The repair and regeneration of the diseases and damaged cartilage tissue are one of the most challenging issues in the field of tissue engineering and regenerative medicine. As the cartilage is a non-vascularized and ...The repair and regeneration of the diseases and damaged cartilage tissue are one of the most challenging issues in the field of tissue engineering and regenerative medicine. As the cartilage is a non-vascularized and comparatively acellular connective tissue, its ability to the self-restoration is limited to a large extent. Although there is a countless deal of experimental documents on this field, no quantifiable cure exists to bring back the healthy organization and efficacy of the impaired articular cartilage. Tissue reformative approaches have been of excessive curiosity in restoring injured cartilage. Bioengineering of the cartilage has progressed from the cartilage focal damages treatment to bioengineering tactics progress aiming the osteoarthritis procedures. The main focus of the present study is on the diverse potential development of strategies such as various categories of biomaterials applied in the reconstruction of the cartilage tissue.展开更多
This study explores the potential of Mg/Carbon Nanotubes/Baghdadite composites as biomaterials for bone regeneration and repair while addressing the obstacles to their clinical application.BAG powder was synthesized u...This study explores the potential of Mg/Carbon Nanotubes/Baghdadite composites as biomaterials for bone regeneration and repair while addressing the obstacles to their clinical application.BAG powder was synthesized using the sol-gel method to ensure a fine distribution within the Mg/CNTs matrix.Mg/1.5 wt.%CNT composites were reinforced with BAG at weight fractions of 0.5,1.0,and 1.5 wt.%using spark plasma sintering at 450℃and 50 MPa after homogenization via ball milling.The cellular bioactivity of these nanocomposites was evaluated using human osteoblast-like cells and adipose-derived mesenchymal stromal cells.The proliferation and attachment of MG-63cells were assessed and visualized using the methylthiazol tetrazolium(MTT)assay and SEM,while AD-MSC differentiation was measured using alkaline phosphatase activity assays.Histograms were also generated to visualize the diameter distributions of particles in SEM images using image processing techniques.The Mg/CNTs/0.5 wt.%BAG composite demonstrated optimal mechanical properties,with compressive strength,yield strength,and fracture strain of 259.75 MPa,180.25 MPa,and 31.65%,respectively.Machine learning models,including CNN,LSTM,and GRU,were employed to predict stress-strain relationships across varying BAG amounts,aiming to accurately model these curves without requiring extensive physical experiments.As shown by contact angle measurements,enhanced hydrophilicity promoted better cell adhesion and proliferation.Furthermore,corrosion resistance improved with a higher BAG content.This study concludes that Mg/CNTs composites reinforced with BAG concentrations below 1.0 wt.%offer promising biodegradable implant materials for orthopedic applications,featuring adequate load-bearing capacity and improved corrosion resistance.展开更多
文摘The repair and regeneration of the diseases and damaged cartilage tissue are one of the most challenging issues in the field of tissue engineering and regenerative medicine. As the cartilage is a non-vascularized and comparatively acellular connective tissue, its ability to the self-restoration is limited to a large extent. Although there is a countless deal of experimental documents on this field, no quantifiable cure exists to bring back the healthy organization and efficacy of the impaired articular cartilage. Tissue reformative approaches have been of excessive curiosity in restoring injured cartilage. Bioengineering of the cartilage has progressed from the cartilage focal damages treatment to bioengineering tactics progress aiming the osteoarthritis procedures. The main focus of the present study is on the diverse potential development of strategies such as various categories of biomaterials applied in the reconstruction of the cartilage tissue.
文摘This study explores the potential of Mg/Carbon Nanotubes/Baghdadite composites as biomaterials for bone regeneration and repair while addressing the obstacles to their clinical application.BAG powder was synthesized using the sol-gel method to ensure a fine distribution within the Mg/CNTs matrix.Mg/1.5 wt.%CNT composites were reinforced with BAG at weight fractions of 0.5,1.0,and 1.5 wt.%using spark plasma sintering at 450℃and 50 MPa after homogenization via ball milling.The cellular bioactivity of these nanocomposites was evaluated using human osteoblast-like cells and adipose-derived mesenchymal stromal cells.The proliferation and attachment of MG-63cells were assessed and visualized using the methylthiazol tetrazolium(MTT)assay and SEM,while AD-MSC differentiation was measured using alkaline phosphatase activity assays.Histograms were also generated to visualize the diameter distributions of particles in SEM images using image processing techniques.The Mg/CNTs/0.5 wt.%BAG composite demonstrated optimal mechanical properties,with compressive strength,yield strength,and fracture strain of 259.75 MPa,180.25 MPa,and 31.65%,respectively.Machine learning models,including CNN,LSTM,and GRU,were employed to predict stress-strain relationships across varying BAG amounts,aiming to accurately model these curves without requiring extensive physical experiments.As shown by contact angle measurements,enhanced hydrophilicity promoted better cell adhesion and proliferation.Furthermore,corrosion resistance improved with a higher BAG content.This study concludes that Mg/CNTs composites reinforced with BAG concentrations below 1.0 wt.%offer promising biodegradable implant materials for orthopedic applications,featuring adequate load-bearing capacity and improved corrosion resistance.
