Background:Diffusion cell test is one of the most commonly used in vitro model to detect the percutaneous absorption of cosmetic ingredients.Although PRC State Administration of Quality Supervision and Quarantine has ...Background:Diffusion cell test is one of the most commonly used in vitro model to detect the percutaneous absorption of cosmetic ingredients.Although PRC State Administration of Quality Supervision and Quarantine has issued the guideline for the in vitro test method for the percutaneous absorption of drug molecules,there is still a lack of guideline for the percutaneous absorption test of cosmetic components.Objective:In order to improve the standardized level and make the in vitro percutaneous absorption test of cosmetic ingredients more comparable,based on the international and domestic experience,Transdermal Drug Delivery Committee of the World Federation of Chinese Medicine Societies organized the experts to discuss and formed this consensus as reference for the percutaneous absorption test of cosmetic components.Materials and Methods:To standardize the in vitro diffusion cell test technique for transdermal penetration of functional cosmetic ingredients,the Transdermal Drug Delivery Professional Committee of the World Federation of Societies of Traditional Chinese Medicine has organized many discussions among experts.展开更多
Background At present,neurointerventional surgery requires angiographers to perform operations in the digital subtraction angiography(DSA)room.Ionising radiation and chronic joint damage are still unavoidable for angi...Background At present,neurointerventional surgery requires angiographers to perform operations in the digital subtraction angiography(DSA)room.Ionising radiation and chronic joint damage are still unavoidable for angiographers.Therefore,we researched and developed a neurointerventional robot-assisted system,which is operated by angiographers in an operating room outside the DSA room.We have conducted a prospective,multicentre,randomised controlled trial to evaluate the safety and efficacy of a robot-assisted system in human cerebral angiography.In the future,this research will provide a platform for the research and development of an intelligent surgical system and bring revolutionary progress in neurointerventional surgery.Methods From December 2020 to December 2021,260 patients were enrolled from three medical centres,who were randomly and equally divided into a robot-assisted system group and a clinical routine cerebral angiography group.The success rate of angiography,the rate of the catheter reaching the target vessel,the operation time,X-ray radiation exposure and the incidence of related adverse events were compared between the two groups.Results A total of 257 patients completed this trial;baseline characteristics of the two groups did not differ significantly.The success rate of angiography in both the control group and the experimental group was 100%.The rate of the catheter reaching the target vessel was 99.23%and 100.00%in the control and experimental groups,respectively.For the control versus experimental groups,the angiographic operation time was 48.59±25.60min versus 47.94±27.49min,respectively;the X-ray radiation dose was 735.01±554.77mGy versus 821.65±705.45mGy,respectively;and the incidence of adverse events was 23.44%versus 22.48%,respectively.No statistical differences were present between the two groups.Conclusion The robot-assisted surgical system is more convenient for cerebral angiography and is as safe and effective as the traditional cerebral angiography.展开更多
文摘Background:Diffusion cell test is one of the most commonly used in vitro model to detect the percutaneous absorption of cosmetic ingredients.Although PRC State Administration of Quality Supervision and Quarantine has issued the guideline for the in vitro test method for the percutaneous absorption of drug molecules,there is still a lack of guideline for the percutaneous absorption test of cosmetic components.Objective:In order to improve the standardized level and make the in vitro percutaneous absorption test of cosmetic ingredients more comparable,based on the international and domestic experience,Transdermal Drug Delivery Committee of the World Federation of Chinese Medicine Societies organized the experts to discuss and formed this consensus as reference for the percutaneous absorption test of cosmetic components.Materials and Methods:To standardize the in vitro diffusion cell test technique for transdermal penetration of functional cosmetic ingredients,the Transdermal Drug Delivery Professional Committee of the World Federation of Societies of Traditional Chinese Medicine has organized many discussions among experts.
基金supported by the Research on industrialisation and demonstration application of high-precision minimally invasive vascular interventional surgery robot[grant numbers 2017YFB1304400].
文摘Background At present,neurointerventional surgery requires angiographers to perform operations in the digital subtraction angiography(DSA)room.Ionising radiation and chronic joint damage are still unavoidable for angiographers.Therefore,we researched and developed a neurointerventional robot-assisted system,which is operated by angiographers in an operating room outside the DSA room.We have conducted a prospective,multicentre,randomised controlled trial to evaluate the safety and efficacy of a robot-assisted system in human cerebral angiography.In the future,this research will provide a platform for the research and development of an intelligent surgical system and bring revolutionary progress in neurointerventional surgery.Methods From December 2020 to December 2021,260 patients were enrolled from three medical centres,who were randomly and equally divided into a robot-assisted system group and a clinical routine cerebral angiography group.The success rate of angiography,the rate of the catheter reaching the target vessel,the operation time,X-ray radiation exposure and the incidence of related adverse events were compared between the two groups.Results A total of 257 patients completed this trial;baseline characteristics of the two groups did not differ significantly.The success rate of angiography in both the control group and the experimental group was 100%.The rate of the catheter reaching the target vessel was 99.23%and 100.00%in the control and experimental groups,respectively.For the control versus experimental groups,the angiographic operation time was 48.59±25.60min versus 47.94±27.49min,respectively;the X-ray radiation dose was 735.01±554.77mGy versus 821.65±705.45mGy,respectively;and the incidence of adverse events was 23.44%versus 22.48%,respectively.No statistical differences were present between the two groups.Conclusion The robot-assisted surgical system is more convenient for cerebral angiography and is as safe and effective as the traditional cerebral angiography.
