[Objectives] To analyze the volatile components,the contents of total flavonoids and total polysaccharides of the roots of Artemisia argyi Levl. et Van. var. argyi cv. Qiai,and to provide a scientific basis for the co...[Objectives] To analyze the volatile components,the contents of total flavonoids and total polysaccharides of the roots of Artemisia argyi Levl. et Van. var. argyi cv. Qiai,and to provide a scientific basis for the comprehensive development and utilization of the resources.[Methods]The volatile components of the roots were extracted by solid phase micro-extraction( SPME),and its volatile components were analyzed by gas chromatography-mass spectrometry( GC-MS); the contents of total flavonoids and total polysaccharides in the samples were measured by UV-spectrophotometry. [Results] 44 peaks were isolated from the roots and 30 components were identified,accounting for 80. 9% of the total volatile components; the content of total flavonoids in the roots was 9. 42%; the content of total polysaccharides in the roots was 11. 05%.[Conclusions] After a comprehensive investigation,the olefins in the roots generally have antibacterial activity,the contents of the total flavonoids and total polysaccharides contained in the roots were relatively high,the roots of Artemisia argyi do have broad prospects for the development.展开更多
Higher alcohols are key factors affecting sensory quality and post-drinking comfort of alcoholic beverages. A strategy combining solid-phase extraction and gas chromatography-mass spectrometry(SPE-GC-MS) was establish...Higher alcohols are key factors affecting sensory quality and post-drinking comfort of alcoholic beverages. A strategy combining solid-phase extraction and gas chromatography-mass spectrometry(SPE-GC-MS) was established to analyze the metabolism pattern of higher alcohols in rat plasma after gavage of 4 common alcoholic beverages including huangjiu, baijiu, wine and brandy. 7 mL of dichloromethane was determined as the optimal extraction condition, and 8 higher alcohols were precisely quantified with detection limits of 1.82-11.65 μg/L, recoveries of 89.07%-110.89% and fine repeatability. The fastest absorption and elimination rates of plasma total higher alcohols were observed in baijiu and huangjiu group, respectively, and the highest peak concentration was found in brandy group. Additionally, the metabolic rate of plasma isoamyl alcohol in huangjiu group was faster than that in wine group at the same intragastric administration dosage. This study may provide potential insight for evaluation of alcoholic beverage quality.展开更多
Insomnia significantly impacts university students’health and academic performance,making it essential to incorporate their experiences with insomnia into research.This study aims to explore the needs and expectation...Insomnia significantly impacts university students’health and academic performance,making it essential to incorporate their experiences with insomnia into research.This study aims to explore the needs and expectations of university students in coping with insomnia and the implications for theory and practice.The research involved a survey of 110 students,with five participating in semi-structured in-depth interviews.The results revealed that students’needs and expectations for managing insomnia fall into three categories:online services,integrated university medical services,and socially interactive and shareable service models.The study found that addressing students’insomnia requires an understanding of these needs and expectations,with a human-centered approach proving effective in identifying and addressing students’actual requirements.These findings provide a foundation for further discussions on improving the accessibility of insomnia coping strategies for university students.展开更多
AIM： To investigate the incidence of various types of postoperative pulmonary complications （POPCs） and to evaluate the significance of perioperative arterial blood gases in patients with esophageal cancer accompan...AIM： To investigate the incidence of various types of postoperative pulmonary complications （POPCs） and to evaluate the significance of perioperative arterial blood gases in patients with esophageal cancer accompanied with chronic obstructive pulmonary disease （COPD） after esophagectomy. MEHTODS： Three hundred and fifty-eight patients were divided into POPC group and COPD group. We performed a retrospective review of the 358 consecutive patients after esophagectomy for esophageal cancer with or without COPD to assess the possible influence of COPD on postoperative pulmonary complications. We classified COPD into four grades according to percent-predicted forced expiratory volume in 1 s （FEV1） and analyzed the incidence rate of complications among the four grades. Perioperative arterial blood gases were tested in patients with or without pulmonary complications in COPD group and compared with POP（： group. RESULTS： Patients with COPD （29/86, 33.7%）had more pulmonary complications than those without COPD （36/272, 13.2%） （P〈0.001）. Pneumonia （15/29, 51.7%）, atelectasis （13/29, 44.8%）, prolonged 02 supplement （10/29, 34.5%）, and prolonged mechanical ventilation （8/29, 27.6%） were the major complications in COPD group. Moreover, patients with severe COPD （grade Ⅱ B, FEV1 〈 50% of predicted） had more POPCs than those with moderate（gradeⅡA,50%-80% of predicted） and mild （grade Ⅰ≥80% of predicted） COPD （P〈0.05）. PaO2 was decreased and PaCO2 was increased in patients with pulmonary complications in COPD group in the first postoperative week.CONCLUSION： The criteria of COPD are the critical predictor for pulmonary complications in esophageal cancer patients undergoing esophagectomy. Severity of COPD affects the incidence rate of the pulmonary complication,and percent-predicted FEV1 is a good predictive variable for pulmonary complication in patients-with COPD.Arterial blood gases are helpful in directing perioperative management.展开更多
Objective We performed experiments using Neuregulin-1β （NRG-1β） treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions （GJs） during heart failu...Objective We performed experiments using Neuregulin-1β （NRG-1β） treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions （GJs） during heart failure （HF）. Methods Rat models of I-IF were established by aortocaval fistula. Forty-eight rats were divided randomly into the HF （HF, n = 16）, NRG-1β trealanent （NRG, n = 16）, and sham operation （S, n = 16） group. The rats in the NRG group were administered NRG-1β （10 μg/kg per day） for 7 days via the tail vein, whereas the other groups were injected with the same doses of saline, Twelve weeks after operation, Connexin 43 （Cx43） expression in single myocytes obtained from the left ventricle was determined by immunocytochemistry. Total protein was extracted from frozen left ventricular tissues for immunoblotting assay, and the ultrastmcture of myocytes was observed by transmission electron microscopy. Results Compared with the HF group, the cardiac fimction of rats in the NRG group was markedly improved, irregular distribution and deceased Cx43 expression were relieved. The ultrastmcture of myocytes was seriously damaged in HF rats, and NRG-1β reduced these pathological damages. Conclusions Short-term NRG-1β treatment can rescue pump failure in experimental models of volume overload-induced HF, which is related to the recovery of GJs structure and the improvement of Cx43 expression.展开更多
