Due to the unique physical and chemical properties,rare earth elements(REEs)play a significant role in the high-tech field.In the past few decades,the rare earth reserve in China has been gradually decreasing and more...Due to the unique physical and chemical properties,rare earth elements(REEs)play a significant role in the high-tech field.In the past few decades,the rare earth reserve in China has been gradually decreasing and more pressure has been exerted on the global rare earth supply for the increasing demand of REEs,which indicates that it is essential to recycle secondary resources to meet the rare earth demand.As for rare earth molten salt electrolytic slag(REMES),although its high rare earth content has potential huge economic value,its high fluorine content of approximately 10 wt%-20 wt%can pollute the environment.Three methods are used to treat REMES.Hydro metallurgical and pyro-hydrometallurgical methods have gotten a big success for solving most of the hydrometallurgical problems,while some problems,like long route and waste water,need to be solved.Vacuum distillation is a new and promising method with a short process due to its harmlessness and high efficiency,but has shortcomings such as high energy consumption and material adaptability.This review presents these above three treatment methods,and the challenges and chances of using the recovery technique of REMES in an environmentally friendly way.展开更多
Diamond coatings possess numerous excellent properties,making them desirable materials for high-performance surface applications.However,without a revolutionary surface modification method,the surface roughness and fr...Diamond coatings possess numerous excellent properties,making them desirable materials for high-performance surface applications.However,without a revolutionary surface modification method,the surface roughness and friction behavior of diamond coatings can impede their ability to meet the demanding requirements of advanced engineering surfaces.This study proposed the thermal stress control at coating interfaces and demonstrated a novel process of precise graphenization on conventional diamond coatings surface through laser induction and mechanical cleavage,without causing damage to the metal substrate.Through experiments and simulations,the influence mechanism of surface graphitization and interfacial thermal stress was elucidated,ultimately enabling rapid conversion of the diamond coating surface to graphene while controlling the coating’s thickness and roughness.Compared to the original diamond coatings,the obtained surfaces exhibited a 63%-72%reduction in friction coefficients,all of which were below 0.1,with a minimum of 0.06,and a 59%-67%decrease in specific wear rates.Moreover,adhesive wear in the friction counterpart was significantly inhibited,resulting in a reduction in wear by 49%-83%.This demonstrated a significant improvement in lubrication and inhibition of mechanochemical wear properties.This study provides an effective and cost-efficient avenue to overcome the application bottleneck of engineered diamond surfaces,with the potential to significantly enhance the performance and expand the application range of diamond-coated components.展开更多
Despite the widespread use of traditional Chinese medicine （TCM） in clinical settings, proving its effectiveness via scientific trials is still a challenge. TCM views the human body as a complex dynamical system, an...Despite the widespread use of traditional Chinese medicine （TCM） in clinical settings, proving its effectiveness via scientific trials is still a challenge. TCM views the human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. Such fundamental concepts require investigations using system-level quantification approaches, which are beyond conventional reductionism. Only methods that quantify dynamical complexity can bring new insights into the evaluation of TCM. In a previous article, we briefly introduced the potential value of Multiscale Entropy （MSE） analysis in TCM. This article aims to explain the existing challenges in TCM quantification, to introduce the consistency of dynamical complexity theories and TCM theories, and to inspire future system-level research on health and disease.展开更多
Traditional Chinese medicine （TCM） has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the f...Traditional Chinese medicine （TCM） has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach arc not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy （MSE） analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.展开更多
