With the increasing development of Internet technology,computer Internet,intelligent terminal,cloud computing and other new technologies continue to emerge.All kinds of app based on mobile intelligent terminal are wid...With the increasing development of Internet technology,computer Internet,intelligent terminal,cloud computing and other new technologies continue to emerge.All kinds of app based on mobile intelligent terminal are widely used because of its convenience and intelligence.However,for the safety of the coal industry,how to use these technologies based on mobile intelligent terminal to establish a set of efficient long-term mechanism of safety inspection and risk control is a necessary method to upgrade the safety management mode.Therefore,in order to meet the requirements of hidden danger investigation and management,this paper designs an intelligent hidden danger investigation and management system.Based on Ionic,the system constructs a cross platform mixed mode mobile app development framework.The paper shows that the system can realize the basic hidden danger investigation requirements.展开更多
Advancements in forming technology offer significant advantages for the manufacturing industry,including enhanced efficiency,energy conservation,and improved material utilization[1].However,traditional additive manufa...Advancements in forming technology offer significant advantages for the manufacturing industry,including enhanced efficiency,energy conservation,and improved material utilization[1].However,traditional additive manufacturing[2],thermoplastic forming[3],and laser cutting[4]encounter challenges when applied in under-liquid environments,mainly due to difficulties in temperature control and heat source provision.展开更多
Dialect is important in our live,we can find our culture and identity through it.As the economic center of China,Shanghai enjoys high prosperity and rich culture,people in Shanghai have different attitude towards dial...Dialect is important in our live,we can find our culture and identity through it.As the economic center of China,Shanghai enjoys high prosperity and rich culture,people in Shanghai have different attitude towards dialect compare with people in Beijing.This thesis goes to analysis the reason behind this interesting phenomenon.展开更多
Lycium ruthenicum Murray,a plant widely cultivated in northwestern China,is integral to traditional Chinese medicine,with applications in treating menstrual disorders,cardiovascular diseases,and menopausal symptoms.De...Lycium ruthenicum Murray,a plant widely cultivated in northwestern China,is integral to traditional Chinese medicine,with applications in treating menstrual disorders,cardiovascular diseases,and menopausal symptoms.Despite its recognized medicinal value and use as a functional food,comprehensive knowledge of its metabolites and their pharmacological effects remains limited.This study presents an innovative approach using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC–QTOF/MS)to conduct a detailed analysis of both wild and cultivated L.ruthenicum samples.A total of 62 peaks were detected in the total ion current profile,with 59 metabolites identified based on accurate mass and MS/MS fragmentation patterns.Multivariate analyses revealed distinct chemical profiles that effectively differentiate between wild and cultivated samples,identifying six key chemical markers crucial for the classification of L.ruthenicum varieties.Furthermore,a comprehensive interaction network was constructed,highlighting the top 20 significant pathways,which elucidates the components–targets–pathways–disease relationships.These findings not only provide a robust methodology for quality assessment and geographical discrimination of L.ruthenicum but also lay a theoretical foundation for its future exploration in traditional Chinese medicine,thereby enhancing its potential as both a medicinal and functional food source.展开更多
The amorphization of alloys is of both broad scientific interests and engineering significance.Despite considered as an efficient strategy to regulate and even achieve record-breaking properties of metallic materials,...The amorphization of alloys is of both broad scientific interests and engineering significance.Despite considered as an efficient strategy to regulate and even achieve record-breaking properties of metallic materials,a facile and rapid method to trigger solid-state amorphization is still being pursued.Here we report such a method to utilize ultrasonic vibration to trigger amorphization of intermetallic compound.The ultrasonic vibrations can cause tunable amorphization at room temperature and low stress(2 MPa)conveniently.Remarkably,the ultrasonic-induced amorphization could be achieved in 60 s,which is 360 times faster than the ball milling(2.16×10^(4) s)with the similar proportion of amorphization.The elements redistribute uniformly and rapidly via the activated short-circuit diffusion.Both experimental evidences and simulations show that the amorphous phase initiates and expands at nanograin boundaries,owing to the induction of lattice instability.This work provides a groundbreaking strategy for developing novel materials with tunable structures and properties.展开更多
