Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced B...Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving CWM.Methods:This trial involved four centers in China and was conducted from September 2016 to March 2020.Patients received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable toxicity.Progression-free survival(PFS)was the primary endpoint.Results:We evaluated 26 patients for efficacy.The median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,respectively.The objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine therapy.PFS improved significantly in patients with HR+status who did not receive chest wall radiotherapy.However,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment.展开更多
The triple cation mixed perovskites(Cs FAMA)are known as one of the most efficient candidates for perovskite solar cells(PSCs).It is found that the power conversion efficiency(PCE)of triple-cation based devices would ...The triple cation mixed perovskites(Cs FAMA)are known as one of the most efficient candidates for perovskite solar cells(PSCs).It is found that the power conversion efficiency(PCE)of triple-cation based devices would increase with the test time extending,and the maximum efficiency is normally obtained after several days aging storage.Here,the relationship between enhanced device performance,excess PbI_(2)and its evolution in triple cation perovskite films of initial days was systematically explored.The Cs FAMA-PSCs are prepared by two-step methods under two environmental conditions,including in the glove box and the ambient air(30%humidity).After 7 days testing,the maximum PCE of PSCs under two conditions dramatically increased 12.4%and 12.2%,reached 21.68%and 21.89%,respectively.At initial days,the XRD peak intensities of perovskite phase gradually decreased and those corresponding to PbI_(2)increased.Along with time-resolved photoluminescence(TRPL)and kelvin probe force microscopy(KPFM),it was found that the defects were passivated with the evolution of PbI_(2).This work reveals the excess PbI_(2)and its evolution in perovskite film,which can further supplement the understanding of PbI_(2)defect passivation.展开更多
Multi-channel can be used to provide higher transmission ability to the bandwidth-intensive and delay-sensitive real-time streams. However, traditional channel capacity theories and coding schemes are seldom designed ...Multi-channel can be used to provide higher transmission ability to the bandwidth-intensive and delay-sensitive real-time streams. However, traditional channel capacity theories and coding schemes are seldom designed for the real-time streams with strict delay constraint, especially in multi-channel context. This paper considers a real-time stream system, where real-time messages with different importance should be transmitted through several packet erasure channels, and be decoded by the receiver within a fixed delay. Based on window erasure channels and i.i.d.(identically and independently distributed) erasure channels, we derive the Multi-channel Real-time Stream Transmission(MRST) capacity models for Symmetric Real-time(SR) streams and Asymmetric Real-time(AR) streams respectively. Moreover, for window erasures, a Maximum Equilibrium Intra-session Code(MEIC) is presented for SR and AR streams, and is shown able to asymptotically achieve the theoretical MRST capacity. For i.i.d. erasures, we propose an Adaptive Maximum Equilibrium Intra-session Code(AMEIC), and then prove AMEIC can closely approach the MRST transmission capacity. Finally, the performances of the proposed codes are verified by simulations.展开更多
The central environmental protection inspection (CEPI) system in China is a significant institutional innova‐tion in national environmental governance. The CEPI applies a joint supervision strategy to address salient...The central environmental protection inspection (CEPI) system in China is a significant institutional innova‐tion in national environmental governance. The CEPI applies a joint supervision strategy to address salient en‐vironmental issues and strictly enforce the environmental responsibilities of local governments. This study col‐lects and organizes CEPI inspection reports covering three stages that encompass the first round, the “look back”, and the second round, applying text analysis to obtain sample data and conduct statistical quantifica‐tion of word frequency in inspection reports and identify notable changes. The study explores the allocation of CEPI attention between policy objectives and the intensity of policy instruments. We determine that in con‐junction with public opinion feedback, the CEPI conducts targeted inspections and focuses more on pollutant governance, which has high severity and can be addressed quickly. The CEPI fills the gap of normalized gover‐nance with a campaign-style governance approach. Regarding the intensity of policy measures, the CEPI pri‐marily uses economic incentive policy instruments, supplemented by command-and-control and public guid‐ance approaches, advancing the sustainability of regulatory effectiveness through economic, social, and politi‐cal activities. This study extends knowledge in the field of CEPI policy priorities and implementation, expand‐ing the literature related to outcomes of environmental policy in developing countries.展开更多