The chemical reaction and dissolution processes of RE2 O3 in REF3-LiF（RE = La and Nd） molten salts were studied by X-ray diffraction, differential thermal analysis and chemical analysis. Firstly, RE2 O3 disperses in...The chemical reaction and dissolution processes of RE2 O3 in REF3-LiF（RE = La and Nd） molten salts were studied by X-ray diffraction, differential thermal analysis and chemical analysis. Firstly, RE2 O3 disperses in molten salts and reacts with REF3 and LiF, which lead to the generation of a new phase REOF, resulting in the dissociation or formation of complex ions by part of REOF, and the sedimentation of excessive REOF at the bottom. The RE contents in molten salts were used to determine the solubility of RE2 O3. The results show that with 20 mol%-40 mol% of REF3, the solubility ranges from 1.79 to 3.05 g RE2 O3 per100 g electrolyte and the corresponding mole concentration is 0.33%-0.87%. RE2 O3 solubility increases with increasing temperature and REF3 concentration. The natural logarithm of the RE2 O3 solubility is plotted against 1/T and can be interpreted by linear relationship. The fitting parameters can be used to estimate the solubility of RE2 O3 with minimized experimental efforts and difficult experiment conditions.展开更多
The electrical conductivity of REF3-LiF(RE=La and Nd) molten salts(xREF3=5 mol%-40 mol%) was systematically measured over the temperature range from 1223 to 1423 K by using continuously varying cell constant(CVCC) met...The electrical conductivity of REF3-LiF(RE=La and Nd) molten salts(xREF3=5 mol%-40 mol%) was systematically measured over the temperature range from 1223 to 1423 K by using continuously varying cell constant(CVCC) method.Electrical conductivity values of LaF3-LiF and NdF3-LiF molten salts within the studied ranges are 4.11-9.39 and 3.62-9.51 S/cm,respectively.The composition and temperature dependences of electrical conductivity and the factor of RE2 O3 on electrical conductivity were investigated.The electrical conductivity nonlinearly decreases with the increasing mole percent of REF3 for the changing of structural ion in molten salts.A good linear relationship between the natural logarithm of electrical conductivity(lnκ) and the reciprocal of the absolute temperature(T-1) can be interpreted by the trend that electrical conductivity linearly increases with increasing temperature.Although it is an important factor of RE2 O3 on electrical conductivity,the influence of RE2 O3 on conductivity is small for the very limited solubility of RE2 O3 in REF3-LiF molten salts.The results of this work supplement the present electrical conductivity data of rare earth fluoride electrolyte.展开更多
Background High energy photon source(HEPS)is the fourth-generation light source,which uses a large number of highperformance insertion devices to generate synchrotron radiation.The control system is an important part ...Background High energy photon source(HEPS)is the fourth-generation light source,which uses a large number of highperformance insertion devices to generate synchrotron radiation.The control system is an important part of the insertion device(ID).Purpose Cryogenic permanent magnet undulator(CPMU)is one kind of IDs that works in liquid nitrogen temperature and ultra-high vacuum environment,and its control system is more difficult and complex than in-air ID.The design of the control system for CPMU will be introduced in detail.Method The sub-systems include high-precision magnetic gap control,safety protection,measurement and compensation of magnetic gap at cryogenic temperature and cryogenic temperature monitoring.Mature,reliable,stable technical schemes are designed to meet the technical specifications of sub-systems.Results The experiment results show that the magnetic gap motion accuracy can be controlled within 0.2–0.3μm under the step size of 1μm.The safety protection system has been tested in turn,and the predetermined protection can be achieved.The average value of magnetic gap cold contraction is 1.512 mm measured by optical micrometer,and the compensation is realized by software.The average temperature of the main magnet structure measured by the temperature sensors is 81.0 K,and the temperature gradient is 0.7 K/m.The temperature monitoring is reliable and stable.Conclusion The CPMU control system which is based on EPICS has been successfully applied to the CPMU prototype,and the test results have met the design specifications.展开更多