Introduction:To explore the feasibility of pulsed ultraviolet(UV)light technology for low-temperature disinfection,a series of experiments were conducted.Methods:Pulsed UV technology’s effectiveness in disinfecting G...Introduction:To explore the feasibility of pulsed ultraviolet(UV)light technology for low-temperature disinfection,a series of experiments were conducted.Methods:Pulsed UV technology’s effectiveness in disinfecting Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli on different carriers were studied under varying temperatures.Results:Under different temperatures and constant radiation illumination(i.e.,distance),the disinfection effect was correlated with irradiation time;among the three carriers,the disinfection effect of cloth sheets was the best,followed by stainless steel sheets,and corrugated paper sheet.The disinfection effect on Gram-negative bacteria Escherichia coli was better than that on Gram-positive bacteria Staphylococcus aureus overall.Discussion:Temperature has a limited effect on pulsed UV disinfection.Irradiation times and carrier types are influencing factors.展开更多
A facile,precise,and controllable manufacturing technology is desired for hierarchical functional surfaces.In this work,we successfully manufactured porous metallic glass using a water-dissolution material as template...A facile,precise,and controllable manufacturing technology is desired for hierarchical functional surfaces.In this work,we successfully manufactured porous metallic glass using a water-dissolution material as template and the excellent thermoplastic property of metallic glass.The prepared micro/nanostructures have excellent tunability,and the proposed approach can be used to prepare large-area disordered porous structures and ordered regular arrays with nanoscale replication accuracy.In particular,the disordered porous structure prepared by the dissolvable template strategy exhibits a water contact angle of~140°and an oil contact angle of~0°,making it suitable for oil/water separation.It also shows stable wettability after being soaked in strong acid or alkali environments and maintains a~130°water contact angle and a~4°oil contact angle even after severe wear.The proposed strategy also possesses excellent recycling properties.We reconstructed porous structures on the same surface three times and found no significant change in wettability for each reconstructed porous structure.Our research provides a facile and controllable approach for the preparation of hierarchical porous structures and paves the way for the design of other functional surfaces.展开更多
To investigate the potential of direct ultrasonic vibration on improving the performance of magnesium alloys,this study first employed the ultrasonic vibration compression(UVC)on the solid solution treated AZ91 alloy,...To investigate the potential of direct ultrasonic vibration on improving the performance of magnesium alloys,this study first employed the ultrasonic vibration compression(UVC)on the solid solution treated AZ91 alloy,and explored its microstructure evolution and mechanical properties under UVC.Within only two seconds,the UVC alloys showed large deformation strains of 34.8–54.4%,and sudden increase of sample temperature to 243℃.Microstructure characterizations proved that UVC promoted the formation of abundant shear bands,fine grains,and the bimodal distribution of Mg17Al12 precipitates consisting of submicron particles located within the shear bands and nano-sized ones within the matrix.Owing to the unique microstructure,the micro-hardness(and nano-hardness)value of UVC alloy was increased by 37.7%(35%)when compared with the solution-treated alloy.Moreover,the nano-modulus of the developed AZ91 alloy was also significantly increased to 62 GPa by statistical nanoindentation tests,which could be ascribed to increased Mg_(17)Al_(12) precipitates and decreased c/a value to some extent.In general,this work provides a new insight into the design and preparation of high-performance magnesium alloys by UVC at room temperature.展开更多
