[Objectives]To study the anti-inflammatory effect of Simiao Liangxue granule on the rats with acute gouty arthritis(AGA).[Methods]A total of 60 male SD rats were randomly divided into 6 groups with 10 rats in each gro...[Objectives]To study the anti-inflammatory effect of Simiao Liangxue granule on the rats with acute gouty arthritis(AGA).[Methods]A total of 60 male SD rats were randomly divided into 6 groups with 10 rats in each group.The rats in the colchicine group were intragastrically administered with 0.65 mg/kg colchicine,and the rats in low,medium and high dose groups of Simiao Liangxue granule were intragastrically administered with Simiao Liangxue granule with mass concentration of 0.4,0.8 and 1.6 g/kg,respectively.The rats in the normal control group and the model group were given the same amount of normal saline for 7 d,and the acute gouty arthritis model was prepared 1 h after administration on the 5th d.At the end of the experiment,the degree of joint swelling and joint inflammation index,the content of interleukin-1β,tumor necrosis factor-a and cyclooxygenase-2 in articular cartilage,and the content of interleukin-8,NO and UA in serum of rats were measured,and the histomorphological observation was performed.[Results]Compared with the normal control group,the joints of rats were swollen to different degrees,the inflammation score was significantly increased,and the content of IL-1β,TNF-αand COX-2 in the soft tissue of the joints was significantly increased in each group(P<0.05);compared with the model group,the joint swelling degree and inflammation score of rats in the colchicine group and Simiao Liangxue granule group were significantly decreased,the content of IL-1β,TNF-αand COX-2 in the joint soft tissue was also significantly decreased(P<0.05),and the indexes of each dose group of Simiao Liangxue granule were similar to those of the colchicine group;compared with the normal control group,the content of IL-8,NO and UA in the joint soft tissue of rats was significantly increased in each group(P<0.05);compared with the model group,the content of all indexes in joint soft tissue of rats in normal control group,colchicine group and Simiao Liangxue granule group were significantly decreased(P<0.05);the content of various indexes in the joint soft tissue of rats in the low and medium dose groups of Simiao Liangxue granule was higher than that in the colchicine group,and decreased significantly with the increase of the dose of Simiao Liangxue granule(P<0.05);the inflammatory index decreased significantly with the increase of the dose of Simiao Liangxue granule(P<0.05);the inflammation and degeneration in each dose group of Simiao Liangxue granule were milder than those in the model group,and the symptoms were relieved to some extent with the increase of dose(P<0.05).[Conclusions]Simiao Liangxue granule has the effect of anti-inflammation and detumescence,and its mechanism may be related to the content of factors that reduce inflammation including IL-1β,TNF-α,C0X-2,IL-8,NO and UA.展开更多
[Objectives]This study aims to investigate the effects of Dachengqi decoctions made from different processed products of rhubarb on water intake,defecation amount,urination amount,urination volume,dryness of stool,men...[Objectives]This study aims to investigate the effects of Dachengqi decoctions made from different processed products of rhubarb on water intake,defecation amount,urination amount,urination volume,dryness of stool,mental state and activity of ABP mice.[Methods]Total 165 mice were randomly divided into Dachengqi decoction groups(made from different processed products of rhubarb,6 and 10 g/kg),positive control group,blank control group and model group.The administration dosage was 20 mL/kg.With the metabolic cage integral method,the effects of Dachengqi decoctions made from different processed products of rhubarb on the water intake,defecation amount,urination volume,dryness of stool,mental state and activity of ABP mice were compared.[Results]Dachengqi decoctions all could soften stool and promote rapid defecation of the mice with fecal peritonitis of excess heat stagnation type except that made from carbonized rhubarb.The water intakes of all the Dachengqi decoction groups were higher than those of the positive control group and the model group,except the carbonized rhubarb-made Dachengqi decoction groups.[Conclusions]Dachengqi decoctions all have obvious purgative effect except those made from carbonized rhubarb.展开更多
