Hodgkin's lymphoma(HL)is a common,malignant hematological tumor of the lymph nodes and lymphatic system,accounting for 10%of all lymphomas.HL comprises 2 main subtypes:classical HL(cHL)and nodular lymphocyte predo...Hodgkin's lymphoma(HL)is a common,malignant hematological tumor of the lymph nodes and lymphatic system,accounting for 10%of all lymphomas.HL comprises 2 main subtypes:classical HL(cHL)and nodular lymphocyte predominant HL.展开更多
The key application technology for sex pheromone of Grapholitha molesta was studied from the aspects of different hanging heights and orientations, dif- ferent doses and types of traps through the tests on trapping qu...The key application technology for sex pheromone of Grapholitha molesta was studied from the aspects of different hanging heights and orientations, dif- ferent doses and types of traps through the tests on trapping quantity of G. molesta in fields. The results showed that the trapping effect was enhanced when the hanging height was increased, and the trapping effect was the best in west direction. The trapping effect was enhanced when the dosage was increased. When it was up to 6 lures, the trapping effect was the best with 38.75 head/trap; the next was 2 lures with 31.00 head/trap. All types of traps had trapping ability to G. mo- lesta, among which triangle trapper was the best, followed by self-made bottle trap. Their trapping effects were 138.75 and 100.25 head/trap, respectively.展开更多
In recent years, Apolygus htcorum has become the main pest of winter jujube. It sucks juice of young parts of winter jujube and causes falling of buds and flowers, leaf perforations, deformities and fall- off of fruit...In recent years, Apolygus htcorum has become the main pest of winter jujube. It sucks juice of young parts of winter jujube and causes falling of buds and flowers, leaf perforations, deformities and fall- off of fruits, leading to serious economic loss. Considering the occurrence characteristics and control problems, the distribution, occurrence regularity, damage characteristics and outbreak reasons of A. lucorum are overviewed and analyzed in this paper, and the pollution-free control measures are also put forward.展开更多
Athetis lepigone Moschler is a new kind of insect pest occurring in summer corn production areas. By investigation, it was found especially serious in straw returning fields. In this paper, its damage status was inves...Athetis lepigone Moschler is a new kind of insect pest occurring in summer corn production areas. By investigation, it was found especially serious in straw returning fields. In this paper, its damage status was investigated in straw returning and chemical controlled fields, respectively. The results showed that the rate of damaged plants was 82% and the maximum pest number per 100 plants was 88 heads in the straw returning fields without chemical control. The application of herbicides and pesticides had no significant effects on occurrence quantity and damage rate, but the pest number per 100 plants decreased a little compared to the fields without chemical control. In the surer er maize fields without straw returning, the application of herbicides and pesticides could significantly decrease the damage of Athetis lepigone, the rate of damaged plants was 20%, and the pest number per 100 plants was 6.展开更多
Plant cell walls are a critical site where plants and pathogens continuously struggle for physiological domi-nance.Here we show that dynamic remodeling of pectin methylesterification of plant cell walls is a compo-nen...Plant cell walls are a critical site where plants and pathogens continuously struggle for physiological domi-nance.Here we show that dynamic remodeling of pectin methylesterification of plant cell walls is a compo-nent of the physiological and co-evolutionary struggles between hosts and pathogens.A pectin methyles-terase(PsPME1)secreted by Phytophthora sojae decreases the degree of pectin methylesterification,thus synergizing with an endo-polygalacturonase(PsPG1)to weaken plant cell walls.To counter PsPME1-mediated susceptibility,a plant-derived pectin methylesterase inhibitor protein,GmPMl1,protects pectin to maintain a high methylesterification status.GmPMl1 protects plant cell walls from enzymatic degrada-tion by inhibiting both soybean and P.sojae pectin methylesterases during infection.However,constitutive expression of GmPMl1 disrupted the trade-off between host growth and defense responses.We therefore used AlphaFold structure tools to design a modified form of GmPMI1(GmPMI1R)that specifically targets and inhibits pectin methylesterases secreted from pathogens but notfrom plants.Transient expression of GmPMi1R enhanced plant resistance to oomycete and fungal pathogens.In summary,our work highlights the biochemical modification of the cell wall as an important focal point in the physiological and co-evolutionary conflict between hosts and microbes,providing an important proof of concept that Al-driven structure-based tools can accelerate the development of new strategies for plant protection.展开更多
