In order to find out the main nutrient content of tobacco planting soil and the changing characteristics of tobacco quality in Linli County,the sampling survey data of tobacco planting soil samples in Linli in 2000 an...In order to find out the main nutrient content of tobacco planting soil and the changing characteristics of tobacco quality in Linli County,the sampling survey data of tobacco planting soil samples in Linli in 2000 and 2015,and the main chemical components,appearances and sensory qualities and physical indexes of B2F and C3F tobacco leaves from 2000 to 2015 were comprehensively analyzed and evaluated.The results showed that:the available phosphorus increased by 6.10%per year and the pH value of tobacco planting soil increased in a small range year by year,the organic matter content decreased year by year,the alkali hydrolyzable nitrogen showed a downward trend,and the water-soluble chlorine showed a rapid downward trend;the soil fertility index(SFI)was at the"high"level;in 2000—2015,the quality of tobacco leaf was relatively stable and the quality was good.In Linli tobacco planting area,the application of nitrogen control,phosphorus reduction and chlorine supplement and increase of organic matter could help us achieve the goal of high quality and efficiency of tobacco production.展开更多
Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor prognosis.Chemotherapy is the mainstay of treatment for osteosarcoma.Currently...Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor prognosis.Chemotherapy is the mainstay of treatment for osteosarcoma.Currently,there are no molecular targeted drugs approved for osteosarcoma treatment,particularly effective drugs for osteosarcoma with pulmonary metastases.It has been reported that fibroblast activation protein alpha(FAPa)is upregulated in osteosarcoma and critically associated with osteosarcoma progression and metastasis,demonstrating that FAPa-targeted agents might be a promising therapeutic strategy for osteosarcoma.In the present study,we reported that the FAPa-activated vinblastine prodrug Z-GP-DAVLBH exhibited potent antitumor activities against FAPa-positive osteosarcoma cells in vitro and in vivo.Z-GP-DAVLBH inhibited the growth and induced the apoptosis of osteosarcoma cells.Importantly,it also decreased the migration and invasion capacities and reversed epithelial-mesenchymal transition(EMT)of osteosarcoma cells in vitro and suppressed pulmonary metastasis of osteosarcoma xenografts in vivo.Mechanistically,Z-GP-DAVLBH suppressed the AXL/AKT/GSK-3β/β-catenin pathway,leading to inhibition of the growth and metastatic spread of osteosarcoma cells.These findings demonstrate that Z-GP-DAVLBH is a promising agent for the treatment of FAPa-positive osteosarcoma,particularly osteosarcoma with pulmonary metastases.展开更多
We deeply regret that the representative image of invaded 143B cells treated with Z-GP-DAVLBH + AXL-KD in the lower panel of Fig. 6C was incorrect due to inadvertent mistake of copying and pasting in the process of as...We deeply regret that the representative image of invaded 143B cells treated with Z-GP-DAVLBH + AXL-KD in the lower panel of Fig. 6C was incorrect due to inadvertent mistake of copying and pasting in the process of assembling figures with Adobe Illustrator software. The image has now been corrected, and the quantification of cell invasion in Fig. 6C remains correct. The corrected version of Fig. 6C has been provided below, and the change did not affect the results and conclusions of this study. We have provided the original data of this figure to Editorial Office, and the Editorial Office or the corresponding authors can be contacted for original data access.展开更多
文摘In order to find out the main nutrient content of tobacco planting soil and the changing characteristics of tobacco quality in Linli County,the sampling survey data of tobacco planting soil samples in Linli in 2000 and 2015,and the main chemical components,appearances and sensory qualities and physical indexes of B2F and C3F tobacco leaves from 2000 to 2015 were comprehensively analyzed and evaluated.The results showed that:the available phosphorus increased by 6.10%per year and the pH value of tobacco planting soil increased in a small range year by year,the organic matter content decreased year by year,the alkali hydrolyzable nitrogen showed a downward trend,and the water-soluble chlorine showed a rapid downward trend;the soil fertility index(SFI)was at the"high"level;in 2000—2015,the quality of tobacco leaf was relatively stable and the quality was good.In Linli tobacco planting area,the application of nitrogen control,phosphorus reduction and chlorine supplement and increase of organic matter could help us achieve the goal of high quality and efficiency of tobacco production.
基金supported by National Natural Science Foundation of China(grant numbers:82003796,81803566,81973340 and 81630095)Local Innovative and Research Teams Project of the Guangdong Pearl River Talents Program(grant number:2017BT01Y036,China)+5 种基金National High-level Personnel of the Special Support Program(DM Zhang,China)National Science and Technology Major Project(grant number:2018ZX09711001008-008,China)Key-Area Research and Development Program of Guangdong Province(grant number:2020B1111110004,China)Natural Science Foundation of Guangdong Province(grant number:2019A1515010144,China)Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy(grant number:2020B1212060076,China)Special Funds for the Cultivation of Guangdong College Students’Scientific and Technological Innovation(grant number:pdjh2021a0052,China)。
文摘Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor prognosis.Chemotherapy is the mainstay of treatment for osteosarcoma.Currently,there are no molecular targeted drugs approved for osteosarcoma treatment,particularly effective drugs for osteosarcoma with pulmonary metastases.It has been reported that fibroblast activation protein alpha(FAPa)is upregulated in osteosarcoma and critically associated with osteosarcoma progression and metastasis,demonstrating that FAPa-targeted agents might be a promising therapeutic strategy for osteosarcoma.In the present study,we reported that the FAPa-activated vinblastine prodrug Z-GP-DAVLBH exhibited potent antitumor activities against FAPa-positive osteosarcoma cells in vitro and in vivo.Z-GP-DAVLBH inhibited the growth and induced the apoptosis of osteosarcoma cells.Importantly,it also decreased the migration and invasion capacities and reversed epithelial-mesenchymal transition(EMT)of osteosarcoma cells in vitro and suppressed pulmonary metastasis of osteosarcoma xenografts in vivo.Mechanistically,Z-GP-DAVLBH suppressed the AXL/AKT/GSK-3β/β-catenin pathway,leading to inhibition of the growth and metastatic spread of osteosarcoma cells.These findings demonstrate that Z-GP-DAVLBH is a promising agent for the treatment of FAPa-positive osteosarcoma,particularly osteosarcoma with pulmonary metastases.
文摘We deeply regret that the representative image of invaded 143B cells treated with Z-GP-DAVLBH + AXL-KD in the lower panel of Fig. 6C was incorrect due to inadvertent mistake of copying and pasting in the process of assembling figures with Adobe Illustrator software. The image has now been corrected, and the quantification of cell invasion in Fig. 6C remains correct. The corrected version of Fig. 6C has been provided below, and the change did not affect the results and conclusions of this study. We have provided the original data of this figure to Editorial Office, and the Editorial Office or the corresponding authors can be contacted for original data access.
