Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos exposure.The ban on asbestos has helped to lower the incidence,but in ...Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos exposure.The ban on asbestos has helped to lower the incidence,but in developing countries like India,it is expected to rise.It has an extended latency period usually progressing over decades and presents with nonspecific symptoms.It has a median survival ranging between 10-22 months.The diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography(CT),magnetic resonance imaging,or positron emission tomography-CT,with the last two predicting the resectability of the tumor better than CT alone.A pleural biopsy along with an array of immunohistochemical markers,such as p16,BRCA1 associated protein 1,and claudin-4,are required for a definitive diagnosis.Several genetic alterations have prognostic significance as well.The current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being explored.The combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid subtypes.However,the latter continues to be a robust treatment option for patients with the epithelioid subtype.Surgery is recommended for resectable cases with radiotherapy being indicated in neoadjuvant,adjuvant,and palliative settings along with systemic treatment.This review article provides an overview of epidemiology,etiology,clinical manifestations,diagnostic approaches(including immunohistochemical and genetic markers),staging,and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery,chemotherapy,immunotherapy,and radiotherapy.It also sheds light on some recent studies(EMPHACIS,CALGB30901,Checkmate-743,etc.)that have led to significant developments in recent years with clinically meaningful results.展开更多
Tuberculosis (TB), caused by Mycobacterium tuberculosis is an infectious deadly disease and the treatment of which is one of the most severe challenges at the global level. Currently more than 20 chemical medications ...Tuberculosis (TB), caused by Mycobacterium tuberculosis is an infectious deadly disease and the treatment of which is one of the most severe challenges at the global level. Currently more than 20 chemical medications are described for the treatment of TB. Regardless of availability of several drugs to treat TB, the causative agent, M. tuberculosis is nowadays getting resistant toward the conventional drugs and leading to conditions known as Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB). This situation has terrified the global health community and raised a demand for new anti-tuberculosis drugs. Medicinal plants have been used to cure different common as well as lethal diseases by ancient civilizations due to its virtue of variety of chemical compounds which may have some important remedial properties. The aim of the present review is to focus the anti-tubercular medicinal plants native to India as well as the plants effective against MDR or XDR-TB across the globe. In the present review, we have addressed 25 medicinal plants for TB and 16 plants effective against MDR-TB testified from India and 23 herbal plants described for MDR-TB across the world during 2011-2015. These herbal plants can serve as promising candidates for developing novel medications to combat multidrug resistant M. tuberculosis.展开更多
The attempt has been taken to calculate the density of stars possessing quark matter core using sphere packing concept of crystallography. The quark matter has been taken as solid in nature as predicted in references ...The attempt has been taken to calculate the density of stars possessing quark matter core using sphere packing concept of crystallography. The quark matter has been taken as solid in nature as predicted in references 36 and 37, and due to immense gravitational pressure at the core of the star the densest packing of quarks as spheres has been assumed to calculate the packing fraction Φ, thus the density ρ of the matter. Three possible types of pickings—mono-sized sphere packing, binary sphere packing and ternary sphere packing, have been worked out using three possible types of quark matter. It has been concluded that no value about the ρ of quark matter can be calculated using binary and ternary packing conditions and for mono-sized packing condition different flavor quark matters of different values in the density have been calculated using results from the experiments done by HI, ZEUS, L3 and CDF Collaborations about the radius limit of quark. For example, for u quark matter ρ ranges from 4.0587 × 1048 - 7.40038 × 1048 MeV/c2 cm3 using results of L3 Collaboration, for s quark matter 15.91794 × 1048 - 17.6866 × 1048 MeV/c2 cm3, etc.展开更多
