AIM:To evaluate the long-term effect and safety of focal laser photocoagulation treatment in eyes with polypoidal choroidal vasculopathy(PCV).METHODS:Medical records of 13 eyes of 13 patients with PCV were followed-up...AIM:To evaluate the long-term effect and safety of focal laser photocoagulation treatment in eyes with polypoidal choroidal vasculopathy(PCV).METHODS:Medical records of 13 eyes of 13 patients with PCV were followed-up for more than 2 y after focal laser photocoagulation treatment.The patients were diagnosed with PCV using indocyanine green angiography,and eyes with other comorbid ocular diseases were excluded.The measurement outcomes of the study were the post-treatment regression and recurrence of polyps,complications,and changes in visual acuities.Paired t-test was performed to compare visual outcome before and after the treatment.RESULTS:The mean age of the 13 patients was 70.2±5.5 y,and the follow-up period was 72.3±31.0(range,25-118)mo.Three eyes had juxtafoveal polyps and 10 eyes had extrafoveal polyps.Of the 13 eyes,9 eyes(69.2%)had regression of polyps 1.7±1.2(range,0.9-4)mo after focal laser photocoagulation.Five eyes(55.6%)showed recurrence of polyps during the follow-up periods,and the recurrence period was 12.8±18.9(range,1.9-48)mo.Mild subretinal hemorrhage occurred in two eyes(15.4%)27 and 72 d after laser treatment,respectively.There were no statistically significant differences in visual acuities at baseline;1,2,3 y post-treatment(all P>0.05);and last follow-up(0.63±0.5,0.73±0.70,0.67±0.57,0.75±0.7,and 0.95±0.8 log MAR,respectively).CONCLUSION:Focal laser photocoagulation is beneficial for early regression of polyps in eyes with PCV and does not result in significant submacular hemorrhage during the long-term follow-up.Furthermore,it can be primarily considered in eyes with PCV with extrafoveal or juxtafoveal polyps to regress risky polyps as well as to maintain visual acuity without serious hemorrhagic complications.展开更多
AIM: To describe the clinical features and multimodal images of unilateral foveomacular retinitis in young Korean soldiers. METHODS: Ten patients having foveomacular retinitis were included. Fluorescein angiography, f...AIM: To describe the clinical features and multimodal images of unilateral foveomacular retinitis in young Korean soldiers. METHODS: Ten patients having foveomacular retinitis were included. Fluorescein angiography, fundus autofluorescence(FAF), infrared reflectance(IR), and spectral-domain optical coherence tomography(SD-OCT) were analyzed.RESULTS: All patients were young males experienced insidious visual decline without exposure to bright light. Initial and final vision ranged from hand movement to 20/20(median 20/200) and 20/2000 to 20/20(median 20/500), respectively. Vision decreased in 6 patients while improved in two. Typical macular abnormality was yellow granular spots. SD-OCT showed ellipsoid zone(EZ) or interdigitation zone(IZ) disruption of fovea. The degree of EZ/IZ damage correlated with vision. Lesions were clearly visualized through IR and matched with SD-OCT findings.CONCLUSION: This is the first case series of foveomacular retinitis diagnosed with multimodal imaging. Foveomacular retinitis should be suspected in sudden unilateral visual decline especially in young soldiers. SD-OCT is the most important diagnostic modality.展开更多
Dear Editor,Central retinal artery or ophthalmic artery occlusion is a rare complication of facial filler injection,which causes irreversible blindness.Studies have reported failed attempts of retrobulbar,peribulbar,o...Dear Editor,Central retinal artery or ophthalmic artery occlusion is a rare complication of facial filler injection,which causes irreversible blindness.Studies have reported failed attempts of retrobulbar,peribulbar,or intraarterial(inside the ophthalmic artery)injections of hyaluronidase to restore retinal arterial。展开更多
Retinal vascular disease is the leading cause of visual impairment.Although intravitreal drug injections are the most suitable approach for addressing retinal disorders,existing clinical treatments necessitate repeate...Retinal vascular disease is the leading cause of visual impairment.Although intravitreal drug injections are the most suitable approach for addressing retinal disorders,existing clinical treatments necessitate repeated administration,imposing a substantial burden on patients with various intraocular complications.This study introduces an injectable and biodegradable hyaluronan microgel(Hm)-embedded gelatin-PEG-tyramine hydrogel(HmGh)designed for sustained intravitreal ranibizumab(RBZ)delivery to reduce patient burden and minimize the side effects associated with frequent injections.Hm exhibited a controlled RBZ loading capacity and release profile.HmGh effectively controlled the initial burst release and overall release profile.Cytocompatibility and cellular drug efficacy were also demonstrated.In an animal study,HmGh maintained RBZ concentrations in the vitreous and retina for>120 d.Pharmacokinetic studies showed that the half-life of RBZ-loaded HmGh in the vitreous and retina was 2.55 and 2.05 times longer than that of RBZ-loaded Hm and 9.58 and 38.46 times longer than that of RBZ solution.Importantly,the initial RBZ elimination from HmGh to the aqueous humor was significantly reduced compared to that from Hm and RBZ solutions.Intraocular degradation and safety were comprehensively evaluated using fundus imaging and histological analyses.In conclusion,this injectable hydrogel is a promising prolonged drug delivery system for treating various posterior segment eye diseases.展开更多
基金the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSITNo.2020R1F1A1072795)。
