With the growing popularity of digital devices, lntemet has become an integral part of teenagers＇ daily life. As teenagers are in a complicated period of development, parents struggle in supervising their use of the ...With the growing popularity of digital devices, lntemet has become an integral part of teenagers＇ daily life. As teenagers are in a complicated period of development, parents struggle in supervising their use of the intemet. This study takes the teenagers＇ standpoint and explores how the teenagers perceive their parents＇ involvement in their Internet use. Survey was conducted towards teenagers in the UAE, which has the highest penetration of digital devices in the Gulf region as well as one of the highest in the world. The results showed that girls usually receive more supervision fi＇om parents than boys. The older the teenagers are and the more they depend on the Internet, the more they perceive parents＇ supervision to be beneficial. However, not enough supervision has been given to those who access the Internet more frequently. The findings indicate more parents＇ supervision is needed from the teenagers＇ point of view. Discussions are made from psychological and socio-cultural perspectives and suggestions for future research are presented.展开更多
Dear Editor,The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern(VOCs),most notably the Omicron variant,which continues to evolve and diversify into a range of s...Dear Editor,The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern(VOCs),most notably the Omicron variant,which continues to evolve and diversify into a range of sub-lineages.Our previous research has shown that these Omicron sub-lineages,spanning BA.1-BA.2.86,have been evolving to exhibit increased neutralization escape capabilities.展开更多
Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obe...Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain.展开更多
In this paper, we consider a second-order periodic boundary value problem. By the topological degree theory and fixed point index theory, we prove the existence of positive solutions which gives the relationship betwe...In this paper, we consider a second-order periodic boundary value problem. By the topological degree theory and fixed point index theory, we prove the existence of positive solutions which gives the relationship between the first positive eigenvalue of the associated eigenvalue problem and the behavior of the nonlinear term of the system.展开更多
Aim:Patients with chronic liver disease(CLD),especially cirrhosis,are at a high risk of severe illness or death from coronavirus disease-2019(COVID-19)and may have a suboptimal immune response to the severe acute resp...Aim:Patients with chronic liver disease(CLD),especially cirrhosis,are at a high risk of severe illness or death from coronavirus disease-2019(COVID-19)and may have a suboptimal immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine.This study aimed to evaluate the safety and immunogenicity of the COVID-19 booster vaccination in patients with CLD.Methods:The study protocol was prospectively registered at ClinicalTrials.gov(No.NCT05204602)after approval by the Ethics Committee.Adult participants with CLD were enrolled in this multicenter prospective study.They completed two doses of the inactivated COVID-19 vaccine and received booster doses at least 6 months later.Adverse reactions were recorded within 14 days after the booster dose.Serum samples of the enrolled patients were collected before and after booster vaccination and tested for SARS-CoV-2 receptor-binding domain(RBD)immunoglobulin G and neutralizing anti-bodies.The chi-squared or Fisher's exact test was used to compare categorical data,and the Mann-Whitney U test was used to compare continuous variables.Two-sided p<0.05 were considered statistically significant.Results:In total,63 patients were enrolled from four hospitals in China,including 29 patients with cirrhosis.The median age of all patients was 55 years,and 61.9%(39/63)were male.The vaccines were well tolerated;most adverse reactions were mild and transient,and injection site pain(6.4%;4/63)and fatigue(3.2%,2/63)were the most frequent local and systemic adverse events.Following the booster vaccination,our results showed that in the whole cohort,the levels and positive rates of anti-RBD IgG and neutralizing antibodies were significantly higher than baseline levels(all p<0.05).Conclusions:The inactivated COVID-19 booster vaccine was safe and significantly increased antibody levels and positivity rates following standard vaccination regimens in patients with CLD,especially those with cirrhosis.展开更多
文摘With the growing popularity of digital devices, lntemet has become an integral part of teenagers＇ daily life. As teenagers are in a complicated period of development, parents struggle in supervising their use of the intemet. This study takes the teenagers＇ standpoint and explores how the teenagers perceive their parents＇ involvement in their Internet use. Survey was conducted towards teenagers in the UAE, which has the highest penetration of digital devices in the Gulf region as well as one of the highest in the world. The results showed that girls usually receive more supervision fi＇om parents than boys. The older the teenagers are and the more they depend on the Internet, the more they perceive parents＇ supervision to be beneficial. However, not enough supervision has been given to those who access the Internet more frequently. The findings indicate more parents＇ supervision is needed from the teenagers＇ point of view. Discussions are made from psychological and socio-cultural perspectives and suggestions for future research are presented.