The bastnaesite was defluorinated by steam roasting process,and fluorine was removed in the form of hydrogen fluoride to realize the separation from rare earth.The effects of particle size of raw material,roasting tem...The bastnaesite was defluorinated by steam roasting process,and fluorine was removed in the form of hydrogen fluoride to realize the separation from rare earth.The effects of particle size of raw material,roasting temperature and time on defluorination rate of bastnaesite were studied.The suitable conditions of steam roasting process are that the particle size of raw material is less than 74μm,the roasting temperature is 1000℃and the roasting time is 4 h.The defluorination rate of bastnaesite is close to 100%under above these conditions.When the temperature rises to 1000℃,the voids on the surface of the particles increase obviously,and there is a developed network of voids,which indicates that the fluorine oxides in bastnaesite react fully with the saturated water vapor at this stage,and a large amount of fluorine escapes in the form of hydrogen fluoride from the surface and inside of the mineral.X-ray diffraction results show that there are only rare-earth oxides in the form of Ce_(0.33)La_(0.33)Ca_(0.33)O_(1.5)and Ce_(7)O_(12)in the slag.The results of energy spectra and chemical analysis show that the fluorine in the baking sand was basically completely removed.展开更多
The tensile and fracture behavior of DZ68 directionally solidified Ni-base superalloy was studied in the temperature range of room temperature （RT） to 1000℃. The fracture mode was examined by scanning electron micr...The tensile and fracture behavior of DZ68 directionally solidified Ni-base superalloy was studied in the temperature range of room temperature （RT） to 1000℃. The fracture mode was examined by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. The results show the tensile strength and yield strength of DZ68 alloy increase slightly with increasing temperature, so that at 760℃ its reach maxima value： 1214 and 1019 MPa, respectively. When the experimental temperature is higher than 760℃, the tensile and yield strengths decrease evidently and the ductility increases remarkably. The fractograph of fracture surface for the tensile specimen at room temperature shows a dimple-ductile fracture mode. The fractograph from 760 to 850℃ shows a slide fracture mode. The fractograph from 900 to 1000℃ exhibits a creep rupture mode with uneven deformation.展开更多
Introduction A novel type of pure permanent cryogenic Delta–Knot Undulator was developed at IHEP to supply a high flux of full adjustable polarization synchrotron radiation with low on-axis power density.This prototy...Introduction A novel type of pure permanent cryogenic Delta–Knot Undulator was developed at IHEP to supply a high flux of full adjustable polarization synchrotron radiation with low on-axis power density.This prototype was an active attempt and early exploration for future APPLE–Knot undulator,which will be used at high energy photon source(HEPS).Materials and methods There are several challenges to develop a cryogenic delta undulator,such as the complicated structure,the influence of large magnetic force,and the magnetic measurement difficulty due to the very small gap.In this paper,the mechanical design for overcoming these difficulties will be presented in detail.Conclusion A special hall measuring system is developed,and the preliminary results agree with the theoretical results.This undulator prototype will provide valuable experience for angle magnetization technology,intricate magnetic attraction structure design,and magnetic field measurement under closed small space.展开更多
A new stretched-wire system is built for a cryogenic permanent magnet undulator in High Energy Photon Source Testing Facility.The system has two functions:integral field measurement and magnet gap measurement.Integral...A new stretched-wire system is built for a cryogenic permanent magnet undulator in High Energy Photon Source Testing Facility.The system has two functions:integral field measurement and magnet gap measurement.Integral field measurement and gap measurement are important for evaluation and optimization of the magnetic performance of the undulator in cryogenic-vacuum environment.Two high-precision,high-load motion stages are used for accurate positioning.A special fix structure of stretched wire is adopted for vacuum environment.To reduce the deflection of the 3-meter-long wire,constant tension is maintained along the wire.The measurement repeatability of field integral and magnetic gap is the key performance which depends on the stability of wire and suppression of the electric noise.Strategy of improving the measurement accuracy and stability is presented.展开更多
Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive meningiomas.There is hence a...Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive meningiomas.There is hence an urgent demand to decrypt the biological and molecular landscape of malignant meningioma.Here,through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients,we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma,and a high CBX7 expression level predicts a favorable prognosis in meningioma patients.CBX7 restoration significantly induces cell cycle arrest and inhibits meningioma cell proliferation.iTRAQ-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative phosphorylation.The mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase,USP44,consequently attenuates c-MYC-mediated transactivation of LDHA transcripts,and further inhibits glycolysis and subsequent cell proliferation.More importantly,the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma patients.Altogether,our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.展开更多