Enhancing the semiconductor-metal phase transition temperature(TSMT)of VO_(2) is of great consequence for further exploring the potential applications of VO_(2) at elevated temperatures.In this study,Ge^(4+)-doped VO_...Enhancing the semiconductor-metal phase transition temperature(TSMT)of VO_(2) is of great consequence for further exploring the potential applications of VO_(2) at elevated temperatures.In this study,Ge^(4+)-doped VO_(2)(Ge_(x)V_(1-x)O_(2))samples were prepared by the hydrothermal and annealing approach.X-ray diffraction(XRD),high-resolution transmission electron microscopy(HRTEM),differential scanning calorimetry(DSC)and resistivity-temperature(R-T)analyses were used to investigate the influence of Ge doping on the lattice structures and phase transition properties of Ge_(x)V_(1-x)O_(2) samples.We found that the lattice parameter of Ge_(x)V_(1-x)O_(2) decreased with the Ge concentration increasing from 2 at%to 18 at%,which was further supported by density functional theory(DFT)-based first-principle simulations.TSMT firstly increased from 64.5 to 73.0℃ at 8 at% Ge and then decreased to 71.5℃ at higher Ge concentration.Furthermore,DFT analysis revealed that the impact of lattice distortion induced by Ge doping rather than the changes in electronic structure is more pronounced on modulating TSMT of Ge_(x)V_(1-x)O_(2).The present work has pointed out the direction that the TSMT could be enhanced and illustrated the physical reason behind the regulation of TSMT in ionsdoped VO_(2) systems.展开更多
Two-dimensional(2-D)layered metal-organic coordination(lead methacrylate(LDMA))networks have been prepared in aqueous solution under mild conditions and their structure determined by single crystal diffraction.As the ...Two-dimensional(2-D)layered metal-organic coordination(lead methacrylate(LDMA))networks have been prepared in aqueous solution under mild conditions and their structure determined by single crystal diffraction.As the ligand used in our experiments is easily polymerized,these metal-organic coordination layers are therefore employed as precursors to fabricate cross-linked polymer layered materials throughγ-irradiated polymerization.The stabilities of the samples are signifi cantly improved afterγ-irradiation.To our knowledge,this is the fi rst time that covalent bonded polymer layered structures have been fabricated without the assistance of added surfactant or template.Such layered polymer materials cannot only act as alternatives to layered inorganic materials in some caustic environments,but also allow the generation of PbS nanoparticles(NPs)without aggregation in the polymer matrix.By exposing the polymer layer to H2S gas at room temperature,uniform PbS nanoparticles with an average size of about 6 nm are generated in situ.In addition,the resulting PbS NPs exhibit near-infrared(NIR)luminescent properties,which suggests the composite materials may be useful as active optical elements at communication wavelengths from 1300 to 1550 nm.展开更多
Dense nano-grained Ni_(0.7)Mn_(2.3O4) negative temperature coefficient(NTC) thermistors were fabricated by a novel two-step sintering approach that combines rapid sintering and principle of conventional two-step sinte...Dense nano-grained Ni_(0.7)Mn_(2.3O4) negative temperature coefficient(NTC) thermistors were fabricated by a novel two-step sintering approach that combines rapid sintering and principle of conventional two-step sintering technique.Samples were sintered at 1042℃ for 30 s in the first rapid step and then at 850-950℃ for 20 h in the second soaking step.Crystal phase,microstructure and electrical properties of sintered samples were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),resistance temperature relationship and aging performance.Sintered samples show a single-phase cubic spinel structure and indicate a high relative density ranging from 84% to 91% of the theoretical density.Moreover,average grain sizes of sintered samples under SEM are distributed between 254 and 570 nm.Meanwhile,the resistivity and the aging coefficient significantly decrease when soaking sintering temperature rises.In addition,the obtained material constant(B) ranges from 3931 to 3981 K.Ni_(0.7)Mn_(2.3)O_(4)-3(soaking at 900℃) and Ni_(0.7)Mn_(2.3O4)-4(soaking at 950℃) present little aging behavior,implying great electrical stability.展开更多
基金Guangxi Natural Science Foundation(2020GXNSFAA259059)National Training Program for Characteristic Technology Inheritance of Traditional Chinese Medicine(20184828005)In-hospital Preparation Development Project of the First Affiliated Hospital of Guangxi University of Chinese Medicine in 2017(2017ZJ001).
