In recent years,the utilization of 3D printing technology in micro and nano device manufacturing has garneredsignificant attention.Advancements in 3D printing have enabled achieving sub-micron level precision.Unlikeco...In recent years,the utilization of 3D printing technology in micro and nano device manufacturing has garneredsignificant attention.Advancements in 3D printing have enabled achieving sub-micron level precision.Unlikeconventional micro-machining techniques,3D printing offers versatility in material selection,such as polymers.3Dprinting technology has been gradually applied to the general field of microelectronic devices such as sensors,actuators and flexible electronics due to its adaptability and efficacy in microgeometric design and manufacturingprocesses.Furthermore,3D printing technology has also been instrumental in the fabrication of microfluidic devices,both through direct and indirect processes.This paper provides an overview of the evolving landscape of 3D printingtechnology,delineating the essential materials and processes involved in fabricating microelectronic and microfluidicdevices in recent times.Additionally,it synthesizes the diverse applications of these technologies across differentdomains.展开更多
Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water in...Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water interface for enhancing the acoustic transmission because of the interface instability.Previous strategies overcoming this difficulty were limited in practical usage,as well as the wide-angle and multifrequency acoustic transmission.Here,we report a simple and practical way to obtain the wide-angle and multifrequency water-air acoustic transmission with a tunable fluid-type acoustic metasurface(FAM).The FAM has a transmission enhancement of acoustic energy over 200 times,with a thickness less than the wavelength in water by three orders of magnitude.The FAM can work at an almost arbitrary water-to-air incident angle,and the operating frequencies can be flexibly adjusted.Multifrequency transmissions can be obtained with multilayer FAMs.In experiments,the FAM is demonstrated to be stable enough for practical applications and has the transmission enhancement of over 20 dB for wide frequencies.The transmission enhancement of music signal across the water-air interface was performed to demonstrate the applications in acoustic communications.The FAM will benefit various applications in hydroacoustics and oceanography.展开更多
Circulating tumor cells(CTCs)have tremendous potential to indicate disease progression and monitor therapeutic response using minimally invasive approaches.Considering the limitations of affinity strategies based on t...Circulating tumor cells(CTCs)have tremendous potential to indicate disease progression and monitor therapeutic response using minimally invasive approaches.Considering the limitations of affinity strategies based on their cost,effectiveness,and simplicity,size-based enrichment methods that involve low-cost,label-free,and relatively simple protocols have been further promoted.Nevertheless,the key challenges of these methods are clogging issues and cell aggregation,which reduce the recovery rates and purity.Inspired by the natural phenomenon that the airflow around a windmill is disturbed,in this study,a windmill-like hole array on the SU-8 membrane was designed to perturb the fluid such that cells in a fluid would be able to self-mix and that the pressure acting on cells or the membrane would be dispersed to allow a greater velocity.In addition,based on the advantages of fluid coatings,a lipid coating was used to modify the membrane surface to prevent cell aggregation and clogging of the holes.Under the optimal conditions,recovery rates of 93%and 90%were found for A549 and HeLa cells in a clinical simulation test of our platform with a CTC concentration of 20-100 cells per milliliter of blood.The white blood cell(WBC)depletion rate was 98.7%(n=15),and the CTC detection limit was less than 10 cells per milliliter of blood(n=6).Moreover,compared with conventional membrane filtration,the advantages of the proposed device for the rapid(2 mL/min)and efficient enrichment of CTCs without clogging were shown both experimentally and theoretically.Due to its advantages in the efficient,rapid,uniform,and clog-free enrichment of CTCs,our platform offers great potential for metastatic detection and therapy analyses.展开更多
Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water in...Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water interface for enhancing the acoustic transmission because of the interface instability.Previous strategies overcoming this difficulty were limited in practical usage,as well as the wide-angle and multifrequency acoustic transmission.Here,we report a simple and practical way to obtain the wide-angle and multifrequency water-air acoustic transmission with a tunable fluid-type acoustic metasurface(FAM).The FAM has a transmission enhancement of acoustic energy over 200 times,with a thickness less than the wavelength in water by three orders of magnitude.The FAM can work at an almost arbitrary water-to-air incident angle,and the operating frequencies can be flexibly adjusted.Multifrequency transmissions can be obtained with multilayer FAMs.In experiments,the FAM is demonstrated to be stable enough for practical applications and has the transmission enhancement of over 20 dB for wide frequencies.The transmission enhancement of music signal across the water-air interface was performed to demonstrate the applications in acoustic communications.The FAM will benefit various applications in hydroacoustics and oceanography.展开更多
文摘In recent years,the utilization of 3D printing technology in micro and nano device manufacturing has garneredsignificant attention.Advancements in 3D printing have enabled achieving sub-micron level precision.Unlikeconventional micro-machining techniques,3D printing offers versatility in material selection,such as polymers.3Dprinting technology has been gradually applied to the general field of microelectronic devices such as sensors,actuators and flexible electronics due to its adaptability and efficacy in microgeometric design and manufacturingprocesses.Furthermore,3D printing technology has also been instrumental in the fabrication of microfluidic devices,both through direct and indirect processes.This paper provides an overview of the evolving landscape of 3D printingtechnology,delineating the essential materials and processes involved in fabricating microelectronic and microfluidicdevices in recent times.Additionally,it synthesizes the diverse applications of these technologies across differentdomains.