The novel coronavirus has played a disastrous role in many countries worldwide.The outbreak became a major epidemic,engulfing the entire world in lockdown and it is now speculated that its economic impact might be wor...The novel coronavirus has played a disastrous role in many countries worldwide.The outbreak became a major epidemic,engulfing the entire world in lockdown and it is now speculated that its economic impact might be worse than economic deceleration and decline.This paper identifies two different models to capture the trend of closing stock prices in Brazil(BVSP),Russia(IMOEX.ME),India(BSESN),and China(SSE),i.e.,(BRIC)countries.We predict the stock prices for three daily time periods,so appropriate preparations can be undertaken to solve these issues.First,we compared the ARIMA,SutteARIMA and Holt-Winters(H-W)methods to determine the most effective model for predicting data.The stock closing price of BRIC country data was obtained from Yahoo Finance.That data dates from 01 November 2019 to 11 December 2020,then divided into two categories-training data and test data.Training data covers 01 November 2019 to 02 December 2020.Seven days(03December 2020 to 11December 2020)of datawas tested to determine the accuracy of the models using training data as a reference.To measure the accuracy of the models,we obtained the means absolute percentage error(MAPE)and mean square error(MSE).Prediction model Holt-Winters was found to be the most suitable for forecasting the Brazil stock price(BVSP)while MAPE(0.50)and MSE(579272.65)with Holt-Winters(smaller than ARIMA and SutteARIMA),model SutteARIMA was found most appropriate to predict the stock prices of Russia(IMOEX.ME),India(BSESN),and China(SSE)when compared to ARIMA and Holt-Winters.MAPE andMSE with SutteARIMA:Russia(MAPE:0.7;MSE:940.20),India(MAPE:0.90;MSE:207271.16),and China(MAPE:0.72;MSE:786.28).Finally,Holt-Winters predicted the daily forecast values for the Brazil stock price(BVSP)(12 December to 14 December 2020 i.e.,115757.6,116150.9 and 116544.1),while SutteARIMA predicted the daily forecast values of Russia stock prices(IMOEX.ME)(12 December to 14 December 2020 i.e.,3238.06,3241.54 and 3245.01),India stock price(BSESN)(12 December to 14 December 2020 i.e.,.45709.38,45828.71 and 45948.05),and China stock price(SSE)(11 December to 13 December 2020 i.e.,3397.56,3390.59 and 3383.61)for the three time periods.展开更多
Flooding in rice fields,especially in coastal regions and low-lying river basins,causes significant devastation to crops.Rice is highly susceptible to prolonged flooding,with a drastic decline in yields if inundation ...Flooding in rice fields,especially in coastal regions and low-lying river basins,causes significant devastation to crops.Rice is highly susceptible to prolonged flooding,with a drastic decline in yields if inundation persists for more than 7 d,especially during the reproductive stage.Although the SUB1 QTL,which confers tolerance to complete submergence during the vegetative stage,has been incorporated into breeding programs,the development of alternative sources is crucial.These alternatives would broaden the genetic base,mitigate the influence of the genomic background,and extend the efficacy of SUB1 QTL to withstand longer submergence periods(up to approximately 21 d).Contemporary breeding strategies predominantly target submergence stress at the vegetative stage.However,stagnant flooding(partial submergence of vegetative parts)during the reproductive phase inflicts severe damage on the rice crop,leading to reduced yields,heightened susceptibility to pests and diseases,lodging,and inferior grain quality.The ability to tolerate stagnant flooding can be ascribed to several adaptive traits:accelerated aerenchyma formation,efficient underwater photosynthesis,reduced radial oxygen loss in submerged tissues,reinforced culms,enhanced reactive oxygen species scavenging within cells,dehydration tolerance post-flooding,and resistance to pests and diseases.A thorough investigation of the genetics underlying these traits,coupled with the integration of key alleles into elite genetic backgrounds,can significantly enhance food and income security in flood-prone rice-growing regions,particularly in coastal high-rainfall areas and low-lying river basins.This review aims to delineate an innovative breeding strategy that employs genomic,phenomic,and traditional breeding methodologies to develop rice varieties resilient to various dimensions of flooding stress at both the vegetative and reproductive stages.展开更多
This article explores the most recent evidence-based information on ethnomedicinal, phytochemical and pharmacological understanding of Hygrophila auriculata for the treatment of various diseases and health conditions....This article explores the most recent evidence-based information on ethnomedicinal, phytochemical and pharmacological understanding of Hygrophila auriculata for the treatment of various diseases and health conditions. Various ethnomedicinal writings suggest the use of the plant or its parts for the treatment of jaundice, oedema, gastrointestinal ailments, diarrhoea, dysentery, urinogenital disorder, gall stones, urinary calculi, kidney stone, leucorrhoea, rheumatism, tuberculosis, anaemia, body pain, constipation, skin disease, and as an aphrodisiac. The plant