基金Project supported by the National Key R&D Program of China(2020YFC1909003)。
文摘Due to the unique physical and chemical properties,rare earth elements(REEs)play a significant role in the high-tech field.In the past few decades,the rare earth reserve in China has been gradually decreasing and more pressure has been exerted on the global rare earth supply for the increasing demand of REEs,which indicates that it is essential to recycle secondary resources to meet the rare earth demand.As for rare earth molten salt electrolytic slag(REMES),although its high rare earth content has potential huge economic value,its high fluorine content of approximately 10 wt%-20 wt%can pollute the environment.Three methods are used to treat REMES.Hydro metallurgical and pyro-hydrometallurgical methods have gotten a big success for solving most of the hydrometallurgical problems,while some problems,like long route and waste water,need to be solved.Vacuum distillation is a new and promising method with a short process due to its harmlessness and high efficiency,but has shortcomings such as high energy consumption and material adaptability.This review presents these above three treatment methods,and the challenges and chances of using the recovery technique of REMES in an environmentally friendly way.
基金support from the National Natural Science Foundation of China(NSFC)[No.52475464,52475463]National Natural Science Foundation of Jiangsu Province(No.BK20231442)+4 种基金the Fundamental Research Funds for the Central Universities(No.NS2024032)the International Joint Laboratory of Sustainable Manufacturing,Ministry of Education and the Fundamental Research Funds for the Central Universities(No.NG2024007)China Scholarship Council(No.202206830048)the Foundation of the Graduate Innovation Center,Nanjing University of Aeronautics and Astronautics(No.kfjj20200510)Funding for Outstanding Doctoral Dissertation in NUAA(No.BCXJ23-09)。
文摘Diamond coatings possess numerous excellent properties,making them desirable materials for high-performance surface applications.However,without a revolutionary surface modification method,the surface roughness and friction behavior of diamond coatings can impede their ability to meet the demanding requirements of advanced engineering surfaces.This study proposed the thermal stress control at coating interfaces and demonstrated a novel process of precise graphenization on conventional diamond coatings surface through laser induction and mechanical cleavage,without causing damage to the metal substrate.Through experiments and simulations,the influence mechanism of surface graphitization and interfacial thermal stress was elucidated,ultimately enabling rapid conversion of the diamond coating surface to graphene while controlling the coating’s thickness and roughness.Compared to the original diamond coatings,the obtained surfaces exhibited a 63%-72%reduction in friction coefficients,all of which were below 0.1,with a minimum of 0.06,and a 59%-67%decrease in specific wear rates.Moreover,adhesive wear in the friction counterpart was significantly inhibited,resulting in a reduction in wear by 49%-83%.This demonstrated a significant improvement in lubrication and inhibition of mechanochemical wear properties.This study provides an effective and cost-efficient avenue to overcome the application bottleneck of engineered diamond surfaces,with the potential to significantly enhance the performance and expand the application range of diamond-coated components.
文摘Despite the widespread use of traditional Chinese medicine （TCM） in clinical settings, proving its effectiveness via scientific trials is still a challenge. TCM views the human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. Such fundamental concepts require investigations using system-level quantification approaches, which are beyond conventional reductionism. Only methods that quantify dynamical complexity can bring new insights into the evaluation of TCM. In a previous article, we briefly introduced the potential value of Multiscale Entropy （MSE） analysis in TCM. This article aims to explain the existing challenges in TCM quantification, to introduce the consistency of dynamical complexity theories and TCM theories, and to inspire future system-level research on health and disease.
文摘Traditional Chinese medicine （TCM） has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach arc not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy （MSE） analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.