基金J.Yang is thankful to the Natural Sciences and Engineering Research Council of Canada(NSERC:RGPIN-2016-05198)M.Su and Y.Song thank for the financial support from the National Key R&D Program of China(Grant no.2018YFA0208501)+6 种基金the National Natural Science Foundation of China(Grant nos.51803217,51773206,91963212,and 51961145102)Beijing Nova Program(no.Z201100006820037)the Youth Innovation Promotion Association CAS(no.2020032)the K.C.Wong Education Foundation,and Beijing National Laboratory for Molecular Sciences(no.BNLMS-CXXM-202005)S.Zhao is thankful to the National Natural Science Foundation of China(Grant no.11902171)the Postdoctoral Science Foundation(Grant no.2019M662297)C.Zhang gratefully acknowledges the financial support by the German Research Foundation(DFG,project no.ZH 15/27-1)。
文摘Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water interface for enhancing the acoustic transmission because of the interface instability.Previous strategies overcoming this difficulty were limited in practical usage,as well as the wide-angle and multifrequency acoustic transmission.Here,we report a simple and practical way to obtain the wide-angle and multifrequency water-air acoustic transmission with a tunable fluid-type acoustic metasurface(FAM).The FAM has a transmission enhancement of acoustic energy over 200 times,with a thickness less than the wavelength in water by three orders of magnitude.The FAM can work at an almost arbitrary water-to-air incident angle,and the operating frequencies can be flexibly adjusted.Multifrequency transmissions can be obtained with multilayer FAMs.In experiments,the FAM is demonstrated to be stable enough for practical applications and has the transmission enhancement of over 20 dB for wide frequencies.The transmission enhancement of music signal across the water-air interface was performed to demonstrate the applications in acoustic communications.The FAM will benefit various applications in hydroacoustics and oceanography.
基金This work was supported by the National Key R&D Program of China(No.2021YFC2500401)the National Natural Science Foundation of China(No.61874133,No.61901469,No.22005331)+4 种基金the Key Research and Development Program of Jiangsu Province(No.BE2018080,No.BE2019684,No.BE2020768)the Jihua Laboratory Foundation(No.X190181TD190)the Youth Innovation Promotion Association of CAS(No.2019322,No.2018360,No.Y201856)the Instrument Developing Project of the Chinese Academy of Sciences(No.YJKYYQ20190057,No.YJKYYQ20200046,No.ZDKYYQ20210004)the Science and Technology Development Program of Suzhou(No.SYG201907).
文摘Circulating tumor cells(CTCs)have tremendous potential to indicate disease progression and monitor therapeutic response using minimally invasive approaches.Considering the limitations of affinity strategies based on their cost,effectiveness,and simplicity,size-based enrichment methods that involve low-cost,label-free,and relatively simple protocols have been further promoted.Nevertheless,the key challenges of these methods are clogging issues and cell aggregation,which reduce the recovery rates and purity.Inspired by the natural phenomenon that the airflow around a windmill is disturbed,in this study,a windmill-like hole array on the SU-8 membrane was designed to perturb the fluid such that cells in a fluid would be able to self-mix and that the pressure acting on cells or the membrane would be dispersed to allow a greater velocity.In addition,based on the advantages of fluid coatings,a lipid coating was used to modify the membrane surface to prevent cell aggregation and clogging of the holes.Under the optimal conditions,recovery rates of 93%and 90%were found for A549 and HeLa cells in a clinical simulation test of our platform with a CTC concentration of 20-100 cells per milliliter of blood.The white blood cell(WBC)depletion rate was 98.7%(n=15),and the CTC detection limit was less than 10 cells per milliliter of blood(n=6).Moreover,compared with conventional membrane filtration,the advantages of the proposed device for the rapid(2 mL/min)and efficient enrichment of CTCs without clogging were shown both experimentally and theoretically.Due to its advantages in the efficient,rapid,uniform,and clog-free enrichment of CTCs,our platform offers great potential for metastatic detection and therapy analyses.
基金J.Yang is thankful to the Natural Sciences and Engineering Research Council of Canada(NSERC:RGPIN-2016-05198)M.Su and Y.Song thank for the financial support from the National Key R&D Program of China(Grant no.2018YFA0208501)+6 种基金the National Natural Science Foundation of China(Grant nos.51803217,51773206,91963212,and 51961145102)Beijing Nova Program(no.Z201100006820037)the Youth Innovation Promotion Association CAS(no.2020032)the K.C.Wong Education Foundation,and Beijing National Laboratory for Molecular Sciences(no.BNLMS-CXXM-202005)S.Zhao is thankful to the National Natural Science Foundation of China(Grant no.11902171)the Postdoctoral Science Foundation(Grant no.2019M662297)C.Zhang gratefully acknowledges the financial support by the German Research Foundation(DFG,project no.ZH 15/27-1)。
文摘Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water interface for enhancing the acoustic transmission because of the interface instability.Previous strategies overcoming this difficulty were limited in practical usage,as well as the wide-angle and multifrequency acoustic transmission.Here,we report a simple and practical way to obtain the wide-angle and multifrequency water-air acoustic transmission with a tunable fluid-type acoustic metasurface(FAM).The FAM has a transmission enhancement of acoustic energy over 200 times,with a thickness less than the wavelength in water by three orders of magnitude.The FAM can work at an almost arbitrary water-to-air incident angle,and the operating frequencies can be flexibly adjusted.Multifrequency transmissions can be obtained with multilayer FAMs.In experiments,the FAM is demonstrated to be stable enough for practical applications and has the transmission enhancement of over 20 dB for wide frequencies.The transmission enhancement of music signal across the water-air interface was performed to demonstrate the applications in acoustic communications.The FAM will benefit various applications in hydroacoustics and oceanography.
