Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporou...Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m<sup>2</sup>/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO<sub>2</sub> materials were proved to be a suitable system for controlled release of paracetamol.展开更多
Thymic epithelial tumours(TET)are rare,heterogeneous neoplasms that range from resectable indolent tumours to aggressive thymic carcinomas with a strong tendency to metastasize.The pathological diagnosis is complex,in...Thymic epithelial tumours(TET)are rare,heterogeneous neoplasms that range from resectable indolent tumours to aggressive thymic carcinomas with a strong tendency to metastasize.The pathological diagnosis is complex,in part due to the management of TETs is scant and mainly based on non-randomised studies and retrospective series.Consequently,the clinical management of TETs tends to be highly heterogenous,which makes it difficult to improve the evidence level.The role of technological advances in the field of radiotherapy and new systemic therapies in the treatment of TETs has received little attention to date.In the present clinical guidelines,developed by the GOECP/SEOR,we review recent developments in the diagnosis and classification of TETs.We also present a consensus-based therapeutic strategy for each disease stage that takes into consideration the best available evidence.These guidelines focus primarily on the role of radiotherapy,including recent advances,in the management of TETs.The main aim of this document is to promote the standardisation of clinical practice and lay the foundations for future studies to clarify the main unresolved questions related to the optimal management of TET.展开更多
文摘Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m<sup>2</sup>/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO<sub>2</sub> materials were proved to be a suitable system for controlled release of paracetamol.
文摘Thymic epithelial tumours(TET)are rare,heterogeneous neoplasms that range from resectable indolent tumours to aggressive thymic carcinomas with a strong tendency to metastasize.The pathological diagnosis is complex,in part due to the management of TETs is scant and mainly based on non-randomised studies and retrospective series.Consequently,the clinical management of TETs tends to be highly heterogenous,which makes it difficult to improve the evidence level.The role of technological advances in the field of radiotherapy and new systemic therapies in the treatment of TETs has received little attention to date.In the present clinical guidelines,developed by the GOECP/SEOR,we review recent developments in the diagnosis and classification of TETs.We also present a consensus-based therapeutic strategy for each disease stage that takes into consideration the best available evidence.These guidelines focus primarily on the role of radiotherapy,including recent advances,in the management of TETs.The main aim of this document is to promote the standardisation of clinical practice and lay the foundations for future studies to clarify the main unresolved questions related to the optimal management of TET.