Soybean rust(SBR),caused by an obligate biotrophic pathogen Phakopsora pachyrhizi,is a devastating disease of soybean worldwide.However,the mechanisms underlying plant invasion by P.pachyrhizi are poorly understood,wh...Soybean rust(SBR),caused by an obligate biotrophic pathogen Phakopsora pachyrhizi,is a devastating disease of soybean worldwide.However,the mechanisms underlying plant invasion by P.pachyrhizi are poorly understood,which hinders the development of effective control strategies for SBR.Here we performed detailed histological characterization on the infection cycle of P.pachyrhizi in soybean and conducted a high-resolution transcriptional dissection of P.pachyrhizi during infection.This revealed P.pachyrhizi infection leads to significant changes in gene expression with 10 co-expressed gene modules,representing dramatic transcriptional shifts in metabolism and signal transduction during different stages throughout the infection cycle.Numerous genes encoding secreted protein are biphasic expressed,and are capable of inhibiting programmed cell death triggered by microbial effectors.Notably,three co-expressed P.pachyrhizi apoplastic effectors(PpAE1,PpAE2,and PpAE3) were found to suppress plant immune responses and were essential for P.pachyrhizi infection.Double-stranded RNA coupled with nanomaterials significantly inhibited SBR infection by targeting PpAE1,PpAE2,and PpAE3,and provided long-lasting protection to soybean against P.pachyrhizi.Together,this study revealed prominent changes in gene expression associated with SBR and identified P.pachyrhizi virulence effectors as promising targets of RNA interference-based soybean protection strategy against SBR.展开更多
A distributed secondary control(DSC) strategy that combines Q-learning and pinning control is originally proposed to achieve a fully optimal DSC for droop-controlled microgrids(MGs). It takes advantages of cross-fusio...A distributed secondary control(DSC) strategy that combines Q-learning and pinning control is originally proposed to achieve a fully optimal DSC for droop-controlled microgrids(MGs). It takes advantages of cross-fusion of the two algorithms to realize the high efficiency and self-adaptive control in MGs. It has the following advantages. Firstly, it adopts the advantages of reinforcement learning in autonomous learning control and intelligent decision-making, driving the action value of pinning control for feedback adaptive correction. Secondly, only a small part of points selected as pinned points needs to be controlled and pre-learned, hence the actual control problem is transformed into a synchronous tracking problem and the installation number of controllers is further reduced.Thirdly, the pinning matrix can be modified to adapt to plugand-play operation under the distributed control architecture.Finally, the effectiveness and versatility of the proposed strategy are demonstrated with a typical droop-controlled MG model.展开更多
Soybean(Glycine max) is an economically important oilbearing crop that is widely planted worldwide(Babu et al.,2017). Many diseases seriously limit soybean yield. Soybean root rot disease, one of the most destructive ...Soybean(Glycine max) is an economically important oilbearing crop that is widely planted worldwide(Babu et al.,2017). Many diseases seriously limit soybean yield. Soybean root rot disease, one of the most destructive soybean diseases, occurs throughout the growth period, resulting in considerable yield losses(Kamoun et al., 2015).展开更多
Monitoring of wind turbines under variablespeed operating conditions has become an important issue in recent years. The gearbox of a wind turbine is the most important transmission unit; it generally exhibits complex ...Monitoring of wind turbines under variablespeed operating conditions has become an important issue in recent years. The gearbox of a wind turbine is the most important transmission unit; it generally exhibits complex vibration signatures due to random variations in operating conditions. Spectral analysis is one of the main approaches in vibration signal processing. However, spectral analysis is based on a stationary assumption and thus inapplicable to the fault diagnosis of wind turbines under variable-speed operating conditions. This constraint limits the application of spectral analysis to wind turbine diagnosis in industrial applications. Although order-tracking methods have been proposed for wind turbine fault detection in recent years, current methods are only applicable to cases in which the instantaneous shaft phase is available. For wind turbines with limited structural spaces, collecting phase signals with tachometers or encoders is difficult. In this study, a tacholess order-tracking method for wind turbines is proposed to overcome the limitations of traditional techniques. The proposed method extracts the instantaneous phase from the vibration signal, resamples the signal at equiangular increments, and calculates the order spectrum for wind turbine fault identification. The effectiveness of the proposed method is experimentally validated with the vibration signals of wind turbines.展开更多
Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China ...Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China could lift non-pharmacological interventions(NPIs)against COVID-19 in 2022.Methods:Using a modified susceptible-infectiousrecovered(SIR)mathematical model,we projected the COVID-19 epidemic situation and required medical resources in Guangdong Province,China.Results:If the number of people entering from overseas recovers to 20%of the number in 2019,the epidemic in 2022 could be controlled at a low level by a containment(215 local cases)or suppression strategy(1,397 local cases).A mitigation strategy would lead to 21,722 local cases.A coexistence strategy would lead to a large epidemic with 6,850,083 local cases that would overwhelm Guangdong’s medical system.With 50%or 100%recovery of the 2019 level of travelers from overseas,the epidemic could also be controlled with containment or suppression,but enormous resources,including more hotel rooms for border quarantine,will be required.However,coexistence would lead to an uncontrollable epidemic with 12,922,032 local cases.Discussion:With booster vaccinations,the number of travelers from overseas could increase slightly in 2022,but a suppression strategy would need to be maintained to ensure a controllable epidemic.展开更多
Phytophthora pathogens secrete numerous apoplastic effectors to manipulate host immunity.Herein,we identified a polysaccharide lyase 1 protein,PsPL1,which acts as an essential virulence factor of P.sojae infection in ...Phytophthora pathogens secrete numerous apoplastic effectors to manipulate host immunity.Herein,we identified a polysaccharide lyase 1 protein,PsPL1,which acts as an essential virulence factor of P.sojae infection in soybean.However,the overexpression of PsPL1 in P.sojae reduced infection and triggered enhanced immune responses in soybean.PsPL1 exhibited pectin lyase activity and degraded plant pectin to generate pectin oligosaccharides(POSs)with a polymerization degree of 3–14,exhibiting different levels of acetylation and methylation modifications.PsPL1 and the degraded pectin products triggered immune responses in soybean and different Solanaceous plants.The PsPL1-triggered immune responses required RSPL1,a membrane-localized leucine-rich repeat receptor-like protein,which is essential for Phytophthora resistance.Conversely,the PsPL1-degraded product-triggered immune responses depended on the membrane-localized lysin motif receptor-like kinase CERK1.This study reveals that the pectin lyase exhibits a dual immunogenic role during P.sojae infection,which activates plant resistance through different immune receptors and provides novel insights into the function of pectin lyase in host-pathogen interactions.展开更多
文摘Hodgkin's lymphoma(HL)is a common,malignant hematological tumor of the lymph nodes and lymphatic system,accounting for 10%of all lymphomas.HL comprises 2 main subtypes:classical HL(cHL)and nodular lymphocyte predominant HL.
基金Supported by Special Fund for Agro-scientific Research in the Public Interest( 201103024)
文摘The key application technology for sex pheromone of Grapholitha molesta was studied from the aspects of different hanging heights and orientations, dif- ferent doses and types of traps through the tests on trapping quantity of G. molesta in fields. The results showed that the trapping effect was enhanced when the hanging height was increased, and the trapping effect was the best in west direction. The trapping effect was enhanced when the dosage was increased. When it was up to 6 lures, the trapping effect was the best with 38.75 head/trap; the next was 2 lures with 31.00 head/trap. All types of traps had trapping ability to G. mo- lesta, among which triangle trapper was the best, followed by self-made bottle trap. Their trapping effects were 138.75 and 100.25 head/trap, respectively.
基金Supported by Special Fund for Agro-scientific Research in the Public Interest ( 201103012)
文摘In recent years, Apolygus htcorum has become the main pest of winter jujube. It sucks juice of young parts of winter jujube and causes falling of buds and flowers, leaf perforations, deformities and fall- off of fruits, leading to serious economic loss. Considering the occurrence characteristics and control problems, the distribution, occurrence regularity, damage characteristics and outbreak reasons of A. lucorum are overviewed and analyzed in this paper, and the pollution-free control measures are also put forward.
基金Supported by China Agricultural Research System ( CARS-02)
文摘Athetis lepigone Moschler is a new kind of insect pest occurring in summer corn production areas. By investigation, it was found especially serious in straw returning fields. In this paper, its damage status was investigated in straw returning and chemical controlled fields, respectively. The results showed that the rate of damaged plants was 82% and the maximum pest number per 100 plants was 88 heads in the straw returning fields without chemical control. The application of herbicides and pesticides had no significant effects on occurrence quantity and damage rate, but the pest number per 100 plants decreased a little compared to the fields without chemical control. In the surer er maize fields without straw returning, the application of herbicides and pesticides could significantly decrease the damage of Athetis lepigone, the rate of damaged plants was 20%, and the pest number per 100 plants was 6.
