Objective:To study the correlation of Nod-like receptor protein 3 (NLRP3) polymorphism with inflammasome activity and endothelial damage in patients with acute coronary syndrome. Methods:Patients diagnosed with acute ...Objective:To study the correlation of Nod-like receptor protein 3 (NLRP3) polymorphism with inflammasome activity and endothelial damage in patients with acute coronary syndrome. Methods:Patients diagnosed with acute coronary syndrome and stable angina pectoris in Mianyang Central Hospital between May 2013 and August 2016 were selected and included in ACS group and SAP group respectively, and healthy volunteers who received physical examination during the same period were selected as control group. Peripheral blood was collected to detect NLRP3 gene rs10754558 loci polymorphism, and serum was separated to determine inflammasome activity indexes and endothelial injury indexes.Results:NLRP3 gene GG genotype and GC genotype constituent ratio of ACS group were significantly higher than those of SAP group and control group while CC genotype constituent ratio was significantly lower than that of SAP group and control group, and serum IL-1β, IL-18, E-selectin, vWF and ET-1 levels were significantly higher than those of SAP group and control group while serum NO level was significantly lower than that of SAP group and control group;serum IL-1β, IL-18, E-selectin, vWF and ET-1 levels in ACS patients with GG genotype and GC genotype were significantly higher than those in patients with CC genotype while NO levels were significantly lower than those in patients with CC genotype, and serum IL-1β, IL-18, E-selectin, vWF and ET-1 levels in ACS patients with GG genotype were significantly higher than those in patients with GC genotype while NO level was significantly lower than that in patients with GC genotype.Conclusions: The increased NLRP3 gene rs10754558 loci alleles G in patients with ACS will increase inflammasome activity and endothelial injury.展开更多
文摘Objective:To study the correlation of Nod-like receptor protein 3 (NLRP3) polymorphism with inflammasome activity and endothelial damage in patients with acute coronary syndrome. Methods:Patients diagnosed with acute coronary syndrome and stable angina pectoris in Mianyang Central Hospital between May 2013 and August 2016 were selected and included in ACS group and SAP group respectively, and healthy volunteers who received physical examination during the same period were selected as control group. Peripheral blood was collected to detect NLRP3 gene rs10754558 loci polymorphism, and serum was separated to determine inflammasome activity indexes and endothelial injury indexes.Results:NLRP3 gene GG genotype and GC genotype constituent ratio of ACS group were significantly higher than those of SAP group and control group while CC genotype constituent ratio was significantly lower than that of SAP group and control group, and serum IL-1β, IL-18, E-selectin, vWF and ET-1 levels were significantly higher than those of SAP group and control group while serum NO level was significantly lower than that of SAP group and control group;serum IL-1β, IL-18, E-selectin, vWF and ET-1 levels in ACS patients with GG genotype and GC genotype were significantly higher than those in patients with CC genotype while NO levels were significantly lower than those in patients with CC genotype, and serum IL-1β, IL-18, E-selectin, vWF and ET-1 levels in ACS patients with GG genotype were significantly higher than those in patients with GC genotype while NO level was significantly lower than that in patients with GC genotype.Conclusions: The increased NLRP3 gene rs10754558 loci alleles G in patients with ACS will increase inflammasome activity and endothelial injury.
