Objective:To evaluate the anti-ulcer activity and acute toxicity ofFicus religiosa(F. religiosa)leaf ethanolic extract in animal models.Methods:Anti-ulcer activity ofF. religiosaethanolicextract(250 and 500 mg/kg body...Objective:To evaluate the anti-ulcer activity and acute toxicity ofFicus religiosa(F. religiosa)leaf ethanolic extract in animal models.Methods:Anti-ulcer activity ofF. religiosaethanolicextract(250 and 500 mg/kg body weight) was studied on stress induced ulcer animal models.Ranitidine was used as standard. The anti-ulcer activity ofF. religiosawas evaluated with thehelp of ulcer area and histopatholgical examination. Preliminary phyto-chemical screeningand acute toxicity studies ofF. religiosaalso carried out.Results:Results showed that theextract treatments prevented ulcer area and gastric secretion in a dose-dependent manner.Administration of 2000 mg/kg extract did not show any acute toxicity in albino mice. Preliminaryphytochemical analysis identified the presence of flavonoids in the ethanolic extract ofF. religiosa.Conclusions:The extract is non-toxic even at relatively high concentrations. The anti-ulceractivity is probably due to the presence of flavanoids.展开更多
Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(P.eous) mushroom.Methods:The dried fruiting bodies were extracted with ethyl acetate,methanol and water....Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(P.eous) mushroom.Methods:The dried fruiting bodies were extracted with ethyl acetate,methanol and water.The analgesic effect of extracts of P.eous were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip tests.Results:P.eous extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P【0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P【0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P【0.05).Conclusions:The results of present study suggest that extracts of P.eous possess potent analgesic property and could serve as a base for future drugs.展开更多
AIM: This study was aimed at evaluating the anti-diabetic activity of the ethanol and aqueous extracts of the leaf material of Barringtonia acutangula in a diabetic animal model. METHODS: The ethanolic and aqueous ext...AIM: This study was aimed at evaluating the anti-diabetic activity of the ethanol and aqueous extracts of the leaf material of Barringtonia acutangula in a diabetic animal model. METHODS: The ethanolic and aqueous extracts(250 and 500 mg kg 1body weight) of the leaves of B. acutangula were assessed for antidiabetic activity in a streptozotocin(STZ)-induced diabetes animal model following 21 days of treatment. Glibenclamide(0.6 mg kg 1p.o.) was used as a positive control. The hematological parameters, such as blood glucose level, urea, creatinin, cholesterol, HDL-C, and LDL-C levels were examined. RESULTS: An acute toxicity study(5 000 mg kg 1, p.o.) did not produce any symptoms of toxicity. Significant reductions in blood glucose level, and serum total cholesterol and triglyceride levels were noted in animals treated with the extract. The high density lipoprotein-cholesterol(HDLC) level was found to increase as compared with the diabetic control group. CONCLUSION: These results suggest that the leaf aqueous and ethanolic extracts of B. acutangula have anti-diabetic effects. The aqueous extract of B. acutangula produced a similar effect when compared with the ethanol extract. It is proposed that consumption of B. acutangula in some form like tea may help the management of diabetes.展开更多
文摘Objective:To evaluate the anti-ulcer activity and acute toxicity ofFicus religiosa(F. religiosa)leaf ethanolic extract in animal models.Methods:Anti-ulcer activity ofF. religiosaethanolicextract(250 and 500 mg/kg body weight) was studied on stress induced ulcer animal models.Ranitidine was used as standard. The anti-ulcer activity ofF. religiosawas evaluated with thehelp of ulcer area and histopatholgical examination. Preliminary phyto-chemical screeningand acute toxicity studies ofF. religiosaalso carried out.Results:Results showed that theextract treatments prevented ulcer area and gastric secretion in a dose-dependent manner.Administration of 2000 mg/kg extract did not show any acute toxicity in albino mice. Preliminaryphytochemical analysis identified the presence of flavonoids in the ethanolic extract ofF. religiosa.Conclusions:The extract is non-toxic even at relatively high concentrations. The anti-ulceractivity is probably due to the presence of flavanoids.
文摘Objective:To evaluate the analgesic activity of the ethyl acetate,methanol and aqueous extracts of Plewotus eous(P.eous) mushroom.Methods:The dried fruiting bodies were extracted with ethyl acetate,methanol and water.The analgesic effect of extracts of P.eous were investigated at doses 250 500 and 1 000 mg/kg body weight,using acetic-acid induced writhing,hot-plate,tail immersion and tail-clip tests.Results:P.eous extracts produced significant reduction in number of writhes induced by intraperitoneal injection of acetic-acid(P【0.05).Moreover,in hot-plate and tail immersion test,all the three extracts significantly raised the pain threshold at different time of observation(0-60 min) in comparison with control(P【0.05).In tail-clip test the extracts also caused a significant inhibition of pain at both the doses used(P【0.05).Conclusions:The results of present study suggest that extracts of P.eous possess potent analgesic property and could serve as a base for future drugs.
基金supported by University Grant Commission(UGC),New Delhi,India(No.32/135/2006(SR))
文摘AIM: This study was aimed at evaluating the anti-diabetic activity of the ethanol and aqueous extracts of the leaf material of Barringtonia acutangula in a diabetic animal model. METHODS: The ethanolic and aqueous extracts(250 and 500 mg kg 1body weight) of the leaves of B. acutangula were assessed for antidiabetic activity in a streptozotocin(STZ)-induced diabetes animal model following 21 days of treatment. Glibenclamide(0.6 mg kg 1p.o.) was used as a positive control. The hematological parameters, such as blood glucose level, urea, creatinin, cholesterol, HDL-C, and LDL-C levels were examined. RESULTS: An acute toxicity study(5 000 mg kg 1, p.o.) did not produce any symptoms of toxicity. Significant reductions in blood glucose level, and serum total cholesterol and triglyceride levels were noted in animals treated with the extract. The high density lipoprotein-cholesterol(HDLC) level was found to increase as compared with the diabetic control group. CONCLUSION: These results suggest that the leaf aqueous and ethanolic extracts of B. acutangula have anti-diabetic effects. The aqueous extract of B. acutangula produced a similar effect when compared with the ethanol extract. It is proposed that consumption of B. acutangula in some form like tea may help the management of diabetes.
