Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological,cellular,and clinical levels.Rheumatologists have marked them as ...Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological,cellular,and clinical levels.Rheumatologists have marked them as two entirely distinct arthropathies.Given recent dis-coveries in disease initiation and progression,potential mechanisms,cellular signaling path-ways,and ongoing clinical therapeutics,there are now more opportunities for discovering osteoarthritis drugs.This review summarized the osteoarthritis and psoriasis arthritis signaling pathways,crosstalk between BMP,WNT,TGF-β,VEGF,TLR,and FGF signaling pathways,bio-markers,and anatomical pathologies.Through bench research,we demonstrated that regen-erative medicine is a promising alternative for treating osteoarthritis by highlighting significant scientific discoveries on entheses,multiple signaling blockers,and novel molecules such as immunoglobulin new antigen receptors targeted for potential drug evaluation.Furthermore,we offered valuable therapeutic approaches with a multidisciplinary strategy to treat patients with osteoarthritis or psoriasis arthritis in the coming future in the clinic.展开更多
This paper reviews the three-pattern decomposition of global atmospheric circulation(3P-DGAC)developed in recent years,including the decomposition model and the dynamical equations of global horizontal,meridional,and ...This paper reviews the three-pattern decomposition of global atmospheric circulation(3P-DGAC)developed in recent years,including the decomposition model and the dynamical equations of global horizontal,meridional,and zonal circulations.Compared with the traditional two-dimensional(2D)circulation decomposition method,the 3P-DGAC can effectively decompose the actual vertical vorticity into two components that are caused by the horizontal circulation and convergent/divergent movement(associated with the meridional and zonal circulations).It also decomposes the vertical velocity into the components of the meridional vertical circulation and the zonal vertical circulation,thus providing a new method to study the dynamical influences of convergent/divergent motions on the evolution of actual vertical vorticity and an accurate description of local vertical circulations.The 3P-DGAC is a three-dimensional(3D)circulation decomposition method based on the main characteristics of the actual atmospheric movements.The horizontal,meridional,and zonal circulations after the 3P-DGAC are the global generalization of Rossby waves in the middle-high latitudes and Hadley and Walker circulations in low latitudes.Therefore,the three-pattern decomposition model and its dynamical equations provide novel theoretical tools for studying complex interactions between middle-high and low latitude circulations as well as the physical mechanisms of the abnormal evolution of large-scale atmospheric circulations under the background of global warming.展开更多
文摘Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological,cellular,and clinical levels.Rheumatologists have marked them as two entirely distinct arthropathies.Given recent dis-coveries in disease initiation and progression,potential mechanisms,cellular signaling path-ways,and ongoing clinical therapeutics,there are now more opportunities for discovering osteoarthritis drugs.This review summarized the osteoarthritis and psoriasis arthritis signaling pathways,crosstalk between BMP,WNT,TGF-β,VEGF,TLR,and FGF signaling pathways,bio-markers,and anatomical pathologies.Through bench research,we demonstrated that regen-erative medicine is a promising alternative for treating osteoarthritis by highlighting significant scientific discoveries on entheses,multiple signaling blockers,and novel molecules such as immunoglobulin new antigen receptors targeted for potential drug evaluation.Furthermore,we offered valuable therapeutic approaches with a multidisciplinary strategy to treat patients with osteoarthritis or psoriasis arthritis in the coming future in the clinic.
基金supported by the National Key R&D Program of China(Grant No.2017YFC1502305)the National Natural Science Foundation of China(Grant Nos.41775069&41975076)。
文摘This paper reviews the three-pattern decomposition of global atmospheric circulation(3P-DGAC)developed in recent years,including the decomposition model and the dynamical equations of global horizontal,meridional,and zonal circulations.Compared with the traditional two-dimensional(2D)circulation decomposition method,the 3P-DGAC can effectively decompose the actual vertical vorticity into two components that are caused by the horizontal circulation and convergent/divergent movement(associated with the meridional and zonal circulations).It also decomposes the vertical velocity into the components of the meridional vertical circulation and the zonal vertical circulation,thus providing a new method to study the dynamical influences of convergent/divergent motions on the evolution of actual vertical vorticity and an accurate description of local vertical circulations.The 3P-DGAC is a three-dimensional(3D)circulation decomposition method based on the main characteristics of the actual atmospheric movements.The horizontal,meridional,and zonal circulations after the 3P-DGAC are the global generalization of Rossby waves in the middle-high latitudes and Hadley and Walker circulations in low latitudes.Therefore,the three-pattern decomposition model and its dynamical equations provide novel theoretical tools for studying complex interactions between middle-high and low latitude circulations as well as the physical mechanisms of the abnormal evolution of large-scale atmospheric circulations under the background of global warming.