基金supported bythe National Key Research and Development Program of China(2022YFF1001500)the National Natural Science Foundation of China(32102172)and(31721004)+1 种基金the China National Postdoctoral Program for Innovative Talents(BX2021130)the China Postdoctoral Science Foundation(2021M700074).
文摘Plant cell walls are a critical site where plants and pathogens continuously struggle for physiological domi-nance.Here we show that dynamic remodeling of pectin methylesterification of plant cell walls is a compo-nent of the physiological and co-evolutionary struggles between hosts and pathogens.A pectin methyles-terase(PsPME1)secreted by Phytophthora sojae decreases the degree of pectin methylesterification,thus synergizing with an endo-polygalacturonase(PsPG1)to weaken plant cell walls.To counter PsPME1-mediated susceptibility,a plant-derived pectin methylesterase inhibitor protein,GmPMl1,protects pectin to maintain a high methylesterification status.GmPMl1 protects plant cell walls from enzymatic degrada-tion by inhibiting both soybean and P.sojae pectin methylesterases during infection.However,constitutive expression of GmPMl1 disrupted the trade-off between host growth and defense responses.We therefore used AlphaFold structure tools to design a modified form of GmPMI1(GmPMI1R)that specifically targets and inhibits pectin methylesterases secreted from pathogens but notfrom plants.Transient expression of GmPMi1R enhanced plant resistance to oomycete and fungal pathogens.In summary,our work highlights the biochemical modification of the cell wall as an important focal point in the physiological and co-evolutionary conflict between hosts and microbes,providing an important proof of concept that Al-driven structure-based tools can accelerate the development of new strategies for plant protection.
基金supported by grants from the National Key Research and Development Program of China(2022YFF1001500)the Fundamental Research Funds for the Central Universities(CGPY2024001)the Zhongshan Biological Breeding Laboratory(ZSBBL-KY2023-03)。
文摘Soybean rust(SBR),caused by an obligate biotrophic pathogen Phakopsora pachyrhizi,is a devastating disease of soybean worldwide.However,the mechanisms underlying plant invasion by P.pachyrhizi are poorly understood,which hinders the development of effective control strategies for SBR.Here we performed detailed histological characterization on the infection cycle of P.pachyrhizi in soybean and conducted a high-resolution transcriptional dissection of P.pachyrhizi during infection.This revealed P.pachyrhizi infection leads to significant changes in gene expression with 10 co-expressed gene modules,representing dramatic transcriptional shifts in metabolism and signal transduction during different stages throughout the infection cycle.Numerous genes encoding secreted protein are biphasic expressed,and are capable of inhibiting programmed cell death triggered by microbial effectors.Notably,three co-expressed P.pachyrhizi apoplastic effectors(PpAE1,PpAE2,and PpAE3) were found to suppress plant immune responses and were essential for P.pachyrhizi infection.Double-stranded RNA coupled with nanomaterials significantly inhibited SBR infection by targeting PpAE1,PpAE2,and PpAE3,and provided long-lasting protection to soybean against P.pachyrhizi.Together,this study revealed prominent changes in gene expression associated with SBR and identified P.pachyrhizi virulence effectors as promising targets of RNA interference-based soybean protection strategy against SBR.
基金supported by the National Natural Science Foundation of China (No. 52077103)。
文摘A distributed secondary control(DSC) strategy that combines Q-learning and pinning control is originally proposed to achieve a fully optimal DSC for droop-controlled microgrids(MGs). It takes advantages of cross-fusion of the two algorithms to realize the high efficiency and self-adaptive control in MGs. It has the following advantages. Firstly, it adopts the advantages of reinforcement learning in autonomous learning control and intelligent decision-making, driving the action value of pinning control for feedback adaptive correction. Secondly, only a small part of points selected as pinned points needs to be controlled and pre-learned, hence the actual control problem is transformed into a synchronous tracking problem and the installation number of controllers is further reduced.Thirdly, the pinning matrix can be modified to adapt to plugand-play operation under the distributed control architecture.Finally, the effectiveness and versatility of the proposed strategy are demonstrated with a typical droop-controlled MG model.