A blasting experiment was conducted on iron ore samples by considering multiple coupling charge coefficients.The resulting internal fracture and damage characteristics were quantitatively analyzed via computerized tom...A blasting experiment was conducted on iron ore samples by considering multiple coupling charge coefficients.The resulting internal fracture and damage characteristics were quantitatively analyzed via computerized tomography(CT),scanning,and three-dimensional(3D)model reconstruction.The results show that the iron ore primarily displayed radial and circumferential cracks along the blast hole under an explosive load.When the decoupling coefficient was small,the crack surface was dominated by transgranular fractures in the form of intracrystalline fractures.As the uncoupling coefficient increased,the crack surface exhibited transgranular and intergranular coupled fracture modes.Using fractal theory to analyze crack distribution characteristics,as the decoupled coefficient increased,the body fractal dimension tended to decrease,and the degree of damage gradually decreased.The degree of damage reached a turning point when the decoupling charge coefficient was approximately 1.33.A numerical simulation suggested that the explosion energy transmitted to the iron ore and the effective stress decrease sharply when the decoupling coefficient exceeds 1.33.In some optimal uncoupling coefficient range,excessive fragmentation of the ore body is prevented,thereby allowing full use of the explosive energy.展开更多
Interlaid rock is an important component in the construction of neighborhood tunnels that supports and reinforces the area between two tunnels.However,the blasting load during excavation can sometimes damage the inter...Interlaid rock is an important component in the construction of neighborhood tunnels that supports and reinforces the area between two tunnels.However,the blasting load during excavation can sometimes damage the interlaid rock and threaten the stability of a tunnel’s structure.This paper presents a case study of the small clearance section of the Liantang highway tunnel project in Shenzhen,China,where the minimum distance between the two tunnels involved is only 0.5 m.To reduce the damage to the interlaid rock caused by blasting loads,we proposed a four-part excavation method with a vibrationcushioning rock layer in the following tunnel of neighborhood tunnels.Numerical simulation was used to model the damage prevention mechanism of the vibration-cushioning rock layer and to better understand the propagation of cracks in the interlaid rock.Furthermore,based on the simulation results,combined microseismic controlled-blasting technology was implemented,using innovative blasting patterns combined with different charge structures and blasting equipment designed according to the varying thickness of the interlaid rock.Finally,this implementation succeeded in protecting interlaid rock during blasting operations.展开更多
Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a r...Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine,Soochow University,China(approval No.XD-2016-1)on January 15,2016.展开更多
AIM:To assess the efficacy versus the adverse effects of various concentrations of atropine in the prevention of myopia in Asian children.METHODS:Databases(PubMed,EMBASE,the Cochrane Library and Web of science)were co...AIM:To assess the efficacy versus the adverse effects of various concentrations of atropine in the prevention of myopia in Asian children.METHODS:Databases(PubMed,EMBASE,the Cochrane Library and Web of science)were comprehensively searched from inception to April 2022.Types of studies included were randomized clinical trials(RCTs).The published languages were limited to English.Two researchers assessed the quality of included studies independently using Cochrane risk of bias tool based on the Cochrane Handbook for Systematic Reviews of Interventions.Funnel plots and Egger’s test were used for detection of publication bias.Meta-analyses were conducted using STATA(version 15.0;StataCorp).RESULTS:A total of 15 RCTs involving 2268 patients were included in the study.In the atropine group,spherical equivalent progressed at a significantly lower rate[weighted mean difference(WMD)=0.39,95%confidence interval(CI):0.23,0.54]than in the control group.A WMD of 0.15 mm was associated with less axial elongation(95%CI-0.19,-0.10).Different doses showed statistically significant differences(P<0.05)and an improved effect could result from a higher concentration.Changes in photopic pupil size and mesopic pupil size in atropine group is 0.70 mm(95%CI:0.33,1.06)and 0.38 mm(95%CI:0.22,0.54)more than the control group.In the present Meta-analysis,no changes in accommodative amplitude(AA)were associated with atropine administration.Atropine administration increased the risk of adverse effects by 1.37 times.CONCLUSION:Concentrations of less than 1%atropine are able to effectively retard diopter and axis growth of myopia in Asian children in a dose-dependent manner.Meanwhile,it caused pupil enlargement,but induced no change in the AA within this range.Further study is required to determine the dosage needed to achieve maximum efficacy and minimal side effects.展开更多
Cucumber mosaic virus(CMV) is one of the most severe viral diseases transmitted by aphids infecting Solanum crops in China, causing great losses of crop yields and income in rural communities.The tobacco cultivars NC8...Cucumber mosaic virus(CMV) is one of the most severe viral diseases transmitted by aphids infecting Solanum crops in China, causing great losses of crop yields and income in rural communities.The tobacco cultivars NC82 and Taiyan 8 are closely related but differ in resistance to CMV.NC82 is susceptible to infection and Taiyan 8 is resistant, but the mechanisms underlying this difference in resistance are not clear.In this study, we conducted RNA sequencing to analyze changes in gene expression induced in the leaves of Taiyan 8 and NC82 upon systemic infection with CMV, compared with gene expression in the leaves of mock-inoculated plants.Leaves were sampled at one, three, eight, and 15 days after infection.In total, 3443 and 747 differentially expressed genes were identified in Taiyan 8 and NC82, respectively.Gene ontology and pathway enrichment analyses revealed that the different responses to CMV infection between cultivars were based on microtubulebased processes, pentose and glucuronate interconversions, plant–pathogen interaction,and hormone signal transduction pathways.Genes encoding pathogenesis-related proteins, disease-resistance proteins, lipoxygenase, cellulose synthase, an auxin response factor, and an ethylene receptor showed different expression patterns.The differences in gene expression following CMV infection likely contributed to the different resistance levels of these two tobacco cultivars.The comprehensive transcriptome dataset described here,which includes candidate response genes, will serve as a resource for further studies of the molecular mechanisms associated with tobacco defense responses against CMV.展开更多
