Myelin damage and a wide range of symptoms are caused by the immune system targeting the central nervous system in Multiple Sclerosis(MS),a chronic autoimmune neurological condition.It disrupts signals between the bra...Myelin damage and a wide range of symptoms are caused by the immune system targeting the central nervous system in Multiple Sclerosis(MS),a chronic autoimmune neurological condition.It disrupts signals between the brain and body,causing symptoms including tiredness,muscle weakness,and difficulty with memory and balance.Traditional methods for detecting MS are less precise and time-consuming,which is a major gap in addressing this problem.This gap has motivated the investigation of new methods to improve MS detection consistency and accuracy.This paper proposed a novel approach named FAD consisting of Deep Neural Network(DNN)fused with an Artificial Neural Network(ANN)to detect MS with more efficiency and accuracy,utilizing regularization and combat over-fitting.We use gene expression data for MS research in the GEO GSE17048 dataset.The dataset is preprocessed by performing encoding,standardization using min-max-scaler,and feature selection using Recursive Feature Elimination with Cross-Validation(RFECV)to optimize and refine the dataset.Meanwhile,for experimenting with the dataset,another deep-learning hybrid model is integrated with different ML models,including Random Forest(RF),Gradient Boosting(GB),XGBoost(XGB),K-Nearest Neighbors(KNN)and Decision Tree(DT).Results reveal that FAD performed exceptionally well on the dataset,which was evident with an accuracy of 96.55%and an F1-score of 96.71%.The use of the proposed FAD approach helps in achieving remarkable results with better accuracy than previous studies.展开更多
Volcanic eruptions release large amounts of ash clouds and gas aerosols into the atmosphere,which can be simulated by air quality prediction models.However,the performance of these models remains unsatisfactory,even t...Volcanic eruptions release large amounts of ash clouds and gas aerosols into the atmosphere,which can be simulated by air quality prediction models.However,the performance of these models remains unsatisfactory,even though both relevant physics and chemistry are considered.Hence,exploring the approaches for improvement such as inclusion of data assimilation is significative.In this study,we depict the modeling of the volcanic ash dispersion from the Hunga Tonga–Hunga Ha’apai underwater volcano,which erupted in a series of large explosions in late December 2021 and early January 2022.On 15 January 2022,a particularly significant explosion sent a massive ash cloud high into the atmosphere.We used the inline Weather Research and Forecasting model coupled with chemistry(WRF-Chem)and incorporated meteorological data assimilation within the Flux Adjusting Surface Data Assimilation System(FASDAS).We compared three forecast scenarios:one with only meteorology and no chemistry(OMET),one with gas and aerosol chemistry and no assimilation(NODA),and one with both chemistry and assimilation(FASDAS).We found that FASDAS resulted in lower planetary boundary layer height(PBLH),downward surface shortwave flux,and 2-m temperature by up to 800 m,200 W m^(−2),and 6℃ on the land portion,respectively,while the opposite was observed near the eruption site.We validated the model against the observations and the results showed that FASDAS significantly enhanced the model performance in retrieving meteorological variables.However,the simulations also revealed significant biases in the concentration of volcanic ash around the ash clouds.Data from the Copernicus TROPOspheric Monitoring Instrument Sentinel-5 Precursor(TROPOMI-S5P)showed a westward trend of the total SO2 emissions.This work demonstrates the significant contribution of data assimilation to the results of operational air quality predictions during violent volcanic eruption events.展开更多
基金supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2024R503),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘Myelin damage and a wide range of symptoms are caused by the immune system targeting the central nervous system in Multiple Sclerosis(MS),a chronic autoimmune neurological condition.It disrupts signals between the brain and body,causing symptoms including tiredness,muscle weakness,and difficulty with memory and balance.Traditional methods for detecting MS are less precise and time-consuming,which is a major gap in addressing this problem.This gap has motivated the investigation of new methods to improve MS detection consistency and accuracy.This paper proposed a novel approach named FAD consisting of Deep Neural Network(DNN)fused with an Artificial Neural Network(ANN)to detect MS with more efficiency and accuracy,utilizing regularization and combat over-fitting.We use gene expression data for MS research in the GEO GSE17048 dataset.The dataset is preprocessed by performing encoding,standardization using min-max-scaler,and feature selection using Recursive Feature Elimination with Cross-Validation(RFECV)to optimize and refine the dataset.Meanwhile,for experimenting with the dataset,another deep-learning hybrid model is integrated with different ML models,including Random Forest(RF),Gradient Boosting(GB),XGBoost(XGB),K-Nearest Neighbors(KNN)and Decision Tree(DT).Results reveal that FAD performed exceptionally well on the dataset,which was evident with an accuracy of 96.55%and an F1-score of 96.71%.The use of the proposed FAD approach helps in achieving remarkable results with better accuracy than previous studies.
基金Supported by the Research Supporting Project(PNURSP2024R503)of Princess Nourah Bint Abdulrahman University,Saudi Arabia.
文摘Volcanic eruptions release large amounts of ash clouds and gas aerosols into the atmosphere,which can be simulated by air quality prediction models.However,the performance of these models remains unsatisfactory,even though both relevant physics and chemistry are considered.Hence,exploring the approaches for improvement such as inclusion of data assimilation is significative.In this study,we depict the modeling of the volcanic ash dispersion from the Hunga Tonga–Hunga Ha’apai underwater volcano,which erupted in a series of large explosions in late December 2021 and early January 2022.On 15 January 2022,a particularly significant explosion sent a massive ash cloud high into the atmosphere.We used the inline Weather Research and Forecasting model coupled with chemistry(WRF-Chem)and incorporated meteorological data assimilation within the Flux Adjusting Surface Data Assimilation System(FASDAS).We compared three forecast scenarios:one with only meteorology and no chemistry(OMET),one with gas and aerosol chemistry and no assimilation(NODA),and one with both chemistry and assimilation(FASDAS).We found that FASDAS resulted in lower planetary boundary layer height(PBLH),downward surface shortwave flux,and 2-m temperature by up to 800 m,200 W m^(−2),and 6℃ on the land portion,respectively,while the opposite was observed near the eruption site.We validated the model against the observations and the results showed that FASDAS significantly enhanced the model performance in retrieving meteorological variables.However,the simulations also revealed significant biases in the concentration of volcanic ash around the ash clouds.Data from the Copernicus TROPOspheric Monitoring Instrument Sentinel-5 Precursor(TROPOMI-S5P)showed a westward trend of the total SO2 emissions.This work demonstrates the significant contribution of data assimilation to the results of operational air quality predictions during violent volcanic eruption events.