Introduction:Since the outbreak of coronavirus disease 2019(COVID-19)in Beijing Xinfadi Wholesale Market,a series of COVID-19 outbreaks has indicated the threat of transmission due to outer surfaces of objects under l...Introduction:Since the outbreak of coronavirus disease 2019(COVID-19)in Beijing Xinfadi Wholesale Market,a series of COVID-19 outbreaks has indicated the threat of transmission due to outer surfaces of objects under low temperatures.Therefore,2 kinds of chlorine-containing disinfectants for−18℃and−40℃were developed in order to solve the problem of low temperature disinfection.Methods:The properties of two cryogenic disinfectants were evaluated by low-temperature test.Staphylococcus aureus and Escherichia coli were used as two indicator microorganisms to evaluate the effects of the two cryogenic disinfectants in the laboratory and field tests according to Technical Specifications for Disinfection(2002 version)and Test method for bactericidal effect of disinfectants in laboratory(GB/T 38502-2020).Results:Two disinfectants could remain in the liquid state at−18℃or−40℃in 72 hours without crystallization and precipitation,and the average log values of microbial reduction before and after disinfection(the average killing log value)both on Staphylococcus aureus and Escherichia coli were>3 in the laboratory and field tests.Discussion:The results showed that these two disinfectants remained functional at low temperature to disinfect the packaging of imported cold chain food and surrounding packaging to prevent transmission of COVID-19 from material to people.展开更多
Alzheimer’s disease(AD)is the major form of dementia in the elderly and is closely related to the toxic effects of microglia sustained activation.In AD,sustained microglial activation triggers impaired synaptic pruni...Alzheimer’s disease(AD)is the major form of dementia in the elderly and is closely related to the toxic effects of microglia sustained activation.In AD,sustained microglial activation triggers impaired synaptic pruning,neuroinflammation,neurotoxicity,and cognitive deficits.Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with regulating microglia function.Here,we use RNA sequencing to identify a deubiquitinase YOD1 as a regulator of microglial function and AD pathology.Further study showed that YOD1 knockout significantly improved the migration,phagocytosis,and inflammatory response of microglia,thereby improving the cognitive impairment of AD model mice.Through LCeMS/MS analysis combined with Co-IP,we found that Myosin heavy chain 9(MYH9),a key regulator maintaining microglia homeostasis,is an interacting protein of YOD1.Mechanistically,YOD1 binds to MYH9 and maintains its stability by removing the K48 ubiquitin chain from MYH9,thereby mediating the microglia polarization signaling pathway to mediate microglia homeostasis.Taken together,our study reveals a specific role of microglial YOD1 in mediating microglia homeostasis and AD pathology,which provides a potential strategy for targeting microglia to treat AD.展开更多
文摘With the increasing development of Internet technology,computer Internet,intelligent terminal,cloud computing and other new technologies continue to emerge.All kinds of app based on mobile intelligent terminal are widely used because of its convenience and intelligence.However,for the safety of the coal industry,how to use these technologies based on mobile intelligent terminal to establish a set of efficient long-term mechanism of safety inspection and risk control is a necessary method to upgrade the safety management mode.Therefore,in order to meet the requirements of hidden danger investigation and management,this paper designs an intelligent hidden danger investigation and management system.Based on Ionic,the system constructs a cross platform mixed mode mobile app development framework.The paper shows that the system can realize the basic hidden danger investigation requirements.
基金supported by the Key Basic and Applied Research Program of Guangdong Province,China(2019B030302010)the National Natural Science Foundation of China(52122105,51971150)+2 种基金the Shenzhen Fundamental Research Program(JCYJ20210324121011031)the Science and Technology Innovation Commission Shenzhen(RCJC20221008092730037 and 20220804091920001)the National Key Research and Development Program of China(2018YFA0703605).
文摘Advancements in forming technology offer significant advantages for the manufacturing industry,including enhanced efficiency,energy conservation,and improved material utilization[1].However,traditional additive manufacturing[2],thermoplastic forming[3],and laser cutting[4]encounter challenges when applied in under-liquid environments,mainly due to difficulties in temperature control and heat source provision.
文摘Dialect is important in our live,we can find our culture and identity through it.As the economic center of China,Shanghai enjoys high prosperity and rich culture,people in Shanghai have different attitude towards dialect compare with people in Beijing.This thesis goes to analysis the reason behind this interesting phenomenon.
基金supported by Qinghai Science and Technology Achievement Transformation Project(2021-SF-149),awarded to C.ChenInnovation and Entrepreneurship Training Program for College Students(S202410373040),awarded to C.ChenAnhui Provincial College Student Innovation and Entrepreneurship Project(20221502032),awarded to C.Chen.
