load,the wind resis...A large,fully steerable radio telescope is susceptible to the wind load,leading to structure deformation andpointing deviation of the telescope.To effectively suppress the influence of dynamic wind load,the wind resistancecontrol of the telescope is carried out based on wind speed forecasting.This study developed a wind speedforecasting model to efficiently forecast the wind speed at the telescope position.The proposed model successfullyeliminates the random noise of the original wind speed,effectively extracts the wind speed features and solves theautomatic optimization of the hyperparameters of the forecasting network.This model significantly improves theaccuracy and reliability of wind speed forecasting.To verify the forecasting performance of the proposed model,the wind data from the Qitai Radio Telescope site is examined as a case study.The wind speed forecasting model’sMAE,RMSE and MAPE are 0.0361,0.0703 and 3.87%,respectively.The performance of the proposed modelmeets the requirements of wind resistance control and can provide data support for the radio telescope.展开更多
Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy.Group B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which prim...Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy.Group B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which primarily affects children and young adults.Due to the lack of vaccines,the development of antiviral medicines is crucial to controlling CVB infection and the progression of myocarditis.In this study,we investigated the antiviral effect of baicalein,a flavonoid extracted from Scutellaria baicaleinsis.Our results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected cells.In addition,significant reductions in viral protein 3D,viral RNA,and viral particles were observed in CVB3-infected cells treated with baicalein.We found that baicalein exerted its inhibitory effect in the early stages of CVB3 infection.Baicalein also suppressed viral replication in the myocardium and effectively alleviated myocarditis induced by CVB3 infection.Our study revealed that baicalein exerts its antiviral effect by inhibiting the activity of caspase-1 and viral protease 2A.Taken together,our findings demonstrate that baicalein has antiviral activity against CVB3 infection and may serve as a potential therapeutic option for the myocarditis caused by enterovirus infection.展开更多
Below-cloud aerosol scavenging process by precipitation is important for cleaning the polluted aerosols in the atmosphere, and is also a main process for acid rain formation. However, the related physical mechanism ha...Below-cloud aerosol scavenging process by precipitation is important for cleaning the polluted aerosols in the atmosphere, and is also a main process for acid rain formation. However, the related physical mechanism has not been well documented and clarified yet. In this paper, we investigated the below-cloud PM_(2.5)(particulate matter with aerodynamic diameter being 2.5 μm or less) scavenging by different-intensity rains under polluted conditions characterized by high PM_(2.5) concentrations, based on in-situ measurements from March 2014 to July 2016 in Beijing city. It was found that relatively more intense rainfall events were more efficient in removing the polluted aerosols in the atmosphere. The mean PM_(2.5) scavenging ratio and its standard deviation(SD) were 5.1% ± 25.7%, 38.5% ± 29.0%,and 50.6% ± 21.2% for light, moderate, and heavy rain events, respectively. We further found that the key impact factors on below-cloud PM_(2.5) scavenging ratio for light rain events were rain duration and wind speed rather than raindrop size distribution. However, the impacts of rain duration and wind speed on scavenging ratio were not important for moderate and heavy rain events. To our knowledge, this is the first statistical result about the effects of rain intensity, rain duration, and raindrop size distribution on below-cloud scavenging in China.展开更多
In this paper, we investigate the use of ultra weak variational formulation to solve a wave scattering problem in near field optics. In order to capture the sub-scale features of waves, we utilize evanescent wave func...In this paper, we investigate the use of ultra weak variational formulation to solve a wave scattering problem in near field optics. In order to capture the sub-scale features of waves, we utilize evanescent wave functions together with plane wave functions to approximate the local properties of the field. We analyze the global convergence and give an error estimation of the method. Numerical examples are also presented to demonstrate the effectiveness of the strategy.展开更多