基金supported by funding from the National Natural Science Foundation of China(32270142 to P.W.)the Shanghai Rising-Star Program(22QA1408800 to P.W.)+5 种基金the Program of Science and Technology Cooperation with Hong Kong region,Macao region,and Taiwan region(23410760500 to P.W.)Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine(YBZX2022 to Y.Z.)NATCM’s Project of High-level Construction of Key TCM Disciplinessupport from AI for Science project of Hehai University(XM06231724)Open Research Fund of State Key Laboratory of Genetic Engineering,Hehai University(No.SKLGE-2304)Xiaomi Young Talents Program.
文摘Dear Editor,The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern(VOCs),most notably the Omicron variant,which continues to evolve and diversify into a range of sub-lineages.Our previous research has shown that these Omicron sub-lineages,spanning BA.1-BA.2.86,have been evolving to exhibit increased neutralization escape capabilities.
基金This work was supported by the National Natural Science Foundation of China(Grant 31301217)the Ministry of Science and Technology of China(Grants 2015BAI08B02 and 2014BAI02B01).
文摘Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain.
基金Supported by National Natural Science Foundation of China (11161022)Natural Science Foundation of Jiangxi Province (20114BAB211006 and 20122BAB201015)Educational Department of Jiangxi Province (GJJ12280)
文摘In this paper, we consider a second-order periodic boundary value problem. By the topological degree theory and fixed point index theory, we prove the existence of positive solutions which gives the relationship between the first positive eigenvalue of the associated eigenvalue problem and the behavior of the nonlinear term of the system.
基金prospectively registered at ClinicalTrials.gov (NCT05204602)after approval by the ethics committee (The Third Central Hospital of Tianjin,No.IRB2021-026-01Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,No.KY2021133+1 种基金Jincheng People's Hospital,No.20210603Lishui People's Hospital,No.2021[007-01]).
文摘Aim:Patients with chronic liver disease(CLD),especially cirrhosis,are at a high risk of severe illness or death from coronavirus disease-2019(COVID-19)and may have a suboptimal immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine.This study aimed to evaluate the safety and immunogenicity of the COVID-19 booster vaccination in patients with CLD.Methods:The study protocol was prospectively registered at ClinicalTrials.gov(No.NCT05204602)after approval by the Ethics Committee.Adult participants with CLD were enrolled in this multicenter prospective study.They completed two doses of the inactivated COVID-19 vaccine and received booster doses at least 6 months later.Adverse reactions were recorded within 14 days after the booster dose.Serum samples of the enrolled patients were collected before and after booster vaccination and tested for SARS-CoV-2 receptor-binding domain(RBD)immunoglobulin G and neutralizing anti-bodies.The chi-squared or Fisher's exact test was used to compare categorical data,and the Mann-Whitney U test was used to compare continuous variables.Two-sided p<0.05 were considered statistically significant.Results:In total,63 patients were enrolled from four hospitals in China,including 29 patients with cirrhosis.The median age of all patients was 55 years,and 61.9%(39/63)were male.The vaccines were well tolerated;most adverse reactions were mild and transient,and injection site pain(6.4%;4/63)and fatigue(3.2%,2/63)were the most frequent local and systemic adverse events.Following the booster vaccination,our results showed that in the whole cohort,the levels and positive rates of anti-RBD IgG and neutralizing antibodies were significantly higher than baseline levels(all p<0.05).Conclusions:The inactivated COVID-19 booster vaccine was safe and significantly increased antibody levels and positivity rates following standard vaccination regimens in patients with CLD,especially those with cirrhosis.