基金supported by the National High Technology Research and Development Program(2011AA03A409)Fundamental Research Funds for the Central Universities(N110202002)
文摘The chemical reaction and dissolution processes of RE2 O3 in REF3-LiF（RE = La and Nd） molten salts were studied by X-ray diffraction, differential thermal analysis and chemical analysis. Firstly, RE2 O3 disperses in molten salts and reacts with REF3 and LiF, which lead to the generation of a new phase REOF, resulting in the dissociation or formation of complex ions by part of REOF, and the sedimentation of excessive REOF at the bottom. The RE contents in molten salts were used to determine the solubility of RE2 O3. The results show that with 20 mol%-40 mol% of REF3, the solubility ranges from 1.79 to 3.05 g RE2 O3 per100 g electrolyte and the corresponding mole concentration is 0.33%-0.87%. RE2 O3 solubility increases with increasing temperature and REF3 concentration. The natural logarithm of the RE2 O3 solubility is plotted against 1/T and can be interpreted by linear relationship. The fitting parameters can be used to estimate the solubility of RE2 O3 with minimized experimental efforts and difficult experiment conditions.
基金the National High Technology Research and Development Program(2011AA03A409)Fundamental Research Funds for the Central Universities(N110202002)。
文摘The electrical conductivity of REF3-LiF(RE=La and Nd) molten salts(xREF3=5 mol%-40 mol%) was systematically measured over the temperature range from 1223 to 1423 K by using continuously varying cell constant(CVCC) method.Electrical conductivity values of LaF3-LiF and NdF3-LiF molten salts within the studied ranges are 4.11-9.39 and 3.62-9.51 S/cm,respectively.The composition and temperature dependences of electrical conductivity and the factor of RE2 O3 on electrical conductivity were investigated.The electrical conductivity nonlinearly decreases with the increasing mole percent of REF3 for the changing of structural ion in molten salts.A good linear relationship between the natural logarithm of electrical conductivity(lnκ) and the reciprocal of the absolute temperature(T-1) can be interpreted by the trend that electrical conductivity linearly increases with increasing temperature.Although it is an important factor of RE2 O3 on electrical conductivity,the influence of RE2 O3 on conductivity is small for the very limited solubility of RE2 O3 in REF3-LiF molten salts.The results of this work supplement the present electrical conductivity data of rare earth fluoride electrolyte.
文摘Background High energy photon source(HEPS)is the fourth-generation light source,which uses a large number of highperformance insertion devices to generate synchrotron radiation.The control system is an important part of the insertion device(ID).Purpose Cryogenic permanent magnet undulator(CPMU)is one kind of IDs that works in liquid nitrogen temperature and ultra-high vacuum environment,and its control system is more difficult and complex than in-air ID.The design of the control system for CPMU will be introduced in detail.Method The sub-systems include high-precision magnetic gap control,safety protection,measurement and compensation of magnetic gap at cryogenic temperature and cryogenic temperature monitoring.Mature,reliable,stable technical schemes are designed to meet the technical specifications of sub-systems.Results The experiment results show that the magnetic gap motion accuracy can be controlled within 0.2–0.3μm under the step size of 1μm.The safety protection system has been tested in turn,and the predetermined protection can be achieved.The average value of magnetic gap cold contraction is 1.512 mm measured by optical micrometer,and the compensation is realized by software.The average temperature of the main magnet structure measured by the temperature sensors is 81.0 K,and the temperature gradient is 0.7 K/m.The temperature monitoring is reliable and stable.Conclusion The CPMU control system which is based on EPICS has been successfully applied to the CPMU prototype,and the test results have met the design specifications.