文摘目的构建经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤的预防性护理策略。方法于中国知网、维普、万方、Google学术、Cochrane Library、Up To Date等期刊数据库检索其2018至2022年收录关于经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤的主题文献及质量评价,组成院内决策小组评价文献质量并制定2次专家函询问卷,比较调查结果并汇总统计后确定静脉导管置入部位及预防护理策略,将81例患者分为对照组(n=41例)和实验组(n=40例)实施护理干预,比较2组医用粘胶相关性皮肤损伤发生率。结果2轮函询结束后构建31条预防经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤的护理策略,全部条目重要性评分CV为0.01~0.11、可操作性评分CV为0.09~0.38(W=0.56、0.59,2=304.51、318.86,均P<0.001),全部条目可操作性及重要性评分均存在一致性;实施干预后,试验组观察组仅有1例发生医用粘胶相关性皮肤损伤,发生率2.50%(1/40),低于对照组14.63%(6/41)(χ^(2)=2.613,P=0.045)。结论经外周静脉置入中心静脉导管患者医用粘胶相关性皮肤损伤预防性护理策略的构建可行性较高,降低其发生率并满足临床要求,促进护理操作标准化、规范化发展。
基金funded by the National Key R&D Program of China(Grant No.2018YFC0213902,2019YFC0214605,2016YFC0202000)the open project of the Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration,Nanjing University of Information Science and Technology(KDW 1803)+1 种基金the Scientific and Technological Innovation Team Project of Guangzhou Joint Research Center of Atmospheric Sciences,China Meteorological Administration(Grant No.201704)the Science and Technology Research Project of Guangdong Meteorological Bureau(Grant No.GRMC2018M01)。
文摘Mole fractions of atmospheric CO2(XCO2)have been continuously measured from October 2014 to March 2016 at the Guangzhou Panyu Atmospheric Composition Site(23.00°N,113.21°E;140 m MSL)in the Pearl River Delta(PRD)region using a cavity ring-down spectrometer.Approximately 66.63%,19.28%,and 14.09%of the observed values were filtered as background,pollutant source,and sink due to biospheric uptake,respectively,by applying a robust local regression procedure.Their corresponding mean values were 424.12±10.12 ppm(×10-6 mol mol-1),447.83±13.63 ppm,and 408.83±7.75 ppm.The background XCO2 levels were highest in spring and winter,moderate in autumn,and lowest in summer.The diurnal XCO2 was at a minimum from 1400-1600 LST(Local Standard Time)and a maximum at 0500 LST the next day.The increase of XCO2 in spring and summer was mainly associated with polluted air masses from south coastal Vietnam,the South China Sea,and the southeast Pearl River Estuary.With the exception of summer,airflow primarily from marine regions southeast of Taiwan that passed over the Pearl River Estuary had a greater impact on XCO2,suggesting an important potential source region.
基金the National Key Research and Development Program of China under No.2021YFC2203600the National Natural Science Foundation of China under Nos.52005377 and 52275268+2 种基金the National Defense Basic Scientific Research Program of China under No.JCKY2021210B007Wuhu and Xidian University Special Fund for Industry-University-Research Cooperation under No.XWYCXY-012021012Youth Innovation Team of Shaanxi Universities under No.201926.
文摘Obtaining the wind load distribution on the telescope aperture is very important to estimate its influence and reduce the wind disturbance on the telescope system.The aperture of the radio telescope structure can be as large as 100 m and therefore,the uniform wind load on the aperture assumption is not suitable for the radio telescope with large aperture.In this paper,a gradient segments superposition method for calculating the wind load has been proposed.The proposed method has been constructed by combining two regional divisions.First,reflecting surface has been evenly divided in the altitudinal direction.Second,the reflecting surface has been divided into several uniform rings assuming that the wind load coefficient on different rings are different.For the 110 m aperture radio telescope,the wind load estimation results differ by 28%.After that,a structural dynamics model of telescope has been established and a fuzzy PID controller has been designed to reduce wind disturbance.The Root Mean Square Error of telescope pointing under wind disturbance has been reduced by 67.8%.It is suggested that the proposed wind load estimation method has lay a solid foundation for the design of the large telescope system under wind disturbance.
基金the National Key Research and Development Program of China(grant No.2021YFC2203600)National Natural Science Foundation of China(NSFC,grant No.52275268)+3 种基金National Defense Basic Scientific Research Program of China(grant No.JCKY2021210B007)Wuhu and Xidian University Special Fund for Industry-University-Research Cooperation(grant No.XWYCXY-012021012)Youth Innovation Team of Shaanxi Universities(grant No.201926)Fundamental Research Funds for the Central Universities(grant No.XJSJ23122).