To solve the uneven burden of same-type holes reducing the blasting efficiency due to the limitation of drilling equipment,we need a double-face program-controlled planning method for hole position parameters used on ...To solve the uneven burden of same-type holes reducing the blasting efficiency due to the limitation of drilling equipment,we need a double-face program-controlled planning method for hole position parameters used on a computer-controlled drilling jumbo.The cross-section splits into even and uneven areas.It also considers the uneven burden at the hole’s entrance and bottom.In the uneven area,various qualifying factors are made to optimize the hole spacing and maximize the burden uniformity,combined with the features of the area edges and gridbased segmentation methods.The hole position coordinates and angles in the even area are derived using recursion and iteration algorithms.As a case,this method presents all holes in a 4.8 m wide and 3.6 m high cross-section.Compared with the design produced by the drawing method,our planning in the uneven area improved the standard deviation of the hole burden by 40%.The improved hole layout facilitates the evolution of precise,efficient,and intelligent blasting in underground mines.展开更多
AIM:To evaluate the difference and the correlation between the concentrations of cytokines in the aqueous humor of eyes with macular edema secondary to diabetic retinopathy(DR)or retinal vein occlusion(RVO).METHODS:Th...AIM:To evaluate the difference and the correlation between the concentrations of cytokines in the aqueous humor of eyes with macular edema secondary to diabetic retinopathy(DR)or retinal vein occlusion(RVO).METHODS:This is a retrospective case control study.The aqueous humor samples were collected during intravitreal injection of anti-vascular endothelial growth factor(VEGF)for patients diagnosed with macular edema secondary to DR(DME)or RVO(RVO-ME)at Xijing Hospital from August 2021 to July 2022.Meanwhile,aqueous humor samples during vitrectomy from patients with idiopathic macular hole(IMH)were also collected and served as controls.The aqueous humor concentrations of VEGF,platelet-derived factor(PDGF),interleukin(IL)-6,IL-8,IL-18,tumor necrosis factor-α(TNF-α)and monocyte chemoattractant protein 1(MCP-1)were measured with Human Premixed Multi-Analyte Kit(Luminex).The difference of the aqueous cytokines and the correlation between the two diseases were analyzed.RESULTS:A total of 40 eyes of 38 patients were enrolled in the study,including 13 eyes of 11 DME patients(DME group),16 eyes of 16 RVO-ME patients(RVO-ME group)and 11 eyes of 11 IMH patients(control group).The VEGF,PDGF,IL-6,IL-8,and MCP-1 levels of the aqueous humor were higher in both DME and RVO-ME groups compared with the control group(all P<0.05),the levels of TNF-αwas higher in the DME group than in the control group(P<0.05).The VEGF,IL-6,MCP-1,and TNF-αlevels in the aqueous humor were significantly higher in the DR group than those in the RVO group(all P<0.05).Correlation analyses revealed that there were complex positive correlations between IL-6,IL-8,IL-18,MCP-1,and TNF-αlevels in the aqueous humor of eyes with two diseases.CONCLUSION:Although ischemic and inflammatory factors are similarly involved in the pathogenesis of DME and RVO-ME,the roles of these factors are more significant or more likely to be activated in DR patients,suggesting different treatment strategies should be considered for the two diseases.展开更多
Fast data synchronization in wireless ad hoc networks is a challenging and critical problem.It is fundamental for efficient information fusion,control and decision in distributed systems.Previously,distributed data sy...Fast data synchronization in wireless ad hoc networks is a challenging and critical problem.It is fundamental for efficient information fusion,control and decision in distributed systems.Previously,distributed data synchronization was mainly studied in the latency-tolerant distributed databases,or assuming the general model of wireless ad hoc networks.In this paper,we propose a pair of linear network coding(NC)and all-to-all broadcast based fast data synchronization algorithms for wireless ad hoc networks whose topology is under operator’s control.We consider both data block selection and transmitting node selection for exploiting the benefits of NC.Instead of using the store-and-forward protocol as in the conventional uncoded approach,a compute-and-forward protocol is used in our scheme,which improves the transmission efficiency.The performance of the proposed algorithms is studied under different values of network size,network connection degree,and per-hop packet error rate.Simulation results demonstrate that our algorithms significantly reduce the times slots used for data synchronization compared with the baseline that does not use NC.展开更多
As a special type of mobile ad hoc network(MANET),the flying ad hoc network(FANET)has the potential to enable a variety of emerging applications in both civilian wireless communications(e.g.,5G and 6G)and the defense ...As a special type of mobile ad hoc network(MANET),the flying ad hoc network(FANET)has the potential to enable a variety of emerging applications in both civilian wireless communications(e.g.,5G and 6G)and the defense industry.The routing protocol plays a pivotal role in FANET.However,when designing the routing protocol for FANET,it is conventionally assumed that the aerial nodes move randomly.This is clearly inappropriate for a mission-oriented FANET(MO-FANET),in which the aerial nodes typically move toward a given destination from given departure point(s),possibly along a roughly deterministic flight path while maintaining a well-established formation,in order to carry out certain missions.In this paper,a novel cyber–physical routing protocol exploiting the particular mobility pattern of an MO-FANET is proposed based on cross-disciplinary integration,which makes full use of the missiondetermined trajectory dynamics to construct the time sequence of rejoining and separating,as well as the adjacency matrix for each node,as prior information.Compared with the existing representative routing protocols used in FANETs,our protocol achieves a higher packet-delivery ratio(PDR)at the cost of even lower overhead and lower average end-to-end latency,while maintaining a reasonably moderate and stable network jitter,as demonstrated by extensive ns-3-based simulations assuming realistic configurations in an MO-FANET.展开更多
Citation:Gong M,Hui YN,Du HJ.A rare case of severe toxic optic neuropathy induced by formaldehyde vapor under working in mushroom cultivation room.Int J Ophthalmol 2021;14(12):1993-1996 Dear Editor,We are writing this...Citation:Gong M,Hui YN,Du HJ.A rare case of severe toxic optic neuropathy induced by formaldehyde vapor under working in mushroom cultivation room.Int J Ophthalmol 2021;14(12):1993-1996 Dear Editor,We are writing this letter to present a rare case of severe toxic optic neuropathy induced by formaldehyde(FA)vapor under working in mushroom cultivation room.Since such circumstance exists popularly in rural China,this case warns us to pay more attention to avoid similar cases.A 49-year-old male complained of bilateral vision loss after continuous working for 11h in an air-tight greenhouse filled with FA vapor on 03/15/2018.Soon after work,the patient felt weakness,dizziness,and nausea.Instead of asking for medical consultation,he went home to sleep.The next day,the patient was found to be in a coma with dyspnea and was taken to the local hospital by his family.His blood pressure waved around 70-80/50-65 mm Hg,and then maintained at 100/80 mm Hg by catecholamines.He was diagnosed with acute FA poisoning,pulmonary edema,metabolic acidosis,respiratory alkalosis,and hypotension and was given symptomatic relief and supportive measures.展开更多