The core of hepatic fibrosis is the activation of hepatic stellate cells.Through the lipopolysaccharide/TLR4/MyD88/NF-κB signal transduction pathway,the inflammatory response in the liver is directly enhanced,and the...The core of hepatic fibrosis is the activation of hepatic stellate cells.Through the lipopolysaccharide/TLR4/MyD88/NF-κB signal transduction pathway,the inflammatory response in the liver is directly enhanced,and then returns to promote the activation of hepatic stellate cells.And TLR4/MyD88/NF-κB signaling pathway can directly regulate the activation of NLRP3 inflammasome and is an important pathway for activating hepatic stellate cells.TLR4/MyD88/NF-κB/NLRP3 inflammasome pathway is regulated by upstream microRNAs.These miRNAs can significantly regulate the inflammatory response of the liver and the activation behavior of hepatic stellate cells,affecting the formation of liver fibrosis.Previous studies have found that the active ingredient of Guangxi specialty ethnic medicine,plumbagin,has a definite anti liver fibrosis effect,but its mechanism of action is not clear.This paper provides a review of the research progress on the above issues,and further research ideas have been derived from this,stating that"the anti liver fibrosis effect of plumbagin is achieved by regulating miRNA/TLR4/MyD88/NF-κB inflammatory pathway and activating downstream NLRP3 inflammasome".展开更多
Liver fibrosis is a necessary stage in the progression of chronic liver disease to cirrhosis.So far,no satisfactory drugs have been found to intervene in liver fibrosis.Liver microcirculation disorders are one of the ...Liver fibrosis is a necessary stage in the progression of chronic liver disease to cirrhosis.So far,no satisfactory drugs have been found to intervene in liver fibrosis.Liver microcirculation disorders are one of the important pathogenesis of chronic liver disease,and hepatic sinusoidal endothelial cells(HSECs)are the main cells that constitute the liver microcirculation barrier.In clinical practice,W-P bodies have been detected in HSECs of most patients with liver fibrosis.W-P bodies serve as a site for the synthesis and storage of vW factors,ET-1 and other cytokines that promote liver fibrosis.They can disrupt the structure and function of HSECs,cause liver microcirculation disorders,and exacerbate the progression of liver fibrosis.Previous studies have found that the Guangxi specialty ethnic medicine,C.kwangsiensis S.G.Lee et C.F.Liang,has definite effects in promoting blood circulation,resolving blood stasis,and resisting liver fibrosis.Based on this,a further research idea has been derived,stating that the blood circulation-promoting,blood stasis-resolving,and anti-liver fibrosis effects of C.kwangsiensis are produced by affecting the formation of W-P bodies,the synthesis and storage of contents in W-P bodies,and intervening in their exocytosis capacity.展开更多
Understanding of genetic diversity among sengon(paraseranthes falcataria)is very important for selection and improvement of its breeding.This study determined the genetic diversity among the previous preferred 36 clon...Understanding of genetic diversity among sengon(paraseranthes falcataria)is very important for selection and improvement of its breeding.This study determined the genetic diversity among the previous preferred 36 clones which selected from 6 districts.Of 8 Paraserianthes falcataria SSR markers and 76 SSR markers selected from Acacia species,only 13 markers showed polymorphic pattern and amplified a total of 61 alleles.The polymorphism information content(PIC)value at a locus ranged from 0.099 to 0.799.The average number of alleles per locus ranged from 2 to 9 with an average of 4.92.Six SSR markers were highly informative and had PIC values above 0.60.The results demonstrated that the SSR DNA-markers developed from Acacia species could be successfully used to differentiate genotypes of P.falcataria.Cluster analysis of SSR data using UPGMA separated 36 clones into 2 divergent clusters at similarity coefficient of 0.56.The diverse clones identified in the study would be useful for developing intraspecific hybrids to exploit hybrid vigour and for commercial cultivation to broaden genetic base.Meanwhile,the DNA fingerprints obtained for each clone can be used for identification of breeding population and accelerate research of P.falcataria breeding.展开更多
