Constructing an artificial intelligence interactive system is still challenging due to the lack of an integrated artificial sensing and processing system with high performance.In this work,an artificial tactile percep...Constructing an artificial intelligence interactive system is still challenging due to the lack of an integrated artificial sensing and processing system with high performance.In this work,an artificial tactile perception system with integrated sensing,storage,and computing functions is designed based on silk fibroin composite memristors and piezoresistive pressure sensors.The sensors based on polydimethylsiloxane/silver nanowires can sense the external pressure stimulation with fast response speed.In addition,the composite memristor based on silk fibroin possesses good cyclic stability and synaptic plasticity simulation and acts as an artificial synapse to process tactile information.As a result,the integrated tactile perception system realizes the perception,storage,and processing of pressure information,demonstrating the possibility to simulate the biological tactile perception nervous system.This type of system may promote potential applications in artificial intelligence,such as autonomous driving,wearable,flexible electronic devices,and bionic robots.展开更多
The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment...The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment.Herein,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.展开更多
基金supported by Shanghai Rising-Star Program(22QA1400400)the Basic Research Project of the Science and Technology Commission of Shanghai Municipality(21JC1400100)+1 种基金the National Natural Science Foundation of China(52173031)the Oriental Talent Plan(Leading Talent Program,152)。
文摘Constructing an artificial intelligence interactive system is still challenging due to the lack of an integrated artificial sensing and processing system with high performance.In this work,an artificial tactile perception system with integrated sensing,storage,and computing functions is designed based on silk fibroin composite memristors and piezoresistive pressure sensors.The sensors based on polydimethylsiloxane/silver nanowires can sense the external pressure stimulation with fast response speed.In addition,the composite memristor based on silk fibroin possesses good cyclic stability and synaptic plasticity simulation and acts as an artificial synapse to process tactile information.As a result,the integrated tactile perception system realizes the perception,storage,and processing of pressure information,demonstrating the possibility to simulate the biological tactile perception nervous system.This type of system may promote potential applications in artificial intelligence,such as autonomous driving,wearable,flexible electronic devices,and bionic robots.
基金the National Natural Science Foundation of China(82072060 and 22008201)the Fundamental Research Funds for the Central Universities(SWU-XDPY22006)+2 种基金the Venture&Innovation Support Program for Chongqing Overseas Returnees(2205012980212766)the Natural Science Foundation Project of Chongqing(cstc2020jcyj-msxmX0292)the Natural Science Foundation Project of Chongqing for Distinguished Young Scholar.
文摘The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment.Herein,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.