文摘A large,fully steerable radio telescope is susceptible to the wind load,leading to structure deformation andpointing deviation of the telescope.To effectively suppress the influence of dynamic wind load,the wind resistancecontrol of the telescope is carried out based on wind speed forecasting.This study developed a wind speedforecasting model to efficiently forecast the wind speed at the telescope position.The proposed model successfullyeliminates the random noise of the original wind speed,effectively extracts the wind speed features and solves theautomatic optimization of the hyperparameters of the forecasting network.This model significantly improves theaccuracy and reliability of wind speed forecasting.To verify the forecasting performance of the proposed model,the wind data from the Qitai Radio Telescope site is examined as a case study.The wind speed forecasting model’sMAE,RMSE and MAPE are 0.0361,0.0703 and 3.87%,respectively.The performance of the proposed modelmeets the requirements of wind resistance control and can provide data support for the radio telescope.
基金supported by the National Natural Science Foundation of China(82172247 and 81971920 to WZ,82072278 to ZZ,and 82202493 to LL,82302502 to Yao Wang)Natural Science Foundation of Heilongjiang Province of China(YQ2023H003)+1 种基金China Postdoctoral Science Foundation(2021M693818)Heilongjiang Postdoctoral Fund,Heilongjiang Province of China(LBH-Z21023).
文摘Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy.Group B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which primarily affects children and young adults.Due to the lack of vaccines,the development of antiviral medicines is crucial to controlling CVB infection and the progression of myocarditis.In this study,we investigated the antiviral effect of baicalein,a flavonoid extracted from Scutellaria baicaleinsis.Our results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected cells.In addition,significant reductions in viral protein 3D,viral RNA,and viral particles were observed in CVB3-infected cells treated with baicalein.We found that baicalein exerted its inhibitory effect in the early stages of CVB3 infection.Baicalein also suppressed viral replication in the myocardium and effectively alleviated myocarditis induced by CVB3 infection.Our study revealed that baicalein exerts its antiviral effect by inhibiting the activity of caspase-1 and viral protease 2A.Taken together,our findings demonstrate that baicalein has antiviral activity against CVB3 infection and may serve as a potential therapeutic option for the myocarditis caused by enterovirus infection.
基金Supported by the China Meteorological Administration Special Public Welfare Research Fund(GYHY200806001 and GYHY201406001)National Natural Science Foundation of China(41605111)Research Funds of the Chinese Academy of Meteorological Sciences(2016Z004)
文摘Below-cloud aerosol scavenging process by precipitation is important for cleaning the polluted aerosols in the atmosphere, and is also a main process for acid rain formation. However, the related physical mechanism has not been well documented and clarified yet. In this paper, we investigated the below-cloud PM_(2.5)(particulate matter with aerodynamic diameter being 2.5 μm or less) scavenging by different-intensity rains under polluted conditions characterized by high PM_(2.5) concentrations, based on in-situ measurements from March 2014 to July 2016 in Beijing city. It was found that relatively more intense rainfall events were more efficient in removing the polluted aerosols in the atmosphere. The mean PM_(2.5) scavenging ratio and its standard deviation(SD) were 5.1% ± 25.7%, 38.5% ± 29.0%,and 50.6% ± 21.2% for light, moderate, and heavy rain events, respectively. We further found that the key impact factors on below-cloud PM_(2.5) scavenging ratio for light rain events were rain duration and wind speed rather than raindrop size distribution. However, the impacts of rain duration and wind speed on scavenging ratio were not important for moderate and heavy rain events. To our knowledge, this is the first statistical result about the effects of rain intensity, rain duration, and raindrop size distribution on below-cloud scavenging in China.
基金The authors would like to thank the reviewers and Dr.Zheng Enxi for many valuable suggcstions. This work is supported by the National Natural Science Foundation of China （Grant No. 11371172, 51178001）, Science and technology research project of the education department of Jilin Province （Grant No. 2014213）.
文摘In this paper, we investigate the use of ultra weak variational formulation to solve a wave scattering problem in near field optics. In order to capture the sub-scale features of waves, we utilize evanescent wave functions together with plane wave functions to approximate the local properties of the field. We analyze the global convergence and give an error estimation of the method. Numerical examples are also presented to demonstrate the effectiveness of the strategy.