Hydrogen,meeting the requirements of sustainable development,is regarded as the ultimate energy in the 21st century.Due to the inexhaustible and feasible of solar energy,solar water splitting is an immensely promising...Hydrogen,meeting the requirements of sustainable development,is regarded as the ultimate energy in the 21st century.Due to the inexhaustible and feasible of solar energy,solar water splitting is an immensely promising strategy for environmental-friendly hydrogen production,which not only overcomes the fluctuation and intermittency but also contributes to achieving the mission of global“Carbon Neutrality and Carbon Peaking”.However,there is still a lack of a comprehensive overview focusing on hydrogen progress with a discussion of development from solar energy to solar cells.Herein,we emphasize several solar-to-hydrogen pathways from the basic concepts and principles and focus on photovoltaic-electrolysis and photoelectrochemical/photovoltaic systems,which have achieved solar-to-hydrogen(STH)efficiency of over 10%and have extremely promising for large-scale application.In addition,we summarize the challenges and opportunities faced in this field including configuration design,electrode materials,and performance evaluation.Finally,perspectives on the potential commercial application and scientific research for the further development of solar-to-hydrogen are analyzed and presented.展开更多
文摘Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving CWM.Methods:This trial involved four centers in China and was conducted from September 2016 to March 2020.Patients received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable toxicity.Progression-free survival(PFS)was the primary endpoint.Results:We evaluated 26 patients for efficacy.The median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,respectively.The objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine therapy.PFS improved significantly in patients with HR+status who did not receive chest wall radiotherapy.However,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment.
基金the financial support from the Young Scholars Development Fund of SWPU(201699010017)the Sichuan Science and Technology Program(2018JY0015)+1 种基金the National Nature Science Foundation of China(61774022)the 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant(2020LKSFG01A)。
文摘The triple cation mixed perovskites(Cs FAMA)are known as one of the most efficient candidates for perovskite solar cells(PSCs).It is found that the power conversion efficiency(PCE)of triple-cation based devices would increase with the test time extending,and the maximum efficiency is normally obtained after several days aging storage.Here,the relationship between enhanced device performance,excess PbI_(2)and its evolution in triple cation perovskite films of initial days was systematically explored.The Cs FAMA-PSCs are prepared by two-step methods under two environmental conditions,including in the glove box and the ambient air(30%humidity).After 7 days testing,the maximum PCE of PSCs under two conditions dramatically increased 12.4%and 12.2%,reached 21.68%and 21.89%,respectively.At initial days,the XRD peak intensities of perovskite phase gradually decreased and those corresponding to PbI_(2)increased.Along with time-resolved photoluminescence(TRPL)and kelvin probe force microscopy(KPFM),it was found that the defects were passivated with the evolution of PbI_(2).This work reveals the excess PbI_(2)and its evolution in perovskite film,which can further supplement the understanding of PbI_(2)defect passivation.
基金supported by National Key Technology Research and Development Program of China under Grant No.2015BAH08F01the joint fund of the Ministry of Education of People's Republic of China and China Mobile Communications Corporation under Grant No.MCM20160304
文摘Multi-channel can be used to provide higher transmission ability to the bandwidth-intensive and delay-sensitive real-time streams. However, traditional channel capacity theories and coding schemes are seldom designed for the real-time streams with strict delay constraint, especially in multi-channel context. This paper considers a real-time stream system, where real-time messages with different importance should be transmitted through several packet erasure channels, and be decoded by the receiver within a fixed delay. Based on window erasure channels and i.i.d.(identically and independently distributed) erasure channels, we derive the Multi-channel Real-time Stream Transmission(MRST) capacity models for Symmetric Real-time(SR) streams and Asymmetric Real-time(AR) streams respectively. Moreover, for window erasures, a Maximum Equilibrium Intra-session Code(MEIC) is presented for SR and AR streams, and is shown able to asymptotically achieve the theoretical MRST capacity. For i.i.d. erasures, we propose an Adaptive Maximum Equilibrium Intra-session Code(AMEIC), and then prove AMEIC can closely approach the MRST transmission capacity. Finally, the performances of the proposed codes are verified by simulations.