文摘AIM:To evaluate the long-term effect and safety of focal laser photocoagulation treatment in eyes with polypoidal choroidal vasculopathy(PCV).METHODS:Medical records of 13 eyes of 13 patients with PCV were followed-up for more than 2 y after focal laser photocoagulation treatment.The patients were diagnosed with PCV using indocyanine green angiography,and eyes with other comorbid ocular diseases were excluded.The measurement outcomes of the study were the post-treatment regression and recurrence of polyps,complications,and changes in visual acuities.Paired t-test was performed to compare visual outcome before and after the treatment.RESULTS:The mean age of the 13 patients was 70.2±5.5 y,and the follow-up period was 72.3±31.0(range,25-118)mo.Three eyes had juxtafoveal polyps and 10 eyes had extrafoveal polyps.Of the 13 eyes,9 eyes(69.2%)had regression of polyps 1.7±1.2(range,0.9-4)mo after focal laser photocoagulation.Five eyes(55.6%)showed recurrence of polyps during the follow-up periods,and the recurrence period was 12.8±18.9(range,1.9-48)mo.Mild subretinal hemorrhage occurred in two eyes(15.4%)27 and 72 d after laser treatment,respectively.There were no statistically significant differences in visual acuities at baseline;1,2,3 y post-treatment(all P>0.05);and last follow-up(0.63±0.5,0.73±0.70,0.67±0.57,0.75±0.7,and 0.95±0.8 log MAR,respectively).CONCLUSION:Focal laser photocoagulation is beneficial for early regression of polyps in eyes with PCV and does not result in significant submacular hemorrhage during the long-term follow-up.Furthermore,it can be primarily considered in eyes with PCV with extrafoveal or juxtafoveal polyps to regress risky polyps as well as to maintain visual acuity without serious hemorrhagic complications.
基金Supported by the National Research Foundation of Korea(No.2016R1D1A1B03934724)funded by the Korean government(Ministry of Science,ICT and Future Planning+1 种基金 MSIP)Seoul National University Bundang Hospital(No.02-2017-059)
文摘AIM: To describe the clinical features and multimodal images of unilateral foveomacular retinitis in young Korean soldiers. METHODS: Ten patients having foveomacular retinitis were included. Fluorescein angiography, fundus autofluorescence(FAF), infrared reflectance(IR), and spectral-domain optical coherence tomography(SD-OCT) were analyzed.RESULTS: All patients were young males experienced insidious visual decline without exposure to bright light. Initial and final vision ranged from hand movement to 20/20(median 20/200) and 20/2000 to 20/20(median 20/500), respectively. Vision decreased in 6 patients while improved in two. Typical macular abnormality was yellow granular spots. SD-OCT showed ellipsoid zone(EZ) or interdigitation zone(IZ) disruption of fovea. The degree of EZ/IZ damage correlated with vision. Lesions were clearly visualized through IR and matched with SD-OCT findings.CONCLUSION: This is the first case series of foveomacular retinitis diagnosed with multimodal imaging. Foveomacular retinitis should be suspected in sudden unilateral visual decline especially in young soldiers. SD-OCT is the most important diagnostic modality.
基金Supported by the NRF Bio&Medical Technology Development Program(No.2018M3A9B5021319)funded by the Korean government(MSIP and MSIT)。
文摘Dear Editor,Central retinal artery or ophthalmic artery occlusion is a rare complication of facial filler injection,which causes irreversible blindness.Studies have reported failed attempts of retrobulbar,peribulbar,or intraarterial(inside the ophthalmic artery)injections of hyaluronidase to restore retinal arterial。
基金This study was supported by a grant(2019R1A6A1A11051471)from Priority Research Centers Program which was funded by the National Research Foundation of Korea(NRF)the Bio&Medical Technology Development Program(2018M3A9B5021319)which was funded by the Ministry of Science and ICT,South Korea(MSIT)+2 种基金a grant from Seoul National University Bundang Hospital(14-2023-0001)a grant from Korea Medical Device Development Fund by the Korea government(RS-2020-KD000033)a grant from the Alchemist Project of Korea Evaluation Institute of Industrial Technology(KEIT 20018560,NTIS 1415184668)which was funded by the Ministry of Trade,Industry&Energy.
文摘Retinal vascular disease is the leading cause of visual impairment.Although intravitreal drug injections are the most suitable approach for addressing retinal disorders,existing clinical treatments necessitate repeated administration,imposing a substantial burden on patients with various intraocular complications.This study introduces an injectable and biodegradable hyaluronan microgel(Hm)-embedded gelatin-PEG-tyramine hydrogel(HmGh)designed for sustained intravitreal ranibizumab(RBZ)delivery to reduce patient burden and minimize the side effects associated with frequent injections.Hm exhibited a controlled RBZ loading capacity and release profile.HmGh effectively controlled the initial burst release and overall release profile.Cytocompatibility and cellular drug efficacy were also demonstrated.In an animal study,HmGh maintained RBZ concentrations in the vitreous and retina for>120 d.Pharmacokinetic studies showed that the half-life of RBZ-loaded HmGh in the vitreous and retina was 2.55 and 2.05 times longer than that of RBZ-loaded Hm and 9.58 and 38.46 times longer than that of RBZ solution.Importantly,the initial RBZ elimination from HmGh to the aqueous humor was significantly reduced compared to that from Hm and RBZ solutions.Intraocular degradation and safety were comprehensively evaluated using fundus imaging and histological analyses.In conclusion,this injectable hydrogel is a promising prolonged drug delivery system for treating various posterior segment eye diseases.