基金supported by grants from the National Science Foundation of China (NSFC32172499, 31901957)+2 种基金China National Funds for Innovative Research Groups (31721004)the Chinese Modern Agricultural Industry Technology System (CARS004-PS14)Fundamental Research Funds for the Central Universities (JCQY201903)。
文摘Soybean(Glycine max) is an economically important oilbearing crop that is widely planted worldwide(Babu et al.,2017). Many diseases seriously limit soybean yield. Soybean root rot disease, one of the most destructive soybean diseases, occurs throughout the growth period, resulting in considerable yield losses(Kamoun et al., 2015).
文摘Monitoring of wind turbines under variablespeed operating conditions has become an important issue in recent years. The gearbox of a wind turbine is the most important transmission unit; it generally exhibits complex vibration signatures due to random variations in operating conditions. Spectral analysis is one of the main approaches in vibration signal processing. However, spectral analysis is based on a stationary assumption and thus inapplicable to the fault diagnosis of wind turbines under variable-speed operating conditions. This constraint limits the application of spectral analysis to wind turbine diagnosis in industrial applications. Although order-tracking methods have been proposed for wind turbine fault detection in recent years, current methods are only applicable to cases in which the instantaneous shaft phase is available. For wind turbines with limited structural spaces, collecting phase signals with tachometers or encoders is difficult. In this study, a tacholess order-tracking method for wind turbines is proposed to overcome the limitations of traditional techniques. The proposed method extracts the instantaneous phase from the vibration signal, resamples the signal at equiangular increments, and calculates the order spectrum for wind turbine fault identification. The effectiveness of the proposed method is experimentally validated with the vibration signals of wind turbines.
基金Supported by National Key Research and Development Program of China(2021YFC2301604)Chinese Postdoctoral Science Foundation(2020T130020ZX)+1 种基金the Science and Technology Program of Guangzhou(202102021285)Innovation and Development Project of China Meteorological Administration(CXFZ2021J045).
文摘Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China could lift non-pharmacological interventions(NPIs)against COVID-19 in 2022.Methods:Using a modified susceptible-infectiousrecovered(SIR)mathematical model,we projected the COVID-19 epidemic situation and required medical resources in Guangdong Province,China.Results:If the number of people entering from overseas recovers to 20%of the number in 2019,the epidemic in 2022 could be controlled at a low level by a containment(215 local cases)or suppression strategy(1,397 local cases).A mitigation strategy would lead to 21,722 local cases.A coexistence strategy would lead to a large epidemic with 6,850,083 local cases that would overwhelm Guangdong’s medical system.With 50%or 100%recovery of the 2019 level of travelers from overseas,the epidemic could also be controlled with containment or suppression,but enormous resources,including more hotel rooms for border quarantine,will be required.However,coexistence would lead to an uncontrollable epidemic with 12,922,032 local cases.Discussion:With booster vaccinations,the number of travelers from overseas could increase slightly in 2022,but a suppression strategy would need to be maintained to ensure a controllable epidemic.
基金supported by the Natural Science Foundation of Jiangsu Province (BK20210386)the Fundamental Research Funds for the Central Universities (CGPY2024001)+6 种基金the National Natural Science Foundation of China (32102233,32270210,32102172)the Innovation Fund of DICP (DICPI202412)the China Postdoctoral Science Foundation (2024T170421)Jiangsu Funding Program for Excellent Postdoctoral Talent (2023ZB236)the Postdoctoral Fellowship Program of CPSF (GZC20231129)the Key Research and Development Program of Guangdong Province (2022B0202080004)China Agriculture Research System (CARS-004-PS14)。
文摘Phytophthora pathogens secrete numerous apoplastic effectors to manipulate host immunity.Herein,we identified a polysaccharide lyase 1 protein,PsPL1,which acts as an essential virulence factor of P.sojae infection in soybean.However,the overexpression of PsPL1 in P.sojae reduced infection and triggered enhanced immune responses in soybean.PsPL1 exhibited pectin lyase activity and degraded plant pectin to generate pectin oligosaccharides(POSs)with a polymerization degree of 3–14,exhibiting different levels of acetylation and methylation modifications.PsPL1 and the degraded pectin products triggered immune responses in soybean and different Solanaceous plants.The PsPL1-triggered immune responses required RSPL1,a membrane-localized leucine-rich repeat receptor-like protein,which is essential for Phytophthora resistance.Conversely,the PsPL1-degraded product-triggered immune responses depended on the membrane-localized lysin motif receptor-like kinase CERK1.This study reveals that the pectin lyase exhibits a dual immunogenic role during P.sojae infection,which activates plant resistance through different immune receptors and provides novel insights into the function of pectin lyase in host-pathogen interactions.
