Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any tre...Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P【0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals.展开更多
Objective:To present a detailed pharmacognostic study of the leaf of Cayratia trifolia(C.trifolia)Linn.(Vitaceae),an important plant in the Indian system of medicine.Methods:The macroscopy,microscopy,physiochemical an...Objective:To present a detailed pharmacognostic study of the leaf of Cayratia trifolia(C.trifolia)Linn.(Vitaceae),an important plant in the Indian system of medicine.Methods:The macroscopy,microscopy,physiochemical analysis,preliminary testing,fluorescence analysis of powder of the plant and other WHO recommended methods for standardization were investigated.Results:Leaves are trifoliolated with petioles(2-3 cm)long.Leaflets are ovate to oblong-ovate,(2-8 cm)long,(1.5-5 cm)wide,pointed at the tip.The leaf surface shows the anisocytic type stomata covered with guard cells followed by epidermis layer.Leaf surface contents including veins.vein islet and vein termination were also determined.Transverse section of leaf shows the epidermis layer followed by cuticle layer and vascular bandies(xylem and phloem).The mesophyll is differentiated into palisade and spongy parenchyma.Abundant covering trichomes emerge from the upper epidermis.Trichomes are uniseriate and multicellular.Strips of collenchyma are present below and upper layer of epidermis.Conclusions:It can be concluded that the pharmacognostic profile of the C.trifolia is helpful in developing standards for quality,purity and sample identification.展开更多
文摘Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P【0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals.
基金Supported by a grant from University Grants Committee,New Delhi(grant No.39-955/2010 SR)
文摘Objective:To present a detailed pharmacognostic study of the leaf of Cayratia trifolia(C.trifolia)Linn.(Vitaceae),an important plant in the Indian system of medicine.Methods:The macroscopy,microscopy,physiochemical analysis,preliminary testing,fluorescence analysis of powder of the plant and other WHO recommended methods for standardization were investigated.Results:Leaves are trifoliolated with petioles(2-3 cm)long.Leaflets are ovate to oblong-ovate,(2-8 cm)long,(1.5-5 cm)wide,pointed at the tip.The leaf surface shows the anisocytic type stomata covered with guard cells followed by epidermis layer.Leaf surface contents including veins.vein islet and vein termination were also determined.Transverse section of leaf shows the epidermis layer followed by cuticle layer and vascular bandies(xylem and phloem).The mesophyll is differentiated into palisade and spongy parenchyma.Abundant covering trichomes emerge from the upper epidermis.Trichomes are uniseriate and multicellular.Strips of collenchyma are present below and upper layer of epidermis.Conclusions:It can be concluded that the pharmacognostic profile of the C.trifolia is helpful in developing standards for quality,purity and sample identification.
