Elevated atmospheric carbon dioxide(CO_(2)) concentrations have caused global climate change such as global warming and more frequent climate extremes. Countries worldwide have proposed carbon neutrality strategies to...Elevated atmospheric carbon dioxide(CO_(2)) concentrations have caused global climate change such as global warming and more frequent climate extremes. Countries worldwide have proposed carbon neutrality strategies to curb the rising CO_(2) concentrations. To investigate the impact of China's carbon neutrality goal on atmospheric CO_(2) concentrations, we conducted a series of ideal simulations from 2015 to 2019 using a global 3D chemistry transport model, Goddard Earth Observing System Chemistry(GEOS-Chem). Compared with the column-averaged dry-air mole fraction of atmospheric CO_(2) (XCO_(2) ) from Orbiting Carbon Observatory-2(OCO-2) and surface CO_(2) measurements in Obs Pack, we find that GEOS-Chem effectively reproduces the spatiotemporal variability of CO_(2) . The model exhibits a root mean square error(RMSE) of 1.51 ppm(R^(2)=0.89) for OCO-2 XCO_(2) in China and 2.65 ppm(R^(2)=0.75) for surface CO_(2) concentrations at the WLG station. Further, compared to 2.83 ppm yr^(-1)in the control experiment, we suggest that net-zero CO_(2) emissions in China decelerate the increasing trends of XCO_(2) to 1.81 ppm yr^(-1),making a decrease of approximately 35.89%. Meanwhile, the seasonal cycle amplitude(SCA) of XCO_(2) is moderately reduced from 7.39±0.81 to 6.75±0.70 ppm, representing a relative reduction of 9.91%. Spatially, net-zero CO_(2) emissions induce a more significant decrease in XCO_(2) trends over northern and southern China, while their impact on SCA is more evident in northern and northeastern China. Moreover, ideal experiments demonstrate that zero fossil CO_(2) emissions lead to a greater attenuation of the linear trends of XCO_(2) by 40.81%, while the absence of terrestrial CO_(2) sinks largely diminishes the SCA by 16.61%. Additionally,trends and SCA in surface CO_(2) concentrations exhibit almost identical decreasing responses to net-zero CO_(2) emissions but display greater sensitivities compared to XCO_(2) . Overall, our study underscores the potential of China's carbon neutrality goal in mitigating global warming, underscoring the need for concerted and collaborative efforts from nations worldwide.展开更多
Objective:To explore the effect of allocating case managers for gestational diabetes patients.Methods:200 patients with gestational diabetes mellitus from December 2021 to December 2022 were included in this study,and...Objective:To explore the effect of allocating case managers for gestational diabetes patients.Methods:200 patients with gestational diabetes mellitus from December 2021 to December 2022 were included in this study,and the collection period.They were divided into groups according to the interventions received.Each patient in the observation group was managed by a case manager,while the control group were managed with conventional methods without the supervision of a case manager.There were 100 cases in each group,and the curative effects of the two groups were compared.Results:The fasting blood glucose and 2-hour postprandial blood glucose in the observation group were significantly lower than those of the control group(P<0.05).The re-admission rate of patients due to poor blood sugar control in the observation group was lower than that in the control group(P<0.05).The pregnancy outcome of the observation group was better than that of the control group(P<0.05).Conclusion:Case management of gestational diabetes can not only control the blood glucose of pregnant women,but also improve pregnancy outcomes.展开更多
在抗原-抗体分子对接模拟所生成的大量计算生成构象中筛选出近天然结构,即接近真实情况的抗原-抗体结合模式。借鉴QSAR原理,定义抗原-抗体接触面描述符并利用Discovery Studio 4.5软件平台计算出各对接模拟构象的接触面描述符和能量参...在抗原-抗体分子对接模拟所生成的大量计算生成构象中筛选出近天然结构,即接近真实情况的抗原-抗体结合模式。借鉴QSAR原理,定义抗原-抗体接触面描述符并利用Discovery Studio 4.5软件平台计算出各对接模拟构象的接触面描述符和能量参数。构造训练集数据进行回归分析,建立预测对接模拟构象是否是近天然结构的数学模型。通过测试集和实际应用情况检验该数学模型。通过回归分析所建立的数学模型能够在成百上千的抗原-抗体对接模拟构象中有效筛选出其中的近天然结构,在测试集验证和4G7抗体结合模式预测应用中具有良好的表现,验证了该数学模型的有效性和实用性。经验性的抗原-抗体接触面特征如氢键密度、氨基酸对偏好性指数等以及能量参数能够共同有效表征近天然结构,所建立的数学模型有效增强了通过分子对接预测抗原-抗体结合模式的可行性。展开更多