文摘Lycium ruthenicum Murray,a plant widely cultivated in northwestern China,is integral to traditional Chinese medicine,with applications in treating menstrual disorders,cardiovascular diseases,and menopausal symptoms.Despite its recognized medicinal value and use as a functional food,comprehensive knowledge of its metabolites and their pharmacological effects remains limited.This study presents an innovative approach using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC–QTOF/MS)to conduct a detailed analysis of both wild and cultivated L.ruthenicum samples.A total of 62 peaks were detected in the total ion current profile,with 59 metabolites identified based on accurate mass and MS/MS fragmentation patterns.Multivariate analyses revealed distinct chemical profiles that effectively differentiate between wild and cultivated samples,identifying six key chemical markers crucial for the classification of L.ruthenicum varieties.Furthermore,a comprehensive interaction network was constructed,highlighting the top 20 significant pathways,which elucidates the components–targets–pathways–disease relationships.These findings not only provide a robust methodology for quality assessment and geographical discrimination of L.ruthenicum but also lay a theoretical foundation for its future exploration in traditional Chinese medicine,thereby enhancing its potential as both a medicinal and functional food source.
基金financially supported by the Key Basic and Applied Research Program of Guangdong Province,China(No.2019B030302010)the National Natural Science Foundation of China(Nos.52122105,51971150,51871157)+3 种基金the National Key Research and Development Program of China(No.2018YFA0703605)the financial support from the National Natural Science Foundation of China(No.12072344)the Youth Innovation Promotion Association of the Chinese Academy of Sciencessupported by the Beijing Electron Positron Collider(BEPC)project(No.2020-BEPC-PT-004661).
文摘The amorphization of alloys is of both broad scientific interests and engineering significance.Despite considered as an efficient strategy to regulate and even achieve record-breaking properties of metallic materials,a facile and rapid method to trigger solid-state amorphization is still being pursued.Here we report such a method to utilize ultrasonic vibration to trigger amorphization of intermetallic compound.The ultrasonic vibrations can cause tunable amorphization at room temperature and low stress(2 MPa)conveniently.Remarkably,the ultrasonic-induced amorphization could be achieved in 60 s,which is 360 times faster than the ball milling(2.16×10^(4) s)with the similar proportion of amorphization.The elements redistribute uniformly and rapidly via the activated short-circuit diffusion.Both experimental evidences and simulations show that the amorphous phase initiates and expands at nanograin boundaries,owing to the induction of lattice instability.This work provides a groundbreaking strategy for developing novel materials with tunable structures and properties.
文摘Introduction:To explore the feasibility of pulsed ultraviolet(UV)light technology for low-temperature disinfection,a series of experiments were conducted.Methods:Pulsed UV technology’s effectiveness in disinfecting Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli on different carriers were studied under varying temperatures.Results:Under different temperatures and constant radiation illumination(i.e.,distance),the disinfection effect was correlated with irradiation time;among the three carriers,the disinfection effect of cloth sheets was the best,followed by stainless steel sheets,and corrugated paper sheet.The disinfection effect on Gram-negative bacteria Escherichia coli was better than that on Gram-positive bacteria Staphylococcus aureus overall.Discussion:Temperature has a limited effect on pulsed UV disinfection.Irradiation times and carrier types are influencing factors.
基金supported by the Key Basic and Applied Research Program of Guangdong Province,China(2019B030302010)the National Natural Science Foundation of China(52122105,51871157,and 51971150)the National Key Research and Development Program of China(2018YFA0703604)。
文摘A facile,precise,and controllable manufacturing technology is desired for hierarchical functional surfaces.In this work,we successfully manufactured porous metallic glass using a water-dissolution material as template and the excellent thermoplastic property of metallic glass.The prepared micro/nanostructures have excellent tunability,and the proposed approach can be used to prepare large-area disordered porous structures and ordered regular arrays with nanoscale replication accuracy.In particular,the disordered porous structure prepared by the dissolvable template strategy exhibits a water contact angle of~140°and an oil contact angle of~0°,making it suitable for oil/water separation.It also shows stable wettability after being soaked in strong acid or alkali environments and maintains a~130°water contact angle and a~4°oil contact angle even after severe wear.The proposed strategy also possesses excellent recycling properties.We reconstructed porous structures on the same surface three times and found no significant change in wettability for each reconstructed porous structure.Our research provides a facile and controllable approach for the preparation of hierarchical porous structures and paves the way for the design of other functional surfaces.