It has been reported that splenic stromal cells(SSCs)are capable of directly supporting the development of CD11c ^(lo)CD45RB^(+) IL-10-producing dendritic cells(DCs)from lineage-negative c-kit^(+) progenitor cells in ...It has been reported that splenic stromal cells(SSCs)are capable of directly supporting the development of CD11c ^(lo)CD45RB^(+) IL-10-producing dendritic cells(DCs)from lineage-negative c-kit^(+) progenitor cells in the absence of exogenous cytokines.In vitro,DCs that differentiate on stromal cells suppress mixed leukocyte reaction responses and induce primary alloreactive CD4^(+) T cells to differentiate into IL-10-producing Tr1 cells.However,the precise mechanisms by which these SSCs exert their regulatory functions in vivo remain undefined.Furthermore,their possible contribution to the development of allograft transplantation tolerance has yet to be examined.Here,we have used both murine skin and cardiac allograft transplantation models to explore whether in vivo alloresponses can be regulated by infusion with donor-derived SSCs and to investigate the possible mechanisms by which SSCs exert regulatory effects to prevent allograft rejection.We show that intravenous SSC infusion prolonged murine skin allograft survival.The prolonged graft survival is associated with augmentation of the generation of regulatory DC subsets and CD4^(+) CD25^(+) Foxp3^(+) regulatory T cells(Tregs),as well as upregulation of the production of suppressive cytokines IL-10 and transforming growth factor(TGF)-b.Moreover,we found that indoleamine 2,3-dioxygenase and SSC-derived regulatory DCs contribute to allograft protection by infusion of donor-specific SSCs.Our data suggest that donor-derived SSCs could be used as a therapeutic target to promote transplantation tolerance.展开更多
Circularly polarized organic light-emitting diode(CP-OLED) has attracted increasing interest for its efficient ability to generate circularly polarized light directly. So far, many CP-OLEDs were successfully fabricate...Circularly polarized organic light-emitting diode(CP-OLED) has attracted increasing interest for its efficient ability to generate circularly polarized light directly. So far, many CP-OLEDs were successfully fabricated with chiral emitters or chiral hosts. In this study, a new strategy based on chiral electron transporting layer is proposed to construct CP-OLEDs. A pair of chiral electron transporting materials, 1,3,5-tris((R/S)-4-isopropyl-4,5-dihydrooxazol-2-yl)benzene((R/S)-TOx^(i)Pr), are firstly designed and synthesized. The crystalline films of(R/S)-TOx^(i)Pr show circularly polarized photoluminescence with photoluminescence dissymmetry factors of-0.067 and +0.041, respectively. The CP-OLEDs based on(R/S)-TOx^(i)Pr and three types of achiral emitters all exhibit circularly polarized electroluminescence, showing feasibility and strong versatility of this new strategy. The mechanism is attributed to in-situ electrical excitation instead of simply light filtering of non-circularly polarized light. This work demonstrates a new approach for realizing circularly polarized electroluminescence which may provide a valuable strategy to develop CP-OLEDs.展开更多
Moderate ultraviolet(UV)radiation from sunlight is essential for human health,but overexposure to UV rays can cause serious adverse effects.It is important to detect UV radiation from sunlight in time to prevent damag...Moderate ultraviolet(UV)radiation from sunlight is essential for human health,but overexposure to UV rays can cause serious adverse effects.It is important to detect UV radiation from sunlight in time to prevent damage from excessive exposure.Here,a ready-to-use,easy-to-interpret,inexpensive,reusable,and wearable all-in-one UV monitoring and shielding sensor SP-TPE@PU textile has been developed.The SP-TPE@PU textiles are constructed by photochromic molecule SP-TPE and commercial polymer polyurethane(PU)through electrospinning.The SP-TPE molecule acts as the sensor component,and PU contributes to high flexibility.The SP-TPE@PU textiles show remarkable durability(against repeated twisting,curling,bending deformations,and water immersion)and good permeability,making them durable and breathable wearable materials.When exposed to sunlight,the SP-TPE@PU textiles rapidly exhibit significant color changes due to the efficient isomerization of SP-TPE,serving as an early warning and monitoring of UV radiation.In addition,the SP-TPE@PU textiles can revert to the initial state with visible light irradiation for reuse.Furthermore,the SP-TPE@PU textiles possess excellent UV shielding ability,contributing to human body protection.Simple and easy operation,significant and reversible color changes,good breathability and mechanical properties make SP-TPE@PU textiles reusable and wearable all-in-one UV monitoring and shielding sensors.展开更多
The physiology and behaviors related to energy balance are monitored by the nervous and humoral systems. Because of the difficulty in treating diabetes and obesity, elucidating the energy balance mechanism and identif...The physiology and behaviors related to energy balance are monitored by the nervous and humoral systems. Because of the difficulty in treating diabetes and obesity, elucidating the energy balance mechanism and identifying critical targets for treatment are important research goals. Therefore, the purpose of this article is to describe energy regulation by the central nervous system(CNS) and peripheral humoral pathway. Homeostasis and rewarding are the basis of CNS regulation. Anorexigenic or orexigenic effects reflect the activities of the POMC/CART or NPY/AgRP neurons within the hypothalamus. Neurotransmitters have roles in food intake, and responsive brain nuclei have different functions related to food intake, glucose monitoring, reward processing. Peripheral gut-or adipose-derived hormones are the major source of peripheral humoral regulation systems. Nutrients or metabolites and gut microbiota affect metabolism via a discrete pathway. We also review the role of peripheral organs, the liver,adipose tissue, and skeletal muscle in peripheral regulation. We discuss these topics and how the body regulates metabolism.展开更多
文摘[Objectives] To analyze the volatile components,the contents of total flavonoids and total polysaccharides of the roots of Artemisia argyi Levl. et Van. var. argyi cv. Qiai,and to provide a scientific basis for the comprehensive development and utilization of the resources.[Methods]The volatile components of the roots were extracted by solid phase micro-extraction( SPME),and its volatile components were analyzed by gas chromatography-mass spectrometry( GC-MS); the contents of total flavonoids and total polysaccharides in the samples were measured by UV-spectrophotometry. [Results] 44 peaks were isolated from the roots and 30 components were identified,accounting for 80. 9% of the total volatile components; the content of total flavonoids in the roots was 9. 42%; the content of total polysaccharides in the roots was 11. 05%.[Conclusions] After a comprehensive investigation,the olefins in the roots generally have antibacterial activity,the contents of the total flavonoids and total polysaccharides contained in the roots were relatively high,the roots of Artemisia argyi do have broad prospects for the development.
