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电针对慢性应激抑郁大鼠中缝核脑区P11-tPA-BDNF通路的影响 被引量:2
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作者 牟埈辉 王巧侠 +3 位作者 罗彤 赵俊 赛音朝克图 李志刚 《针灸临床杂志》 2020年第8期72-76,共5页
目的:观察电针对慢性应激抑郁模型大鼠中缝核中P11、tPA及BDNF的影响,进一步研究电针治疗抑郁症可能的通路。方法:将24只健康雄性SD大鼠随机分为正常组、模型组、药物组和电针组,每组6只。除正常组外,其余各组均孤养,并接受慢性不可预... 目的:观察电针对慢性应激抑郁模型大鼠中缝核中P11、tPA及BDNF的影响,进一步研究电针治疗抑郁症可能的通路。方法:将24只健康雄性SD大鼠随机分为正常组、模型组、药物组和电针组,每组6只。除正常组外,其余各组均孤养,并接受慢性不可预知应激刺激造模。各组大鼠分别于实验前1 d和实验的第28天进行体质量检测和糖水偏好实验,观察大鼠的行为学变化。实验第28天断头取脑,采用免疫荧光染色技术检测中缝核中三者的表达情况;逆转录酶聚合酶链反应检测中缝核中P11、tPA、BDNF mRNA的含量。结果:模型组大鼠的行为学指标明显低于正常组(P<0.05),药物组和电针组大鼠行为学指标均明显高于模型组(P<0.05);模型组免疫荧光染色结果显示模型组三者在中缝核的表达明显低于正常组,药物组和电针组明显高于模型组;模型组中缝核P11、tPA、BDNF的mRNA含量低于正常组(P<0.01),药物组和电针组则显著高于模型组(P<0.01)。结论:电针有明显的抗抑郁效果,可以改善慢性应激抑郁大鼠的行为;电针可以增加慢性应激抑郁大鼠模型中缝核P11、tPA、BDNF mRNA的含量,提高其表达量,电针的这种抗抑郁作用可能是通过影响P11-tPA-BDNF通路发挥作用的。 展开更多
关键词 抑郁 慢性应激 电针 P11 TPA BDNF
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Characteristics of mining gas channel expansion in the remote overlying strata and its control of gas flow 被引量:1
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作者 Liu Hongyong Cheng Yuanping +2 位作者 Chen Haidong mou junhui Kong Shengli 《International Journal of Mining Science and Technology》 SCIE EI 2013年第4期480-486,共7页
The technology of pressure relief gas drainage is one of the most effective and economic for preventing gas emissions in underground mines.Based on current understanding of strata breakage and fracture development in ... The technology of pressure relief gas drainage is one of the most effective and economic for preventing gas emissions in underground mines.Based on current understanding of strata breakage and fracture development in overlying strata,the current study divides the overlying strata into the following three longitudinal zones in terms of the state of gas flow:a turbulent channel zone,a transitional circulation channel zone and a seepage channel zone.According to the key strata discrimination theory of controlling the overlying strata,the calculation method establishes that the step-type expansion of the mining gas channel corresponds to the advancing distance of working face,and this research also confrms the expanding rule that the mining gas channel in overlying strata follows the advancing distance of mining working face.Based on the geological conditions of Xinjing Coal Mine of Yangquan,this paper researches the expanding rule of mining gas channel as well as the control action of the channel acting on the pressure relief flow under the condition of the remote protective layer,and got the distance using inversion that the step-type expanding of mining gas channel is corresponding to the advancing distance of working face,which verifes the accuracy and feasibility of theoretical calculation method proposed in this study.The research provides the theoretical basis for choosing the technology of pressure relief gas drainage and designing the parameters of construction. 展开更多
关键词 Remote mining overlying strata Gas channel expansion Gas flow Control action Key strata
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