has been reported to contain flavonoids （apigenin, luteolin, ellagic acid, gallic acid and quercetin）, alkaloids （asteracanthine and asteracanthicine）, triterpenes （lupeol, lupenone, hentricontane and betulin）, sterols （stigmasterol and asterol）, minerals, amino acids, fatty acids, aliphatic esters and essential oils. Extracts and bioactive compounds from the plant have been found to possess antimicrobial, anthelmintic, antitermite, nephroprotective, hepatoprotective, central nervous system protective, antitumour, antidiabetic, anticataract, antioxidant, haematopoietic, diuretic, antinociceptive, anti-inflammatory, antipyretic, antimotility, aphrodisiac, neuroprotection, anti- endotoxin and anti-urolithiatic activities. For this paper, we reviewed patents, clinical studies, analytical studies and marketed formulations from the earliest found examples from 1887 to the end of 2017.展开更多
文摘Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos exposure.The ban on asbestos has helped to lower the incidence,but in developing countries like India,it is expected to rise.It has an extended latency period usually progressing over decades and presents with nonspecific symptoms.It has a median survival ranging between 10-22 months.The diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography(CT),magnetic resonance imaging,or positron emission tomography-CT,with the last two predicting the resectability of the tumor better than CT alone.A pleural biopsy along with an array of immunohistochemical markers,such as p16,BRCA1 associated protein 1,and claudin-4,are required for a definitive diagnosis.Several genetic alterations have prognostic significance as well.The current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being explored.The combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid subtypes.However,the latter continues to be a robust treatment option for patients with the epithelioid subtype.Surgery is recommended for resectable cases with radiotherapy being indicated in neoadjuvant,adjuvant,and palliative settings along with systemic treatment.This review article provides an overview of epidemiology,etiology,clinical manifestations,diagnostic approaches(including immunohistochemical and genetic markers),staging,and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery,chemotherapy,immunotherapy,and radiotherapy.It also sheds light on some recent studies(EMPHACIS,CALGB30901,Checkmate-743,etc.)that have led to significant developments in recent years with clinically meaningful results.
文摘Tuberculosis (TB), caused by Mycobacterium tuberculosis is an infectious deadly disease and the treatment of which is one of the most severe challenges at the global level. Currently more than 20 chemical medications are described for the treatment of TB. Regardless of availability of several drugs to treat TB, the causative agent, M. tuberculosis is nowadays getting resistant toward the conventional drugs and leading to conditions known as Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB). This situation has terrified the global health community and raised a demand for new anti-tuberculosis drugs. Medicinal plants have been used to cure different common as well as lethal diseases by ancient civilizations due to its virtue of variety of chemical compounds which may have some important remedial properties. The aim of the present review is to focus the anti-tubercular medicinal plants native to India as well as the plants effective against MDR or XDR-TB across the globe. In the present review, we have addressed 25 medicinal plants for TB and 16 plants effective against MDR-TB testified from India and 23 herbal plants described for MDR-TB across the world during 2011-2015. These herbal plants can serve as promising candidates for developing novel medications to combat multidrug resistant M. tuberculosis.
文摘The attempt has been taken to calculate the density of stars possessing quark matter core using sphere packing concept of crystallography. The quark matter has been taken as solid in nature as predicted in references 36 and 37, and due to immense gravitational pressure at the core of the star the densest packing of quarks as spheres has been assumed to calculate the packing fraction Φ, thus the density ρ of the matter. Three possible types of pickings—mono-sized sphere packing, binary sphere packing and ternary sphere packing, have been worked out using three possible types of quark matter. It has been concluded that no value about the ρ of quark matter can be calculated using binary and ternary packing conditions and for mono-sized packing condition different flavor quark matters of different values in the density have been calculated using results from the experiments done by HI, ZEUS, L3 and CDF Collaborations about the radius limit of quark. For example, for u quark matter ρ ranges from 4.0587 × 1048 - 7.40038 × 1048 MeV/c2 cm3 using results of L3 Collaboration, for s quark matter 15.91794 × 1048 - 17.6866 × 1048 MeV/c2 cm3, etc.