基金supported by the National Natural Science Foundation of China(22138004 and 32001828).
文摘Higher alcohols are key factors affecting sensory quality and post-drinking comfort of alcoholic beverages. A strategy combining solid-phase extraction and gas chromatography-mass spectrometry(SPE-GC-MS) was established to analyze the metabolism pattern of higher alcohols in rat plasma after gavage of 4 common alcoholic beverages including huangjiu, baijiu, wine and brandy. 7 mL of dichloromethane was determined as the optimal extraction condition, and 8 higher alcohols were precisely quantified with detection limits of 1.82-11.65 μg/L, recoveries of 89.07%-110.89% and fine repeatability. The fastest absorption and elimination rates of plasma total higher alcohols were observed in baijiu and huangjiu group, respectively, and the highest peak concentration was found in brandy group. Additionally, the metabolic rate of plasma isoamyl alcohol in huangjiu group was faster than that in wine group at the same intragastric administration dosage. This study may provide potential insight for evaluation of alcoholic beverage quality.
文摘Insomnia significantly impacts university students’health and academic performance,making it essential to incorporate their experiences with insomnia into research.This study aims to explore the needs and expectations of university students in coping with insomnia and the implications for theory and practice.The research involved a survey of 110 students,with five participating in semi-structured in-depth interviews.The results revealed that students’needs and expectations for managing insomnia fall into three categories:online services,integrated university medical services,and socially interactive and shareable service models.The study found that addressing students’insomnia requires an understanding of these needs and expectations,with a human-centered approach proving effective in identifying and addressing students’actual requirements.These findings provide a foundation for further discussions on improving the accessibility of insomnia coping strategies for university students.
文摘AIM： To investigate the incidence of various types of postoperative pulmonary complications （POPCs） and to evaluate the significance of perioperative arterial blood gases in patients with esophageal cancer accompanied with chronic obstructive pulmonary disease （COPD） after esophagectomy. MEHTODS： Three hundred and fifty-eight patients were divided into POPC group and COPD group. We performed a retrospective review of the 358 consecutive patients after esophagectomy for esophageal cancer with or without COPD to assess the possible influence of COPD on postoperative pulmonary complications. We classified COPD into four grades according to percent-predicted forced expiratory volume in 1 s （FEV1） and analyzed the incidence rate of complications among the four grades. Perioperative arterial blood gases were tested in patients with or without pulmonary complications in COPD group and compared with POP（： group. RESULTS： Patients with COPD （29/86, 33.7%）had more pulmonary complications than those without COPD （36/272, 13.2%） （P〈0.001）. Pneumonia （15/29, 51.7%）, atelectasis （13/29, 44.8%）, prolonged 02 supplement （10/29, 34.5%）, and prolonged mechanical ventilation （8/29, 27.6%） were the major complications in COPD group. Moreover, patients with severe COPD （grade Ⅱ B, FEV1 〈 50% of predicted） had more POPCs than those with moderate（gradeⅡA,50%-80% of predicted） and mild （grade Ⅰ≥80% of predicted） COPD （P〈0.05）. PaO2 was decreased and PaCO2 was increased in patients with pulmonary complications in COPD group in the first postoperative week.CONCLUSION： The criteria of COPD are the critical predictor for pulmonary complications in esophageal cancer patients undergoing esophagectomy. Severity of COPD affects the incidence rate of the pulmonary complication,and percent-predicted FEV1 is a good predictive variable for pulmonary complication in patients-with COPD.Arterial blood gases are helpful in directing perioperative management.
基金This research was supported by the Key Program，the National Natural Science Foundation of China
文摘Objective We performed experiments using Neuregulin-1β （NRG-1β） treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions （GJs） during heart failure （HF）. Methods Rat models of I-IF were established by aortocaval fistula. Forty-eight rats were divided randomly into the HF （HF, n = 16）, NRG-1β trealanent （NRG, n = 16）, and sham operation （S, n = 16） group. The rats in the NRG group were administered NRG-1β （10 μg/kg per day） for 7 days via the tail vein, whereas the other groups were injected with the same doses of saline, Twelve weeks after operation, Connexin 43 （Cx43） expression in single myocytes obtained from the left ventricle was determined by immunocytochemistry. Total protein was extracted from frozen left ventricular tissues for immunoblotting assay, and the ultrastmcture of myocytes was observed by transmission electron microscopy. Results Compared with the HF group, the cardiac fimction of rats in the NRG group was markedly improved, irregular distribution and deceased Cx43 expression were relieved. The ultrastmcture of myocytes was seriously damaged in HF rats, and NRG-1β reduced these pathological damages. Conclusions Short-term NRG-1β treatment can rescue pump failure in experimental models of volume overload-induced HF, which is related to the recovery of GJs structure and the improvement of Cx43 expression.
基金supported by China Postdoctoral Science Foundation(No.2020TQ0032)the Key Projects of National Natural Science Foundation of China(No.51934001)+1 种基金the Fundamental Research Funds for the Central Universities(FRF-TP-20-037A1)the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities)(FRF-IDRY-20-019)。
文摘A blasting experiment was conducted on iron ore samples by considering multiple coupling charge coefficients.The resulting internal fracture and damage characteristics were quantitatively analyzed via computerized tomography(CT),scanning,and three-dimensional(3D)model reconstruction.The results show that the iron ore primarily displayed radial and circumferential cracks along the blast hole under an explosive load.When the decoupling coefficient was small,the crack surface was dominated by transgranular fractures in the form of intracrystalline fractures.As the uncoupling coefficient increased,the crack surface exhibited transgranular and intergranular coupled fracture modes.Using fractal theory to analyze crack distribution characteristics,as the decoupled coefficient increased,the body fractal dimension tended to decrease,and the degree of damage gradually decreased.The degree of damage reached a turning point when the decoupling charge coefficient was approximately 1.33.A numerical simulation suggested that the explosion energy transmitted to the iron ore and the effective stress decrease sharply when the decoupling coefficient exceeds 1.33.In some optimal uncoupling coefficient range,excessive fragmentation of the ore body is prevented,thereby allowing full use of the explosive energy.