基金supported by the National Natural Science Foundation of China(Nos.52271101,51901068)the Project on Excellent Post-graduate Dissertation of Hohai University(No.422003518)+3 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX23_0175)the Key Research and Development Program of Jiangsu Province(No.BE2021027)the Suzhou Science and Technology Project(Nos.SYG202312,SJC2023005,SZS2023023)the Nanjing Major Science and Technology Project(No.202309015).
文摘To investigate the potential of direct ultrasonic vibration on improving the performance of magnesium alloys,this study first employed the ultrasonic vibration compression(UVC)on the solid solution treated AZ91 alloy,and explored its microstructure evolution and mechanical properties under UVC.Within only two seconds,the UVC alloys showed large deformation strains of 34.8–54.4%,and sudden increase of sample temperature to 243℃.Microstructure characterizations proved that UVC promoted the formation of abundant shear bands,fine grains,and the bimodal distribution of Mg17Al12 precipitates consisting of submicron particles located within the shear bands and nano-sized ones within the matrix.Owing to the unique microstructure,the micro-hardness(and nano-hardness)value of UVC alloy was increased by 37.7%(35%)when compared with the solution-treated alloy.Moreover,the nano-modulus of the developed AZ91 alloy was also significantly increased to 62 GPa by statistical nanoindentation tests,which could be ascribed to increased Mg_(17)Al_(12) precipitates and decreased c/a value to some extent.In general,this work provides a new insight into the design and preparation of high-performance magnesium alloys by UVC at room temperature.
文摘Introduction:Since the outbreak of coronavirus disease 2019(COVID-19)in Beijing Xinfadi Wholesale Market,a series of COVID-19 outbreaks has indicated the threat of transmission due to outer surfaces of objects under low temperatures.Therefore,2 kinds of chlorine-containing disinfectants for−18℃and−40℃were developed in order to solve the problem of low temperature disinfection.Methods:The properties of two cryogenic disinfectants were evaluated by low-temperature test.Staphylococcus aureus and Escherichia coli were used as two indicator microorganisms to evaluate the effects of the two cryogenic disinfectants in the laboratory and field tests according to Technical Specifications for Disinfection(2002 version)and Test method for bactericidal effect of disinfectants in laboratory(GB/T 38502-2020).Results:Two disinfectants could remain in the liquid state at−18℃or−40℃in 72 hours without crystallization and precipitation,and the average log values of microbial reduction before and after disinfection(the average killing log value)both on Staphylococcus aureus and Escherichia coli were>3 in the laboratory and field tests.Discussion:The results showed that these two disinfectants remained functional at low temperature to disinfect the packaging of imported cold chain food and surrounding packaging to prevent transmission of COVID-19 from material to people.
基金supported by the National Natural Science Foundation of China(21961142009 to Guang Liang and 82360805 to Jinfeng Sun)Zhejiang Provincial Key Scientific Project(2021C03041 to Guang Liang)+1 种基金Natural Science Foundation of Zhejiang province(LQ23H090018 to Xia Zhao)Medical and health Science and Technology Project of Zhejiang Province(2024KY055 to Xia Zhao).
文摘Alzheimer’s disease(AD)is the major form of dementia in the elderly and is closely related to the toxic effects of microglia sustained activation.In AD,sustained microglial activation triggers impaired synaptic pruning,neuroinflammation,neurotoxicity,and cognitive deficits.Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with regulating microglia function.Here,we use RNA sequencing to identify a deubiquitinase YOD1 as a regulator of microglial function and AD pathology.Further study showed that YOD1 knockout significantly improved the migration,phagocytosis,and inflammatory response of microglia,thereby improving the cognitive impairment of AD model mice.Through LCeMS/MS analysis combined with Co-IP,we found that Myosin heavy chain 9(MYH9),a key regulator maintaining microglia homeostasis,is an interacting protein of YOD1.Mechanistically,YOD1 binds to MYH9 and maintains its stability by removing the K48 ubiquitin chain from MYH9,thereby mediating the microglia polarization signaling pathway to mediate microglia homeostasis.Taken together,our study reveals a specific role of microglial YOD1 in mediating microglia homeostasis and AD pathology,which provides a potential strategy for targeting microglia to treat AD.