文摘The novel coronavirus has played a disastrous role in many countries worldwide.The outbreak became a major epidemic,engulfing the entire world in lockdown and it is now speculated that its economic impact might be worse than economic deceleration and decline.This paper identifies two different models to capture the trend of closing stock prices in Brazil(BVSP),Russia(IMOEX.ME),India(BSESN),and China(SSE),i.e.,(BRIC)countries.We predict the stock prices for three daily time periods,so appropriate preparations can be undertaken to solve these issues.First,we compared the ARIMA,SutteARIMA and Holt-Winters(H-W)methods to determine the most effective model for predicting data.The stock closing price of BRIC country data was obtained from Yahoo Finance.That data dates from 01 November 2019 to 11 December 2020,then divided into two categories-training data and test data.Training data covers 01 November 2019 to 02 December 2020.Seven days(03December 2020 to 11December 2020)of datawas tested to determine the accuracy of the models using training data as a reference.To measure the accuracy of the models,we obtained the means absolute percentage error(MAPE)and mean square error(MSE).Prediction model Holt-Winters was found to be the most suitable for forecasting the Brazil stock price(BVSP)while MAPE(0.50)and MSE(579272.65)with Holt-Winters(smaller than ARIMA and SutteARIMA),model SutteARIMA was found most appropriate to predict the stock prices of Russia(IMOEX.ME),India(BSESN),and China(SSE)when compared to ARIMA and Holt-Winters.MAPE andMSE with SutteARIMA:Russia(MAPE:0.7;MSE:940.20),India(MAPE:0.90;MSE:207271.16),and China(MAPE:0.72;MSE:786.28).Finally,Holt-Winters predicted the daily forecast values for the Brazil stock price(BVSP)(12 December to 14 December 2020 i.e.,115757.6,116150.9 and 116544.1),while SutteARIMA predicted the daily forecast values of Russia stock prices(IMOEX.ME)(12 December to 14 December 2020 i.e.,3238.06,3241.54 and 3245.01),India stock price(BSESN)(12 December to 14 December 2020 i.e.,.45709.38,45828.71 and 45948.05),and China stock price(SSE)(11 December to 13 December 2020 i.e.,3397.56,3390.59 and 3383.61)for the three time periods.
基金the University Grants Commission(UGC),Government of India for the UGC-Non-NET Fellowship during the PhD degree program(Grant No.R/Dev/IX-Sch/BHU-Res-Sch/2022-23/51137).
文摘Flooding in rice fields,especially in coastal regions and low-lying river basins,causes significant devastation to crops.Rice is highly susceptible to prolonged flooding,with a drastic decline in yields if inundation persists for more than 7 d,especially during the reproductive stage.Although the SUB1 QTL,which confers tolerance to complete submergence during the vegetative stage,has been incorporated into breeding programs,the development of alternative sources is crucial.These alternatives would broaden the genetic base,mitigate the influence of the genomic background,and extend the efficacy of SUB1 QTL to withstand longer submergence periods(up to approximately 21 d).Contemporary breeding strategies predominantly target submergence stress at the vegetative stage.However,stagnant flooding(partial submergence of vegetative parts)during the reproductive phase inflicts severe damage on the rice crop,leading to reduced yields,heightened susceptibility to pests and diseases,lodging,and inferior grain quality.The ability to tolerate stagnant flooding can be ascribed to several adaptive traits:accelerated aerenchyma formation,efficient underwater photosynthesis,reduced radial oxygen loss in submerged tissues,reinforced culms,enhanced reactive oxygen species scavenging within cells,dehydration tolerance post-flooding,and resistance to pests and diseases.A thorough investigation of the genetics underlying these traits,coupled with the integration of key alleles into elite genetic backgrounds,can significantly enhance food and income security in flood-prone rice-growing regions,particularly in coastal high-rainfall areas and low-lying river basins.This review aims to delineate an innovative breeding strategy that employs genomic,phenomic,and traditional breeding methodologies to develop rice varieties resilient to various dimensions of flooding stress at both the vegetative and reproductive stages.
文摘This article explores the most recent evidence-based information on ethnomedicinal, phytochemical and pharmacological understanding of Hygrophila auriculata for the treatment of various diseases and health conditions. Various ethnomedicinal writings suggest the use of the plant or its parts for the treatment of jaundice, oedema, gastrointestinal ailments, diarrhoea, dysentery, urinogenital disorder, gall stones, urinary calculi, kidney stone, leucorrhoea, rheumatism, tuberculosis, anaemia, body pain, constipation, skin disease, and as an aphrodisiac. The plant has been reported to contain flavonoids （apigenin, luteolin, ellagic acid, gallic acid and quercetin）, alkaloids （asteracanthine and asteracanthicine）, triterpenes （lupeol, lupenone, hentricontane and betulin）, sterols （stigmasterol and asterol）, minerals, amino acids, fatty acids, aliphatic esters and essential oils. Extracts and bioactive compounds from the plant have been found to possess antimicrobial, anthelmintic, antitermite, nephroprotective, hepatoprotective, central nervous system protective, antitumour, antidiabetic, anticataract, antioxidant, haematopoietic, diuretic, antinociceptive, anti-inflammatory, antipyretic, antimotility, aphrodisiac, neuroprotection, anti- endotoxin and anti-urolithiatic activities. For this paper, we reviewed patents, clinical studies, analytical studies and marketed formulations from the earliest found examples from 1887 to the end of 2017.