基金the National Natural Science Foundation of China(No.51934001).
文摘Interlaid rock is an important component in the construction of neighborhood tunnels that supports and reinforces the area between two tunnels.However,the blasting load during excavation can sometimes damage the interlaid rock and threaten the stability of a tunnel’s structure.This paper presents a case study of the small clearance section of the Liantang highway tunnel project in Shenzhen,China,where the minimum distance between the two tunnels involved is only 0.5 m.To reduce the damage to the interlaid rock caused by blasting loads,we proposed a four-part excavation method with a vibrationcushioning rock layer in the following tunnel of neighborhood tunnels.Numerical simulation was used to model the damage prevention mechanism of the vibration-cushioning rock layer and to better understand the propagation of cracks in the interlaid rock.Furthermore,based on the simulation results,combined microseismic controlled-blasting technology was implemented,using innovative blasting patterns combined with different charge structures and blasting equipment designed according to the varying thickness of the interlaid rock.Finally,this implementation succeeded in protecting interlaid rock during blasting operations.
基金This study was supported by the National Natural Science Foundation of China,Nos.81871193(to XD),81671532(to BS),81771625&81701490(to XF),81801505(to MG)Jiangsu Provincial Medical Youth Talent of China,Nos.QNRC2016763(to XD),QNRC2016758(to LXX),QNRC2016762(to ML)+7 种基金the Science and Technology Project of Suzhou City of China,No.SS201709(to XD)the Natural Science Foundation of Jiangsu Province of China,No.BK20180205(to XD)the Training Program Foundation for Health Talents of Gusu of China,No.GSWS2019049(to XD)the Jiangsu Provincial Key Medical Discipline of China,No.ZDXKA2016013(to XF)the Jiangsu Province Women and Children Health Research Project of China,No.F201750(to LXX)the Pediatric Clinical Center of Suzhou City of China,No.Szzx201504(to XF)Suzhou Industrial Technology Innovation Project of China,No.SYS201765(to LZ)the Project of Suzhou Science,Education and Health and Technology,China,No.KJXW2018018(to ML).
文摘Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine,Soochow University,China(approval No.XD-2016-1)on January 15,2016.
文摘AIM:To assess the efficacy versus the adverse effects of various concentrations of atropine in the prevention of myopia in Asian children.METHODS:Databases(PubMed,EMBASE,the Cochrane Library and Web of science)were comprehensively searched from inception to April 2022.Types of studies included were randomized clinical trials(RCTs).The published languages were limited to English.Two researchers assessed the quality of included studies independently using Cochrane risk of bias tool based on the Cochrane Handbook for Systematic Reviews of Interventions.Funnel plots and Egger’s test were used for detection of publication bias.Meta-analyses were conducted using STATA(version 15.0;StataCorp).RESULTS:A total of 15 RCTs involving 2268 patients were included in the study.In the atropine group,spherical equivalent progressed at a significantly lower rate[weighted mean difference(WMD)=0.39,95%confidence interval(CI):0.23,0.54]than in the control group.A WMD of 0.15 mm was associated with less axial elongation(95%CI-0.19,-0.10).Different doses showed statistically significant differences(P<0.05)and an improved effect could result from a higher concentration.Changes in photopic pupil size and mesopic pupil size in atropine group is 0.70 mm(95%CI:0.33,1.06)and 0.38 mm(95%CI:0.22,0.54)more than the control group.In the present Meta-analysis,no changes in accommodative amplitude(AA)were associated with atropine administration.Atropine administration increased the risk of adverse effects by 1.37 times.CONCLUSION:Concentrations of less than 1%atropine are able to effectively retard diopter and axis growth of myopia in Asian children in a dose-dependent manner.Meanwhile,it caused pupil enlargement,but induced no change in the AA within this range.Further study is required to determine the dosage needed to achieve maximum efficacy and minimal side effects.
基金funded by the Agricultural Science and Technology Innovation Program (ASTIP-TRIC01)the Science Foundation for Young Scientists of the Tobacco Research Institute of the Chinese Academy of Agricultural Sciences(2016A04)+2 种基金the National Natural Science Foundation of China (31301678)Fundamental Research Funds for Central Nonprofit Scientific InstitutionTobacco Genome Project of China National Tobacco Corporation (110201601028, 110201402006, 110201301009)
文摘Cucumber mosaic virus(CMV) is one of the most severe viral diseases transmitted by aphids infecting Solanum crops in China, causing great losses of crop yields and income in rural communities.The tobacco cultivars NC82 and Taiyan 8 are closely related but differ in resistance to CMV.NC82 is susceptible to infection and Taiyan 8 is resistant, but the mechanisms underlying this difference in resistance are not clear.In this study, we conducted RNA sequencing to analyze changes in gene expression induced in the leaves of Taiyan 8 and NC82 upon systemic infection with CMV, compared with gene expression in the leaves of mock-inoculated plants.Leaves were sampled at one, three, eight, and 15 days after infection.In total, 3443 and 747 differentially expressed genes were identified in Taiyan 8 and NC82, respectively.Gene ontology and pathway enrichment analyses revealed that the different responses to CMV infection between cultivars were based on microtubulebased processes, pentose and glucuronate interconversions, plant–pathogen interaction,and hormone signal transduction pathways.Genes encoding pathogenesis-related proteins, disease-resistance proteins, lipoxygenase, cellulose synthase, an auxin response factor, and an ethylene receptor showed different expression patterns.The differences in gene expression following CMV infection likely contributed to the different resistance levels of these two tobacco cultivars.The comprehensive transcriptome dataset described here,which includes candidate response genes, will serve as a resource for further studies of the molecular mechanisms associated with tobacco defense responses against CMV.
基金financially supported by the Fundamental Research Funds for the Central Universities(No.FRF-AT-19-005)the National Natural Science Foundation of China(No.51934001).