The propagation and underlying mechanisms of the boreal summer quasi-biweekly oscillation（QBWO）over the entire Asian monsoon region are investigated,based on ECMWF Interim reanalysis（ERA-Interim）data,GPCP precipit...The propagation and underlying mechanisms of the boreal summer quasi-biweekly oscillation（QBWO）over the entire Asian monsoon region are investigated,based on ECMWF Interim reanalysis（ERA-Interim）data,GPCP precipitation data,and an atmospheric general circulation model（AGCM）.Statistical analyses indicate that the QBWO over the Asian monsoon region derives its main origin from the equatorial western Pacific and moves northwestward to the Bay of Bengal and northern India,and then northward to the Tibetan Plateau（TP）area,with a baroclinic vertical structure.Northward propagation of the QBWO is promoted by three main mechanisms：barotropic vorticity,boundary moisture advection,and surface sensible heating（SSH）.It is dominated by the barotropic vorticity effect when the QBWO signals are situated to the south of 20°N.During the propagation taking place farther north toward the TP,the boundary moisture advection and SSH are the leading mechanisms.We use an AGCM to verify the importance of SSH on the northward propagation of the QBWO.Numerical simulations confirm the diagnostic conclusion that the equatorial western Pacific is the source of the QBWO.Importantly,the model can accurately simulate the propagation pathway of the QBWO signals over the Asian monsoon region.Simultaneously,sensitivity experiments demonstrate that the SSH over northern India and the southern slope of the TP greatly contributes to the northward propagation of the QBWO as far as the TP area.展开更多
基金supported by the National Key Research and Development Program of China (Grant No. 2022YFB3904801)the National Natural Science Foundation of China (Grant No. 42475129)+2 种基金the Natural Science Foundation of Jiangsu Province, China (Grant No. BK20221449)the Xizang Science and Technology Innovation Base Construction Project (Grant No. XZ202401YD0008)the National Key Scientific and Technological Infrastructure project “Earth System Numerical Simulation Facility” (Grant No. 2023-EL-ZD-00022)。
文摘Elevated atmospheric carbon dioxide(CO_(2)) concentrations have caused global climate change such as global warming and more frequent climate extremes. Countries worldwide have proposed carbon neutrality strategies to curb the rising CO_(2) concentrations. To investigate the impact of China's carbon neutrality goal on atmospheric CO_(2) concentrations, we conducted a series of ideal simulations from 2015 to 2019 using a global 3D chemistry transport model, Goddard Earth Observing System Chemistry(GEOS-Chem). Compared with the column-averaged dry-air mole fraction of atmospheric CO_(2) (XCO_(2) ) from Orbiting Carbon Observatory-2(OCO-2) and surface CO_(2) measurements in Obs Pack, we find that GEOS-Chem effectively reproduces the spatiotemporal variability of CO_(2) . The model exhibits a root mean square error(RMSE) of 1.51 ppm(R^(2)=0.89) for OCO-2 XCO_(2) in China and 2.65 ppm(R^(2)=0.75) for surface CO_(2) concentrations at the WLG station. Further, compared to 2.83 ppm yr^(-1)in the control experiment, we suggest that net-zero CO_(2) emissions in China decelerate the increasing trends of XCO_(2) to 1.81 ppm yr^(-1),making a decrease of approximately 35.89%. Meanwhile, the seasonal cycle amplitude(SCA) of XCO_(2) is moderately reduced from 7.39±0.81 to 6.75±0.70 ppm, representing a relative reduction of 9.91%. Spatially, net-zero CO_(2) emissions induce a more significant decrease in XCO_(2) trends over northern and southern China, while their impact on SCA is more evident in northern and northeastern China. Moreover, ideal experiments demonstrate that zero fossil CO_(2) emissions lead to a greater attenuation of the linear trends of XCO_(2) by 40.81%, while the absence of terrestrial CO_(2) sinks largely diminishes the SCA by 16.61%. Additionally,trends and SCA in surface CO_(2) concentrations exhibit almost identical decreasing responses to net-zero CO_(2) emissions but display greater sensitivities compared to XCO_(2) . Overall, our study underscores the potential of China's carbon neutrality goal in mitigating global warming, underscoring the need for concerted and collaborative efforts from nations worldwide.
