脑卒中是一种高发病率的急性脑血管疾病,常伴随肢体运动功能障碍的后遗症。经颅磁刺激(transcranial magnetic stimulation,TMS)作为一种非侵入式的脑刺激方法,大量临床实验证明其对卒中后运动功能障碍有明显的康复作用,但背后的神经康...脑卒中是一种高发病率的急性脑血管疾病,常伴随肢体运动功能障碍的后遗症。经颅磁刺激(transcranial magnetic stimulation,TMS)作为一种非侵入式的脑刺激方法,大量临床实验证明其对卒中后运动功能障碍有明显的康复作用,但背后的神经康复机制仍不明确,需要更多的研究和探索。本文从TMS在运动功能评估、干预和康复预测模型的建立等方面入手,梳理、总结了近年来TMS在脑卒中运动康复领域的发展进程和研究现状,以期为后续研究提供参考。展开更多
Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their interfaces.This competition arises from the interplay between Coope...Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their interfaces.This competition arises from the interplay between Cooper pairs and ferromagnetic exchange interactions.The proximity effects between transition metal nitrides(TMNs)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM interfaces.We fabricated heterostructures comprising SC titanium nitride(TiN)and FM iron nitride(Fe_(3)N)with precise chemical compositions and atomically well-defined interfaces.The magnetoresistance of Fe_(3)N/TiN heterostructures shows a distinct magnetic anisotropy and strongly depends on the external perturbations.Moreover,the superconducting transition temperatureT_(C) and critical field of TiN experience notable suppression when proximity to Fe_(3)N.We observe the intriguing competition of interfacial spin orientations near𝑇T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the interplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices.展开更多
目的分析前期合成的5个二氢苯并呋喃醇类化合物的抗衣原体活性及其作用机制,为寻找新型抗衣原体活性物质提供参考。方法通过免疫荧光染色和测定感染性子代滴度的方法,评估化合物对沙眼衣原体L2(Chlamydia trachomatis L2,C t L2)和肺炎...目的分析前期合成的5个二氢苯并呋喃醇类化合物的抗衣原体活性及其作用机制,为寻找新型抗衣原体活性物质提供参考。方法通过免疫荧光染色和测定感染性子代滴度的方法,评估化合物对沙眼衣原体L2(Chlamydia trachomatis L2,C t L2)和肺炎衣原体AR39(Chlamydia pneumonia,Cpn AR39)的抑制作用,并计算子代滴度的半数抑制浓度(IC_(50))值。通过Evans Blue细胞形态染色、4',6-二脒基-2-苯基吲哚(DAPI)细胞核染色和增殖细胞计数,评估化合物对宿主细胞活力的影响。通过细胞和衣原体预处理实验,检测化合物对衣原体感染过程的影响;通过后加药和撤药实验,检测化合物对衣原体增殖过程的影响。结果5个化合物均能浓度依赖性抑制C t L2和Cpn AR39生长,其抑制感染性子代滴度的IC_(50)均在5μmol·L^(-1)附近,同时在16μmol·L^(^(-1))时没有明显的细胞毒性。5个化合物均对衣原体感染过程没有影响;化合物1,3,5对衣原体的增殖全过程均具有较强的抑制作用,化合物2,4的抑制作用较弱且需要全过程的持续作用。结论5个二氢苯并呋喃醇类化合物均具有广谱抗衣原体活性,其作用机制与衣原体的感染过程无关,主要作用于衣原体的增殖过程。展开更多
文摘脑卒中是一种高发病率的急性脑血管疾病,常伴随肢体运动功能障碍的后遗症。经颅磁刺激(transcranial magnetic stimulation,TMS)作为一种非侵入式的脑刺激方法,大量临床实验证明其对卒中后运动功能障碍有明显的康复作用,但背后的神经康复机制仍不明确,需要更多的研究和探索。本文从TMS在运动功能评估、干预和康复预测模型的建立等方面入手,梳理、总结了近年来TMS在脑卒中运动康复领域的发展进程和研究现状,以期为后续研究提供参考。
基金supported by the National Key Research and Development Program of China(Grant Nos.2020YFA0309100 and 2019YFA0308500)the National Natural Science Foundation of China(Grant Nos.U22A20263,52250308,and 11974390)+3 种基金the CAS Project for Young Scientists in Basic Research(Grant No.YSBR-084)(E.J.G.)Special Research Assistant(Q.J.),the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant No.XDB33030200)(K.J.)the China Postdoctoral Science Foundation(Grant No.2022M723353)the Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology(Grant No.HTCSNS-DG-CD-0080/2021).
文摘Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their interfaces.This competition arises from the interplay between Cooper pairs and ferromagnetic exchange interactions.The proximity effects between transition metal nitrides(TMNs)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM interfaces.We fabricated heterostructures comprising SC titanium nitride(TiN)and FM iron nitride(Fe_(3)N)with precise chemical compositions and atomically well-defined interfaces.The magnetoresistance of Fe_(3)N/TiN heterostructures shows a distinct magnetic anisotropy and strongly depends on the external perturbations.Moreover,the superconducting transition temperatureT_(C) and critical field of TiN experience notable suppression when proximity to Fe_(3)N.We observe the intriguing competition of interfacial spin orientations near𝑇T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the interplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices.