文摘To solve the uneven burden of same-type holes reducing the blasting efficiency due to the limitation of drilling equipment,we need a double-face program-controlled planning method for hole position parameters used on a computer-controlled drilling jumbo.The cross-section splits into even and uneven areas.It also considers the uneven burden at the hole’s entrance and bottom.In the uneven area,various qualifying factors are made to optimize the hole spacing and maximize the burden uniformity,combined with the features of the area edges and gridbased segmentation methods.The hole position coordinates and angles in the even area are derived using recursion and iteration algorithms.As a case,this method presents all holes in a 4.8 m wide and 3.6 m high cross-section.Compared with the design produced by the drawing method,our planning in the uneven area improved the standard deviation of the hole burden by 40%.The improved hole layout facilitates the evolution of precise,efficient,and intelligent blasting in underground mines.
基金Supported by National Natural Science Foundation of China(No.81470654)Natural Science Foundation of Shaanxi Province(No.2019SF-047)。
文摘AIM:To evaluate the difference and the correlation between the concentrations of cytokines in the aqueous humor of eyes with macular edema secondary to diabetic retinopathy(DR)or retinal vein occlusion(RVO).METHODS:This is a retrospective case control study.The aqueous humor samples were collected during intravitreal injection of anti-vascular endothelial growth factor(VEGF)for patients diagnosed with macular edema secondary to DR(DME)or RVO(RVO-ME)at Xijing Hospital from August 2021 to July 2022.Meanwhile,aqueous humor samples during vitrectomy from patients with idiopathic macular hole(IMH)were also collected and served as controls.The aqueous humor concentrations of VEGF,platelet-derived factor(PDGF),interleukin(IL)-6,IL-8,IL-18,tumor necrosis factor-α(TNF-α)and monocyte chemoattractant protein 1(MCP-1)were measured with Human Premixed Multi-Analyte Kit(Luminex).The difference of the aqueous cytokines and the correlation between the two diseases were analyzed.RESULTS:A total of 40 eyes of 38 patients were enrolled in the study,including 13 eyes of 11 DME patients(DME group),16 eyes of 16 RVO-ME patients(RVO-ME group)and 11 eyes of 11 IMH patients(control group).The VEGF,PDGF,IL-6,IL-8,and MCP-1 levels of the aqueous humor were higher in both DME and RVO-ME groups compared with the control group(all P<0.05),the levels of TNF-αwas higher in the DME group than in the control group(P<0.05).The VEGF,IL-6,MCP-1,and TNF-αlevels in the aqueous humor were significantly higher in the DR group than those in the RVO group(all P<0.05).Correlation analyses revealed that there were complex positive correlations between IL-6,IL-8,IL-18,MCP-1,and TNF-αlevels in the aqueous humor of eyes with two diseases.CONCLUSION:Although ischemic and inflammatory factors are similarly involved in the pathogenesis of DME and RVO-ME,the roles of these factors are more significant or more likely to be activated in DR patients,suggesting different treatment strategies should be considered for the two diseases.
基金This work is financially supported by Beijing Municipal Natural Science Foundation(No.L202012)the Open Research Project of the State Key Laboratory of Media Convergence and Communication,Communication University of China(No.SKLMCC2020KF008)the Fundamental Research Funds for the Central Universities(No.2020RC05).
文摘Fast data synchronization in wireless ad hoc networks is a challenging and critical problem.It is fundamental for efficient information fusion,control and decision in distributed systems.Previously,distributed data synchronization was mainly studied in the latency-tolerant distributed databases,or assuming the general model of wireless ad hoc networks.In this paper,we propose a pair of linear network coding(NC)and all-to-all broadcast based fast data synchronization algorithms for wireless ad hoc networks whose topology is under operator’s control.We consider both data block selection and transmitting node selection for exploiting the benefits of NC.Instead of using the store-and-forward protocol as in the conventional uncoded approach,a compute-and-forward protocol is used in our scheme,which improves the transmission efficiency.The performance of the proposed algorithms is studied under different values of network size,network connection degree,and per-hop packet error rate.Simulation results demonstrate that our algorithms significantly reduce the times slots used for data synchronization compared with the baseline that does not use NC.
基金This work is financially supported by the Beijing Municipal Natural Science Foundation(L202012)the Open Research Project of the State Key Laboratory of Media Convergence and Communication,Communication University of China(SKLMCC2020KF008)the Fundamental Research Funds for the Central Universities(2020RC05).The authors would like to thank Professor Ping Zhang(Member of the Chinese Academy of Engineering,Beijing University of Posts and Telecommunications)and Professor Quan Yu(Member of the Chinese Academy of Engineering,Peng Cheng Laboratory)for their insightful comments and suggestions.
文摘As a special type of mobile ad hoc network(MANET),the flying ad hoc network(FANET)has the potential to enable a variety of emerging applications in both civilian wireless communications(e.g.,5G and 6G)and the defense industry.The routing protocol plays a pivotal role in FANET.However,when designing the routing protocol for FANET,it is conventionally assumed that the aerial nodes move randomly.This is clearly inappropriate for a mission-oriented FANET(MO-FANET),in which the aerial nodes typically move toward a given destination from given departure point(s),possibly along a roughly deterministic flight path while maintaining a well-established formation,in order to carry out certain missions.In this paper,a novel cyber–physical routing protocol exploiting the particular mobility pattern of an MO-FANET is proposed based on cross-disciplinary integration,which makes full use of the missiondetermined trajectory dynamics to construct the time sequence of rejoining and separating,as well as the adjacency matrix for each node,as prior information.Compared with the existing representative routing protocols used in FANETs,our protocol achieves a higher packet-delivery ratio(PDR)at the cost of even lower overhead and lower average end-to-end latency,while maintaining a reasonably moderate and stable network jitter,as demonstrated by extensive ns-3-based simulations assuming realistic configurations in an MO-FANET.
文摘Citation:Gong M,Hui YN,Du HJ.A rare case of severe toxic optic neuropathy induced by formaldehyde vapor under working in mushroom cultivation room.Int J Ophthalmol 2021;14(12):1993-1996 Dear Editor,We are writing this letter to present a rare case of severe toxic optic neuropathy induced by formaldehyde(FA)vapor under working in mushroom cultivation room.Since such circumstance exists popularly in rural China,this case warns us to pay more attention to avoid similar cases.A 49-year-old male complained of bilateral vision loss after continuous working for 11h in an air-tight greenhouse filled with FA vapor on 03/15/2018.Soon after work,the patient felt weakness,dizziness,and nausea.Instead of asking for medical consultation,he went home to sleep.The next day,the patient was found to be in a coma with dyspnea and was taken to the local hospital by his family.His blood pressure waved around 70-80/50-65 mm Hg,and then maintained at 100/80 mm Hg by catecholamines.He was diagnosed with acute FA poisoning,pulmonary edema,metabolic acidosis,respiratory alkalosis,and hypotension and was given symptomatic relief and supportive measures.