基金supported by National Natural Science Foundation of China[Grant No.72304124]Spring Sunshine Collaborative Re‐search Project of the Ministry of Education in China[Grant No.202201660]+2 种基金Youth Project of Gansu Natural Science Foundation[Grant No.22JR5RA542]General Project of Gansu Philosophy and Social Science Foundation[Grant No.2022YB014]Fundamental Re‐search Funds for the Central Universities[Grant No.2023lzdxjb‐kyzx008].
文摘The central environmental protection inspection (CEPI) system in China is a significant institutional innova‐tion in national environmental governance. The CEPI applies a joint supervision strategy to address salient en‐vironmental issues and strictly enforce the environmental responsibilities of local governments. This study col‐lects and organizes CEPI inspection reports covering three stages that encompass the first round, the “look back”, and the second round, applying text analysis to obtain sample data and conduct statistical quantifica‐tion of word frequency in inspection reports and identify notable changes. The study explores the allocation of CEPI attention between policy objectives and the intensity of policy instruments. We determine that in con‐junction with public opinion feedback, the CEPI conducts targeted inspections and focuses more on pollutant governance, which has high severity and can be addressed quickly. The CEPI fills the gap of normalized gover‐nance with a campaign-style governance approach. Regarding the intensity of policy measures, the CEPI pri‐marily uses economic incentive policy instruments, supplemented by command-and-control and public guid‐ance approaches, advancing the sustainability of regulatory effectiveness through economic, social, and politi‐cal activities. This study extends knowledge in the field of CEPI policy priorities and implementation, expand‐ing the literature related to outcomes of environmental policy in developing countries.
基金Supported by the National Natural Science Foundation of China(81960761,82060825)Guangxi Natural Science Foundation(2020GXNSFAA297119)+3 种基金Traditional Chinese Medicine,a First-class Discipline in Guangxi(GUIJIAOKEYAN[2022]1)Guangxi Famous Traditional Chinese Medicine Linjiang Inheritance Studio(GUIZHONGYIYAOKEJIAOFA[2021]6)Guangxi Graduate Education Innovation Program Project(YCSY2023004,YCSZ2022002)Key Laboratory Project of Integrated Traditional Chinese and Western Medicine Translational Medicine of Guangxi High-incidence Infectious Diseases.
文摘The core of hepatic fibrosis is the activation of hepatic stellate cells.Through the lipopolysaccharide/TLR4/MyD88/NF-κB signal transduction pathway,the inflammatory response in the liver is directly enhanced,and then returns to promote the activation of hepatic stellate cells.And TLR4/MyD88/NF-κB signaling pathway can directly regulate the activation of NLRP3 inflammasome and is an important pathway for activating hepatic stellate cells.TLR4/MyD88/NF-κB/NLRP3 inflammasome pathway is regulated by upstream microRNAs.These miRNAs can significantly regulate the inflammatory response of the liver and the activation behavior of hepatic stellate cells,affecting the formation of liver fibrosis.Previous studies have found that the active ingredient of Guangxi specialty ethnic medicine,plumbagin,has a definite anti liver fibrosis effect,but its mechanism of action is not clear.This paper provides a review of the research progress on the above issues,and further research ideas have been derived from this,stating that"the anti liver fibrosis effect of plumbagin is achieved by regulating miRNA/TLR4/MyD88/NF-κB inflammatory pathway and activating downstream NLRP3 inflammasome".