基金Project supported by the National Key Research and Development Program of China(2020YFC1907500)the Fundamental Research Funds of the Ministry of Education of China(N2125033)。
文摘The bastnaesite was defluorinated by steam roasting process,and fluorine was removed in the form of hydrogen fluoride to realize the separation from rare earth.The effects of particle size of raw material,roasting temperature and time on defluorination rate of bastnaesite were studied.The suitable conditions of steam roasting process are that the particle size of raw material is less than 74μm,the roasting temperature is 1000℃and the roasting time is 4 h.The defluorination rate of bastnaesite is close to 100%under above these conditions.When the temperature rises to 1000℃,the voids on the surface of the particles increase obviously,and there is a developed network of voids,which indicates that the fluorine oxides in bastnaesite react fully with the saturated water vapor at this stage,and a large amount of fluorine escapes in the form of hydrogen fluoride from the surface and inside of the mineral.X-ray diffraction results show that there are only rare-earth oxides in the form of Ce_(0.33)La_(0.33)Ca_(0.33)O_(1.5)and Ce_(7)O_(12)in the slag.The results of energy spectra and chemical analysis show that the fluorine in the baking sand was basically completely removed.
文摘The tensile and fracture behavior of DZ68 directionally solidified Ni-base superalloy was studied in the temperature range of room temperature （RT） to 1000℃. The fracture mode was examined by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. The results show the tensile strength and yield strength of DZ68 alloy increase slightly with increasing temperature, so that at 760℃ its reach maxima value： 1214 and 1019 MPa, respectively. When the experimental temperature is higher than 760℃, the tensile and yield strengths decrease evidently and the ductility increases remarkably. The fractograph of fracture surface for the tensile specimen at room temperature shows a dimple-ductile fracture mode. The fractograph from 760 to 850℃ shows a slide fracture mode. The fractograph from 900 to 1000℃ exhibits a creep rupture mode with uneven deformation.
基金The Grant No.is 11675207.Project name:The Physical and Technical Study of Quasi-eriodic DELTA Undulator working at liquid nitrogen temperature.
文摘Introduction A novel type of pure permanent cryogenic Delta–Knot Undulator was developed at IHEP to supply a high flux of full adjustable polarization synchrotron radiation with low on-axis power density.This prototype was an active attempt and early exploration for future APPLE–Knot undulator,which will be used at high energy photon source(HEPS).Materials and methods There are several challenges to develop a cryogenic delta undulator,such as the complicated structure,the influence of large magnetic force,and the magnetic measurement difficulty due to the very small gap.In this paper,the mechanical design for overcoming these difficulties will be presented in detail.Conclusion A special hall measuring system is developed,and the preliminary results agree with the theoretical results.This undulator prototype will provide valuable experience for angle magnetization technology,intricate magnetic attraction structure design,and magnetic field measurement under closed small space.
文摘A new stretched-wire system is built for a cryogenic permanent magnet undulator in High Energy Photon Source Testing Facility.The system has two functions:integral field measurement and magnet gap measurement.Integral field measurement and gap measurement are important for evaluation and optimization of the magnetic performance of the undulator in cryogenic-vacuum environment.Two high-precision,high-load motion stages are used for accurate positioning.A special fix structure of stretched wire is adopted for vacuum environment.To reduce the deflection of the 3-meter-long wire,constant tension is maintained along the wire.The measurement repeatability of field integral and magnetic gap is the key performance which depends on the stability of wire and suppression of the electric noise.Strategy of improving the measurement accuracy and stability is presented.
基金supported by grants from the National Natural Science Foundation of China(82072788 and 81772674 to Y.G.,82271595 to X.W.,and 81900287 to Z.J.).
文摘Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive meningiomas.There is hence an urgent demand to decrypt the biological and molecular landscape of malignant meningioma.Here,through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients,we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma,and a high CBX7 expression level predicts a favorable prognosis in meningioma patients.CBX7 restoration significantly induces cell cycle arrest and inhibits meningioma cell proliferation.iTRAQ-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative phosphorylation.The mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase,USP44,consequently attenuates c-MYC-mediated transactivation of LDHA transcripts,and further inhibits glycolysis and subsequent cell proliferation.More importantly,the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma patients.Altogether,our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.