基金This work was supported by the National Natural Science Foundation of China(grants 30772039 and 81072440)the National Natural Science Foundation of China-Guangdong Province Union Grant(U0832003)the Ministry of Science and Technology of China(grant 2007CB512402).
文摘It has been reported that splenic stromal cells(SSCs)are capable of directly supporting the development of CD11c ^(lo)CD45RB^(+) IL-10-producing dendritic cells(DCs)from lineage-negative c-kit^(+) progenitor cells in the absence of exogenous cytokines.In vitro,DCs that differentiate on stromal cells suppress mixed leukocyte reaction responses and induce primary alloreactive CD4^(+) T cells to differentiate into IL-10-producing Tr1 cells.However,the precise mechanisms by which these SSCs exert their regulatory functions in vivo remain undefined.Furthermore,their possible contribution to the development of allograft transplantation tolerance has yet to be examined.Here,we have used both murine skin and cardiac allograft transplantation models to explore whether in vivo alloresponses can be regulated by infusion with donor-derived SSCs and to investigate the possible mechanisms by which SSCs exert regulatory effects to prevent allograft rejection.We show that intravenous SSC infusion prolonged murine skin allograft survival.The prolonged graft survival is associated with augmentation of the generation of regulatory DC subsets and CD4^(+) CD25^(+) Foxp3^(+) regulatory T cells(Tregs),as well as upregulation of the production of suppressive cytokines IL-10 and transforming growth factor(TGF)-b.Moreover,we found that indoleamine 2,3-dioxygenase and SSC-derived regulatory DCs contribute to allograft protection by infusion of donor-specific SSCs.Our data suggest that donor-derived SSCs could be used as a therapeutic target to promote transplantation tolerance.
基金supported by the National Natural Science Foundation of China (92156016, U23A20593 and 22071003)the National Key R&D Program of China (2021YFB3500400, 2021YFB3501800 and 2022YFB3503700)the China Postdoctoral Science Foundation (2023TQ0004)。
文摘Circularly polarized organic light-emitting diode(CP-OLED) has attracted increasing interest for its efficient ability to generate circularly polarized light directly. So far, many CP-OLEDs were successfully fabricated with chiral emitters or chiral hosts. In this study, a new strategy based on chiral electron transporting layer is proposed to construct CP-OLEDs. A pair of chiral electron transporting materials, 1,3,5-tris((R/S)-4-isopropyl-4,5-dihydrooxazol-2-yl)benzene((R/S)-TOx^(i)Pr), are firstly designed and synthesized. The crystalline films of(R/S)-TOx^(i)Pr show circularly polarized photoluminescence with photoluminescence dissymmetry factors of-0.067 and +0.041, respectively. The CP-OLEDs based on(R/S)-TOx^(i)Pr and three types of achiral emitters all exhibit circularly polarized electroluminescence, showing feasibility and strong versatility of this new strategy. The mechanism is attributed to in-situ electrical excitation instead of simply light filtering of non-circularly polarized light. This work demonstrates a new approach for realizing circularly polarized electroluminescence which may provide a valuable strategy to develop CP-OLEDs.
基金This work was financially supported by Beijing Natural Science Foundation(No.2242044)the National Natural Science Foundation of China(Nos.52103049,22005021 and 51373025)+2 种基金the Fundamental Research Funds for the Central Universities(No.FRF-TP-22-003A1)China Postdoctoral Science Foundation(No.2023M730311)the Program for New Century Excellent Talents in University(No.NCET-11-0582).
文摘Moderate ultraviolet(UV)radiation from sunlight is essential for human health,but overexposure to UV rays can cause serious adverse effects.It is important to detect UV radiation from sunlight in time to prevent damage from excessive exposure.Here,a ready-to-use,easy-to-interpret,inexpensive,reusable,and wearable all-in-one UV monitoring and shielding sensor SP-TPE@PU textile has been developed.The SP-TPE@PU textiles are constructed by photochromic molecule SP-TPE and commercial polymer polyurethane(PU)through electrospinning.The SP-TPE molecule acts as the sensor component,and PU contributes to high flexibility.The SP-TPE@PU textiles show remarkable durability(against repeated twisting,curling,bending deformations,and water immersion)and good permeability,making them durable and breathable wearable materials.When exposed to sunlight,the SP-TPE@PU textiles rapidly exhibit significant color changes due to the efficient isomerization of SP-TPE,serving as an early warning and monitoring of UV radiation.In addition,the SP-TPE@PU textiles can revert to the initial state with visible light irradiation for reuse.Furthermore,the SP-TPE@PU textiles possess excellent UV shielding ability,contributing to human body protection.Simple and easy operation,significant and reversible color changes,good breathability and mechanical properties make SP-TPE@PU textiles reusable and wearable all-in-one UV monitoring and shielding sensors.
基金supported by the National Natural Science Foundation of China (81370932)the United States MERCK IISP Fund (40313, 40309)+2 种基金Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai (PWR12014-06)Integrative Medicine special fund of Shanghai Municipal Health Planning Committee (ZHYY-ZXYJHZX2-201712)the Key Studies (Special) Department Fund of the Pudong New Area Health Planning Commission (PWZzk2017-03)
文摘The physiology and behaviors related to energy balance are monitored by the nervous and humoral systems. Because of the difficulty in treating diabetes and obesity, elucidating the energy balance mechanism and identifying critical targets for treatment are important research goals. Therefore, the purpose of this article is to describe energy regulation by the central nervous system(CNS) and peripheral humoral pathway. Homeostasis and rewarding are the basis of CNS regulation. Anorexigenic or orexigenic effects reflect the activities of the POMC/CART or NPY/AgRP neurons within the hypothalamus. Neurotransmitters have roles in food intake, and responsive brain nuclei have different functions related to food intake, glucose monitoring, reward processing. Peripheral gut-or adipose-derived hormones are the major source of peripheral humoral regulation systems. Nutrients or metabolites and gut microbiota affect metabolism via a discrete pathway. We also review the role of peripheral organs, the liver,adipose tissue, and skeletal muscle in peripheral regulation. We discuss these topics and how the body regulates metabolism.