文摘[Objectives]To study the anti-inflammatory effect of Simiao Liangxue granule on the rats with acute gouty arthritis(AGA).[Methods]A total of 60 male SD rats were randomly divided into 6 groups with 10 rats in each group.The rats in the colchicine group were intragastrically administered with 0.65 mg/kg colchicine,and the rats in low,medium and high dose groups of Simiao Liangxue granule were intragastrically administered with Simiao Liangxue granule with mass concentration of 0.4,0.8 and 1.6 g/kg,respectively.The rats in the normal control group and the model group were given the same amount of normal saline for 7 d,and the acute gouty arthritis model was prepared 1 h after administration on the 5th d.At the end of the experiment,the degree of joint swelling and joint inflammation index,the content of interleukin-1β,tumor necrosis factor-a and cyclooxygenase-2 in articular cartilage,and the content of interleukin-8,NO and UA in serum of rats were measured,and the histomorphological observation was performed.[Results]Compared with the normal control group,the joints of rats were swollen to different degrees,the inflammation score was significantly increased,and the content of IL-1β,TNF-αand COX-2 in the soft tissue of the joints was significantly increased in each group(P<0.05);compared with the model group,the joint swelling degree and inflammation score of rats in the colchicine group and Simiao Liangxue granule group were significantly decreased,the content of IL-1β,TNF-αand COX-2 in the joint soft tissue was also significantly decreased(P<0.05),and the indexes of each dose group of Simiao Liangxue granule were similar to those of the colchicine group;compared with the normal control group,the content of IL-8,NO and UA in the joint soft tissue of rats was significantly increased in each group(P<0.05);compared with the model group,the content of all indexes in joint soft tissue of rats in normal control group,colchicine group and Simiao Liangxue granule group were significantly decreased(P<0.05);the content of various indexes in the joint soft tissue of rats in the low and medium dose groups of Simiao Liangxue granule was higher than that in the colchicine group,and decreased significantly with the increase of the dose of Simiao Liangxue granule(P<0.05);the inflammatory index decreased significantly with the increase of the dose of Simiao Liangxue granule(P<0.05);the inflammation and degeneration in each dose group of Simiao Liangxue granule were milder than those in the model group,and the symptoms were relieved to some extent with the increase of dose(P<0.05).[Conclusions]Simiao Liangxue granule has the effect of anti-inflammation and detumescence,and its mechanism may be related to the content of factors that reduce inflammation including IL-1β,TNF-α,C0X-2,IL-8,NO and UA.
基金Supported by National Natural Science Foundation of China(81360524)National Traditional Chinese Medicine Characteristic Technology Inheritance Talent Training Project(20184828005)+2 种基金Youth Foundation of Guangxi University of Chinese Medicine(2019QN036)Natural Science Foundation of Guangxi(2020GXNSFAA259059)In-hospital Preparation Development Project of the First Affiliated Hospital of Guangxi University of Chinese Medicine(2017ZJ001).
文摘[Objectives]This study aims to investigate the effects of Dachengqi decoctions made from different processed products of rhubarb on water intake,defecation amount,urination amount,urination volume,dryness of stool,mental state and activity of ABP mice.[Methods]Total 165 mice were randomly divided into Dachengqi decoction groups(made from different processed products of rhubarb,6 and 10 g/kg),positive control group,blank control group and model group.The administration dosage was 20 mL/kg.With the metabolic cage integral method,the effects of Dachengqi decoctions made from different processed products of rhubarb on the water intake,defecation amount,urination volume,dryness of stool,mental state and activity of ABP mice were compared.[Results]Dachengqi decoctions all could soften stool and promote rapid defecation of the mice with fecal peritonitis of excess heat stagnation type except that made from carbonized rhubarb.The water intakes of all the Dachengqi decoction groups were higher than those of the positive control group and the model group,except the carbonized rhubarb-made Dachengqi decoction groups.[Conclusions]Dachengqi decoctions all have obvious purgative effect except those made from carbonized rhubarb.
