Introduction Mandibular segmental defects result in significant cosmetic and functional deficiencies.Meanwhile,the reconstruction of both the contour and function of the mandible is a challenging task.At present,autol...Introduction Mandibular segmental defects result in significant cosmetic and functional deficiencies.Meanwhile,the reconstruction of both the contour and function of the mandible is a challenging task.At present,autologous vascularized fibula transplantation is the most common method to reconstruct a mandible with long-span defects[1].展开更多
For effective anterior cruciate ligament(ACL)reconstruction,an interference screw(IFS)is employed to force transplantation of the ligament into the bone tunnel.In this study,IFSs were successfully designed and pre-par...For effective anterior cruciate ligament(ACL)reconstruction,an interference screw(IFS)is employed to force transplantation of the ligament into the bone tunnel.In this study,IFSs were successfully designed and pre-pared,and the top tooth width,thread depth,and drive structure were parameterized with a forming accuracy of 80.0±21.1μm using SLA-3D printing technology.To improve the initial stability of ACL reconstruction,a biomechanical model was established,and the results were optimized through insertion torque and tensile test-ing.Consequently,the IFS with the top tooth width of 0.4 mm,thread depth of 0.8 mm,and hexagon drive,matching with theΦ8 mm bone tunnel,exhibits the best mechanical properties(maximum insertion torque of 1.064±0.117 N m,ultimate load of 446.126±37.632 N,stiffness of 66.33±27.48 N/mm).Additionally,the ZrO_(2)/PDA/RGD/Zn^(2+)bioactive coating was found to significantly improve the surface bioactivity of zirconia IFS.In conclusion,this study has significant implications for ACL reconstruction.展开更多
Bioactive coating of ceramic scaffolds is an effective way to ameliorate osseointegration and attenuate implant-induced inflammatory responses,which should be biocompatible and possess suitable mechani-cal properties ...Bioactive coating of ceramic scaffolds is an effective way to ameliorate osseointegration and attenuate implant-induced inflammatory responses,which should be biocompatible and possess suitable mechani-cal properties to regulate cell adhesion and migration.In this study,a poly(ethylene glycol)diacry-late/tricalcium phosphate(PEGDA/TCP)ceramic scaffold was prepared using SLA-3D printing,and its com-pressive strength was 8.9±1.0 MPa.Chitosan(Chi)and chondroitin sulfate(CS)were assembled on the sur-face of the PEGDA/TCP scaffolds and crosslinked with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide(EDC/NHS).Scanning electron microscope(SEM),Fourier transform infrared(FTIR),and laser scanning microscope were used to evaluate the surface modification of the PEGDA/TCP scaffolds.Cellu-lar tests showed that polyelectrolyte multilayers(PEMs)promoted cell adhesion and proliferation of osteoblasts relative to unmodified scaffolds.Furthermore,it can be demonstrated that the SLA-3D printed TCP scaffolds could meet the compressive requirements of trabecular bones,and the bioactivity of the bone scaffolds could be effectively improved by combining them with Chi/CS PEM.展开更多
基金supported in part by grants from the Clinical Research for Crossing Item of Shandong University(No.2020SDUCRCB001)the Shandong Provincial Natural Science Foundation(No.ZR2020MH180)+1 种基金the Rongxiang Regeneration Medicine Fund of Shandong University(No.2019SDRX-11)the Science and Technology Development Plan of Jinan City(No.201805041)。
文摘Introduction Mandibular segmental defects result in significant cosmetic and functional deficiencies.Meanwhile,the reconstruction of both the contour and function of the mandible is a challenging task.At present,autologous vascularized fibula transplantation is the most common method to reconstruct a mandible with long-span defects[1].
基金supported by National Key Research and Development Program of China(Grant No.2022YFB4601400)Major Basic Research Projects of Shandong Province of China(Grant No.ZR2023ZD24).
文摘For effective anterior cruciate ligament(ACL)reconstruction,an interference screw(IFS)is employed to force transplantation of the ligament into the bone tunnel.In this study,IFSs were successfully designed and pre-pared,and the top tooth width,thread depth,and drive structure were parameterized with a forming accuracy of 80.0±21.1μm using SLA-3D printing technology.To improve the initial stability of ACL reconstruction,a biomechanical model was established,and the results were optimized through insertion torque and tensile test-ing.Consequently,the IFS with the top tooth width of 0.4 mm,thread depth of 0.8 mm,and hexagon drive,matching with theΦ8 mm bone tunnel,exhibits the best mechanical properties(maximum insertion torque of 1.064±0.117 N m,ultimate load of 446.126±37.632 N,stiffness of 66.33±27.48 N/mm).Additionally,the ZrO_(2)/PDA/RGD/Zn^(2+)bioactive coating was found to significantly improve the surface bioactivity of zirconia IFS.In conclusion,this study has significant implications for ACL reconstruction.
基金supported by National Key Research and Development Project of China(Grant.No.2022YFB4601403)National Natural Science Foundation of China(Grant.No.52175336).
文摘Bioactive coating of ceramic scaffolds is an effective way to ameliorate osseointegration and attenuate implant-induced inflammatory responses,which should be biocompatible and possess suitable mechani-cal properties to regulate cell adhesion and migration.In this study,a poly(ethylene glycol)diacry-late/tricalcium phosphate(PEGDA/TCP)ceramic scaffold was prepared using SLA-3D printing,and its com-pressive strength was 8.9±1.0 MPa.Chitosan(Chi)and chondroitin sulfate(CS)were assembled on the sur-face of the PEGDA/TCP scaffolds and crosslinked with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide(EDC/NHS).Scanning electron microscope(SEM),Fourier transform infrared(FTIR),and laser scanning microscope were used to evaluate the surface modification of the PEGDA/TCP scaffolds.Cellu-lar tests showed that polyelectrolyte multilayers(PEMs)promoted cell adhesion and proliferation of osteoblasts relative to unmodified scaffolds.Furthermore,it can be demonstrated that the SLA-3D printed TCP scaffolds could meet the compressive requirements of trabecular bones,and the bioactivity of the bone scaffolds could be effectively improved by combining them with Chi/CS PEM.
