The properties of collapsible loess are complex.The self-gravity of overlying soil,sei gravity stress and additional stress act together,which will damage the soil structure and lead to the deformation of the soil str...The properties of collapsible loess are complex.The self-gravity of overlying soil,sei gravity stress and additional stress act together,which will damage the soil structure and lead to the deformation of the soil structure.Collapsible loess is widely distributed in Northwest and Northeast China.A series of problems caused by its structural characteristics will affect the quality of foundation construction.Therefore,construction enterprises need to deeply study the foundation treatment measures of collapsible loess,so as to avoid the uneven settlement after the construction of collapsible yellow soil foundation.This paper analyzes from the judgment and classification of collapsible loess,studies the impact of collapsible loess on building fbxmdation construction,and explores the specific construction treatment measures of collapsible loess,in order to promote the effective application of foundation construction.展开更多
Zinc(Zn)alloys have demonstrated significant potential in healing critical-sized bone defects.However,the clinical application of Zn alloys implants is still hindered by challenges including excessive release of zinc ...Zinc(Zn)alloys have demonstrated significant potential in healing critical-sized bone defects.However,the clinical application of Zn alloys implants is still hindered by challenges including excessive release of zinc ions(Zn^(2+)),particularly in the early stage of implantation,and absence of bio-functions related to complex bone repair processes.Herein,a biodegradable aliphatic polycarbonate drug-eluting coating was fabricated on zinc-lithium(Zn-Li)alloys to inhibit Zn^(2+)release and enhance the osteogenesis,angiogenesis,and bacteriostasis of Zn alloys.Specifically,the photo-curable aliphatic polycarbonates were co-assembled with simvastatin and deposited onto Zn alloys to produce a drug-loaded coating,which was crosslinked by subsequent UV light irradiation.During the 60 days long-term immersion test,the coating showed distinguished stable drug release and Zn^(2+)release inhibition properties.Benefiting from the regulated release of Zn^(2+)and simvastatin,the coating facilitated the adhesion,proliferation,and differentiation of MC3T3-E1 cells,as well as the migration and tube formation of EA.hy926 cells.Astonishingly,the coating also showed remarkable antibacterial properties against both S.aureus and E.coli.The in vivo rabbit critical-size femur bone defects model demonstrated that the drug-eluting coating could efficiently promote new bone formation and the expression of platelet endothelial cell adhesion molecule-1(CD31)and osteocalcin(OCN).The enhancement of osteogenesis,angiogenesis,and bacteriostasis is achieved by precisely controlling of the released Zn^(2+)at an appropriate level,as well as the stable release profile of simvastatin.This tailored aliphatic polycarbonate drug-eluting coating provides significant potential for clinical applications of Zn alloys implants.展开更多
文摘The properties of collapsible loess are complex.The self-gravity of overlying soil,sei gravity stress and additional stress act together,which will damage the soil structure and lead to the deformation of the soil structure.Collapsible loess is widely distributed in Northwest and Northeast China.A series of problems caused by its structural characteristics will affect the quality of foundation construction.Therefore,construction enterprises need to deeply study the foundation treatment measures of collapsible loess,so as to avoid the uneven settlement after the construction of collapsible yellow soil foundation.This paper analyzes from the judgment and classification of collapsible loess,studies the impact of collapsible loess on building fbxmdation construction,and explores the specific construction treatment measures of collapsible loess,in order to promote the effective application of foundation construction.
基金support for this work from the National Natural Science Foundation of China,China (52173127).
文摘Zinc(Zn)alloys have demonstrated significant potential in healing critical-sized bone defects.However,the clinical application of Zn alloys implants is still hindered by challenges including excessive release of zinc ions(Zn^(2+)),particularly in the early stage of implantation,and absence of bio-functions related to complex bone repair processes.Herein,a biodegradable aliphatic polycarbonate drug-eluting coating was fabricated on zinc-lithium(Zn-Li)alloys to inhibit Zn^(2+)release and enhance the osteogenesis,angiogenesis,and bacteriostasis of Zn alloys.Specifically,the photo-curable aliphatic polycarbonates were co-assembled with simvastatin and deposited onto Zn alloys to produce a drug-loaded coating,which was crosslinked by subsequent UV light irradiation.During the 60 days long-term immersion test,the coating showed distinguished stable drug release and Zn^(2+)release inhibition properties.Benefiting from the regulated release of Zn^(2+)and simvastatin,the coating facilitated the adhesion,proliferation,and differentiation of MC3T3-E1 cells,as well as the migration and tube formation of EA.hy926 cells.Astonishingly,the coating also showed remarkable antibacterial properties against both S.aureus and E.coli.The in vivo rabbit critical-size femur bone defects model demonstrated that the drug-eluting coating could efficiently promote new bone formation and the expression of platelet endothelial cell adhesion molecule-1(CD31)and osteocalcin(OCN).The enhancement of osteogenesis,angiogenesis,and bacteriostasis is achieved by precisely controlling of the released Zn^(2+)at an appropriate level,as well as the stable release profile of simvastatin.This tailored aliphatic polycarbonate drug-eluting coating provides significant potential for clinical applications of Zn alloys implants.