基金financially supported by the Natural Science Foundation of Ningxia(No.2020AAC03005)the Western Light Foundation of the Chinese Academy of Sciences。
文摘Enhancing the semiconductor-metal phase transition temperature(TSMT)of VO_(2) is of great consequence for further exploring the potential applications of VO_(2) at elevated temperatures.In this study,Ge^(4+)-doped VO_(2)(Ge_(x)V_(1-x)O_(2))samples were prepared by the hydrothermal and annealing approach.X-ray diffraction(XRD),high-resolution transmission electron microscopy(HRTEM),differential scanning calorimetry(DSC)and resistivity-temperature(R-T)analyses were used to investigate the influence of Ge doping on the lattice structures and phase transition properties of Ge_(x)V_(1-x)O_(2) samples.We found that the lattice parameter of Ge_(x)V_(1-x)O_(2) decreased with the Ge concentration increasing from 2 at%to 18 at%,which was further supported by density functional theory(DFT)-based first-principle simulations.TSMT firstly increased from 64.5 to 73.0℃ at 8 at% Ge and then decreased to 71.5℃ at higher Ge concentration.Furthermore,DFT analysis revealed that the impact of lattice distortion induced by Ge doping rather than the changes in electronic structure is more pronounced on modulating TSMT of Ge_(x)V_(1-x)O_(2).The present work has pointed out the direction that the TSMT could be enhanced and illustrated the physical reason behind the regulation of TSMT in ionsdoped VO_(2) systems.
基金by the National Natural Science Foundation of China(Nos.20504011,20534040,50703046,and 20674026)the National Basic Research Program of China(2007CB936402).
文摘Two-dimensional(2-D)layered metal-organic coordination(lead methacrylate(LDMA))networks have been prepared in aqueous solution under mild conditions and their structure determined by single crystal diffraction.As the ligand used in our experiments is easily polymerized,these metal-organic coordination layers are therefore employed as precursors to fabricate cross-linked polymer layered materials throughγ-irradiated polymerization.The stabilities of the samples are signifi cantly improved afterγ-irradiation.To our knowledge,this is the fi rst time that covalent bonded polymer layered structures have been fabricated without the assistance of added surfactant or template.Such layered polymer materials cannot only act as alternatives to layered inorganic materials in some caustic environments,but also allow the generation of PbS nanoparticles(NPs)without aggregation in the polymer matrix.By exposing the polymer layer to H2S gas at room temperature,uniform PbS nanoparticles with an average size of about 6 nm are generated in situ.In addition,the resulting PbS NPs exhibit near-infrared(NIR)luminescent properties,which suggests the composite materials may be useful as active optical elements at communication wavelengths from 1300 to 1550 nm.
基金financially supported by the National Natural Science Foundation of China(Nos.51302138 and 21663001)the Western Light Talent Training Program of Chinese Academy of Sciences。
文摘Dense nano-grained Ni_(0.7)Mn_(2.3O4) negative temperature coefficient(NTC) thermistors were fabricated by a novel two-step sintering approach that combines rapid sintering and principle of conventional two-step sintering technique.Samples were sintered at 1042℃ for 30 s in the first rapid step and then at 850-950℃ for 20 h in the second soaking step.Crystal phase,microstructure and electrical properties of sintered samples were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),resistance temperature relationship and aging performance.Sintered samples show a single-phase cubic spinel structure and indicate a high relative density ranging from 84% to 91% of the theoretical density.Moreover,average grain sizes of sintered samples under SEM are distributed between 254 and 570 nm.Meanwhile,the resistivity and the aging coefficient significantly decrease when soaking sintering temperature rises.In addition,the obtained material constant(B) ranges from 3931 to 3981 K.Ni_(0.7)Mn_(2.3)O_(4)-3(soaking at 900℃) and Ni_(0.7)Mn_(2.3O4)-4(soaking at 950℃) present little aging behavior,implying great electrical stability.