基金Supported by National Natural Science Foundation of China(81960761,82060825)Natural Science Foundation of Guangxi(2020GXNSFAA297119)+2 种基金First-class Discipline in Guangxi:Traditional Chinese Medicine(GJKY[2022]1)Guangxi Famous Traditional Chinese Medicine Doctor Linjiang Inheritance Studio(GZYYKJF[2021]6)Guangxi Graduate Education Innovation Program(YCSY2023004,YCSZ2022002).
文摘Liver fibrosis is a necessary stage in the progression of chronic liver disease to cirrhosis.So far,no satisfactory drugs have been found to intervene in liver fibrosis.Liver microcirculation disorders are one of the important pathogenesis of chronic liver disease,and hepatic sinusoidal endothelial cells(HSECs)are the main cells that constitute the liver microcirculation barrier.In clinical practice,W-P bodies have been detected in HSECs of most patients with liver fibrosis.W-P bodies serve as a site for the synthesis and storage of vW factors,ET-1 and other cytokines that promote liver fibrosis.They can disrupt the structure and function of HSECs,cause liver microcirculation disorders,and exacerbate the progression of liver fibrosis.Previous studies have found that the Guangxi specialty ethnic medicine,C.kwangsiensis S.G.Lee et C.F.Liang,has definite effects in promoting blood circulation,resolving blood stasis,and resisting liver fibrosis.Based on this,a further research idea has been derived,stating that the blood circulation-promoting,blood stasis-resolving,and anti-liver fibrosis effects of C.kwangsiensis are produced by affecting the formation of W-P bodies,the synthesis and storage of contents in W-P bodies,and intervening in their exocytosis capacity.
文摘Understanding of genetic diversity among sengon(paraseranthes falcataria)is very important for selection and improvement of its breeding.This study determined the genetic diversity among the previous preferred 36 clones which selected from 6 districts.Of 8 Paraserianthes falcataria SSR markers and 76 SSR markers selected from Acacia species,only 13 markers showed polymorphic pattern and amplified a total of 61 alleles.The polymorphism information content(PIC)value at a locus ranged from 0.099 to 0.799.The average number of alleles per locus ranged from 2 to 9 with an average of 4.92.Six SSR markers were highly informative and had PIC values above 0.60.The results demonstrated that the SSR DNA-markers developed from Acacia species could be successfully used to differentiate genotypes of P.falcataria.Cluster analysis of SSR data using UPGMA separated 36 clones into 2 divergent clusters at similarity coefficient of 0.56.The diverse clones identified in the study would be useful for developing intraspecific hybrids to exploit hybrid vigour and for commercial cultivation to broaden genetic base.Meanwhile,the DNA fingerprints obtained for each clone can be used for identification of breeding population and accelerate research of P.falcataria breeding.
基金financial support from the Sichuan Science and Technology Program(No.2022NSFSC0226)Open Fund(PLN2021–17)of State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation(Southwest Petroleum University)Science and Technology Project of Southwest Petroleum University(No.2021JBGS08).
文摘Hydrogen,meeting the requirements of sustainable development,is regarded as the ultimate energy in the 21st century.Due to the inexhaustible and feasible of solar energy,solar water splitting is an immensely promising strategy for environmental-friendly hydrogen production,which not only overcomes the fluctuation and intermittency but also contributes to achieving the mission of global“Carbon Neutrality and Carbon Peaking”.However,there is still a lack of a comprehensive overview focusing on hydrogen progress with a discussion of development from solar energy to solar cells.Herein,we emphasize several solar-to-hydrogen pathways from the basic concepts and principles and focus on photovoltaic-electrolysis and photoelectrochemical/photovoltaic systems,which have achieved solar-to-hydrogen(STH)efficiency of over 10%and have extremely promising for large-scale application.In addition,we summarize the challenges and opportunities faced in this field including configuration design,electrode materials,and performance evaluation.Finally,perspectives on the potential commercial application and scientific research for the further development of solar-to-hydrogen are analyzed and presented.
基金supported by the Open Fund of the State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation(Southwest Petroleum University,PLN2021-17)the Science and Technology Project of Southwest Petroleum University(2021JBGS08)Sichuan Science and Technology Program(2022YFSY0040)。
