BACKGROUND Crossed fused renal ectopia is a rare congenital anomaly of the ascent of the kidney. This anomaly may be observed as a solitary kidney during initial evaluation. A solitary kidney must be evaluated for ass...BACKGROUND Crossed fused renal ectopia is a rare congenital anomaly of the ascent of the kidney. This anomaly may be observed as a solitary kidney during initial evaluation. A solitary kidney must be evaluated for associated anomalies such as duplication,horseshoe kidney,or crossed renal ectopia.CASE SUMMARY An anomaly was observed in a 9-mo-old male child who was subsequently diagnosed with crossed fused renal ectopia and vesicoureteral reflux(VUR). In this condition,recurrent febrile urinary tract infection can be a serious problem,and can easily cause renal damage due to relatively short ureters and high pressure in the kidney.CONCLUSION To prevent urosepsis and preserve renal function,early diagnosis and proper management including surgical correction should be considered for the management of renal ectopia with VUR.展开更多
The mortality rate of neurological disorders is increasing globally,and natural antioxidant geniposidic acid(GPA)holds great potential in the treatment of neuronal oxidative damage.Nevertheless,its inherent instabilit...The mortality rate of neurological disorders is increasing globally,and natural antioxidant geniposidic acid(GPA)holds great potential in the treatment of neuronal oxidative damage.Nevertheless,its inherent instability constrains its pragmatic utilization.Herein,we introduced a drug delivery system capable of protecting unstable natural active compounds from degradation.Among the various methods for preparing drug-loaded microspheres,the emulsification-solvent evaporation technique is one of the most commonly employed due to its efficiency and simplicity.Nevertheless,this method results in microspheres with heterogeneous particle sizes.To address this limitation,we developed a two-step emulsification method involving stirring and homogenization.Using the biocompatible,synthetic,biodegradable polymer polycaprolactone(PCL)as the drug delivery carrier,we prepared GPA-loaded PCL microspheres via the two-step emulsification method.The results demonstrated that the microspheres possessed uniform particle size(polydispersity index=0.12),excellent drug loading capacity(∼4.86%),sustained drug release profiles(∼68.55%in 264 h),and biocompatibility(cell viability>85%).The in vitro tests showed that the microspheres exerted antioxidant effects by scavenging reactive oxygen species(ROS)induced by oxidative stress,thereby protecting neuronal cells from oxidative damage.This work presents a promising new approach for the treatment of neuronal oxidative damage.展开更多
Entity alignment(EA)is an important technique aiming to find the same real entity between two different source knowledge graphs(KGs).Current methods typically learn the embedding of entities for EA from the structure ...Entity alignment(EA)is an important technique aiming to find the same real entity between two different source knowledge graphs(KGs).Current methods typically learn the embedding of entities for EA from the structure of KGs for EA.Most EA models are designed for rich-resource languages,requiring sufficient resources such as a parallel corpus and pre-trained language models.However,low-resource language KGs have received less attention,and current models demonstrate poor performance on those low-resource KGs.Recently,researchers have fused relation information and attributes for entity representations to enhance the entity alignment performance,but the relation semantics are often ignored.To address these issues,we propose a novel Semantic-aware Graph Neural Network(SGNN)for entity alignment.First,we generate pseudo sentences according to the relation triples and produce representations using pre-trained models.Second,our approach explores semantic information from the connected relations by a graph neural network.Our model captures expanded feature information from KGs.Experimental results using three low-resource languages demonstrate that our proposed SGNN approach out performs better than state-of-the-art alignment methods on three proposed datasets and three public datasets.展开更多
文摘BACKGROUND Crossed fused renal ectopia is a rare congenital anomaly of the ascent of the kidney. This anomaly may be observed as a solitary kidney during initial evaluation. A solitary kidney must be evaluated for associated anomalies such as duplication,horseshoe kidney,or crossed renal ectopia.CASE SUMMARY An anomaly was observed in a 9-mo-old male child who was subsequently diagnosed with crossed fused renal ectopia and vesicoureteral reflux(VUR). In this condition,recurrent febrile urinary tract infection can be a serious problem,and can easily cause renal damage due to relatively short ureters and high pressure in the kidney.CONCLUSION To prevent urosepsis and preserve renal function,early diagnosis and proper management including surgical correction should be considered for the management of renal ectopia with VUR.
基金supported by the Fundamental Research Funds for the Central Universities(grant No.PTYX202449).
文摘The mortality rate of neurological disorders is increasing globally,and natural antioxidant geniposidic acid(GPA)holds great potential in the treatment of neuronal oxidative damage.Nevertheless,its inherent instability constrains its pragmatic utilization.Herein,we introduced a drug delivery system capable of protecting unstable natural active compounds from degradation.Among the various methods for preparing drug-loaded microspheres,the emulsification-solvent evaporation technique is one of the most commonly employed due to its efficiency and simplicity.Nevertheless,this method results in microspheres with heterogeneous particle sizes.To address this limitation,we developed a two-step emulsification method involving stirring and homogenization.Using the biocompatible,synthetic,biodegradable polymer polycaprolactone(PCL)as the drug delivery carrier,we prepared GPA-loaded PCL microspheres via the two-step emulsification method.The results demonstrated that the microspheres possessed uniform particle size(polydispersity index=0.12),excellent drug loading capacity(∼4.86%),sustained drug release profiles(∼68.55%in 264 h),and biocompatibility(cell viability>85%).The in vitro tests showed that the microspheres exerted antioxidant effects by scavenging reactive oxygen species(ROS)induced by oxidative stress,thereby protecting neuronal cells from oxidative damage.This work presents a promising new approach for the treatment of neuronal oxidative damage.
基金National Natural Science Foundation of China(Nos.U21B2027,61972186,61732005)Major Science and Technology Projects of Yunnan Province(Nos.202202AD080003,202203AA080004).
文摘Entity alignment(EA)is an important technique aiming to find the same real entity between two different source knowledge graphs(KGs).Current methods typically learn the embedding of entities for EA from the structure of KGs for EA.Most EA models are designed for rich-resource languages,requiring sufficient resources such as a parallel corpus and pre-trained language models.However,low-resource language KGs have received less attention,and current models demonstrate poor performance on those low-resource KGs.Recently,researchers have fused relation information and attributes for entity representations to enhance the entity alignment performance,but the relation semantics are often ignored.To address these issues,we propose a novel Semantic-aware Graph Neural Network(SGNN)for entity alignment.First,we generate pseudo sentences according to the relation triples and produce representations using pre-trained models.Second,our approach explores semantic information from the connected relations by a graph neural network.Our model captures expanded feature information from KGs.Experimental results using three low-resource languages demonstrate that our proposed SGNN approach out performs better than state-of-the-art alignment methods on three proposed datasets and three public datasets.