文摘Objective:To explore the effect of allocating case managers for gestational diabetes patients.Methods:200 patients with gestational diabetes mellitus from December 2021 to December 2022 were included in this study,and the collection period.They were divided into groups according to the interventions received.Each patient in the observation group was managed by a case manager,while the control group were managed with conventional methods without the supervision of a case manager.There were 100 cases in each group,and the curative effects of the two groups were compared.Results:The fasting blood glucose and 2-hour postprandial blood glucose in the observation group were significantly lower than those of the control group(P<0.05).The re-admission rate of patients due to poor blood sugar control in the observation group was lower than that in the control group(P<0.05).The pregnancy outcome of the observation group was better than that of the control group(P<0.05).Conclusion:Case management of gestational diabetes can not only control the blood glucose of pregnant women,but also improve pregnancy outcomes.
基金the National Key Research and Development Program of China(2021YFB3901001)the Natural Science Foundation of Jiangsu Province,China(BK20221449)+2 种基金the Basic Science Center Project of China(42288101)the National Natural Science Foundation of China(42141005 and 41807434)the Research Funds for the Frontiers Science Center for Critical Earth Material Cycling,Nanjing University(090414380031)。
文摘在抗原-抗体分子对接模拟所生成的大量计算生成构象中筛选出近天然结构,即接近真实情况的抗原-抗体结合模式。借鉴QSAR原理,定义抗原-抗体接触面描述符并利用Discovery Studio 4.5软件平台计算出各对接模拟构象的接触面描述符和能量参数。构造训练集数据进行回归分析,建立预测对接模拟构象是否是近天然结构的数学模型。通过测试集和实际应用情况检验该数学模型。通过回归分析所建立的数学模型能够在成百上千的抗原-抗体对接模拟构象中有效筛选出其中的近天然结构,在测试集验证和4G7抗体结合模式预测应用中具有良好的表现,验证了该数学模型的有效性和实用性。经验性的抗原-抗体接触面特征如氢键密度、氨基酸对偏好性指数等以及能量参数能够共同有效表征近天然结构,所建立的数学模型有效增强了通过分子对接预测抗原-抗体结合模式的可行性。
基金Supported by the Startup Fund for Introducing Talent of Nanjing University of Information Science&Technology(2015r032)Open Research Fund of the Plateau Atmosphere and Environment Key Laboratory of Sichuan Province(PAEKL-2017-K4)National Natural Science Foundation of China(91337218 and 41605039)
文摘The propagation and underlying mechanisms of the boreal summer quasi-biweekly oscillation（QBWO）over the entire Asian monsoon region are investigated,based on ECMWF Interim reanalysis（ERA-Interim）data,GPCP precipitation data,and an atmospheric general circulation model（AGCM）.Statistical analyses indicate that the QBWO over the Asian monsoon region derives its main origin from the equatorial western Pacific and moves northwestward to the Bay of Bengal and northern India,and then northward to the Tibetan Plateau（TP）area,with a baroclinic vertical structure.Northward propagation of the QBWO is promoted by three main mechanisms：barotropic vorticity,boundary moisture advection,and surface sensible heating（SSH）.It is dominated by the barotropic vorticity effect when the QBWO signals are situated to the south of 20°N.During the propagation taking place farther north toward the TP,the boundary moisture advection and SSH are the leading mechanisms.We use an AGCM to verify the importance of SSH on the northward propagation of the QBWO.Numerical simulations confirm the diagnostic conclusion that the equatorial western Pacific is the source of the QBWO.Importantly,the model can accurately simulate the propagation pathway of the QBWO signals over the Asian monsoon region.Simultaneously,sensitivity experiments demonstrate that the SSH over northern India and the southern slope of the TP greatly contributes to the northward propagation of the QBWO as far as the TP area.
